Detonation Nanodiamond Soot-A Structurally Tailorable Hybrid Graphite/Nanodiamond Carbon-Based Material.

The results of a comprehensive investigation into the structure and properties of nanodiamond soot (NDS), obtained from the detonation of various explosive precursors (trinitrotoluene, a trinitrotoluene/hexogen mixture, and tetryl), are presented. The colloidal behavior of the NDS particles in different liquid media was studied. The results of the scanning electron microscopy, dynamic light scattering, zeta potential measurements, and laser diffraction analysis suggested a similarity in the morphology of the NDS particle aggregates and agglomerates.

Size Dependence of the Band Gap of Core-Shell Tantalum and Tantalum Oxide (V) Nanoclusters.

Monodisperse films of spherical tantalum oxide (V) nanoclusters and spherical tantalum nanoclusters with a tantalum oxide shell with diameters of 1.4-8 nm were obtained by magnetron sputtering. The size of the deposited nanoclusters was controlled using a quadrupole mass filter.

Tungsten Diselenide Nanoparticles Produced via Femtosecond Ablation for SERS and Theranostics Applications.

Due to their high refractive index, record optical anisotropy and a set of excitonic transitions in visible range at a room temperature, transition metal dichalcogenides have gained much attention. Here, we adapted a femtosecond laser ablation for the synthesis of WSe nanoparticles (NPs) with diameters from 5 to 150 nm, which conserve the crystalline structure of the original bulk crystal. This method was chosen due to its inherently substrate-additive-free nature and a high output level.

Enhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI-Based Mixed Methods Study.

Background: Medical students often struggle to engage with and retain complex pharmacology topics during their preclinical education. Traditional teaching methods can lead to passive learning and poor long-term retention of critical concepts.

Objective: This study aims to enhance the teaching of clinical pharmacology in medical school by using a multimodal generative artificial intelligence (genAI) approach to create compelling, cinematic clinical narratives (CCNs).

Green Light Activated Dual-Action Pt(IV) Prodrug With Enhanced PDT activity.

Light induced release of cisplatin from Pt(IV) prodrugs is a promising tool for precise spatiotemporal control over the antiproliferative activity of Pt-based chemotherapeutic drugs. A combination of light-controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt-based chemotherapy and PDT via a synergetic effect. Herein we report green-light-activated Pt(IV) prodrug GreenPt with BODIPY-based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability.

Destabilization of Glycosyl Cation by an Electron-Withdrawing Substituent at C-5 Makes Sialylation Reaction More α-Stereoselective.

Comparison of the reactivity of sialyl chlorides and bromides based on -acetylneuraminic acid (Neu5Ac) and its deaminated analogue (KDN) in reactions with MeOH and -PrOH without a promoter revealed that the acetoxy group at C-5 in a molecule of a sialic acid glycosyl donor can destabilize the corresponding glycosyl cation making the S1-like reaction pathway unfavorable. A change to the S2-like reaction pathway ensures preferential formation of the α-glycoside.

The Novel Allele HLA-C*12:02:55 Identified by HLA-Typing of a Bone Marrow Donor.

The new HLA-C*12:02:55 allele showed one synonymous nucleotide difference compared to the HLA-С*12:02:02:01 allele in codon 134.

Novel Synonymous HLA-B*35:01:80 Allele Identified by Next-Generation Sequencing.

The new HLA-B*35:01:80 allele showed one synonymous nucleotide difference compared to the HLA-B*35:01:01:01 allele in codon 137.

HELMINTH EGGS FROM PACHYCROCUTA BREVIROSTRIS (CARNIVORA, HYAENIDAE) COPROLITES FROM TAURIDA CAVE (EARLY PLEISTOCENE, CRIMEA).

Twenty-seven Pachycrocuta brevirostris coprolites from Taurida Cave (Early Pleistocene) were studied. Eggs of parasitic worms were found in 6 of them (22.2%).

A retrospective study on ruthenium-106 and strontium-90 eye-plaques treatment for retinoblastoma: 16-years clinical experience.

Purpose: To retrospectively evaluate the efficacy of plaque brachytherapy for the treatment of retinoblastoma.

Methods: We retrospectively reviewed the clinical records of 163 patients (186 eyes, 333 tumors) treated with brachytherapy (Ru or Sr plaques) for intraocular retinoblastoma between November 2007 and August 2023.

Results: Complete tumor control was achieved in 273 tumors (82%).

Endocrinologic Dysfunctions and Neuropsychiatric Sequelae in Pediatric Patients With a History of Central Nervous System Infection (ENDLESS): A Prospective Monocentric Study.

Introduction: Central nervous system (CNS) infections represent some of the most critical pediatric health challenges, characterized by high mortality rates and a notable risk of long-term complications. Despite their significance, standardized guidelines for endocrinological follow-up of CNS infection survivors are lacking, leading to reliance on the expertise of individual centers and clinicians.

Materials And Methods: Prospective monocentric observational study conducted at the Fondazione Policlinico Universitario Agostino Gemelli in Rome, Italy.

Exploring Canadian Dietitians' Knowledge Attitude and Practices Providing Culturally Safe Care to Muslims who fast During the Month of Ramadan: A Cross-sectional Study.

Fasting during Ramadan involves abstaining from food and drink from dawn to dusk for 29 to 30 days, annually. Dietitians, experts in food and nutrition, play a vital role in fostering the well-being of Canadians. Given that 1 in 20 Canadians are Muslim, access to culturally safe care is essential for their health.

25-Hydroxycholesterol modulates synaptic vesicle endocytosis at the mouse neuromuscular junction.

