286 results match your criteria: "Montreal Clinical Research Institute[Affiliation]"
Endocr Rev
December 2024
Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W 1R7, Canada.
Discovered in 1996, PCSK7 is the seventh of the nine-membered proprotein convertase subtilisin-kexin (PCSK) family. This article reviews the various aspects of the multifaceted biology of PCSK7 and what makes it an exciting new target for metabolic dysfunction-associated steatotic liver disease (MASLD) affecting ∼30% of the population globally, dyslipidemia, cardiovascular disease (CVD), and likely cancer/metastasis. We will systematically review and discuss all the available epidemiological data, structural, cell biology, and in vivo evidence that eventually led to the discovery of PCSK7 as a novel post-translational regulator of apolipoprotein B.
View Article and Find Full Text PDFHorm Res Paediatr
December 2024
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In recent years, the availability of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provides additional health benefits but can cause glucose fluctuations, which challenges current AID systems.
View Article and Find Full Text PDFDiabetologia
December 2024
School of Kinesiology and Health Science, York University, Toronto, ON, Canada.
Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In recent years, the availability of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provide additional health benefits but can cause glucose fluctuations, which challenges current AID systems.
View Article and Find Full Text PDFiScience
December 2024
Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada.
J Clin Lipidol
November 2024
Lipids, Nutrition, and Cardiovascular Prevention Clinic of the Montreal Clinical Research Institute, Montreal, Québec, Canada; Department of Medicine, Divisions of Experimental Medicine and Medical Biochemistry, McGill University, Montreal, Québec H3G 2M1, Canada. Electronic address:
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype and severity are more heterogeneous than previously thought. The predictors of atherosclerotic cardiovascular disease (ASCVD) in HoFH patients have never been systematically studied.
View Article and Find Full Text PDFClin Exp Pharmacol Physiol
January 2025
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Circulation
November 2024
Stanford University, Palo Alto, CA.
Metabolism
November 2024
Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai 200032, China. Electronic address:
PCSK9 is a serine protease that regulates plasma levels of low-density lipoprotein (LDL) and cholesterol by mediating the endolysosomal degradation of LDL receptor (LDLR) in the liver. When PCSK9 functions unchecked, it leads to increased degradation of LDLR, resulting in elevated circulatory levels of LDL and cholesterol. This dysregulation contributes to lipid and cholesterol metabolism abnormalities, foam cell formation, and the development of various diseases, including cardiovascular disease (CVD), viral infections, cancer, and sepsis.
View Article and Find Full Text PDFAppetite
January 2025
School of Kinesiology and Physical Activity Sciences, Université de Montréal, Montreal, QC, Canada; CHU Sainte-Justine Azrieli Research Center, Montreal, QC, Canada. Electronic address:
This systematic review and meta-analysis examine the literature (up to August 2nd 2024) on the influence of exercise timing on energy intake in both children and adults. A comprehensive search was conducted using MEDLINE, EMBASE, Cochrane Library, SPORTDiscus, and Web of Science Core Collection, following PRISMA guidelines. The review was registered in Prospero (CRD42024553381) and evaluated using QUADAS-2.
View Article and Find Full Text PDFCurr Opin Lipidol
November 2024
Genetic Dyslipidemias Clinic of the Montreal Clinical Research Institute, Montreal.
Int J Public Health
October 2024
Centre Integre de Sante et de Services Sociaux de Laval, Laval, QC, Canada.
[This corrects the article DOI: 10.3389/ijph.2024.
View Article and Find Full Text PDFLife Sci Alliance
December 2024
Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland
J Gastroenterol Hepatol
December 2024
Genetic Dyslipidemia Clinic, Montreal Clinical Research Institute, Montreal, Quebec, Canada.
Nat Commun
October 2024
McEwen Stem Cell Institute, University Health Network, Toronto, ON, M5G 1L7, Canada.
Sci Signal
October 2024
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
The axon guidance cue netrin-1 signals through its receptor DCC (deleted in colorectal cancer) to attract commissural axons to the midline. Variants in DCC are frequently associated with congenital mirror movements (CMMs). A CMM-associated variant in the cytoplasmic tail of DCC is located in a conserved motif predicted to bind to a regulator of actin dynamics called the WAVE (Wiskott-Aldrich syndrome protein-family verprolin homologous protein) regulatory complex (WRC).
View Article and Find Full Text PDFJ Exp Med
November 2024
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France.
JAMA Netw Open
September 2024
Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio.
Importance: Deep brain stimulation (DBS) results in improvements in motor function and quality of life in patients with Parkinson disease (PD), which might impact a patient's perception of valued personal characteristics. Prior studies investigating whether DBS causes unwanted changes to oneself or one's personality have methodological limitations that should be addressed.
