547 results match your criteria: "Mohammed first University[Affiliation]"

Peritoneal carcinomatosis (PC) is a common condition in oncology. The lack of specificity in radiological and clinical characteristics of carcinomatosis makes their etiological diagnosis difficult. Metastatic infiltrating lobular breast cancer with PC is also a common occurrence in daily medical practice.

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Formulation of a Three-Component Essential Oil Mixture from , , and for Improved Antioxidant Activity.

Pharmaceuticals (Basel)

August 2024

Laboratoire d'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda 60000, Morocco.

The optimization of existing natural antioxidants that are highly effective is crucial for advancements in medicine and the food industry. Due to growing concerns regarding the safety of synthetic antioxidants, researchers are increasingly focusing on natural sources, particularly essential oils (EOs). Combining EOs might enhance antioxidant activity due to increased chemical diversity.

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This study investigates, in the first part, the synthesis and purification of a poorly crystalline hydroxyapatite (HAp) using natural Moroccan phosphate (Boucraa region) as a raw material. Despite its successful preparation, the obtained HAp was contaminated by several metallic cations (mostly Cd, Pb, Sn, Ti, Mn, Mg, Fe, and Al) migrated from the natural rocks during the digestion process, inhibiting HAp application in several sectors. To minimize the existence of these elements, the dissolution-precipitation technique (DP) was investigated as a non-selective purification process.

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The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties of thymol, carvacrol, and their equimolar mixture. Antioxidant activities were assessed using the DPPH, ABTS, and ORAC methods. The thymol/carvacrol mixture exhibited significant synergism, surpassing the individual compounds and ascorbic acid in DPPH (IC = 43.

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Phosphogypsum (PG) is a solid by-product of the phosphate industry, rich in contaminants and produced in large quantities. Raw materials and stabilized specimens, consisting of bentonite-lime-PG mixtures, were characterized by mineralogical, microstructural, chemical, alpha-particle, and gamma-ray spectrometry analysis before hydration and after hardening. Compressive strength and leaching tests were performed on hardened specimens.

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Background: DNA fragmentation index (DFI) enhances routine semen analysis by providing valuable insights into male reproductive potential. Utilizing Halosperm test, a sperm chromatin dispersion (SCD) assay based on induced condensation. The purpose of this study was to assess sperm DNA damage both before and after freezing.

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The Sister Mary Joseph syndrome is characterized by cutaneous metastases localized at the umbilical level. It is a rare clinical sign estimated to occur in 1%-3% of patients with abdominopelvic cancer. The most common histology is adenocarcinoma (75% of cases).

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Primary Immunodeficiency-Type Ataxia-Telangiectasia Revealed by Splenic Abscesses.

Cureus

July 2024

Department of Pediatrics, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.

Article Synopsis
  • - Ataxia-telangiectasia (A-T) is a rare inherited disease caused by a mutation in a gene on chromosome 11 that affects cell cycle regulation and protection.
  • - Major symptoms include unsteady movement (cerebellar ataxia), dilated blood vessels on the skin and eyes (telangiectasia), and a weakened immune system leading to frequent infections.
  • - Diagnosis is often delayed because symptoms appear later in life, and individuals with A-T are especially vulnerable to radiation exposure, increasing their risk of cancer.
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Article Synopsis
  • Ledderhose disease, or plantar fibromatosis, is a rare condition marked by painful fibrous nodules in the foot's plantar fascia, causing mobility issues during activities like walking.
  • A 60-year-old woman experienced significant pain and swelling in her foot, leading to a diagnosis confirmed by clinical examination and ultrasound imaging.
  • The treatment focused on non-surgical options, including medications, orthotics, and physical therapy, demonstrating the effectiveness of personalized care in managing the condition.
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The aim of this study was to determine the phytochemical composition and evaluate the antifungal and insecticidal properties of essential oil (EO). GC-MS was employed to analyze the phytochemical profile of the EO. The antifungal activity of the EO was assessed by calculating growth inhibition rates for , , and .

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Acute psychotic and vitamin B12 deficiency in patient with nitrous oxide misuse: A case report.

SAGE Open Med Case Rep

August 2024

Department of Psychiatry, University Hospital of Mohammed VI-Oujda, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.

Nitrous oxide, also called nitrous monoxide, or nitrous oxide, is a colorless and odorless gas, without toxicological effect, but it can be asphyxiating at high concentration, its misuse is increasing especially among young people. Chronic use of NO may cause psychiatric complications, including depression, hypomania, and paranoid psychosis with visual and auditory hallucinations. We present a case of nitrous oxide abuse "laughing gas" in 25 years old woman with bizarre behavior delusions and hallucinations with a normal neurological examination.

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This article presents a new method for preparing multifunctional composite biomaterials with applications in advanced biomedical fields. The biomaterials consist of dicalcium phosphate (DCPD) and bioactive silicate glasses (SiO/NaO and SiO/KO), containing the antibiotic streptomycin sulfate. Materials were deeply characterized by X-ray diffraction and attenuated total reflectance Fourier transform infrared spectroscopy, and zeta potential analysis, UV-visible spectrophotometry, and ion-exchange measurement were applied in a simulating body fluid (SBF) solution.

