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The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children.
Arch Dis Child
May 2013
Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children NHS Trust, Walrus Ward Level 1, Morgan Stanley Clinical Building, Great Ormond Street, London WC1N 3JH, UK.
Background: Cerebral blood flow velocity (CBFV) and sleep physiology in healthy children exposed to hypoxia and hypocarbia are under-researched.
Aim: To investigate associations between sleep variables, daytime end-tidal carbon dioxide (EtCO2) and CBFV in children during high-altitude ascent.
Methods: Vital signs, overnight cardiorespiratory sleep studies and transcranial Doppler were undertaken in nine children (aged 6-13 years) at low altitude (130 m), and then at moderate (1300 m) and high (3500 m) altitude during a 5-day ascent.