Objective: To determine whether DBS is associated with changes in characteristics that patients with PD identify as personally meaningful.
Int J Public Health
November 2024
Centre Integre de Sante et de Services Sociaux de Laval, Laval, QC, Canada.
Objectives: In the province of Quebec, Canada, interdisciplinary support groups (ISGs) are mandated to support those who are involved in the clinical, administrative, legal and ethical aspects of medical assistance in dying (MAiD). This article presents the results of a mixed-method, multi-phase study carried out in 2021 on ISGs with the aim to describe current ISG practices, critically analyze them and make recommendations on promising practices for provincial implementation.
Method: Semi-structured interviews (42) and focus groups (7) with coordinators of 24 ISGs were used to identify promising practices and confirm their utility with participants.
Can J Diabetes
September 2024
Montreal Clinical Research Institute, Montréal, QC, Canada; Nutrition Department, Faculty of Medicine, University of Montreal, Montréal, QC, Canada; Cystic Fibrosis Clinic, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Québec, Canada; Division of Endocrinology, Faculty of Medicine, Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:
J Clin Endocrinol Metab
September 2024
Lipids, Nutrition, and Cardiovascular Prevention Clinic of the Montreal Clinical Research Institute, Montreal (Québec, H2W 1R7, Canada).
N Engl J Med
September 2024
From the School of Medicine, University of Western Australia, and the Department of Cardiology, Royal Perth Hospital - both in Perth, Australia (G.F.W.); the Metabolism and Lipids Program, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai (R.S.R.), and New York University (NYU) Grossman School of Medicine, NYU Langone Health (I.J.G) - both in New York; Robarts Research Institute, London, ON (R.A.H.), and the Department of Medicine, McGill University, and the Genetic Dyslipidemia Clinic, Montreal Clinical Research Institute (A.B.) and Université de Montréal and ECOGENE-21 (D.G.), Montreal - all in Canada; Sorbonne University, INSERM UMR1166, Lipidology and Cardiovascular Prevention Unit, Department of Nutrition, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris (A.G.); the Department of Endocrinology, University Hospitals Leuven-KU Leuven, Leuven, Belgium (A.M.); and Arrowhead Pharmaceuticals, Pasadena (R.Z., M.M., J.H.), and Stanford University, Palo Alto (N.J.L.) - both in California.
Background: Persistent chylomicronemia is a genetic recessive disorder that is classically caused by familial chylomicronemia syndrome (FCS), but it also has multifactorial causes. The disorder is associated with the risk of recurrent acute pancreatitis. Plozasiran is a small interfering RNA that reduces hepatic production of apolipoprotein C-III and circulating triglycerides.
View Article and Find Full Text PDFDiabetes Metab Res Rev
September 2024
Metabolic Diseases Research Unit, Montreal Clinical Research Institute, Montreal, Canada.
Aims: The prevalence and associations of overweight and obesity in Canadian adult people living with type 1 diabetes (PWT1D) are poorly documented. In a cohort of PWT1D patients, this study assesses (i) overweight and obesity frequencies and associated PWT1D clinicodemographic characteristics, (ii) diabetes characteristics, and (iii) the use of noninsulin adjunctive agents.
Materials And Methods: Cross-sectional analysis of self-reported data from the BETTER registry: 1091 adult PWT1D (aged 44.
Diabetes Obes Metab
October 2024
Montreal Clinical Research Institute (IRCM), Montréal, Québec, Canada.
Aim: The relative contributions of insulin secretory defects and possible additional contribution of insulin resistance for the development of cystic fibrosis (CF)-related diabetes (CFRD) are poorly understood. We aimed to (a) determine which indices of insulin resistance predict progression to CFRD, and (b) to model the relative contributions of insulin secretory function and insulin resistance to predict the risk of CFRD.
Materials And Methods: Three hundred and three individuals living with CF underwent a 2-h oral glucose tolerance test with blood sampling every 30 min at 12-24-month intervals until they developed CFRD or until the end of follow-up (up to 15 years).
Biomed Rep
August 2024
Laboratory of Genomic Diagnostics, National Institute of Genomic Medicine, Mexico City 14610, Mexico.
Perry syndrome (PS) is a rare autosomal dominant disease characterized by parkinsonism, central hypoventilation, weight loss and depression and is caused by pathogenic mutations in the dynactin subunit 1 () gene (encoding p150 protein). To date, only two cases have been reported in Latin America, specifically in Colombia and Argentina. The present study, to the best of our knowledge, reports the first recorded Mexican family with PS.
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