Many synaptic vesicles undergo exocytosis in motor nerve terminals during neuromuscular communication. Endocytosis then recovers the synaptic vesicle pool and presynaptic membrane area. The kinetics of endocytosis may shape neuromuscular transmission, determining its long-term reliability.

Biomarkers.

Background: Dysfunction of the glymphatic system (GS), a recently discovered brain by-product elimination system, is considered to be one of the pathophysiological mechanisms for common neurodegenerative diseases such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease (PD). In 2017 a new way to assess the GS was proposed - a diffusion tensor images analysis along perivascular spaces (DTI-ALPS). In our work we evaluated the DTI-ALPS index in groups of patients with AD, DLB, PD and in a comparison group of patients with normal pressure hydrocephalus (NPH).

Biomarkers.

Background: The priority problem of modern healthcare is irreversible dementia due to the steady increase in morbidity. Among irreversible dementias, Alzheimer's disease takes the first place. Most often, only with sufficiently pronounced cognitive disorders, the doctor can diagnose Alzheimer's disease, although it is obvious that the neurodegenerative process begins even before the clinical manifestations of the disease.

Biomarkers.

Background: The ε4 allele of the apolipoprotein E (APOE4+) genotype and aging synergistically contribute to the risk of Alzheimer's disease (AD), but the mechanisms underlying their influence are not completely understood. The methylation of ELOVL2 DNA accounts for 70% of the variance in the aging epigenetic clock. The ELOVL2 gene is essential for synthesizing long polyunsaturated fatty acids, crucial for cell membrane integrity, inflammation modulation, and energy maintenance.

[Differential Diagnosis of Specific Cardiomyopathy in HIV-Adult With Myocardial Perfusion Imaging Via Single Photon Emission Computed Tomography].

The article presents a clinical case of secondary cardiomyopathy in an HIV patient with plasmablastic lymphoma due to the combined pathology (HIV infection with ongoing antiretroviral therapy in combination with antitumor therapy), in which the use of multimodal imaging contributed to establishing the correct diagnosis and excluding the unjustified use of invasive methods for diagnosing ischemic heart disease.

[The Influence of Antithrombotic Therapy on the Risk Factors for Cardiovascular Complications in Patients With Coronary Artery Disease And Diabetes Mellitus. Emphasis on Hypercoagulation].

Comorbid diabetes mellitus (DM) in patients with ischemic heart disease (IHD) is a serious factor that significantly impairs the life prognosis and increases the risk of cardiovascular complications (CVC) as well as the likelihood of death. The residual risk of developing CVC in such patients is largely determined by the high thrombotic status, that is associated with hypercoagulation characteristic of DM. Hypercoagulation causes activation of both platelet and coagulation pathways, which leads to an increased susceptibility to thrombosis.

Clinical and Diagnostic Value of ABCDE Stress Echocardiography With Exercise in Patients With Myocardial Infarction.

Aim: Evaluation of the clinical and diagnostic role of stepwise stress echocardiography (Stress Echo) with exercise using the ABCDE protocol in patients with myocardial infarction (MI).

Material And Methods: This single-site study included 75 patients (mean age 61.6±9.

The Frequency of Occurrence of Cardiovascular Risk Factors and Awareness оf Them Among Young People in Higher Education Institutions.

Objective: To assess the prevalence of risk factors  of cardiovascular disease (CV RF) development and awareness of them among young people studing at University.

Material And Methods: Сross-sectional study study included 1182 young men and women studying at Lomonosov Moscow State University (age 18-44 years), with no history of chronic non-infectious diseases, who underwent a screening  in April-June 2022. All participants filled out the standard "Questionnaire for citizens under the age of 65 years to identify chronic non-communicable diseases, risk factors for their development, and the use of narcotic drugs and psychotropic substances without prescription", a specially designed questionnaire on socio-demographic characteristics and risk factors for CVD development, and a questionnaire on nighttime sleep status.

Acute Decompensated Heart Failure: Structural and Functional Changes in Mitochondria.

Aim: Comparative assessment of structural changes in cardiomyocyte mitochondria of the right atrial appendage and the mitochondrial respiratory function in peripheral blood leukocytes in a cohort of patients after acute decompensated heart failure (ADHF) and with stable chronic heart failure of ischemic etiology with reduced ejection fraction (CHFrEF) or moderately reduced ejection fraction (CHFmrEF) of the left ventricle.

Material And Methods: The study analyzed 40 micrographs of right atrial appendage cardiomyocytes obtained from 12 patients with CHFrEF and CHFmrEF. The study protocol was registered on ClinicalTrials.

Characteristics of Atherosclerotic Plaques Left after Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome. Assessment According to Computed Tomographic Angiography of the Coronary Arteries.

Aim: To evaluate characteristics of atherosclerotic plaques (ASP) remaining after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) by coronary computed tomography angiography (CCTA).

Material And Methods: Among 249 patients (193 men) with ACS aged 58±10 years, 183 (73.5%) had myocardial infarction, 66 (26.

Biomarkers.

Background: The logopenic variant of primary progressive aphasia (lvPPA) is a disorder centered on language impairment. Alzheimer Disease (AD) is one of the most common underlying pathologies in lvPPA. The aim of our study was to estimate frequency of AD in this phenotype and to analyze clinical features of AD-lvPPA.

Developing Topics.

Background: White matter hyperintensity (WMH), which is considered a sign of vascular lesions, is often found in patients with DLB, but its association with vascular lesions has not been proven. We assessed WMH in patients with DLB and markers of vascular damage and vascular risk factors.

Method: We examined 78 patients that fulfilled clinical criteria of DLB.