Bilateral inverted papilloma: Case report and literature review.

Inverted papilloma is a rare, benign epithelial tumor of the nasal and sinus cavities with an unclear etiology. It usually presents as unilateral nasal obstruction. Diagnosis is histological, and treatment is primarily surgical.

Unveiling the Mineral and Sugar Richness of Moroccan Honeys: A Study of Botanical Origins and Quality Indicators.

This study comprehensively analyzes the mineral and heavy metal profiles of seven honey types, focusing on the contents of potassium (K), calcium (Ca), magnesium (Mg), iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), cadmium (Cd), and lead (Pb), with particular emphasis on honey produced in eastern Morocco. Multifloral honey was found to have the highest total mineral content (661 mg/kg), while rosemary honey had the lowest (201.31 mg/kg), revealing the strong influence of floral and botanical origin.

Machine Learning-Based Modeling of pH-Sensitive Silicon Nanowire (SiNW) for Ion Sensitive Field Effect Transistor (ISFET).

The development of ion-sensitive field-effect transistor (ISFET) sensors based on silicon nanowires (SiNW) has recently seen significant progress, due to their many advantages such as compact size, low cost, robustness and real-time portability. However, little work has been done to predict the performance of SiNW-ISFET sensors. The present study focuses on predicting the performance of the silicon nanowire (SiNW)-based ISFET sensor using four machine learning techniques, namely multilayer perceptron (MLP), nonlinear regression (NLR), support vector regression (SVR) and extra tree regression (ETR).

Evaluation of the anti-spasmodic activity of essential oils of fruits and its main chemical component "perillaldehyde" on intestinal smooth muscle contractions of rodents: and approaches.

Ethnopharmacological Relevance: In Moroccan traditional medicine, plants from the Apiaceae family are widely utilized in folk medicine to treat various diseases associated with the digestive system. plays an important role as an antispasmodic that has been traditionally used, especially to treat digestive tract diseases in children.

Aim Of The Study: The aim of this research was to verify the traditional use by assessing the relaxant and spasmolytic activities of essential oil (ALEO) and then comparing them to the effects and potency of the major constituent of ALEO, which is perillaldehyde.

Revealing the Enigma: A Deep Dive Into Submandibular Adenoid Cystic Carcinoma and Its Management.

Adenoid cystic carcinoma (ACC) of the submandibular gland is a rare and highly aggressive malignancy, distinguished by its tendency for perineural invasion and distant metastasis, particularly to the lungs and bones. The management of ACC is challenging due to its biological variability and the absence of specific randomized controlled trials to guide treatment. This report aims to encapsulate the clinical features, histological profile, diagnostic workup, and management options for submandibular gland ACC, with an emphasis on recent advancements in understanding and treatment.

Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.

Chronic Kidney Disease of Unknown Etiology (CKDu) is a worldwide hidden health threat that is associated with progressive loss of kidney functions without showing any initial symptoms until reaching end-stage renal failure, eventually leading to death. It is a growing health problem in Asia, Central America, Africa, and the Middle East, with identified hotspots. CKDu disease mainly affects young men in rural farming communities, while its etiology is not related to hypertension, kidney stones, diabetes, or other known causes.

Vasorelaxant effect of fennel seeds (Foeniculum vulgare Mill) extracts on rat mesenteric arteries: Assessment of phytochemical profiling and antioxidant potential.

Ethnopharmacological Relevance: Hypertension is a serious health problems and a leading cause of adult mortality worldwide. Foeniculum. vulgare Mill, a plant traditionally used for various ailments, including cardiovascular disorders such as hypertension.

Anorectal melanoma: Report of two cases.

Introduction: Anorectal melanoma (AM) is a rare and aggressive type of cancer. Its symptoms often resemble those of common benign anal conditions, such as hemorrhoids, leading to frequent delays in diagnosis. Consequently, about one-third of patients have metastases at the time of their initial diagnosis.

Corrigendum: Ethnobotanical survey and scientific validation of liver-healing plants in northeastern Morocco.

[This corrects the article DOI: 10.3389/fphar.2024.

Rare case of intrauterine device rectal migration revealed by lower GI bleeding: A case report and literature review.

Rectal migration of an intrauterine device (IUD) is a rare but potentially serious complication requiring prompt diagnosis and management. We present a rare case of rectal migration of an intrauterine device (IUD) in a 26-year-old female, highlighting the clinical presentation, diagnostic evaluation, laparoscopic removal, and postoperative outcomes. This case emphasizes the critical importance of vigilant monitoring, early intervention, and close follow-up in managing IUD migration to ensure optimal patient outcomes.

Case report: Antiphospholipid syndrome revealed by multiple ischemic cerebral strokes in the context of preeclampsia.

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombotic events and pregnancy complications, including preeclampsia. This case report presents a rare manifestation of APS revealed by multiple ischemic cerebral strokes in a patient with severe preeclampsia. A comprehensive review of the literature is included to highlight the clinical presentation, diagnosis, management, and prognosis of APS in the context of preeclampsia.

