Transcriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells.

Gastric cancer (GC) is a common cancer worldwide. Therefore, searching for effective treatments is essential, and drug repositioning can be a promising strategy to find new potential drugs for GC therapy. For the first time, we sought to identify molecular alterations and validate new mechanisms related to Mebendazole (MBZ) treatment in GC cells through transcriptome analysis using microarray technology.

The Montenegrin 2022 Report Card on Physical Activity for Children and Youth.

Background: The main purpose of this study was to summarize the results of the Montenegrin 2022 Report Card on physical activity (PA) for children and youth, which is used to identify and grade PA to help optimize the current situation and provide an improved basis for the creation of a future monitoring system.

Methods: Following the methodology established by the Active Healthy Kids Global Alliance, the Montenegrin team conducted an assessment of PA of Montenegrin children and youth through 12 separate indicators. Grades were awarded based on data found in available articles published up to 2022, including the grey literature, such as government and nongovernment reports, and online content from the same period.

Impact of Acne on the Quality of Life of Adolescents in the Territory of the Northern and Southern Regions of Montenegro.

Background: Acne vulgaris is a chronic inflammatory disease predominantly known as a disease of adolescents. We aimed to assess the quality of life of adolescents with acne in the territory of northern and southern regions of Montenegro.

Methods: This cross-sectional study was conducted in 2024, in four secondary schools in the north and south of Montenegro with total number of 561 subjects.

Analytical modeling of novel equivalent circuits of double diode solar cell circuits using a special transcendental function approach.

Solar photovoltaic (PV) cell modeling is crucial to understanding and optimizing solar energy systems. While the single-diode model (PVSDM) is commonly used, the double-diode model (PVDDM) offers improved accuracy at a reasonable level of complexity. However, finding analytical closed-form solutions for the current-voltage (I-U) dependency in PVDDM circuits has remained a challenge.

AdeABC, AdeFGH, and AdeIJK efflux pumps as key factors in tigecycline resistance of Acinetobacter baumannii: a study from Western Balkan hospitals.

Purpose: The present study investigated the role of resistance-nodulation-cell division (RND) efflux pumps in tigecycline resistance of Acinetobacter baumannii clinical isolates recovered from three Western Balkan countries (Serbia, Bosnia and Herzegovina and Montenegro).

Methods: A total of 37 A. baumannii isolates recovered from seven tertiary care hospitals in 2016 and 2022 were tested against tigecycline using broth microdilution method.

DNA barcode library of Portuguese water mites, with the descriptions of two new species (Acari, Hydrachnidia).

This study presents the first results from the analysis of water mites collected in Portugal as part of the Biodiversity Genomics Europe project. 307 COI DNA barcodes clustered into 75 BINs are provided, with 38 BINs being unique and deposited for the first time in the Barcode of Life Data Systems (BOLD). 65 species have been identified, of which 36 are new to the water mite fauna of Portugal.

A Perspective of Multi-Reflecting TOF MS.

Time-of-flight mass spectrometry (TOF MS) excels in rapid and high-sensitivity analysis, making it a cornerstone of analytical chemistry. But as sample complexity explodes in omics studies, so does the need for higher resolving power to ensure accurate results. Traditional TOF instruments face a challenge: achieving high resolution often requires a very large instrument.

Phytoconstituents, Antioxidant Activity and Cytotoxicity of Mol. Extracts in Colon Cell Lines.

Mol. is a plant of the Bromeliaceae family, which has been traditionally used for medicinal applications in various digestive disorders. In this study, the phytoconstituents of six extracts of stems and flowers of were evaluated: phenols, flavonoids and total anthraquinones, as well as their antioxidant capacity and cytotoxicity in colon cancer cell lines HT-29.

Association between body mass index, muscle-to-fat ratio, and handgrip strength-to-BMI ratio with physical fitness in children from North Macedonia.

Background: this cross-sectional study, conducted on a convenience sample of 2197 Macedonian primary school children, aimed to examine how certain anthropometric indices (body mass index (BMI), muscle-fat ratio (MFR), hand grip strength-BMI ratio) are related to the physical fitness of individuals.

Methods: the sample was split into two groups based on gender: 1096 boys and 1101 girls (average age 8.1 ± 1.

Association of uremic toxins and systemic inflammation with depression and anxiety among hemodialysis patients in Montenegro.

Objective: The purpose of this study was to examine the association between uremic toxins, inflammation, depression and anxiety among hemodialysis patients in Montenegro.

