Horses with previous episodes of laminitis have altered insulin responses to seasonal oral sugar testing and grazing compared to horses with no known history of laminitis.

Forage is essential for equine health and performance, but intake of elevated pasture nonstructural carbohydrates (NSC) may exacerbate metabolic disorders. This study aimed to investigate the influence of laminitis history on metabolic and morphometric responses in grazing horses. Twelve non-pregnant mares (15 ± 3.

Orthopedic Pain Management: Tools for Practicing Critical Care Nurses.

Nurses practicing in critical care units manage all forms of traumatic, acute, and chronic pain. Chronic pain must be managed in critical care scenarios to facilitate patient comfort and eventual recovery and healing. Patients with orthopedic injuries and conditions have distinct care needs that require specialized knowledge on the provider's part.

Strategies for Health Professionals in Managing Patients and Families in Critical Care Units.

The primary objective of this article is to share effective strategies for integrating patients and their families into the critical care setting. Additionally, it aims to address lack of pain management knowledge, burnout syndrome, and stress management tactics tailored for practicing critical care registered nurses.

Management of Neonatal Pain Associated with Circumcision.

Circumcision is a painful procedure that may be performed on newborns. Pain management is provided through pharmacologic and nonpharmacological methods such as administration of anesthetics, analgesia, nutritive sucking, music, and touch during and post procedure. Pain scales may be used to assess physiologic and behavioral changes in the newborn as part of the pain management process.

Summer-Wet Hydrologic Cycle during the Middle Miocene of the United States: New Evidence from Fossil Fungi.

Hydrologic reconstructions from North America are largely unknown for the Middle Miocene. Examination of fungal palynomorph assemblages coupled with traditional plant-based palynology permits delineation of local, as opposed to regional, climate signals and provides a baseline for study of ancient fungas. Here, the Fungi in a Warmer World project presents paleoecology and paleoclimatology of 351 fungal morphotypes from 3 sites in the United States: the Clarkia Konservat-Lagerstätte site (Idaho), the Alum Bluff site (Florida), and the Bouie River site (Mississippi).

Group differences in gender expression discrimination and depressive and anxiety symptoms among transgender and gender-expansive adults: The role of gender identity pride.

Despite established associations between discrimination and mental health, little research has focused on gender expression discrimination and integrated individual strengths such as transgender and gender-expansive (TGE) identity pride. This study examined the roles of gender expression discrimination and pride in mental health among TGE adults across gender identity, race, and class. A national sample of TGE adults (N = 212) completed online measures assessing gender identity, race, income, gender expression-related discrimination, TGE identity pride, and depression and anxiety symptoms.

Increasing culturally relevant science media coverage: exploring the outcomes of a collaboration in Puerto Rico.

CienciaPR, a nonprofit that brings together the largest network of Puerto Rican scientists and one of the largest networks of Hispanic/Latine scientists in the world, has collaborated with El Nuevo Día (END), Puerto Rico's newspaper of record, to increase culturally relevant stories in their science section. This Practice Insight quantifies and compares the presence of culturally relevant elements (e.g.

Repression of DNA damage response requires DdrR-assisted binding of UmuDAb dimers to atypical SOS box.

The DNA damage response of the multi-drug-resistant nosocomial pathogen possesses multiple features that distinguish it from the commonly used LexA repression system. These include the absence of LexA in this genus, the evolution of a UmuD polymerase manager into the UmuDAb repressor of error-prone polymerases, the use of a corepressor unique to (DdrR), and an unusually large UmuDAb binding site. We defined cis- and trans-acting factors required for UmuDAb DNA binding and gene repression, and tested whether DdrR directly enhances its DNA binding.

Bacterial diversity in agricultural drainage ditches shifts with increasing urea-N concentrations.

Urea-based fertilizers applied to crop fields can enter the surface waters of adjacent agricultural drainage ditches and contribute to the nitrogen (N) loading in nearby watersheds. Management practices applied in drainage ditches promote N removal by the bacterial communities, but little is known about the impacts of excess urea fertilizer from crop fields on the bacterial diversity in these ditches. In 2017, sediments from drainage ditches next to corn and soybean fields were sampled to determine if fertilizer application and high urea-N concentrations alters bacterial diversity and urease gene abundances.

DNA damage response coregulator affects many cellular pathways and processes in 17978.

Introduction: strain 17978 is an opportunistic pathogen possessing a DNA damage response (DDR) in which multiple error-prone polymerase genes are co-repressed by a UmuD homolog, UmuDAb, and the small -specific protein DdrR. Additionally, these regulators coactivate nine other genes. We identified the DNA damage-inducible transcriptome for wildtype, , and strains, and later established the DDR transcriptome.

A Proposed Model for the Role of Fear of Intimacy and Social Support in Behavioral Activation: A Cross-Sectional Analysis.

Behavioral theories of depression posit that depression results from the environment not adequately reinforcing non-depressive behaviors. One commonly used treatment based on the behavioral model of depression is Behavioral Activation. While many implementations of Behavioral Activation emphasize social interactions, there is limited empirical investigation into the contribution of specific facets of social engagement in the behavioral model of depression.

Natural sources and controlling factors of urea-nitrogen concentrations in agricultural drainage ditches.

