Pushing the limits of electron donation for -chelating ligands an alliance of phosphonium ylide and anionic abnormal NHC.

The grafting of a -(CH)PR moiety on an NHC ligand backbone in the Mn(I) complex [Cp(CO)Mn(IMes)] followed by double deprotonation opens a route to bidentate ligands with extreme electron-donating character. Such remarkable electronic properties can even allow intramolecular sp C-H functionalization in typically inert square-planar Rh(I) dicarbonyl complexes.

Impact of water stress to plant epigenetic mechanisms in stress and adaptation.

Water is the basic molecule in living beings, and it has a major impact on vital processes. Plants are sessile organisms with a sophisticated regulatory network that regulates how resources are distributed between developmental and adaptation processes. Drought-stressed plants can change their survival strategies to adapt to this unfavorable situation.

Tuberculous adrenal abscess revealed by pleurisy: An extremely rare presentation: About a case.

We report an extremely rare presentation of a tuberculous adrenal abscess discovered accidently during a chest CT scan. This case involves a 21-year-old male patient with pleurisy and a left adrenal abscess simultaneously of tuberculous origin, without clinical or biological signs of adrenal insufficiency. The condition showed complete regression of the abscess after medical treatment.

Retrospective Study of Morton's Neuroma: Clinical, Paraclinical, and Therapeutic Assessment of 10 Cases.

Background Morton's neuroma is a common cause of forefoot pain, typically occurring in the third metatarsal space and characterized by symptomatic nerve compression. This condition often leads to significant functional impairment, affecting weight-bearing activities and limiting appropriate footwear due to pain and discomfort. Objective This study aims to evaluate the outcomes of conservative interventional treatment for Morton's neuroma, specifically focusing on corticosteroid injections.

Study of the Cathode/Electrolyte Interface in an All-Sulfide-Solid-State Battery Using Lithium-Rich Transition Metal Sulfide.

All-solid-state lithium batteries (ASSBs) are among the most promising energy storage technologies, particularly for electric vehicles, due to their enhanced safety. However, performances of these systems are still hindered by interfacial side reactions at electrode/electrolyte interfaces, especially when sulfide electrolytes are used, and additional issues of mechanical nature. In this work, an ASSB system composed of an argyrodite (LiPSCl) electrolyte, a lithium-rich sulfide cathode (LiTiS) operating at moderate voltage, and a lithium metal anode is investigated.

Evaluating the Effects of Mental Health e-Learning on the Knowledge, Attitudes and Practices of Primary Healthcare Professionals in Mali. A Pilot Study.

Background: Despite their high prevalence and significant burden, mental disorders remain grossly under-diagnosed and under-treated. In low-and-middle-income countries, such as Mali, integrating mental health services into primary care is the most viable way of closing the treatment gap. The aim of this study was to assess the effects of a mental health e-learning program on the knowledge, attitudes and practices of primary healthcare professionals in Mali.

Development of a Silver-Based MOF Oxidase-Like nanozyme modified with molecularly imprinted polymer for sensitive and selective colorimetric detection of quercetin.

Antioxidants are vital components in various food, plant, and pharmacological products, making their quantitative, selective, and straightforward assessment essential for evaluating product quality and health benefits. Nanozymes, such as metal-organic frameworks (MOFs) with enzyme-like catalytic activity, hold significant potential for developing highly efficient antioxidant sensing platforms. This is due to their large specific surface area, low density, high porosity, structural diversity, and adjustable pore size.

Comparing voluntary and government-mandated management measures for meeting sustainable fishing targets.

Management of natural resources and environmental systems has often involved top-down approaches in which government agencies set and enforce regulations on extractive activities. More recently, market-driven approaches were introduced to incentivise producers to voluntarily engage in practices that align with management objectives and support regulations. For the first time, we compare government and voluntary approaches within fisheries management systems and quantify their relative influences on the sustainability status of fish populations.

Identification of a de-novo variant of the MEGF10 gene associated with EMARDD.

