Unveiling the catalytic potency of a novel hydrazone-linked covalent organic framework for the highly efficient one-pot synthesis of 1,2,4-triazolidine-3-thiones.

A novel hydrazone-linked covalent organic framework (TRIPOD-DHTH COF) was synthesized through the ultrasonic treatment of 2,5-dihydroxyterephthalohydrazide (DHTH) and 4,4',4''-[1,3,5-triazine-2,4,6-triyltris(oxy)]tris-benzaldehyde (TRIPOD). The COF was extensively analyzed using FT-IR, PXRD, SEM, TEM, BET, XPS, TGA, and DTA techniques. The characterization studies revealed the presence of mesoporous properties and high thermal stability, with a surface area measuring 2.

Intricate relationship between cancer stemness, metastasis, and drug resistance.

Cancer stem cells (CSCs) are widely acknowledged as the drivers of tumor initiation, epithelial-mesenchymal transition (EMT) progression, and metastasis. Originating from both hematologic and solid malignancies, CSCs exhibit quiescence, pluripotency, and self-renewal akin to normal stem cells, thus orchestrating tumor heterogeneity and growth. Through a dynamic interplay with the tumor microenvironment (TME) and intricate signaling cascades, CSCs undergo transitions from differentiated cancer cells, culminating in therapy resistance and disease recurrence.

Oncogenes and tumor suppressor genes: functions and roles in cancers.

Cancer, being the most formidable ailment, has had a profound impact on the human health. The disease is primarily associated with genetic mutations that impact oncogenes and tumor suppressor genes (TSGs). Recently, growing evidence have shown that X-linked TSGs have specific role in cancer progression and metastasis as well.

algae-mediated copper oxide nanoparticles as a robust and recyclable catalyst for the degradation of noxious dyes from wastewater.

The present article explores the synthesis of copper oxide nanoparticles (CuO NPs) utilizing algal extract and examines the effect of various reaction parameters on the size and morphology of the nanoparticles. The samples were thoroughly characterized using XRD, FTIR, UV-vis, FE-SEM, and EDS techniques. The XRD analysis disclosed that the size of the synthesized nanoparticles could be controlled by adjusting the reaction parameters, ranging from 4.

Greener design and characterization of biochar/FeO@SiO-Ag magnetic nanocomposite as efficient catalyst for synthesis of bioactive benzylpyrazolyl coumarin derivatives.

The study aimed to develop an efficient catalyst, biochar/FeO@SiO-Ag magnetic nanocomposite, to synthesize bioactive benzylpyrazolyl coumarin derivatives through a one-pot multicomponent reaction. The catalyst was prepared using Ag nanoparticles synthesized with Lawsonia inermis leaf extract and carbon-based biochar obtained through pyrolysis of bark. The nanocomposite contained a silica-based interlayer, highly dispersed Ag nanoparticles, and a central magnetite core, which responded well to external fields.

Contemporary progress in the green synthesis of spiro-thiazolidines and their medicinal significance: a review.

The development of new strategies for the production of nitrogen and sulfur-containing heterocycles remains an extremely alluring but challenging proposition. Among these heterocyclic compounds, spiro-thiazolidines are a distinct class of heterocyclic motifs with an all-encompassing range of pharmaceutical activities such as anti-histaminic, anti-proliferative, anesthetic, hypnotic, anti-fungal, anti-inflammatory, anti-HIV, anthelmintic, CNS stimulant, and anti-viral potentials. Consequently, investigators have produced these heterocycles through diversified intricate pathways as object structures for medicinal studies.

leaf extract-mediated synthesis of silver nanoparticles and their catalytic dye degradation and antifungal efficacy.

This study describes the biosynthesis of silver nanoparticles (AgNPs) using () leaf extract. The biosynthesized AgNPs were characterized by UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM) and scanning electron microscopy with (SEM-EDS). The AgNPs showed an average size of 10-20 nm, spherical shape, and crystalline nature.

