Reduction of phase thickness is a characteristic reaction of the nucleoli to toxicity as shown by coherent phase microscopy.

Optical parameters of human cell nucleoli (HCT116 colorectal cancer cells) in depolymerization of microtubules and depletion of intracellular ATP pool were studied by coherent phase microscopy. These influences were associated with a rapid (recorded within the first minutes) reduction of the phase thickness of the nucleoli. These changes are similar to the nucleolar response to direct inhibitors of transcription.

Direct determination of traces of beryllium with eriochrome cyanine R by diffuse reflection spectroscopy using chromaticity functions.

Chromaton-N-super and Silasorb C18 (SMT C18) were compared as solid supports for the direct determination of the immobilized beryllium complexes with eriochrome cyanine R by diffuse reflection spectroscopy. The advantage of Silasorb C18 was shown. A detection limit of 0.

Improvement of direct determination of trace nickel in environmental samples by diffuse reflection spectroscopy using chromaticity characteristics.

Cellulose and chromaton-N-super as solid supports for direct determination of the immobilized nickel complexes with dimethylglyoxime and benzyldioxime by diffuse reflection spectroscopy were compared. The advantage of chromaton-N-super with use of benzyldioxime is shown. Detection limit is 0.