Protomix: a Python package for H-NMR metabolomics data preprocessing.

Motivation: NMR-based metabolomics is a field driven by technological advancements, necessitating the use of advanced preprocessing tools. Despite this need, there is a remarkable scarcity of comprehensive and user-friendly preprocessing tools in Python. To bridge this gap, we have developed Protomix-a Python package designed for metabolomics research.

Enhanced antimicrobial and biofilm disruption efficacy of the encapsulated Thymus pallidus and Lavandula stoechas essential oils and their mixture: A synergistic approach.

The antimicrobial and antibiofilm properties of plant essential oils (EOs) have aroused significant interest for their potential as effective alternatives or supplements in combating microbial infections and biofilm-associated challenges. For these applications, EOs must be encapsulated to overcome some key technical limitations, including high volatility, poor stability, and low solubility. This study aimed to develop microencapsulated EOs derived from two valuable Moroccan medicinal plants, Lavandula stoechas L.

Recommendations for protecting against epidemic diseases in Morocco following recent flooding.

The recent floods in Morocco, occurring from September 16 to September 30, 2024, have created significant public health challenges, particularly in the regions of Tata, Ouarzazate, and Errachidia. These flooding events have heightened the risk of epidemic diseases, including vector-borne diseases like malaria and leishmaniasis, as well as waterborne infections. This letter outlines critical recommendations to mitigate these risks, including enhanced epidemiological surveillance, distribution of insecticidetreated nets, targeted vector control programs, and community engagement.

Unraveling the molecular mechanism of temperature-induced destabilization in the PqsE-RhlR complex of Pseudomonas aeruginosa at mammalian body temperature through classical molecular dynamics and metadynamics.

PqsE and RhlR, key regulators of the Pseudomonas aeruginosa quorum sensing (QS) system, form a hetero-tetrameric complex essential for controlling the expression of virulence factors such as pyocyanin. The interaction between the PqsE homodimer and the RhlR homodimer bound to C4-HSL, enables RhlR to bind low-affinity promoters, thereby influencing gene regulation. Recent studies suggest that RhlR transcriptional activity is modulated by temperature, exhibiting higher activity at environmental temperatures (25 °C) compared to mammalian body temperature (37 °C).

A novel sonogel-Leucine electrochemical sensor for the detection of neuroblastoma biomarker in human urine and synthetic cerebrospinal fluid.

A new Sonogel-Carbon (SNGC) electrode modified with an amino acid (l-leucine; Leu) has been developed for the sensitive detection of homovanillic acid (HVA). Electrochemical properties of leucine-modified Sonogel-Carbon (SNGC-Leu) were characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Comprehensive characterization using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier-transform infrared spectroscopy (FTIR), and powder X-ray diffraction (XRD) was conducted to investigate the structure of both SNGC-Leu and SNGC electrodes.

Health Related Quality of Life and Religiosity of Women with Cervical Cancer in the Souss-Massa Region, Morocco: A Cross-Sectional Study.

Background: Cervical cancer is a highly prevalent cancer among women, especially in low- and middle-income countries. This disease affects women in various ways and consequently impacts the quality of life of those diagnosed with this type of cancer. The aim of this study is to assess the quality of life and the degree of religiosity among women with cervical cancer in Morocco.

Amino-functionalized manganese oxide for effective hexavalent chromium adsorption.

This study explores the use of functionalized manganese oxide (K-MnO-NH) for the removal of hexavalent chromium (Cr(VI)) ions, a highly toxic heavy metal contaminant, from wastewater. The synthesis of K-MnO-NH was achieved through a two-step process, followed by comprehensive characterization using various analytical techniques, which confirmed the material's formation as a pure phase. The K-MnO-NH exhibited exceptional chromium removal efficiency, achieving up to 90% (4.

Ability of short-chain fatty acids to reduce inflammation and attract leucocytes to the inflamed skin of gilthead seabream (Sparus aurata L.).

The aim of the study was to investigate the potential preventive use of short-chain fatty acids (SCFAs) to modulate inflammatory responses in gilthead seabream (Sparus aurata) skin. Initially, in vitro experiments were conducted to evaluate the effects of various concentrations of butyric acid, acetic acid and propionic acid, as well as their combination, on the cytotoxicity and cell viability of three different cell lines. The results determined the safe concentration of SCFAs, which was then used for an in vivo study.

