124,313 results match your criteria: "Moscow; V.M. Buyanov's City Clinical Hospital[Affiliation]"

The content of 39 metals and metalloids (MMs) in submicron road dust (PM fraction) was studied in the traffic zone, residential courtyards with parking lots, and on pedestrian roads in parks in Moscow. The geochemical profiles of PM vary slightly between different types of roads and courtyards but differ significantly from those in parks. In Moscow, compared to other cities worldwide, submicron road dust contains less As, Sb, Mo, Cr, Cd, Sn, Tl, Ca, Rb, La, Y, U, but more Cu, Zn, Co, Fe, Mn, Ti, Zr, Al, V.

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Background: Thalamocortical functional and structural connectivity alterations may contribute to clinical phenotype of Autism Spectrum Disorder. As previous studies focused mainly on thalamofrontal connections, we comprehensively investigated between-group differences of thalamic functional networks and white matter pathways projecting also to temporal, parietal, occipital lobes and their associations with core and co-occurring conditions of this population.

Methods: A total of 38 children (19 with Autism Spectrum Disorder) underwent magnetic resonance imaging and behavioral assessment.

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Background: Several chemical studies described the physiological efficacy of 1,4- dihydropyridines (DHPs). DHPs bind to specific sites on the α1 subunit of L-type calcium channels, where they demonstrate a more pronounced inhibition of Ca2+ influx in vascular smooth muscle compared to myocardial tissue. This selective inhibition is the basis for their preferential vasodilatory action on peripheral and coronary arteries, a characteristic that underlies their therapeutic utility in managing hypertension and angina.

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Although microbial fuel cells (MFC) could be a promising energy source, their implementation is largely limited by low performance. There are several approaches to overcome this issue. For example, MFC performance can be enhanced using redox mediators (RM) capable of transferring electrons between microorganisms and MFC electrodes.

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Premise: Considering rapidly changing fire regimes due to anthropogenic disturbances to climate and fuel loads, it is crucial to understand the underpinnings driving fire-adapted trait evolution. Among the oldest lineages affected by fire is Coniferae. This lineage occupies a variety of fire prone and non-fire prone habitats across all hemispheres and has four fire-adapted traits: (1) thick bark; (2) serotiny; (3) seedling grass stage; and (4) resprouting ability.

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Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial.

Br J Anaesth

January 2025

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Background: The impact of noninvasive ventilation (NIV) managed outside the intensive care unit in patients with early acute respiratory failure remains unclear. We aimed to determine whether adding early NIV prevents the progression to severe respiratory failure.

Methods: In this multinational, randomised, open-label controlled trial, adults with mild acute respiratory failure (arterial oxygen partial pressure/fraction of inspiratory oxygen [Pao/FiO] ratio ≥200) were enrolled across 11 hospitals in Italy, Greece, and Kazakhstan.

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Optimizing combination targeted immunotoxin therapy: Insights from HER2 and EpCAM expression profiles.

Biochem Biophys Res Commun

December 2024

Moscow Center for Advanced Studies, Kulakova Str. 20, 123592, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia. Electronic address:

Molecular targeted cancer therapy is a rapidly developing field, driving progress toward greater treatment efficacy. However, targeted monotherapy often fails due to the development of multidrug resistance in tumors. The combination of multiple targeted agents emerges as a possible solution to enhance treatment outcomes by activating different signaling pathways.

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Contrasting effects of arsenic on mycorrhizal-mediated silicon and phosphorus uptake by rice.

J Environ Manage

January 2025

Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.

Silicon (Si) and arbuscular mycorrhizal fungi (AMF) increase plant resistance to various environmental stresses, including heavy metal (and metalloid) toxicity. Although Si and AMF each independently enhance plant tolerance, the nature of their interactions and their combined impacts on nutrient uptake, especially in the context of toxic elements such as arsenic (As), remains to be elucidated. This study investigated AMF-mediated regulation of plant nutrient uptake under As stress using rice, a model Si-accumulating plant.

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Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By combining LSCI and laser speckle entropy imaging with PCA filtering, the method effectively separates static and dynamic components of the speckle signal, significantly improving the accuracy of blood flow assessments, even in the presence of static scattering layers located above and below the vessel. Experiments conducted on optical phantoms, with the vessel depths ranging from 0.

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Extracellular hydrolytic activity (phospholipase, protease and hemolysin production) was evaluated in 178 strains of potentially pathogenic ascomycetous (Candida parapsilosis, Candida tropicalis) and basidiomycetous (Rhodotorula mucilaginosa) yeasts isolated from the excreta of Mew Gulls. Two bird colonies, one nesting in a natural habitat and the other in an urban habitat at the landfill, were studied simultaneously during their 7-month breeding season. Significant differences in phospholipase and protease production were found between natural and anthropophized strains.

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The Replicability Crisis and Human Agency in the Neo-Structured World.

Integr Psychol Behav Sci

January 2025

Department of Psychology, St. Petersburg State University, St. Petersburg, Russian Federation.

The paper analyzes current discussions concerning the so called "replicability crisis" - a notion describing difficulties in attempts to confirm existing research findings by their additional scrutiny or by new empirical studies. We propose interpretation that this "crisis" may be seen as a manifestation of the increasing inconsistency between, on the one hand, the outdated views on a human being and social structures dominating in the academic mainstream across various disciplines, including psychology and sociology, and, on the other hand, the reality of the emerging new stage of societal evolution, neo-structuration, which brings to the forefront individual agency. Our analysis suggests the possibilities for the future inter-disciplinary paradigmatic shift, which implies putting in the center of research not the idea of a constant or predictably developing individual in the context of solid external structures operating in line with a presumably sustainable "progress".