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Vitamin B12 Deficiency in Infants With Axial Hypotonia and Psychomotor Regression: Insights From a Moroccan Case Study.

Cureus

July 2024

Department of Pediatrics/Pediatric Cardiology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, MAR.

Vitamin B12 deficiency is a rare entity in the pediatric population. It is often of maternal origin in exclusively breast-fed infants. Its clinical manifestations are multiple and unspecific, encompassing hematological problems and neurodevelopmental consequences.

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Henoch-Schönlein purpura (HSP) also known as rheumatoid purpura is the most common vasculitis in children. This condition affects small blood vessels, predominantly targeting the skin, digestive system, joints, and kidneys. Short-term prognosis mainly depends on abdominal complications, while long-term prognosis is mainly determined by the severity of kidney involvement, which occurs in about 35% of cases.

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Medicinal herbs used in traditional diabetes treatment are a rich source of anti-diabetic compounds. Pancreatic α-amylase inhibitors offer an effective strategy to reduce postprandial hyperglycemic levels via control of starch degradation. In this context, our study for the first time investigates the effect of stamens extracts on α-amylase inhibition.

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Colorectal cancer is a common cancer worldwide. The major sites of colorectal cancer metastasis are the liver, lungs, peritoneum, lymph nodes, and bones. However, secondary localization in the bladder is extremely rare.

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The intricate workings of uncontrolled diabetes and its effects on the nervous system are not fully understood. However, it is known that this condition can lead to various neurological manifestations, including altered consciousness and epileptic seizures. In this case study, a 66-year-old woman presented with abnormal ballistic movements and chorea due to severe hyperglycemia.

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Ovarian tuberculosis mimicking ovarian malignancy in an unvaccinated patient: A case report.

Int J Surg Case Rep

September 2024

Surgical Oncology Department, Regional Oncology Center, Mohammed VI University Hospital, Oujda, Morocco; Mohammed First University Oujda, Faculty of Medicine and Pharmacy Oujda, Oujda, Morocco.

Introduction: Ovarian tuberculosis is a rare form of extra-pulmonary tuberculosis that usually present with atypical symptoms mimicking ovarian carcinoma.

Case Report: We report a case of non-vaccinated 20-years-old women who present with non-specific symptoms and for whom imaging techniques weren't conclusive for ovarian tuberculosis. The ultrasound shows hydronephrosis secondary to the compressive pelvic mass.

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Article Synopsis
  • * A case of a 47-year-old female with a painless, mobile mass in her right thigh was diagnosed with IMM through imaging and biopsy.
  • * Surgical excision is the recommended treatment for IMM, demonstrating a low chance of recurrence, making it crucial to differentiate these tumors from more serious conditions like soft tissue sarcomas through thorough evaluation.
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Pulmonary Sarcomatoid Carcinoma: What Makes This Rare Lung Cancer So Challenging?

Cureus

June 2024

Department of Respiratory Diseases, Research and Medical Sciences Laboratory, Faculty of Medicine and Pharmacy of Oujda, Mohammed VI University Hospital, Mohammed First University, Oujda, MAR.

Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small cell lung carcinoma (NSCLC). This case report describes a 55-year-old male with a significant smoking history who initially presented with left hemiplegia. Imaging studies revealed brain metastases and a spiculated parenchymal lung nodule in the left apical region.

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Article Synopsis
  • The study evaluated serum albumin levels within 24 hours of admission in 371 patients with acute pancreatitis to determine their impact on outcomes and mortality over a 5-year period.
  • Findings revealed that 33.4% of patients had hypoalbuminemia, which was linked to older age and higher rates of complications, such as systemic inflammatory response syndrome and pleural effusion.
  • The results suggest that low serum albumin levels are a significant indicator for predicting persistent organ failure and increased mortality in acute pancreatitis cases.
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Background: The use of psychoactive substances, including tobacco, alcohol, and others, remains a major public health problem. However, few studies have been conducted on Moroccan university students. This study aimed to assess the prevalence and associated factors of substance use among students at Mohammed First University, Oujda, Morocco.

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Article Synopsis
  • * The case involves a seven-year-old with recent T1D diagnosed one month prior, who presented with severe chest pain and an elevated troponin level, suggesting a heart problem.
  • * Treatment with acetylsalicylic acid, clopidogrel, and heparin led to a positive response and recovery for the patient, emphasizing the need for careful monitoring of T1D-related cardiovascular risks.
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Article Synopsis
  • Sporadic late-onset cerebellar ataxias (SLOCA) are challenging to diagnose due to their diverse causes and symptom variations, as shown in a study of six male patients averaging 55 years old.
  • All patients experienced gait and balance issues, while some also had sensory problems, and neurological exams revealed different types of cerebellar syndromes along with peripheral neuropathy symptoms.
  • Although brain MRIs showed cerebellar atrophy in some, most lab results were normal, except for notable vitamin E deficiency and anti-Hu antibodies in two, leading to treatment with Vitamin E and highlighting the need for better understanding and management strategies for SLOCA.
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