98 results match your criteria: "Montpellier I University[Affiliation]"

Cytomegalovirus infection: friend or foe in rheumatoid arthritis?

Arthritis Res Ther

January 2021

Centre de Physiopathologie Toulouse Purpan, U.1043 INSERM, CNRS, CHU Purpan, BP 3028, 31024, Toulouse cedex 3, France.

Article Synopsis
  • HCMV is a β-herpesvirus that causes lifelong latency and inflammation, with recent findings linking it to rheumatoid arthritis (RA) and bone erosion.
  • Infection with HCMV seems to slow down bone erosion in RA patients by promoting the mRNA-binding protein QKI5, which raises questions about its role in RA's progression.
  • This review explores whether HCMV acts as a beneficial factor against bone erosion while potentially aggravating RA inflammation, also considering its interactions with other pathogens like those causing periodontitis.
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Early management of severe abdominal trauma.

Anaesth Crit Care Pain Med

April 2020

Service d'Anesthésie-Réanimation, Hôpital Beaujon, UMR_S1149, Centre De Recherche Sur L'inflammation, Inserm et Université Paris Diderot, AP-HP, 75000 Paris, France.

Objective: To develop French guidelines on the management of patients with severe abdominal trauma.

Design: A consensus committee of 20 experts from the French Society of Anaesthesiology and Critical Care Medicine (Société française d'anesthésie et de réanimation, SFAR), the French Society of Emergency Medicine (Société française de médecine d'urgence, SFMU), the French Society of Urology (Société française d'urologie, SFU) and from the French Association of Surgery (Association française de chirurgie, AFC), the Val-de-Grâce School (École du Val-De-Grâce, EVG) and the Federation for Interventional Radiology (Fédération de radiologie interventionnelle, FRI-SFR) was convened. Declaration of all conflicts of interest (COI) policy by all participants was mandatory throughout the development of the guidelines.

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Strategic proposal for a national trauma system in France.

Anaesth Crit Care Pain Med

April 2019

Grenoble Alps Trauma centre, Grenoble University Hospital, Grenoble Alps University, 38000 Grenoble, France. Electronic address:

In this road map for trauma in France, we focus on the main challenges for system implementation, surgical and radiology training and upon innovative training techniques. Regarding system organisation: procedures for triage, designation and certification of trauma centres are mandatory to implement trauma networks on a national scale. Data collection with registries must be created, with a core dataset defined and applied through all registries.

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Influence of late fluid management on the outcomes of severe trauma patients: A retrospective analysis of 294 severely-injured patients.

Injury

September 2017

Trauma Intensive and Critical Care Unit, Department of Anesthesiology and Critical Care, Lapeyronie Hospital, Montpellier I University, Montpellier, France. Electronic address:

Background: Liberal late fluid management (LFM) is associated with higher morbi-mortality in critically ill populations. The aim of the study was to assess the association between LFM and duration of mechanical ventilation in a severe trauma population.

Methods: A retrospective analysis of consecutive patients with an ISS≥16 and a length of stay in the intensive care unit (ICU)≥7 days was performed.

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Left ventricles of aging athletes: better untwisters but not more relaxed during exercise.

Clin Res Cardiol

November 2017

EA 2992, Dysfunction of Vascular Interfaces Research Laboratory, Faculty of Medicine, Montpellier I University and Nimes University Hospital Center, Nîmes, France.

Objective: With an aging population and the increasing prevalence of heart failure with preserved ejection fraction, developing strategies to prevent diastolic dysfunction is crucial. Regular endurance training has been suggested to be one such strategy. However, the underlying mechanisms of training, including the effect on left ventricular (LV) untwist, which promotes LV filling, are unclear and studies exploring the heart during exercise in the aging heart are lacking.

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Many therapies are available for patients with rheumatoid arthritis (RA) while biological therapies have limited effects in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). In both cases, biomarkers predicting drug response would be very useful to guide clinicians in their choice. We performed a systematic review to evaluate the value of lymphocyte phenotyping as a marker of therapeutic response.