Method: The cross-sectional study included 88 patients undergoing hemodialysis. Depression and anxiety symptoms were assessed by Patient Health Questionnaire (PHQ-9) and Beck Anxiety Inventory (BAI).

Tolerance of free-living larval stage of a parasite from coastal mining areas in northern Humboldt Current to copper pollution at low and high temperatures.

Metal pollution is a worldwide problem and one of the greatest threats to ecosystem integrity due to its toxicity, persistence, and bioaccumulation in biological systems. Anthropogenic pollution impacts marine organisms and host-parasite dynamics, with the northern Chilean coast experiencing elevated copper levels in marine waters and sediments due to mining activities. In this study, we assessed the effects of exposure to copper concentrations at low and high-water temperatures on the survival and longevity of the marine parasite Himasthla sp.

Serotype-specific epidemiological patterns of inapparent versus symptomatic primary dengue virus infections: a 17-year cohort study in Nicaragua.

Background: Dengue is the most prevalent mosquito-borne viral disease and a major public health problem worldwide. Most primary infections with the four dengue virus serotypes (DENV1-4) are inapparent; nonetheless, whether the distribution of symptomatic versus inapparent infections by serotype varies remains unknown. Here, we present (1) the evaluation of a DENV1-4 envelope domain III multiplex microsphere-based assay (EDIII-MMBA) to serotype inapparent primary infections and (2) its application leveraging 17 years of prospective sample collection from the Nicaraguan Pediatric Dengue Cohort Study (PDCS).

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

Case Report: Trauma group therapy with karate-do for war-traumatized children and adolescents.

Background: From the viewpoint of health and education, traumatized children and adolescents who have fled from war and conflict zones to Switzerland represent a high-risk group, as they suffer from psychiatric symptoms to an above-average extent and on several levels: somatic, psychological, psychosomatic, and psychosocial.

Objectives: The complexity and severity of these problems overwhelm the existing school structures in many cases: There is a clear need for psychotherapeutic interventions here that goes beyond purely verbal conversational therapy and provides an holistic concept.

Methods: We propose the following novel approach: "Trauma group therapy with karate-do for war-traumatized children and adolescents" which integrates and applies the evidence-based methods of integrative Budo-Therapy, trauma-focused Cognitive Behavioral Therapy (TF-CBT), Narrative Exposure Therapy (NET) and Integrative Gestalt Therapy according to Dr.

Ketogenic diet therapy for epilepsy: Clinical pearls.

This manuscript provides practical insights, tips, and lessons particularly valuable for early-career healthcare professionals new to using ketogenic diet therapy (KDT) in clinical practice. The review aims to be accessible, emphasizing actionable knowledge that can be directly applied in a clinical setting. The KDT for epilepsy includes not only the classic KDT but also the modified Atkins diet, the medium-chain triglyceride ketogenic diet, and the low glycemic index treatment.

Synthetic Peptides Induce Human Colorectal Cancer Cell Death via Proapoptotic Pathways.

Cancer resistance to drugs and chemotherapy is a problem faced by public health systems worldwide. Repositioning antimicrobial peptides could be an efficient strategy to overcome that problem. This study aimed at repurposing antimicrobial peptides PepGAT and PepKAA for cancer treatment.

Clinical Outcomes of Bulk-Fill Resin Composite Restorations: A 10-Year Mapping Review and Evidence Gap Map.

Objective: To map the evidence regarding the clinical performance of posterior restorations with bulk-fill resin composites and identify research gaps.

Materials And Methods: This mapping review was conducted following PRISMA-ScR guidelines for scoping reviews, and its protocol was registered on the Open Science Framework platform. Systematic searches were conducted, considering studies published between 2013 and February 2024 in the PubMed, Embase, and Cochrane databases.

Five-factor theory of aging and death due to aging.

This new theory of aging explains that aging and death due to aging are due to five factors, and also explains how these factors are interconnected and jointly lead to aging and death of the organism, pointing to many facts that strongly support it. The first factor is the harmful changes that occur in cellular structures. The second factor is the cessation of cell division in adult organisms, which leads to the inability to restore cellular structures.

Investigating the Hepatic Response to Orlistat and White Tea in Rats on a High-Fat Diet.

High-fat diets have detrimental health impacts that increase the likelihood of developing obesity and metabolic syndrome. This study aimed to examine the potential antioxidant and anti-inflammatory effects of orlistat and white tea in rats fed a high-fat diet. Thirty-two rats were randomized into four groups: control (standard diet), HFD (high-fat diet), HFD+Orlistat (high-fat diet+orlistat), and HFD+WT (high-fat diet+white tea extract).