Agricultural drainage ditches accumulate high urea-nitrogen (N) concentrations even in the absence of urea fertilizer applications to adjacent crop fields. The accumulated urea, and other bioavailable forms of dissolved organic nitrogen (DON), can be flushed downstream during substantial rainfall events altering downstream water quality and phytoplankton communities. Sources of urea-N supporting its accumulation in agricultural drainage ditches are poorly understood.

Honey bee foraging and pesticide exposure in a desert urban agroecosystem.

The negative impacts of industrial farming on honey bee health have been widely recognized regarding pesticide use and natural foraging habitat loss. An assessment of suitability of urban farms regarding honey bee health is necessary for sustainable development of agriculture and apiculture in urban settings. Urban farms that adopt organic farming practices with restrictions on synthetic pesticide use and conservation of natural habitat can potentially create an environment to mitigate these environmental stressors on honey bees.

Ancient Lowland Maya neighborhoods: Average Nearest Neighbor analysis and kernel density models, environments, and urban scale.

Many humans live in large, complex political centers, composed of multi-scalar communities including neighborhoods and districts. Both today and in the past, neighborhoods form a fundamental part of cities and are defined by their spatial, architectural, and material elements. Neighborhoods existed in ancient centers of various scales, and multiple methods have been employed to identify ancient neighborhoods in archaeological contexts.

Dinuclear Complexes of Uranyl, Neptunyl, and Plutonyl: Structures and Oxidation States Revealed by Experiment and Theory.

Dinuclear perchlorate complexes of uranium, neptunium, and plutonium were characterized by reactivity and DFT, with results revealing structures containing pentavalent, hexavalent, and heptavalent actinyls, and actinyl-actinyl interactions (AAIs). Electrospray ionization produced native complexes [(AnO)(ClO)] for An:An = U:U, Np:Np, Pu:Pu, and Np:Pu, which are intuitively formulated as actinyl(V) perchlorates. However, DFT identified lower-energy structures [(AnO)(AnO)(ClO)(ClO)] comprising a perchlorate fragmented to ClO, actinyl(VI) cation AnO, and neutral AnO.

A solution to the challenges of interdisciplinary aggregation and use of specimen-level trait data.

Understanding variation of traits within and among species through time and across space is central to many questions in biology. Many resources assemble species-level trait data, but the data and metadata underlying those trait measurements are often not reported. Here, we introduce FuTRES (Functional Trait Resource for Environmental Studies; pronounced few-tress), an online datastore and community resource for individual-level trait reporting that utilizes a semantic framework.

Acute Alcohol Intoxication, State Anger, and Sexual Assault Perpetration: The Role of State Emotion Regulation.

Objective: Alcohol-involved sexual assault remains a pervasive problem, with extensive individual- and societal-level costs. Emotion regulation (ER), the process through which an individual modulates emotional states, remains an understudied predictor of sexual assault perpetration, with past research focusing on general ER tendencies (e.g.

Alcohol intoxication and sexual risk intentions: Exploring cultural factors among heavy drinking women.

Introduction: Sexually Transmitted Infections (STI) rates are the highest of the last 20 years, with people of color and women particularly affected. Ongoing research has identified risk factors (e.g.

Developing Resilience: Strategies to Adapt Within an Interprofessional Team.

Resilience can be defined as sustaining well-being in the face of adversity by harnessing internal and/or external resources. Many of the strategies that promote highly effective teams, such as regulating emotions, self-reflection, and inclusion, may also contribute to team resilience. Nurse leaders can facilitate social connections, optimism, self-care, mindfulness practices, and meaningful recognition as strategies to promote nurse resilience.

Targeting for nonpoint source pollution reduction: A synthesis of lessons learned, remaining challenges, and emerging opportunities.

The ability to identify, target, and treat critical pollution source areas on a landscape is an ongoing challenge for water quality programs that seek to address nonpoint source (NPS) pollution. In this article, we develop a conceptual framework for targeting program design, and review recent experience with the implementation of targeting programs that corresponds with a wide range of program characteristics. Through this review, we emphasize that the complex and locally dependent nature of NPS generation and transport makes it impossible to define a narrow set of rules to guide targeting programs everywhere.

Capacitive Aptasensor Coupled with Microfluidic Enrichment for Real-Time Detection of Trace SARS-CoV-2 Nucleocapsid Protein.

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has lasted for almost 2 years. Stemming its spread has posed severe challenges for clinical virus detection. A long turnaround time, complicated operation, and low accuracy have become bottlenecks in developing detection techniques.

Developmental and Injury-induced Changes in DNA Methylation in Regenerative versus Non-regenerative Regions of the Vertebrate Central Nervous System.

Background: Because some of its CNS neurons (e.g., retinal ganglion cells after optic nerve crush (ONC)) regenerate axons throughout life, whereas others (e.

Evolutionary clustering and community detection algorithms for social media health surveillance.

The prominent rise of social networks within the past decade have become a gold mine for data mining operations seeking to model the real world through these virtual worlds. One of the most important applications that has been proposed is utilizing information generated from social networks as a supplemental health surveillance system to monitor disease epidemics. At the time this research was conducted in 2020, the COVID-19 virus had evolved into a global pandemic, forcing many countries to implement preventative measures to halt its expanse.