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Introduction: Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease.

Observation: Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation.

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Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?

Clin Rev Allergy Immunol

October 2017

Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, BP 824, 29609, Brest cedex, France.

Considering the implications of B, T, and natural killer (NK) cells in the pathophysiology of systemic autoimmune diseases, the assessment of their distribution in the blood could be helpful for physicians in the complex process of determining a precise diagnosis. In primary Sjögren's syndrome, transitional and active naive B cells are increased and memory B cells are decreased compared to healthy controls and other systemic diseases. However, their utility to improve the accuracy of classification criteria has not been proven.

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Article Synopsis
  • Reduction of LDL-cholesterol (LDLc) is crucial to lower cardiovascular mortality in rheumatoid arthritis (RA), and guidelines implemented between 2006 and 2010 aimed to address this by identifying RA as an additional risk factor.
  • A study analyzed data from 814 patients at high risk for RA and found that 77% were female, with a small percentage using statins to manage cholesterol levels.
  • Despite the guidelines, the number of patients reaching the LDLc target worsened from 2006 to 2010, especially among those at the highest cardiovascular risk, indicating that management of dyslipidaemia remains inadequate in practice.
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Introduction: Use of prediction matrices of risk or rapid radiographic progression (RRP) for early rheumatoid arthritis (RA) in clinical practice could help to better rationalise the first line of treatment. Before use, they must be validated in populations that have not participated in their construction. The main objective is to use the ESPOIR cohort to validate the performance of 3 matrices (ASPIRE, BEST and SONORA) to predict patients at high risk of RRP at 1 year of disease despite initial treatment with methotrexate (MTX).

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Vitamin D, disease activity and comorbidities in early spondyloarthritis.

Clin Exp Rheumatol

August 2016

Rheumatology Department, Paris Descartes University, APHP Cochin Hospital, INSERM (U1153), Paris, France.

Objectives: To assess the vitamin D status in patients presenting inflammatory back pain suggestive of axial spondyloarthritis and to assess the relationship between vitamin D status and disease activity/severity; comorbidities at baseline and during the first two years of follow-up.

Methods: DESIR is a prospective, multicentre, observational study. Vitamin D deficiency was defined as <50 nmol/L and severe deficiency less than 25 nmol/L.

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Investigations on the cardiac function consequences of mountain ultramarathon (MUM) >100 h are lacking. The present study assessed the progressive cardiac responses during the world's most challenging MUM (Tor des Géants; Italy; 330 km; 24,000 m of cumulative elevation gain). Resting echocardiographic evaluation of morphology, function, and mechanics of left and right ventricle (LV and RV) including speckle tracking echocardiography was conducted in 15 male participants (46 ± 13 yr) before (pre), during (mid; 148 km), and after (post) the race.

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Association of Body Mass Index Categories with Disease Activity and Radiographic Joint Damage in Rheumatoid Arthritis: A Systematic Review and Metaanalysis.

J Rheumatol

December 2015

From the Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; Institut of Molecular Genetic of Montpellier, Unité Mixte de Recherche n. 5535 (UMR5535), Montpellier; Rheumatology Department, Hôpital Pellegrin, Bordeaux, France.C. Vidal, MD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; T. Barnetche, PhD, Rheumatology Department, Hôpital Pellegrin; J. Morel, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; B. Combe, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; C. Daïen, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535.

Objective: Obesity and overweight are increasing conditions. Adipose tissue with proinflammatory properties could be involved in rheumatoid arthritis (RA) activity and radiographic progression. This study aims to investigate the influence of overweight and obesity on RA activity and severity.

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Certolizumab Pegol Efficacy Across Methotrexate Regimens: A Pre-Specified Analysis of Two Phase III Trials.

Arthritis Care Res (Hoboken)

March 2016

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals National Health Service Trust, Leeds, UK.

Objective: Anti-tumor necrosis factor (anti-TNF) agents are frequently used in combination with methotrexate (MTX) to treat rheumatoid arthritis (RA). We investigated the effect of a background MTX dose, in combination with anti-TNF certolizumab pegol (CZP), on treatment efficacy and safety in RA patients.