Health risks associated with potentially toxic elements in three fish species from Betoya Bay, Morocco: An integrated approach to human health risk assessment.

This study examines the concentrations of arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), iron (Fe), mercury (Hg) and zinc (Zn) in three fish species (Sardina pilchardus, Engraulis encrasicolus, Trachurus trachurus) from Betoya Bay, collected in winter and summer. Significant variations were observed between tissues (p < 0.05), with the liver being the most contaminated.

The Medicinal Potential of Rosa centifolia L.: Integrating Botany, Geographical Distribution, Pharmacology, Ethnobotanical Uses, Phytochemistry, and Toxicology.

Rosa centifolia L. is widely used to treat various health issues such as digestive, respiratory, and cardiovascular ailments. This study aims to assess the ethnopharmacological, phytochemical, pharmacological, and toxicological research on R.

Comparative Study of Cerebrospinal Fluid Evaluation in Patients With Acute Leukemia Using the Manual Method and Sysmex XN-1000.

Background Many pathological settings can be provided by the cytological analysis of cerebrospinal fluid (CSF). In our work, we aimed to evaluate the concordance between the analysis using the reference manual method and the analysis using Sysmex XN-1000. Methods In our study, we examined 121 CSF samples.

Antidiarrheal and antispasmodic effects of methanol fraction of Ammodaucus leucotrichus in gastrointestinal problems: an integrative medicine approach.

Diarrhea is the second leading cause of death in children under five years of age globally. Traditional medicinal practices often use plants to manage gastrointestinal issues. Ammodaucus leucotrichus is a medicinal plant that holds significant importance in Moroccan traditional medicine for treating gastrointestinal problems.

Atriplex halimus: Phytochemical Insights, Traditional Applications, and Pharmacological Promises.

Medicinal and aromatic plants are used in traditional medicine due to their diverse bioactive chemicals, Atriplex halimus is a saltbush that has an extensive background in traditional medicine giving it a strong argument for further ethnopharmacological research. We aimed in this comprehensive review by using different databases as to illustrate the phytochemical composition, the traditional uses, and the pharmacological properties of A. halimus.

Antidiabetic potential of aqueous extract: insights into pancreatic lipase inhibition, antioxidant activity, antiglycation at multiple stages and anti-inflammatory effects.

Background: With the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel therapeutic interventions. a medicinal plant traditionally used for various ailments, holds promise as a potential agent for T2D management, particularly in Morocco, where it is commonly used to treat diabetes. This study aims to evaluate the pharmacological potential of aqueous extract (AqLs) by assessing its lipase inhibition antioxidant and anti-inflammatory activities, identifying phenolic compounds, and examining its efficacy in reducing diabetic complications.

Synthesis of New Pyrazolo[3,4-]pyrimidine Derivatives: NMR Spectroscopic Characterization, X-Ray, Hirshfeld Surface Analysis, DFT, Molecular Docking, and Antiproliferative Activity Investigations.

Four new pyrazolo[3,4-]pyrimidines (-) were successfully synthesized in good relative yields by reacting 3-methyl-1-phenyl-1H-pyrazolo[3,4-]pyrimidin-4-ol with various alkylating agents (methyl iodide, propargyl bromide, and phenacyl bromide) at room temperature in DMF solvent, employing liquid-solid phase transfer catalysis. The - structures were elucidated using NMR spectroscopy and X-ray diffraction. Intermolecular interactions in - were analyzed via Hirshfeld surface analysis and 2D fingerprint plots.

Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis.

Background: Hemoglobinopathies represent the most commonly inherited autosomal recessive blood disorders in the world. The aim of this study was to determine the carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco. This is the first study of its kind for this country.

Can Primary Knee Tuberculosis Simulate the Clinical and Radiological Profile of Pigmented Villonodular Synovitis?

When faced with clinical and radiological findings suggestive of villonodular synovitis, tuberculosis is not often considered a differential diagnosis, especially when the patient is not a known tuberculosis carrier. In this paper, we present an exceptional case of a patient who had a tumefaction (measuring 17 cm in length) in the anterointernal region of her left knee, with a clinical and radiological picture in favor of villonodular synovitis. However, after tumor resection, the anatomopathological study of the surgical specimen came back in favor of a tuberculous lesion.

Granulomatous Colitis Due to Hermansky-Pudlak Syndrome.

Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder characterized by oculocutaneous albinism, bleeding diathesis, and multiorgan involvement. Granulomatous enterocolitis may occur in a subset of patients. Distinguishing HPS from other diseases such as Crohn's disease can be challenging, and managing HPS-associated colitis is complex.

Evaluation of Phytochemical Content and In Vitro Antioxidant Activities of L. Leaves Extracts, a Medicinal Plant From the Beni-Snassen Forest (Eastern Region of Morocco).

A medicinal plant from the Beni-Snassen Forest in the eastern region of Morocco has been studied. This scientific research was carried out to measure the content of essential phytochemical constituents and their antioxidant capacities from the hydromethanolic extract of leaves of L. located on sites at varying levels of altitudes.