Early-onset Myopathy, Areflexia, Respiratory Distress and Dysphagia (EMARDD) is a congenital neuromuscular disease with a progressive muscle weakness, respiratory failure, joint contractures, and scoliosis without any symptoms of functional brain anomalies caused by variants in the MEGF10 gene. Here, we report the clinical phenotype and genetic features of a Moroccan patient who carries a novel variant associated with EMARDD on the MEGF10 gene. The Whole Exome Sequencing analysis conducted on a 11 year old boy with respiratory and swallowing difficulties revealed the presence of the novel variant c.

[Diagnosis of possession by a djinn in a transcultural consultation].

The transcultural approach is indicated for complex cases where the cultural dimension is useful in fully understanding a problem. The cultural coding of certain symptoms, such as trance or possession, can be difficult to achieve in conventional individual therapy. The clinical case of Aïcha, originally from Morocco, referred by her psychiatrist for a transcultural opinion, illustrates a reflection on diagnostic elaboration in the face of possession by a djinn.

Urethrovesical calcified foreign body: Case report and literature review.

Introduction: Calcified bladder foreign bodies are a rare yet clinically significant entity, often introduced voluntarily or in psychiatric contexts. Their diagnosis is frequently delayed due to nonspecific symptoms and the concealed circumstances of their introduction.

Case Presentation: We report the case of a 37-year-old man, treated for schizophrenia, presenting with chronic urinary symptoms.

Uterine arteriovenous malformations as a rare differential diagnosis of abnormal uterine bleeding: A case report.

Introduction And Importance: Uterine arteriovenous malformations (UAVMs) are rare vascular anomalies caused by abnormal connections between uterine arteries and veins. They can lead to severe bleeding, requiring prompt and accurate diagnosis. Historically treated with hysterectomy, transcatheter vascular embolization has emerged as a fertility-sparing alternative.

Moroccan Adaptation of the 'Self-Care Behaviour Assessment Scale' for Arteriovenous Fistula in Haemodialysis.

Background: Arteriovenous fistula self-care behaviours in patients receiving haemodialysis are essential to maintain patency of vascular access and prevent its life-threatening complications. Assessing arteriovenous fistula self-care behaviours in patients receiving haemodialysis requires a reliable and valid tool.

Objective: The aim of this study was to adapt and translate the Portuguese scale for the assessment of self-care behaviours of arteriovenous fistula in patients receiving haemodialysis into the Moroccan dialect and evaluate its psychometric properties in the Moroccan context.

InCoLoTransNet: An Involution-Convolution and Locality Attention-Aware Transformer for Precise Colorectal Polyp Segmentation in GI Images.

Gastrointestinal (GI) disease examination presents significant challenges to doctors due to the intricate structure of the human digestive system. Colonoscopy and wireless capsule endoscopy are the most commonly used tools for GI examination. However, the large amount of data generated by these technologies requires the expertise and intervention of doctors for disease identification, making manual analysis a very time-consuming task.

Determination of genetic diversity in persimmon accessions using morphological and inter simple sequence repeat markers.

Background: Persimmon (Diospyros kaki L.) belongs to the Ebenaceae family, which includes six genera and about 400 species. This study evaluated the genetic diversity of 100 persimmon accessions from Hatay province, Türkiye using 42 morphological and pomological traits, along with inter simple sequence repeat (ISSR) markers and multivariate analysis.

Biosorption of rhodamine B and sunset yellow dyes on cross-linked chitosan-alginate biocomposite beads: Experimental and theoretical studies.

This research explores the biosorption of Rhodamine B (Rd-B) and Sunset Yellow (SY) dyes using cross-linked chitosan-alginate (Ch-A) biocomposite beads, combining experimental investigations with theoretical studies to elucidate the biosorption mechanisms. The biocomposite beads were synthesized through an eco-friendly cross-linking method, and their structural properties were characterized using various characterization techniques. Complementary theoretical studies using Monte Carlo (MC) simulations and molecular dynamics (MD) calculations provided insights into the molecular interactions between the dyes and the biocomposite beads.

Three-dimensional ordered macro-microporous ZIF-8-α-Glu microreactors for α-glucosidase inhibitors screening from green tea.

Due to the larger pore structure, the macroporous material can be used as the immobilized carrier to not only increase the enzyme loading capacity, but also facilitate the transfer of reactants and substrates. Based on this, a three-dimensional ordered macro-microporous ZIF-8 (SOM-ZIF-8) was prepared using three-dimensional ordered stacked polystyrene spheres as the hard template. The morphology and structure of SOM-ZIF-8 were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR) and so on.