Methods: A pre-specified subgroup analysis comparing 2 MTX dosage categories (<15 mg/week and ≥15 mg/week) was carried out using data pooled from phase III clinical trials, Rheumatoid Arthritis Prevention of Structural Damage 1 (RAPID 1) and RAPID 2, according to treatment group: CZP 200 mg, CZP 400 mg, or placebo, every 2 weeks.

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Objective: Patient-reported outcomes (PROs) reflect treatment efficacy from the patients' perspective. The objective was to assess PROs improvement with rituximab in rheumatoid arthritis.

Methods: Patients with long-standing rheumatoid arthritis received rituximab 1000mg twice at 2 weeks interval, and were assessed over 6 months.

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CO2 Clamping, Peripheral and Central Fatigue during Hypoxic Knee Extensions in Men.

Med Sci Sports Exerc

December 2015

1HP2 Laboratory, Université Grenoble Alpes, Grenoble, FRANCE; 2U1042, INSERM, Grenoble, FRANCE; 3Laboratoire de Physiologie de l'Exercice, Université Savoie Mont Blanc, Chambéry, FRANCE; 4Movement To Health, Montpellier-I University, Euromov, Montpellier, FRANCE; 5Université de Lyon, Saint-Etienne, FRANCE; and 6Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, CANADA.

Introduction: The central nervous system can play a critical role in limiting exercise performance during hypoxic conditions. Hypocapnia, which is associated with hypoxia-induced hyperventilation, may affect cerebral perfusion. We hypothesized that CO2 clamping during hypoxic isometric knee extensions would improve cerebral oxygenation and reduce central fatigue.

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Objectives: Little data are available regarding the rate and predicting factors of serious infections in patients with rheumatoid arthritis (RA) treated with abatacept (ABA) in daily practice. We therefore addressed this issue using real-life data from the Orencia and Rheumatoid Arthritis (ORA) registry.

Methods: ORA is an independent 5-year prospective registry promoted by the French Society of Rheumatology that includes patients with RA treated with ABA.

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Article Synopsis
  • Spontaneous intracranial artery dissection is a rare but often missed cause of stroke, leading to complications like headaches, ischemic strokes, and subarachnoid hemorrhages, mainly affecting the brainstem.
  • While less common in adults of European descent, it's more frequently seen in children and Asian populations; the exact causes and risk factors are not well understood, making diagnosis difficult due to the small size of the arteries involved.
  • Treatment typically involves surgery or endovascular methods for subarachnoid hemorrhage, while those with ischemia are treated with antithrombotics; patients with hemorrhage have a worse prognosis than those without.
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Introduction: Morning stiffness is assessed daily in the diagnostic process of arthralgia and arthritis, but large-scale studies on the discriminative ability are absent. This study explored the diagnostic value of morning stiffness in 5,202 arthralgia and arthritis patients and the prognostic value in early rheumatoid arthritis (RA).

Methods: In arthralgia patients referred to the Early Arthritis Recognition Clinics (EARC) of Leiden (n = 807) and Groningen (n = 481) or included in the Rotterdam Early Arthritis Cohort (REACH) study (n = 353), the associations (cross-sectional analyses) between morning stiffness and presence of arthritis at physical examination were studied.

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Prevalence of large and occult pneumothoraces in patients with severe blunt trauma upon hospital admission: experience of 526 cases in a French level 1 trauma center.

Am J Emerg Med

June 2015

Trauma Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France; Montpellier I University, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, Equipe soutenue par la Région et l'Inserm U1046 (X.C.), Montpellier, France.

Background: Occult pneumothoraces (PTXs), which are not visible on chest x-ray, may progress to tension PTX. The aim of study was to establish the prevalence of large occult PTXs upon admission of patients with severe blunt trauma, according to prehospital mechanical ventilation.

Methods: Patients with severe trauma consecutively admitted to our institution for 5 years were retrospectively analyzed.