Nutritional value, HPLC-DAD analysis and biological activities of Ceratonia siliqua L. pulp based on in vitro and in silico studies.

The phytochemical, nutritional, and biological features of wild carob pulp from Tanzight (TN), Ait-Waada (AW), and Tizi-ghnayn (TG) in Azilal were studied. The results of the study reveal that the carob pulp examined has a low-fat level. AW had the most total sugar (78.

Immunologic assessment of the impact of SARS-CoV-2 vaccine booster doses on humoral immunity: a cross-sectional study in morocco.

To assess the impact of the SARS-CoV-2 booster dose on the immune response against COVID-19, we conducted a cross-sectional study in the Casablanca-Settat region of Morocco. The study included 2,802 participants from 16 provinces, all of whom had received three doses of a SARS-CoV-2 vaccine. IgG antibodies targeting the S1 RBD subunit of the SARS-CoV-2 spike protein were quantified using the SARS-CoV-2 IgG II Quant assay and measured on the Abbott Architect i2000SR instrument.

Surgical management of a large neurofibroma in the thenar Region: A case report.

Introduction: Neurofibromas are rare benign tumors of peripheral nerve sheaths, and hand involvement is particularly uncommon. This case report presents a large neurofibroma located in the thenar region, a critical area for thumb opposition and hand dexterity, posing unique surgical challenges.

Presentation Of Case: A 23-year-old female presented with a 3-year history of a progressively enlarging mass in the thenar region of the right hand, accompanied by nocturnal pain but no neurological deficits.

Follicular Cystitis, a Rare Diagnosis in an Emergency Setting: A case report and literature review.

Introduction And Importance: Follicular cystitis (FC) is a rare inflammatory disorder of the bladder that predominantly affects women. The exact cause of FC remains largely unknown, although it has been associated with inflammatory processes and bacterial infections, particularly following urinary tract infections. Regarding orphan diseases, like follicular cystitis, where large-scale trials seem virtually impossible, case reports find their place and guide the scientific community to find the best course of action.

Transgenic tomato strategies targeting whitefly eggs from apoplastic or ovary-directed proteins.

Background: Transgenic plants expressing proteins that target the eggs of the ubiquitous plant pest Bemisia tabaci (whitefly) could be an effective insecticide strategy. Two approaches for protein delivery are assessed using the mCherry reporter gene in transgenic tomato plants, while accommodating autofluorescence in both the plant, phloem-feeding whitefly and pedicle-attached eggs.

Results: Both transgenic strategies were segregated to homozygous genotype using digital PCR.

Advancing hepatitis B elimination: A systematic review of global immunization progress and future directions.

The World Health Organization (WHO) has set a target of eliminating viral hepatitis B and C by 2030. Vaccination against hepatitis B (HepB) remains the most effective strategy for controlling and eliminating Hepatitis B Virus (HBV) infection. The development of HepB vaccines started with plasma-derived vaccines, which have since been largely replaced by safer and more effective recombinant vaccines, now considered the gold standard for preventing HBV infections.

Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.

Chronic Kidney Disease of Unknown Etiology (CKDu) is a worldwide hidden health threat that is associated with progressive loss of kidney functions without showing any initial symptoms until reaching end-stage renal failure, eventually leading to death. It is a growing health problem in Asia, Central America, Africa, and the Middle East, with identified hotspots. CKDu disease mainly affects young men in rural farming communities, while its etiology is not related to hypertension, kidney stones, diabetes, or other known causes.

Effects of L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression.

Hyperlipidemia is a major contributor to metabolic complications and tissue damage, leading to conditions such as liver steatosis, atherosclerosis, and obesity. This study aimed to investigate the effects of aqueous artichoke bract extract (AE) on lipid metabolism, liver antioxidative defense, and liver steatosis in mice fed a high-fat, high-sucrose diet while elucidating the underlying mechanisms. An 8-week study used hyperlipidemic mice treated with AE at daily doses of 100 and 200 mg/kg bw, compared to fenofibrate.