Small intestinal metastasis of cutaneous melanoma in an elderly woman: Survival benefits of surgery and novel targeted therapies - A case report.

Introduction And Importance: Cutaneous malignant melanoma, originating from melanocytes, is a highly metastatic cancer with an incidence rate of 0.9 per 100,000. The gastrointestinal tract is a common site of metastasis, with the small intestine being particularly affected.

Characterization of phenolic compounds and evaluation of anti-diabetic potential in L. seeds: and studies.

Moroccan L. seeds were investigated for their phenolic profile and antidiabetic potential. Ultra-high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry analysis revealed a rich phenolic composition, including benzoic acid, cannabisin B, genistein, and epicatechin.

Revisiting Africa's Stroke Obstacles and Services (SOS).

Background: As one of the most common non-communicable diseases in Africa, Stroke ought to be dealt with properly with intensifying efforts to control its burden and to face obstacles in its management.

Methods And Results: In this follow-up study we reanalyzed stroke services and related obstacles in 17 African countries that were previously studied in 2021/22 in aspects related to manpower, acute stroke services, rehabilitation programs, number of stroke units/centers, telestroke services, awareness campaigns, and national and international stroke registries through a survey that was sent to stroke specialists and national stroke societies. Overall, there is an improvement in many fields yet many obstacles in the implementation of telestroke services, acute management, secondary prevention, post-discharge services, and follow-ups whether governmental, medical, or societal are prevalent.

Moroccan natural products for multitarget-based treatment of Alzheimer's disease: A computational study.

Alzheimer's disease is a neurodegenerative disorder that impairs neurocognitive functions. Acetylcholinesterase, Butyrylcholinesterase, Monoamine Oxidase B, Beta-Secretase, and Glycogen Synthase Kinase Beta play central roles in its pathogenesis. Current medications primarily inhibit AChE but fail to halt or reverse disease progression due to the multifactorial nature of Alzheimer's.

An in-depth study of indolone derivatives as potential lung cancer treatment.

Lung cancer is a type of cancer that begins in the lungs and is one of the leading causes of cancer-related deaths worldwide. Herein an attempt to explore the relationship between the properties of indolone derivatives and their anticancer activity was investigated, implementing in silico approaches. Four indolone derivatives with the highest anticancer potential were selected to evaluate their pharmacological properties.

Computational Approaches for Multitarget Drug Design in Alzheimer's Disease: A Comprehensive Review.

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative brain disorder, primarily affecting the elderly. Its socio-economic impact and mortality rate are alarming, necessitating innovative approaches to drug discovery. Unlike single-target diseases, Alzheimer's multifactorial nature makes single-target approaches less effective.

Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) presents substantial therapeutic challenges due to its molecular heterogeneity, limited response to conventional therapies, and widespread drug resistance. Recent advancements in molecular research have identified novel targets, such as BUB1B, which has been identified through global transcriptomic profiling and gene co-expression network analysis as critical in ccRCC progression. In this study, we synthesized 40 novel derivatives of TG-101209 to modulate BUB1B expression and activity, leading to the induction of apoptosis in Caki-1 cells.

Elective Sternotomy With Fluoroscopic Guidance for the Removal of a Residual Implantable Cardioverter Defibrillator Lead: A Case Report and Literature Review.

Infectious myocarditis (IM) and infective endocarditis (IE), sometimes associated with infection of the surrounding mediastinal tissue or embolic complications caused by residual implantable cardioverter defibrillator (ICD) lead material embedded in the ventricle, present a significant challenge for cardiac surgeons due to the difficulty of precisely locating the old intracardiac pacing lead remnants because of the heart's continuous movement. We present the case of successful two-stage elective sternotomy extraction of two residual defibrillator leads, one trapped in the left innominate vein, easily removed after veinotomy without cardiopulmonary bypass (CPB), and the other embedded intramyocardially in the inferior wall of the right ventricle, successfully removed under CPB after fluoroscopic guidance. The patient was discharged four weeks post-operation without complications.