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Morgagni Pierantoni Hospital[Affiliation] Publications | LitMetric

842 results match your criteria: "Morgagni Pierantoni Hospital[Affiliation]"

European clinical practice guideline: managing and treating laryngopharyngeal reflux disease.

Eur Arch Otorhinolaryngol

December 2024

Research Committee of Young-Otolaryngologists of the International Federations of Oto-rhino- laryngological Societies (YO-IFOS), Paris, France.

Objective: To propose a European consensus for managing and treating laryngopharyngeal reflux disease (LPRD) to guide primary care and specialist physicians.

Methods: Twenty-three European experts (otolaryngologists, gastroenterologists, surgeons) participated in a modified Delphi process to revise 38 statements about the definition, clinical management, and treatment of LPRD. Three voting rounds were conducted on a 5-point scale and a consensus was defined a priori as agreement by 80% of the experts.

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Objective: To validate the ISGPS complexity grading system for minimally invasive pancreaticoduodenectomy (MIPD).

Background: Although concerns about patient safety persist, MIPD is gaining popularity. The ISGPS recently introduced a difficulty grading system to improve patient selection by aligning procedural complexity with surgeon and center expertise.

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Exploring nanotechnology solutions for improved outcomes in gastrointestinal stromal tumors.

Heliyon

December 2024

Preclinic and Osteoncology Unit, Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy.

Objectives: Gastrointestinal stromal tumors, the most prevalent mesenchymal tumors (80 %) of the gastrointestinal tract, comprise less than 1 % of all gastrointestinal neoplasms and about 5 % of all sarcomas. Despite their rarity, Gastrointestinal stromal tumors present diverse clinical manifestations, anatomic locations, histological subtypes, and prognostic outcomes.

Methods: This scoping review comprehensively explores the epidemiology, clinical characteristics, diagnostic and prognostic modalities, as well as new therapeutic options for Gastrointestinal stromal tumors.

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In the last 6 years, Italy accounted for 36 % of the total autochthonous European West Nile virus (WNV) cases reported to ECDC. Since 2001, the country put in place a multi-species national surveillance plan. The plan was enhanced in 2020 by adopting a fully integrated "One Health" approach, including human, wild bird, equine, and mosquito surveillance for the early detection of WNV.

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Squamous cell carcinoma of the stomach: focus on a heterogeneous disease at diagnosis. Case report and literature review.

Front Oncol

November 2024

Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

Article Synopsis
  • Primary squamous cell carcinoma (SCC) can arise in various body parts, with primary gastric squamous cell carcinoma (GSCC) being particularly rare, exemplified by a case of a 72-year-old woman diagnosed with it.
  • Diagnostic imaging, including CT scans and ultrasound-endoscopy, revealed a significant mass at the celiac tripod, leading to further tests confirming poorly differentiated carcinoma with squamous differentiation.
  • The study emphasizes the need for well-defined diagnostic criteria for GSCC due to the lack of consensus in current classifications, suggesting that a standardized diagnostic panel might improve accuracy.
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Purpose: Patients with Obstructive Sleep Apnea (OSA) often experience poor sleep quality and excessive daytime sleepiness, which significantly affect their daily lives. Among the therapeutic options, Barbed Pharyngoplasty (BP) is widely used, showing an overall improvement in the primary efficacy parameters. However, the impact of this surgical intervention on sleep architecture remains unclear.

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We present a case of ventricular thrombosis occurring in myocarditis due to immune checkpoint inhibitors (ICIs), presenting as myocardial infarction and complicated by refractory cardiogenic shock. Although myocarditis is a well-known adverse event of ICIs, intraventricular thrombus formation in this context is extremely rare. Differential diagnosis between ventricular thrombosis and tumoral mass can be challenging, especially in oncologic patients.

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Objective: To assess the opinion, practices, and challenges of international key opinion leaders about two minimal invasive surgical techniques in supraglottic laryngeal tumours: transoral laser microsurgery (TLM) and the transoral robotic surgery (TORS).

Methods: Design of a questionnaire composed of seven sections and fifty questions covering descriptive data of participants, practitioners experience procedural sequences, considerations related to airways, feeding, and voice, intraoperative haemorrhage, postoperative management, and a comparative analysis of TLM and TORS in treating supraglottic laryngeal cancer.

Results: A total of 27 head and neck surgeons replied to the survey.

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HDAC6 as a Prognostic Factor and Druggable Target in HER2-Positive Breast Cancer.

Cancers (Basel)

November 2024

IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.

Background: Adjuvant trastuzumab is the standard of care for HER2+ breast cancer (BC) patients. However, >50% of patients become resistant. This study aimed at the identification of the molecular factors associated with disease relapse and their further investigation as therapeutically exploitable targets.

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Introduction: No instruments are available to predict preoperatively the risk of posthepatectomy liver failure (PHLF) in HCC patients. The aim was to predict the occurrence of PHLF preoperatively by radiomics and clinical data through machine-learning algorithms.

Materials And Methods: Clinical data and 3-phases CT scans were retrospectively collected among 13 Italian centres between 2008 and 2022.

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Transoral robotic salivary surgery for hilar\parenchymal submandibular stones.

Front Surg

November 2024

Department of Otolaryngology and Head and Neck Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Article Synopsis
  • A study was conducted on 54 adult patients with submandibular stones who underwent a robotic surgery called sialendoscopy-assisted TORSS between January 2019 and June 2023 to evaluate its safety and effectiveness.
  • The overall success rate of the procedure was 81.5%, with better outcomes for patients with palpable stones compared to those with non-palpable stones (92.7% vs. 46.2%).
  • Results indicated that stone characteristics such as size and location are important for predicting surgical success, emphasizing the need for careful pre-operative planning to select appropriate candidates for the procedure.
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Ceus features of liver pecoma: a case report and literature review.

