69 results match your criteria: "Moriyama Memorial Hospital[Affiliation]"

Background: The social burden of nursing care is increasing with age, particularly for patients with heart failure who often require intensive care. This study aimed to clarify the relationship between nursing care needs and the clinical status of patients with a history of cardiovascular disease, focusing on the benefits of cardiac rehabilitation (CR) in reducing these needs.

Methods: This single-gate, multicenter, retrospective observational study included patients of all ages with a history of hospitalization for cardiovascular diseases using government-administered insurance claims and health examination data.

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Background: Hypertension is a risk factor for bleeding events and is included in the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/Alcohol concomitantly)score. However, the effects of blood pressure (BP) and changes in BP on bleeding events in patients undergoing percutaneous coronary intervention (PCI) remain poorly understood. This study is aimed to investigate the relationship between systolic BP (SBP) changes during hospitalisation and bleeding events in patients undergoing PCI.

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Analysis of the Recovery Process and Activities of Daily Living Independence in Pusher Behavior and Unilateral Spatial Neglect.

Arch Phys Med Rehabil

October 2024

Department of Physical Therapy, Faculty of Rehabilitation Sciences, Sendai Seiyo Gakuin University, Sendai, Miyagi, Japan. Electronic address:

Objective: To investigate the recovery processes of pusher behavior (PB) and unilateral spatial neglect (USN) based on the severity of PB and USN, and to determine the relationship between activities of daily living (ADL) independence levels.

Design: This retrospective study aimed to examine the temporal changes and their association with ADL independence levels based on the severity of PB and USN.

Setting: Recovery ward of Moriyama Neurological Center Hospital between March 2017 and October 2022.

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Craniopharyngiomas, including adamantinomatous (ACP) and squamous papillary (PCP) types, are challenging to treat because of their proximity to crucial pituitary structures. This study aimed to characterize the cellular composition, tumor tissue diversity, and cell-cell interactions in ACPs and PCPs using single-cell RNA sequencing. Single-cell clustering revealed diverse cell types, further classified into developing epithelial, calcification, and immune response for ACP and developing epithelial, cell cycle, and immune response for PCP, based on gene expression patterns.

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The Japanese Society of Hypertension have established a blood pressure (BP) target of 130/80 mmHg for patients with coronary artery disease (CAD). We evaluated the data of 8793 CAD patients in the Clinical Deep Data Accumulation System database who underwent cardiac catheterization at six university hospitals and the National Cerebral and Cardiovascular Center (average age 70 ± 11 years, 78% male, 43% with acute coronary syndrome [ACS]). Patients were divided into two groups based on whether or not they achieved the guideline-recommended BP of <130/80 mmHg.

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Article Synopsis
  • - This text discusses a case involving a 42-year-old woman diagnosed with papillary craniopharyngioma (pCP), which was initially misinterpreted as a Rathke's cleft cyst (RCC) due to similar symptoms and imaging findings.
  • - During a transsphenoidal surgery, the surgeons found cystic contents resembling condensed milk, leading to a cyst fenestration procedure instead of full removal, which is typically done for RCC.
  • - Histopathological analysis post-surgery showed papillary structures and confirmed the diagnosis of pCP; the patient’s visual function improved significantly, and follow-up imaging revealed no recurrence, emphasizing the distinct care needed for these lesions.
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Objective: Postoperative nonfunctioning pituitary tumor (NFPT) regrowth is a significant concern, but its predictive factors are not well established. This study aimed to elucidate the pathological characteristics of NFPTs indicated for reoperation for tumor regrowth.

Methods: Pathological, radiological, and clinical data were collected from patients who underwent repeat operation for NFPT at Moriyama Memorial Hospital (MMH) between April 2018 and September 2023.

