Improving the Cellular Internalization of Zr(IV) Nanocages by Tuning Hydrophilicity and Lipophilicity.

Nanoscale molecular materials have emerged as a new class of compounds at the nanometer scale with well-defined chemical structures, remarkable uniformity and high reproducibility. Among these materials, zirconium-based metal-organic cages (MOCs) have attracted significant attention due to their exceptional stability and applications in catalysis, recognition and separation and so on. However, their poor water solubility impedes their biomedical applications.

The toxic effects of and benzo(a)pyrene in inducing atrophic gastritis and gut microbiota dysbiosis in Mongolian gerbils.

Food chemical and microbiological contamination are major global food safety issues. This study investigated the combined effects of the food-borne pathogen () and the pollutant benzo(a)pyrene (Bap) on atrophic gastritis and gut microbiota in Mongolian gerbils. The results demonstrated that simultaneous administration of and Bap caused more severe weight loss, DNA damage, and gastritis in Mongolian gerbils compared with those exposed to or Bap alone.

In vitro and in vivo investigation of the biological action of xylooligosaccharides derived from industrial waste.

Xylooligosaccharides (XOS) are prebiotics of significant biological value that can be obtained through cost-effective purification of agricultural waste. The present research featured in vitro and in vivo investigation of prebiotic effects of xylooligosaccharides derived from wheat bran powder and brewer's spent grain. Prebiotic activity of , and spp.

The inhibitory effect of salidroside on RANKL-induced osteoclast formation via NFκB suppression.

Bone fractures are a prevalent clinical issue, and recent studies highlighted the promising potential of natural bone healing agents in enhancing fracture repair and regeneration. The regulatory interaction mechanism between osteoblasts and osteoclasts is crucial for bone cell biology and bone disease. In Mongolian medicine, people have used the Rhodiola rosea (R.

Surface coal mining in drylands: A multiscale comparison of spatiotemporal patterns and environmental impacts between Inner Mongolia and Mongolia.

Surface coal mining (SCM) poses a great threat to the environment. Previous studies have explored the speed and scale of SCM in the Mongolian Plateau, but landscape-based analysis is needed for creating actionable knowledge required for environmental policy-making. Thus, taking a landscape ecological approach, here we compared the spatiotemporal patterns and major environmental impacts of SCM between Inner Mongolia of China and Mongolia during 1975-2015 at multiple administrative levels.

Relationship Between Genetic and Phenotypic Variations in Natural Populations of Perennial and Biennial Sagebrush.

Plant responses to environmental heterogeneity depend on life-history traits, which could relate to phenotypical and genetic characteristics. To elucidate this relationship, we examined the variation in population genetics and functional traits of short- and long-lived species that are co-occurring in the steppes of Mongolia. Mongolian steppes represent stressful and water-limited habitats, demanding phenotypic modifications in the short term and/or genetic adaptation in the long term.

Engineering cell membrane-camouflaged COF-based nanosatellite for enhanced tumor-targeted photothermal chemoimmunotherapy.

Dendritic cells (DCs) activation is crucial for regulating the antitumor immune response. However, the tumor's immunosuppressive environment significantly impedes antigen presentation and DCs maturation, thereby limiting the effectiveness of cancer immunotherapy. To address this challenge, we developed tumor cell membrane-coated covalent organic framework (COF) nanoparticles, loaded with mannose-modified gold nanoparticles and doxorubicin (Dox).

Water-dispersible fluorescent COFs disturb lysosomal autophagy to boost cascading enzymatic chemodynamic-starvation therapy.

Cascading enzymatic therapy is a promising approach in cancer treatment. However, its effectiveness is often hindered by enzyme inactivation, limited exposure of active sites, cancer cell self-protection mechanisms such as autophagy, and non-specific toxicity, which can lead to treatment failure. To address these challenges, we used a low-temperature aqueous-phase synthesis method to create semi-crystalline, water-dispersible fluorescent COF nanospheres.

Variation in Leaf Functional Traits of Ldb and L. Across Five Contrasting Urban Sites in Ulaanbaatar, Mongolia.

Amid urbanization, studying leaf functional traits of woody plants in urban environments is essential for understanding how urban green spaces function and how they can be effectively managed sustainably. In this study, we investigated the effects of different growing conditions on the morpho-physiological traits of and across five contrasting urban sites. The leaf area (LA), leaf length (LL), leaf width (LW), leaf biomass (LB), specific leaf area (SLA), leaf chlorophyll concentration, chlorophyll fluorescence parameters, leaf water potential at predawn (Ψ) and midday (Ψ), leaf performance index (PI), and phenotypic plasticity index (PPI) were compared across five contrasting urban sites.

Cardiovascular Risk across Glycemic Categories: Insights from a Nationwide Screening in Mongolia, 2022-2023.

(1) : Diabetes mellitus is a significant risk factor for cardiovascular disease (CVD), a leading cause of death globally. Recent studies have highlighted the role of pre-diabetes, particularly impaired fasting glucose (IFG), in elevating CVD risk even before the onset of diabetes. The objective of this study was to assess cardiovascular disease (CVD) risk across specific glycemic categories, including normoglycemia, impaired fasting glucose (IFG), newly diagnosed diabetes, and long-standing diabetes, in a large Mongolian population sample.

Gut microbiota are involved in leptin-induced thermoregulation in the Mongolian gerbil (Meriones unguiculatus).

Leptin is a hormone that is secreted by adipocytes and may promote energy expenditure by increasing thermogenesis. Our previous studies have shown that thermo-transient receptor potentials (thermo-TRPs) and gut microbiota are associated with thermoregulation in Mongolian gerbils, which are characterized by relative high serum leptin concentrations. Here, we tested whether leptin can stimulate non-shivering thermogenesis (NST) in Mongolian gerbils, and whether thermo-TRPs and gut microbiota are involved in leptin-induced thermogenesis.

Tilianin attenuates inflammasome activation in endothelial progenitor cells to mitigate myocardial ischemia-reperfusion injury.

Tilianin (TIL), a bioactive component derived from Dracocephalum Moldavica L., has been recognized for its anti-inflammatory properties. However, its effects on the Nlrp3 inflammasome within endothelial progenitor cells (EPCs) during myocardial ischemia-reperfusion injury (MIRI) remain unexplored.