246 results match your criteria: "Mount Kenya University[Affiliation]"

Background: Maternal and child health remains a global priority, with antenatal care (ANC) recognized as essential for ensuring positive pregnancy outcomes. Despite significant improvements, in low- and middle-income countries, ANC service utilization remains low in Sub-Saharan Africa. This paper contributes to the understanding of the evolution and determinants of ANC service utilization among women of reproductive age in Rwanda.

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Malaria rapid diagnostic tests (RDTs) targeting the Plasmodium falciparum histidine-rich protein 2 (PfHRP2) are widely used to diagnose P. falciparum infection. However, reports of P.

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anti-prostate cancer efficacy and phytochemical composition of the dichloromethane and ethyl acetate leaf extracts of (sweet).

Front Pharmacol

November 2024

Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya.

Background: Prostate cancer is a significant global health concern, particularly among ageing male populations, with a disproportionately higher burden in sub-Saharan Africa. Conventional treatments, though effective, are costly and cause devastating side effects which limit their clinical benefits. Hence, this study evaluated the antiprostate cancer properties and secondary metabolites of dichloromethane and ethyl acetate lead extracts of to explore safer and efficacious natural alternatives based on ethnomedicinal claims.

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Background: The antioxidant and anticancer potential of natural compounds, particularly from medicinal plants, is increasingly being explored as alternatives to synthetic antioxidants and chemotherapeutics. Boascia coriacea (Pax) has been traditionally used for treating various ailments, including oxidative stress-related diseases and prostate cancer. However, there is a paucity of empirical evidence to validate the ethnomedicinal claims, hence this study.

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Background: Patient satisfaction is a crucial indicator of healthcare quality, influencing outcomes and providing insights for improvement. This study aims to assess patient satisfaction levels, and associated factors, and identify areas for enhancement at Remera Rukoma District Hospital (RRDH) in Rwanda, where such data was previously lacking.

Methods: A cross-sectional study using a mixed approach of data collection was conducted, involving 384 participants (164 inpatients, 220 outpatients).

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This study aimed to characterize the cervical cancer diagnosis experience of Kenyan women undergoing treatment for cervical cancer. We analyzed qualitative interviews with 29 women living in rural Kenya who were currently undergoing cervical cancer treatment at Machakos Cancer Care and Research Centre at Machakos Level 5 Referral Hospital in eastern Kenya. Semistructured qualitative interviews were conducted in Kiswahili and English and then de-identified and translated to English during transcription.

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Microbial contamination and the need for sustainable food production are driving the shift toward biodegradable food packaging materials. There is an urgent need to develop smart food packaging materials that can prevent contamination and prolong the shelf life of meat. To achieve this, the physical-chemical characteristics of polyvinyl alcohol (PVA)-based packaging films were enhanced through incorporation of lactic acid and anthocyanins to act as a pH indicator.

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Introduction: Globally, long-distance truck drivers' (LDTDs) risk of exposure to HIV infections is higher compared with other populations in transit. Thus, several HIV prevention interventions have been implemented, though to a narrower extent compared with other most at-risk populations. Consequently, the effectiveness of such interventions is not well understood.

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Article Synopsis
  • * A study conducted in Kirehe District found that out of 201 selected patients, 72.6% had uncontrolled T2DM, with higher risks for those who had previously missed appointments and those with additional health problems.
  • * The study emphasizes the need for healthcare providers to enhance patient follow-up through home visits and regular screenings to better manage and control diabetes and its complications.
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Background: Family planning (FP) is fundamental in addressing unwanted pregnancies, unplanned pregnancies, unsafe abortions, maternal and child mortalities. It plays a crucial role in achieving the Sustainable Development Goals (SDGs), especial Goal 3. However, despite a high FP discontinuation percentage of 30% in Rwanda, there is limited studies on the contributing factors.

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The increasing global population and the challenges associated with fossil fuel has led to a surge in energy demand, necessitating research on renewable and environmentally friendly energy sources. Biodiesel, is produced from biomass materials like vegetable oil and fats, is a promising alternative. Transesterification is a principal method used in biodiesel production, as it is simple, versatile, and efficient.

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  • Cancer is a significant global health crisis, with over 19 million diagnoses and 10 million deaths reported in 2020, and projections indicating that cancer-related deaths could exceed 30 million by 2030, especially in low- and middle-income countries like Kenya.
  • The study focused on Nyandarua County, Kenya, where there is no dedicated cancer registry, making it difficult to gather essential data for effective cancer prevention and management programs.
  • A demographic survey collected data from hospital records (2013-2020) and documented 1,373 cancer cases, identifying the leading cancer types: esophagus, cervix, stomach, breast, and prostate, highlighting the need for continuous cancer data collection through a
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Malaria remains a key health and economic problem, particularly in sub-Saharan Africa. The emergence of artemisinin drug resistance (ART-R) parasite strains poses a serious threat to the control and elimination of this scourge. This is because artemisinin-based combination therapies (ACTs) remain the first-line treatment in the majority of malaria-endemic regions in Sub-Saharan Africa.