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Development of a Draft Core Set of Domains for Measuring Shared Decision Making in Osteoarthritis: An OMERACT Working Group on Shared Decision Making.

J Rheumatol

December 2015

From the Children's Hospital of Eastern Ontario Research Institute and Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada; VA Portland Health Care System, and Oregon Health and Science University, Portland, Oregon, USA; Department of Internal Medicine, Yale University, New Haven, Connecticut, USA; Department of Physical Therapy, University of British Columbia and Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada; School of Rehabilitation Sciences, University of Ottawa, Ottawa, Ontario, Canada; Rheumatic Diseases, University of Lorraine, Nancy, France; Institute of Population Health, Centre for Global Health, and School of Nursing, University of Ottawa, Ottawa, Ontario, Canada; Department of Family Medicine and Emergency Medicine, Université Laval, Québec City, Québec, Canada; Bruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada; University of Twente, Enschede; VU Medical Centre, Amsterdam, The Netherlands; Department of Medicine, University of Sydney, Institute of Bone and Joint Research; University of Western Sydney, Sydney, Australia; Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, University of Copenhagen, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark; Department of Rheumatology, Nîmes University Hospital, Montpellier I University, Nîmes, France; Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center and Caphri Research Institute, Maastricht University, Maastricht, The Netherlands; Department of Internal Medicine II Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Teaching Hospital of the Charité, University Medicine, Berlin, Germany; Rheumatology, Michigan State University College of Human Medic

Objective: Despite the importance of shared decision making for delivering patient-centered care in rheumatology, there is no consensus on how to measure its process and outcomes. The aim of this Outcome Measures in Rheumatology (OMERACT) working group is to determine the core set of domains for measuring shared decision making in intervention studies in adults with osteoarthritis (OA), from the perspectives of patients, health professionals, and researchers.

Methods: We followed the OMERACT Filter 2.

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Narcolepsy with and without cataplexy, idiopathic hypersomnia with and without long sleep time: a cluster analysis.

Sleep Med

February 2015

Department of Neurology, Gui de Chauliac Hospital, Montpellier I University, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.

Background: The successive editions of the International Classification of Sleep Disorders (ICSD) reflect the evolution of the concepts of various sleep disorders. This is particularly the case for central disorders of hypersomnolence, with continuous changes in terminology and divisions of narcolepsy, idiopathic hypersomnia, and recurrent hypersomnia. According to the ICSD 2nd Edition (ICSD-2), narcolepsy with cataplexy (NwithC), narcolepsy without cataplexy (Nw/oC), idiopathic hypersomnia with long sleep time (IHwithLST), and idiopathic hypersomnia without long sleep time (IHw/oLST) are four, well-defined hypersomnias of central origin.

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Background: A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It is unknown whether this relation is linear, referring to a common 'the-earlier-the-better principle', or whether a transient time frame in which the disease is more susceptible to treatment exists, referring to a 'window of opportunity'. To elucidate this, we evaluated the shape of the associations of symptom duration with persistence of RA.

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Objective: Interleukin-6 (IL-6) is a key cytokine in rheumatoid arthritis pathogenesis. We aimed to analyze the association between IL-6 serum levels and joint inflammation at baseline and the correlation of time-integrated IL-6 values with structural damage during the first 36 months of early arthritis.

Methods: IL-6 was assessed by 2 different methods in 813 patients of the French early arthritis cohort ESPOIR (Etude et Suivi des Polyarthrites Indifférenciées Récentes) over 36 months.

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Objectives: To evaluate clinical remission with subcutaneous abatacept plus methotrexate (MTX) and abatacept monotherapy at 12 months in patients with early rheumatoid arthritis (RA), and maintenance of remission following the rapid withdrawal of all RA treatment.

Methods: In the Assessing Very Early Rheumatoid arthritis Treatment phase 3b trial, patients with early active RA were randomised to double-blind, weekly, subcutaneous abatacept 125 mg plus MTX, abatacept 125 mg monotherapy, or MTX for 12 months. Patients with low disease activity (Disease Activity Score (DAS)28 (C reactive protein (CRP)) <3.

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