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Article Synopsis
  • Remote cardiac rehabilitation (RCR) is a method designed for patients recovering from cardiovascular diseases, utilizing real-time monitoring and technology for safety and effectiveness.
  • A study in Japan involved 53 RCR patients exercising at home for 2-3 months, with real-time support, and compared their results to 103 patients who underwent traditional center-based rehabilitation.
  • The findings showed that RCR was just as safe and effective in improving exercise capacity as traditional methods, with no significant complications reported in the RCR group.
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Purpose: The aim of this study was to evaluate the treatment outcomes of neuroendoscopic cyst partial resection (ECPR) combined with stereotactic radiotherapy (SRT) for cystic craniopharyngiomas.

Methods: In this retrospective study, 22 craniopharyngioma patients undergoing ECPR combined with SRT were included. This combination therapy was indicated for suprasellar cystic craniopharyngiomas in patients whose pituitary function was preserved but would be difficult to preserve in direct surgery.

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In clinical practice, patient assessments rely on established scales. Integrating data from these scales into the International Classification of Functioning, Disability, and Health (ICF) framework has been suggested; however, a standardized approach is lacking. Herein, we tested a new approach to develop a conversion table translating clinical scale scores into ICF qualifiers based on a clinician survey.

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Summary: Functioning gonadotroph tumors are rare neoplasms that can cause ovarian hyperstimulation syndrome (OHSS) in women of reproductive age. Here, we present a case of a follicle-stimulating hormone (FSH)-producing pituitary neuroendocrine tumor (PitNET) with irregular menstrual cycles and OHSS in a Japanese woman. A 34-year-old woman with bilateral multi-cystic ovarian mass was referred to our hospital for ovarian surgery.

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Effects of the Cortisol Milieu on Tumor-Infiltrating Immune Cells in Corticotroph Tumors.

Endocrinology

February 2024

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, 650-0017, Japan.

Article Synopsis
  • Corticotroph tumors, specifically ACTHomas, could be potential targets for immunotherapy due to their susceptibility to immune cell attack, particularly in conditions like hypophysitis.
  • The study analyzed tumor-infiltrating immune cells in different cortisol environments and found that ACTHomas had low levels of CD8+ T cells compared to other pituitary tumors, suggesting they may be "immunologically cold."
  • It was observed that CD4+ T cells and certain macrophages were more abundant in cortisol-exposed tumors, indicating a relationship between cortisol levels and immune response, thus highlighting the need for further research on effective immunotherapy approaches.
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Article Synopsis
  • - A patient with FLT3-mutated acute promyelocytic leukemia (APL) relapsed despite treatment with all-trans retinoic acid (ATRA) and chemotherapy, as well as re-induction therapy with arsenic trioxide and high-dose cytarabine, which failed to achieve remission.
  • - The leukemic cells resisted conventional therapies; therefore, the medical team opted for gilteritinib, a selective FLT3 inhibitor, as an alternative treatment option.
  • - The patient achieved complete hematologic remission with gilteritinib, highlighting its potential effectiveness as a single-agent therapy for patients with resistant FLT3-mutated APL prior to transplantation.
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Context: Desmopressin orally disintegrating tablets (ODTs) are widely used to treat arginine vasopressin deficiency (AVP-D). However, limited information is available on the dosage regimen; the dosage for each patient is selected based on their response to the initiation dose.

Objective: To investigate the relationships between clinical characteristics and the daily dose of ODTs and to identify factors that affect ODT dosages.

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Article Synopsis
  • Touch imprint cytology (TIC) and frozen section (FS) are crucial for making quick and accurate diagnoses during surgeries, especially for conditions like pituitary neuroendocrine tumors (PitNETs).
  • These tumors are typically small and slow-growing, making careful surgical procedures like transsphenoidal surgery (TSS) essential for effective treatment without excessive removal of tissue.
  • A study analyzed 104 specimens from patients undergoing TSS and found that TIC was highly effective in identifying PitNET components based on the pattern of endocrine cell adherence to glass slides, outperforming FS in surgical margin evaluation.
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A 62-year-old female experienced an extensive cerebral contusion in the left frontotemporal lobe due to an acute subdural hematoma at the age of 44 years. Six months after the injury, the patient developed epileptic seizures. The seizures were generalized with right cervical rotation and fencing posture.