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Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Moscow, Russia.

Background: Dementia aggravates most cerebrovascular lesions, which requires differentiating the developed microcirculatory changes when making a diagnosis. We consider the features of cerebral microcirculation disorders in Alzheimer's disease (AD), distal cerebral atherosclerosis, Binswanger's disease (BD), and vascular parkinsonism (VP).

Method: The study included 1024 patients who underwent: assessment of CDR, TDR, MMSE, cerebral MRI, MRA, CT, MSCTA, scintigraphy (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA).

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R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

Phys Rev Lett

December 2024

State Key Laboratory of Particle Detection and Electronics, Beijing 100049, Hefei 230026, People's Republic of China.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

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Background: Enumeration of residual DNA repair foci 24 hours or more after exposure to ionizing radiation (IR) is often used to assess the efficiency of DNA double-strand break repair. However, the relationship between the number of residual foci in irradiated cells and the radiation dose is still poorly understood. The aim of this work was to investigate the dose responses for residual DNA repair foci in normal human fibroblasts after X-ray exposure in the absorbed dose range from 0.

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Background: The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021.

Methods: The total number and age-standardized rates of deaths and disability-adjusted life years (DALYs) from primary liver cancer attributable to each metabolic risk factor were extracted from the Global Burden of Disease Study 1990-2021.

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Aims: The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of marine fungal cerebroside flavuside B (FlaB) on Staphylococcus aureus-infected keratinocytes in in vitro skin wounds and to identify FlaB targets in bacterial and human cells.

Methods And Results: A combination of ELISA, plate spectrofluorimetry, and flow cytometry with fluorescence dye staining, scratch assay, and real-time cell imaging techniques was used to investigate the effects of FlaB on S. aureus-infected HaCaT keratinocytes.

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Structural and magnetic phase transitions in EuLaFe(BO) (x = 0, 0.18).

Acta Crystallogr B Struct Sci Cryst Eng Mater

February 2025

Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk 660036, Russian Federation.

The crystal structures and hyperfine magnetic parameters of EuFe(BO) and mixed EuLaFe(BO) were studied over a wide temperature range in order to analyze correlations of the structural and magnetic features and the phase transitions in multiferroic compounds of the rare-earth iron borate family. The chemical compositions of the crystals are reported from X-ray fluorescence analysis. The crystal structures of EuFe(BO) and EuLaFe(BO) were determined using single-crystal X-ray diffraction in the temperature range 25-500 K.

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According to the World Health Organization, the number of people suffering from depressive disorders worldwide is approaching 350 million. The consequences of depressive disorders include considerable worsening of the quality of life, which frequently leads to social isolation. One of the key factors which may cause depression in adulthood is early life stress, in particular, insufficient maternal care during infancy.

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Introduction: Time perception is a fundamental cognitive function, the brain mechanisms of which are not fully understood. Recent electroencephalography (EEG) studies have shown that neural oscillations in specific frequency bands may play a role in this process. In the current study, we sought to investigate how neurophysiological activity of cortical structures relates to subjective time estimations.

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Introduction: Aggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in rodents.

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Optimizing qubit performance through smoothing techniques.

Sci Rep

January 2025

Artificial Intelligence Technology Scientific and Education Center, Bauman Moscow State Technical University, 105005, Moscow, Russia.

This study explores an approach to enhance the performance of qubits by leveraging signal smoothing algorithms applied to qubit chips. The primary aim is to mitigate experimental variability and enhance overall stability, tied to the improvement of the Hamiltonian spectrum. By optimizing qubit operation through smoothing techniques, data processing for subsequent stages of two-tone qubit spectroscopy data transformation is facilitated.

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Gregarines from the families Dactylophoridae and Trichorhynchidae parasitize exclusively centipedes and have a distinct morphology among other terrestrial eugregarines, but their evolutionary relationships have not yet been studied with molecular methods. Here we obtain rDNA operon sequences for the dactylophorids and trichorhynchids. We describe a new species Trichorhynchus efeykini sp.

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All-solid-state batteries (ASSBs) with a garnet-type solid electrolyte have been considered promising alternatives to traditional batteries with a liquid organic electrolyte, due to their enhanced safety and ability to accommodate high energy density electrodes. In this study, we conducted a comprehensive investigation of the high-temperature chemical compatibility between the garnet-like LiGaLaZrO (Ga-LLZO) electrolyte and high-energy-density Li-rich layered LiNiMnO cathode (LNM). Our findings suggest that a high temperature reaction between the Li-rich cathode and Ga-LLZO occurs at 700-900C depending on the form of reactants.

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The coordination of chromatin remodeling is essential for DNA accessibility and gene expression control. The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays a central role in cell type- and context-dependent gene expression. Despite the absence of a defined DNA recognition motif, SWI/SNF binds lineage specific enhancers genome-wide where it actively maintains open chromatin state.

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Aim: to assess the relation of focal and diffuse left ventricular (LV) fibrosis to left bundle branch block (LBBB).

Materials And Methods: 60 patients with dilated cardiomyopathy and LBBB (DCM-LBBB), 50 DCM-nonLBBB patients, 15 patients with LBBB and structurally normal heart (idiopathic LBBB) and 10 healthy volunteers (HV) underwent cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE). LGE LV images were post-proceed for core scar (CS) and gray zone (GZ) calculation.

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