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  • Soil nutrition is essential for agricultural success, but in places like Kenya, access to soil testing is limited, prompting a study on farmers' perceptions and their willingness to pay for new testing technology.
  • A sample of 547 farmers in central Kenya showed that only 1.5% currently test their soils due to high costs and distance to testing facilities, yet they demonstrated a willingness to pay for more accessible testing solutions.
  • The study indicated that farmers, especially youth and women, are open to sharing their soil data, which could enhance agricultural productivity and support commercialization of their activities if efficient soil testing technologies become available.
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  • * A study at Webuye Hospital analyzed the knowledge, attitudes, and practices of 140 pregnant women about IPT, revealing malaria-positive women had significantly better knowledge of side effects and dosing compared to malaria-negative women.
  • * Findings suggest that enhancing knowledge and practices regarding IPT can empower pregnant women in malaria-endemic regions, ultimately improving their health outcomes.
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  • - Air pollution is a major global issue, and this study focused on understanding indoor particulate matter (PM) levels in selected primary schools in Kigali, Rwanda, due to a lack of data on air quality in the region.
  • - Researchers used mobile air sensors to collect PM data from classrooms in six schools during the dry season and performed statistical tests to analyze the differences in PM levels, finding significant variations between schools.
  • - Results showed higher concentrations of indoor PM in schools located in highly exposed areas compared to those in moderately exposed ones, with all measured PM levels exceeding World Health Organization guidelines, indicating a need for interventions to improve air quality in these schools.
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  • This study investigates mixed-species malaria infections in children in the Lake Victoria region of Kenya over multiple years, revealing a high prevalence of both single and co-infections.
  • Results show that while Plasmodium falciparum (Pf) was the dominant species, significant rates of co-infections with P. malariae (Pm) and P. ovale (Po) were found, affecting clinical outcomes.
  • The findings suggest that mixed infections may alter the manifestation of malaria, leading to decreased fever but increased risks of splenomegaly and anemia, highlighting the need for better diagnostic approaches.
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East African countries accounted for ~ 10% of all malaria prevalence worldwide in 2022, with an estimated 23.8 million cases and > 53,000 deaths. Despite recent increases in malaria incidence, high-resolution genome-wide analyses of Plasmodium parasite populations are sparse in Kenya, Tanzania, and Uganda.

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Genetic variation present in the CYP3A4 gene in Ni-Vanuatu and Kenyan populations in malaria endemicity.

Drug Metab Pharmacokinet

August 2024

Department of Parasitology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan; Island Malaria Group, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Article Synopsis
  • The CYP3A4 enzyme is crucial for metabolizing about 30% of drugs, including key antimalarials, and variations in this enzyme can lead to differences in drug metabolism among individuals.
  • Researchers studied CYP3A4 polymorphisms in populations from malaria-affected regions in Lake Victoria, Kenya, and Vanuatu, analyzing archived blood samples to find genetic variations.
  • They identified multiple single nucleotide polymorphisms (SNPs) in both regions, with a higher level of genetic variance in Vanuatu, contributing to better understanding and potential improvements in personalized medicine for antimalarial treatments.
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Background: There is a dearth of data on eczema from the African continent despite the purported increasing burden.

Objectives: To describe the prevalence of eczema at Kiambu Level 5 Hospital and patient skincare.

Methods: A descriptive retrospective cross-sectional research design was performed describing the period between 2016 and 2020.

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Schistosomiasis diagnosis: Challenges and opportunities for elimination.

PLoS Negl Trop Dis

July 2024

Centre for Research in Infectious Diseases, College of Graduate Studies and Research, Mount Kenya University, General Kago Rd, Thika, Kenya.

Article Synopsis
  • * Effective surveillance using accurate diagnostics is crucial for monitoring schistosomiasis control efforts, with microscopy still being the gold standard despite its limitations.
  • * The review discusses various diagnostic methods, their challenges, and highlights potential new approaches to improve schistosomiasis detection to support elimination efforts.
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Background: is a vegetable with therapeutic advantage for human diseases.

Objective: Evaluate nutritive and non-nutritive components, antioxidant activity, and Fourier transform infrared spectroscopy profile of L. cornuta leaves.

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  • - The study examined oral health knowledge, attitudes, and practices among 386 secondary students in Huye district, focusing on public schools while excluding boarding schools.
  • - Results showed that 1.8% of students had good knowledge about oral health, with most (56.2%) having average knowledge, and a significant number (74.6%) exhibiting poor oral hygiene practices.
  • - The findings indicate a need for improved oral health education within schools to promote better long-term oral hygiene practices.
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Objective: Food insecurity has been associated with mobility difficulty (MD) in old age. However, there is a scarcity of research on this topic from low- and middle-income countries, while the bio-psychological factors underlying this association are largely unknown. We investigated the food insecurity-MD link in Ghana and explored how sleep, anxiety, loneliness, and physical activity (PA) mediate the association.

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