Phyto-fabrication of silver nanoparticles and their catalytic dye degradation and antifungal efficacy.

The biogenic synthesis of silver nanoparticles (AgNPs) and their potent application against dye degradation and phytopathogens are attracting many scientists to nanotechnology. An attempt was made to synthesize silver nanoparticles using leaf extract and test their effectiveness in removing organic dyes and antifungal activity. In the present study, stable AgNPs were synthesized from 0.

A review on phytochemical constituents and pharmacological potential of .

is locally known as or in Hindi, milk weed in English and belongs to the family Apocynaceae and subfamily Asclepiadoideae. Although a wasteland plant, it is of sacred use as its flowers are offered for worshipping Lord Shiva, a Hindu God. Tribes all over the world use the plant in treatment of various diseases like snake bite, body pain, asthma, epilepsy, cancer, sexual disorders, skin diseases and many more.

Exome sequencing in individuals with cardiovascular laterality defects identifies potential candidate genes.

The birth prevalence of laterality defects is about 1.1/10,000 comprising different phenotypes ranging from situs inversus totalis to heterotaxy, mostly associated with complex congenital heart defects (CHD) and situs abnormalities such as intestinal malrotation, biliary atresia, asplenia, or polysplenia. A proportion of laterality defects arise in the context of primary ciliary dyskinesia (PCD) accompanied by respiratory symptoms or infertility.

Impact of lockdown during COVID-19 pandemic on the air quality of North Indian cities.

The World Health Organization, which proclaimed the COVID-19 a pandemic in early March 2020, imposed a partial lockdown by the Government of India on 21 March 2020. The aim of this investigation was to measure the change in air pollutants, including particulate matter (PM and PM) and gaseous pollutants (NO, CO and O) during COVID-19 lockdown (25th March to 14th April 2020) across four major polluted cities in North India. In all region, PM, PM, NO and CO were significantly reduced while O has been shown mixed variation with increased in Agra and decreased in all other stations during lockdown.

PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ-DNMT1 Interactions in the Genome.

Background: PPARγ (peroxisome proliferator-activated receptor gamma) is involved in the pathology of numerous diseases, including UM and other types of cancer. Emerging evidence suggests that an interaction between PPARγ and DNMTs (DNA methyltransferase) plays a role in cancer that is yet to be defined.

Methods: The configuration of the repeating elements was performed with CAP3 and MAFFT, and the structural modelling was conducted with HDOCK.

Maximizing EPS production from and its application in Cr and Ni sequestration.

Heavy metal contamination of water bodies has been a cause of grave concern around the globe. Analysis of various industrial effluents has revealed a perilous level of Cr (VI) and Ni (II). is an extracellular polymeric substances (EPSs) producing bacterium.

Antifungal efficacy of leaf extract against and characterization of novel inhibitory compounds by Gas Chromatography-Mass Spectrometry analysis.

, a plant pathogenic fungus causes significant economical losses of potato crop. The disease is controlled primarily through some traditional methods and most commonly via the application of chemical fungicides. Fungicides treatment is not protected as chemicals pollute environment, effect health vulnerability in humans and when these harmful chemicals enter into the food chain become hazardous to all living entities.

Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia.

Introduction: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) occurs approximately 1 in 3.500 live births representing the most common malformation of the upper digestive tract. Only half a century ago, EA/TEF was fatal among affected newborns suggesting that the steady birth prevalence might in parts be due to mutational de novo events in genes involved in foregut development.

Towards a Central Role of in the Bladder Exstrophy⁻Epispadias Complex (BEEC): Computational Characterization of Genetic Variants and Structural Modelling.

Genetic factors play a critical role in the development of human diseases. Recently, several molecular genetic studies have provided multiple lines of evidence for a critical role of genetic factors in the expression of human bladder exstrophy-epispadias complex (BEEC). At this point, (ISL LIM homeobox 1) has emerged as the major susceptibility gene for classic bladder exstrophy (CBE), in a multifactorial disease model.