Assessment of Chicken Fecal Contamination Using Microbial Source Tracking (MST) and Environmental DNA (eDNA) Profiling in Silway River, Philippines.

The Silway River has historically failed to meet safe fecal coliform levels due to improper waste disposal. The river mouth is located in General Santos City, the tuna capital of the Philippines and a leading producer of hogs, cattle, and poultry. The buildup of contaminants due to direct discharge of waste from chicken farms and existing water quality conditions has led to higher fecal matter in the Silway River.

Newborn Screening for Six Primary Conditions in a Clinical Setting in Morocco.

Unlabelled: Newborn screening (NBS) represents an important public health measure for the early detection of specified disorders; such screening can prevent disability and death, not only from metabolic disorders but also from endocrine, hematologic, immune, and cardiac disorders. Screening for critical congenital conditions affecting newborns' health is a great challenge, especially in developing countries such as Morocco, where NBS program infrastructure is lacking. In addition, the consanguinity rate is high in Morocco.

Enhanced YOLOv8 Ship Detection Empower Unmanned Surface Vehicles for Advanced Maritime Surveillance.

The evolution of maritime surveillance is significantly marked by the incorporation of Artificial Intelligence and machine learning into Unmanned Surface Vehicles (USVs). This paper presents an AI approach for detecting and tracking unmanned surface vehicles, specifically leveraging an enhanced version of YOLOv8, fine-tuned for maritime surveillance needs. Deployed on the NVIDIA Jetson TX2 platform, the system features an innovative architecture and perception module optimized for real-time operations and energy efficiency.

Multimodal Machine Learning for Predicting Post-Surgery Quality of Life in Colorectal Cancer Patients.

Colorectal cancer is a major public health issue, causing significant morbidity and mortality worldwide. Treatment for colorectal cancer often has a significant impact on patients' quality of life, which can vary over time and across individuals. The application of artificial intelligence and machine learning techniques has great potential for optimizing patient outcomes by providing valuable insights.

Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from : In Silico and In Vitro Approaches.

Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, (), through phytochemical characterization using liquid chromatography-mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). Phytochemical characterization revealed that the ethanolic extract of (DdEx) is rich in phenolic compounds, with a total of 22 phycocompounds identified.

HLA Class I (A and B) Allele Polymorphism in a Moroccan Population Infected with Hepatitis C Virus.

Hepatitis C virus (HCV) infection is one of the major health burdens worldwide. Its course depends on the virus itself and the host's immune responses. The latter are conditioned by immunogenetic factors, in particular human leukocyte antigens (HLAs), whose role in determining the outcome of infection varies according to populations and ethnic groups.

Patent Overview of Innovative Hyaluronic Acid-Based Hydrogel Biosensors.

Hyaluronic acid-based hydrogels are emerging as highly versatile materials for cost-effective biosensors, capable of sensitive chemical and biological detection. These hydrogels, functionalized with specific groups, exhibit sensitivity modulated by factors such as temperature, pH, and analyte concentration, allowing for a broad spectrum of applications. This study presents a patent-centered overview of recent advancements in hyaluronic acid hydrogel biosensors from 2003 to 2023.

Polysaccharide-Based Drug Carriers-A Patent Analysis.

Polysaccharide-based carriers as biomaterials for drug delivery have been inspiring scientists for years due to their exceptional characteristics, such as nontoxicity, biocompatibility, and degradability, as they are able to protect pharmaceutically active molecules and provide their controlled/modified release. This review focuses on selected drug delivery systems based on natural polymers, namely fucoidan, pullulan, dextran, and pectin, with the aim of highlighting published patent documents. The information contained in patents is very important because it is usually not published in any other document and is much less discussed as the state of the art in the scientific literature.

The Interplay Between Vitamin D Deficiency, Iron Status, and Anemia Risk in Moroccan Women of Reproductive Age: A Cross-Sectional Analysis.

Vitamin D and iron deficiencies are prevalent among Moroccan women of reproductive age (WRA). Research suggests that Vitamin D deficiency (VDD) may impair iron bioavailability, potentially leading to iron deficiency (ID) and anemia. Objectives: This study investigates associations between vitamin D status, iron levels, and anemia risk in WRA, aged 18-49, from Meknes, Morocco.