A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor.

BACKGROUND: The neurochemical and biological effects of antidepressant medications have become better defined over the last decade. When the anti-depressant bupropion was introduced in the United States in 1989, the specific pharmacologic basis of its clinical effects was uncertain. Research conducted over the past decade has significantly advanced the understanding of the neuropharmacology of bupropion and has demonstrated a novel mechanism of antidepressant activity.

Unicompartmental knee arthroplasty: 3- to 10-year results in a community hospital setting.

The results of 40 medial unicompartmental knee arthroplasties, performed by a single surgeon in a community hospital setting, with an average follow-up of 6 years (range, 3-10 years), were analyzed retrospectively. The Knee Society rating system was used, revealing an average score of 80.5 points and 79% good-to-excellent results.