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Octreotide is used in patients with insulinomas to treat hypoglycemia, and somatostatin receptor (SSTR) 2 expression is important for its efficacy. We report a case of insulinoma in a 50-year-old woman that responded to an octreotide test, showed accumulation in somatostatin scintigraphy, and was positive for SSTR2A on immunostaining.

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Article Synopsis
  • The study focused on using 11C-methionine positron emission tomography (MET-PET) to help diagnose and locate recurrent tumors in patients with Cushing's disease who had ambiguous MRI results after several surgeries.
  • A total of 15 patients were evaluated, all of whom had undergone multiple treatments, but their MRI scans could not reliably differentiate between tumor recurrence and post-surgical changes.
  • MET-PET findings led to successful identification of tumors in some patients, guiding treatment decisions, including repeat surgeries and nonsurgical options like temozolomide for those not needing immediate surgery.
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Article Synopsis
  • * The study tested a method called blastocyst complementation (BC) using mouse embryonic stem cells (mESCs) to create functional PTGs from specially altered embryos.
  • * Results showed that these mESC-derived PTGs could regulate calcium levels when transplanted into mice, suggesting BC is a promising strategy for developing treatments for hypoparathyroidism, potentially even in humans.
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Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation.

Stem Cell Reports

August 2023

Department of Endocrinology and Diabetes, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466-8550, Japan.

Pituitary organoids are promising graft sources for transplantation in treatment of hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic organoids (PHOs) using human pluripotent stem cells (hPSCs), we established techniques to generate PHOs using feeder-free hPSCs and to purify pituitary cells. The PHOs were uniformly and reliably generated through preconditioning of undifferentiated hPSCs and modulation of Wnt and TGF-β signaling after differentiation.

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Pituitary neuroendocrine tumors (PitNETs) lacking lineage affiliation are termed "null cell" PitNETs (NCTs). NCTs are characterized as being immunonegative for pituitary hormones as well as transcription factors. We analyzed the ultrastructure and immunohistochemistry of six hormone-negative and transcription factor (TPIT, PIT1, SF1)-negative PitNETs, with less than 1% immunoreactive cells.

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Article Synopsis
  • Adenocarcinoma (AC) with neuroendocrine carcinoma (NEC) and enteroblastic (ENT) differentiation is a rare occurrence in Barrett's esophagus (BE), as demonstrated in a 76-year-old man who underwent surgery for this condition.
  • The tumor exhibited three types of carcinomas—NEC, AC with ENT differentiation, and moderately differentiated AC—each showing distinct histological characteristics and markers.
  • Findings suggest that understanding the combination of these tumor types in a BE background may provide insights into the carcinogenic mechanisms and immune environment related to NEC and ENT tumors.
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Article Synopsis
  • Fractional flow reserve (FFR) is a standard method for assessing heart issues, but its use is limited due to time, cost, and discomfort associated with the procedure.
  • A new method called saline-induced Pd/Pa ratio (SPR) may offer a simpler alternative to FFR, yet its clinical significance is still uncertain.
  • The study found that SPR had a stronger correlation with FFR compared to resting full-cycle ratio (RFR) and showed superior diagnostic accuracy, suggesting SPR could effectively evaluate coronary artery stenosis.
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Background: This study evaluated the safety and effectiveness of alirocumab in Japanese patients with familial hypercholesterolemia (FH) or non-FH in a real-world clinical setting.

Methods and results: This post-marketing surveillance study had a 2-year standard observation period. The study included Japanese patients with hypercholesterolemia who were treatment naïve to alirocumab, had a high risk of developing cardiovascular events, and had an insufficient response to, or were unsuitable for, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

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