[Circadian changes in the structure of cardiac rhythm during pre-symptomatic and symptomatic stages of Parkinson's disease].

Aim: To study circadian regulation of heart rhythm during the pre-symptomatic (PS) and early symptomatic (ESS) stages of Parkinson's disease (PD) and determine the functionally most unfavorable periods during which there is a risk of life-threatening arrhythmias.

Material And Methods: The studies were performed on C57BL/6 mice. ECG monitoring was performed in online mode using a wireless telemetry system (ADInstruments Australia).

Myocardial hypertrophy of the left ventricle during familial arterial hypertension.

In patients with familial arterial hypertension and their relatives preclinical signs of myocardial hypertrophy were observed before the formation of stably increased blood pressure. We evaluated echocardiographic sings of left ventricular myocardial hypertrophy in normotensive relatives of patients with arterial hypertension.