J Ultrasound

November 2024

Diagnostic and Therapeutic Interventional Ultrasound Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, via Massarenti n 9, 40138, Bologna, Italy.

Perivascular epithelioid cell neoplasms (PEComas) and epithelioid angiomyolipomas (EAMLs) are two different denominations for the same "mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells". Hepatic PEComa/EAML is a very rare neoplasm, and only 29 case reports of hepatic PEComa and 25 of hepatic EAML have been reported in the current literature. A clear female predominance with a mean age at diagnosis of 42.

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Background: Intramyocardial dissecting haematoma (IDH) is a rare life-threatening event usually complicating an acute myocardial infarction. Poor data exist about diagnosis, management, and outcome.

Case Summary: We reported a case of giant IDH managed conservatively, thanks to stable clinical status and haemodynamics, which evolved towards resorption.

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Purpose: This multicenter prospective study aims to compare transradial access versus transfemoral access in conventional transarterial chemoembolization (c-TACE) procedures, focusing on operators radiations exposure, patients comfort, technical success and vascular access complications.

Materials And Methods: Patients were affected by hepatocellularcarcinoma (HCC) in intermediate stage or previous stages unfit for ablation and/or surgery; they were randomized into two groups according to arterial access site (Group F: right femoral access in standard position; Group R: radial access with left arm abduced 90°). Overall fluoroscopy time was recorded.

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In the medical field, ultrasound is commonly used for diagnostic imaging due to its ability to provide real-time images. However, High-Intensity Focused Ultrasound (HIFU) is also used for other clinical purposes, such as thermal tissue ablation. In the case of varicose veins, the potential role and benefits of HIFU have been known for a long time despite in-vivo results have mostly been preliminary and experimental, particularly regarding its effect on venous wall.

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Patients suffering from coronavirus disease-19 (COVID-19)-related interstitial pneumonia have variable outcomes, and the risk factors for a more severe course have yet to be comprehensively identified. Cohort studies have suggested that coronary artery calcium (CAC), as estimated at chest computed tomography (CT) scan, correlated with patient outcomes. However, given that the prevalence of CAC is gender- and age-dependent, the influence of baseline confounders cannot be completely excluded.

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Article Synopsis
  • The text refers to a correction made to a previously published article.
  • The specific article mentioned can be identified by its DOI, which is 10.1055/a-2411-1814.
  • Corrections like this are common in academic publishing to address errors or inaccuracies in research.
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Treatment strategies with electrochemotherapy for limb in-transit melanoma: Real-world outcomes from a European, retrospective, cohort study.

Eur J Surg Oncol

October 2024

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK; Division of Oncological Sciences, The University of Manchester, Manchester, UK; Cancer Research UK National Biomarker Centre, The University of Manchester, Manchester, UK.

Background: This study analysed treatment strategies with electrochemotherapy (ECT) in melanoma with limb in-transit metastases (ITM).

Methods: We audited AJCC v.8 stage IIIB-IIID patients treated across 22 centres (2006-2020) within the International Network for Sharing Practices of ECT (InspECT).

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Purpose: To compare the accuracy of intraocular lens (IOL) power calculation formulas for myopic eyes requiring negative diopter powered IOLs.

Design: Retrospective case series.

Setting: K… hospital and Y… Hospital, …, ….

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Article Synopsis
  • - The study investigated outcomes of lumen-apposing metal stents (LAMS) placement in patients with surgically altered anatomy (SAA), which is not well-documented in existing literature, involving 270 patients across 25 tertiary care centers up to November 2023.
  • - Technical success of the procedures was very high at 98%, with clinical success at 97%, although there was a notable adverse event rate of 12%, with various degrees of severity recorded.
  • - The results suggest that while LAMS placement in SAA is effective, due to the risk of complications, these procedures should only be performed by experienced endoscopists in specialized centers.
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Article Synopsis
  • * A total of 41 ENS patients were assessed alongside control groups, revealing that ENS patients exhibited significantly higher LPRD symptoms and severity, as well as a notable prevalence of depression.
  • * The results indicated that LPRD symptoms were much more common in ENS patients than in controls, suggesting a strong association that warrants further research using objective methods to confirm these findings.
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Article Synopsis
  • - The study reviews literature from the past decade on mastoid obliteration in adults, comparing outcomes of autologous (patient's own tissue) vs. heterologous (donor tissue) grafts, using data from various medical databases.
  • - A total of 37 studies were included, focusing on long-term results (over 12 months), highlighting that neither technique is definitively better, but both have unique benefits in cholesteatoma surgery.
  • - The findings reveal that while heterologous grafts generally show lower rates of recurrent cholesteatoma, they have higher rates of complications like otorrhea and tympanic membrane perforations, illustrating a trade-off between the two graft types.
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Takotsubo syndrome (TTS) is a clinical syndrome characterized by a transient left ventricular dysfunction whose diagnosis can be challenging due to its resemblance to acute myocardial infarction (AMI). Despite the growing recognition of TTS, acute complications and long-term mortality rates are comparable to those observed in AMI patients. In this context, a systematic diagnostic approach is imperative for an accurate patient assessment, with due consideration of the distinctive characteristics and optimal timing of each imaging modality.

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Article Synopsis
  • This study looked at how different hospitals approach treating liver cancer, especially regarding liver transplants.
  • They surveyed 75 hospital directors to see if those with liver transplant programs treat patients differently compared to those without.
  • The results showed that hospitals with transplant programs were more likely to recommend transplants for certain types of liver cancer and other liver diseases than those without, showing a need for better communication between the two types of centers.
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