1 results match your criteria: "Mossakowski Medical Reasearch Center Polish Academy of Sciences[Affiliation]"
Vascular effects of a tripeptide fragment of novokinine in hypertensive rats: Mechanism of the hypotensive action.
Pharmacol Rep
October 2014
Department of Renal and Body Fluid Physiology, Mossakowski Medical Reasearch Center Polish Academy of Sciences, Warszawa, Poland.
Background: Activation of angiotensin AT2 receptors (AT2R) counteracts vasoconstrictor effects of AT1R stimulation and contributes to blood pressure control. We examined effects on mean arterial pressure (MAP) and renal hemodynamics of LKP, a tripeptide fragment of novokinine, an established AT2R agonist.
Methods: Effects of intravenous LKP infusion and then superimposed losartan (AT1R antagonist) on MAP, total renal (RBF, Transonic probe) and renal medullary blood flows (laser-Doppler), and on renal excretion, were examined in anesthetized (1) Wistar rats with acute norepinephrine-induced hypertension, untreated or pretreated with AT2R antagonist (PD 123319) and (2) spontaneously hypertensive rats (SHR) maintained on standard or high-sodium (HS) diet.