Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 .

Background: is a differentially expressed gene (DEG) between M1 and M2 macrophages. This study explained why it causes opposite effects in different circumstances.

Methods: Gene expression profiles of various cell subsets were compared by mining a public database.

The New-Meaning Objection: A Reply to Nicolò D'Agruma.

In our paper, "The reference of proper names" (2018), we raised and rebutted the "New-Meaning" objection to our methodology. Our rebuttal rested on theoretical considerations and experimental results. In "Do the Gödel vignettes involve a new descriptivist meaning?", Nicolò D'Agruma provides an interesting argument against our theoretical considerations (but does not address the experimental evidence).

Life cycle assessment and industrial synergy for carbon reduction: A circular economy approach.

In the face of the climate change crisis, circular economy (CE) is put forward as a promising key to the sustainable development goals (SDGs) riddle. In this context that affects developed and developing countries alike, circular initiatives arise, such is the case for Morocco where an industrial synergy based on the CE concept of 'waste is food' can be envisioned between the local phosphate and cement industries. In order to support and guide this initiative, a life cycle assessment (LCA) was conducted to compare the environmental performance of the production of ordinary Portland cement (OPC), limestone calcined clay cement (LC3) and a phosphate waste-based cement known as calcined marl cement (CMC).

GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues.

Background: Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes.

Methods: Fresh RA patients' whole blood was transfused into NOD-SCID mice.

Repositioning of Furin inhibitors as potential drugs against SARS-CoV-2 through computational approaches.

The recent spread of SARS-CoV-2 has led to serious concerns about newly emerging infectious coronaviruses. Drug repurposing is a practical method for rapid development of antiviral agents. The viral spike protein of SARS-CoV-2 binds to its major receptor ACE2 to promote membrane fusion.

Trust in scientists and their role in society across 68 countries.

Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of the best available evidence, especially during crises. However, in recent years the epistemic authority of science has been challenged, causing concerns about low public trust in scientists.

Perceptions of science, science communication, and climate change attitudes in 68 countries - the TISP dataset.

Science is integral to society because it can inform individual, government, corporate, and civil society decision-making on issues such as public health, new technologies or climate change. Yet, public distrust and populist sentiment challenge the relationship between science and society. To help researchers analyse the science-society nexus across different geographical and cultural contexts, we undertook a cross-sectional population survey resulting in a dataset of 71,922 participants in 68 countries.

Comparative analysis of seasonal wind power using Weibull, Rayleigh and Champernowne distributions.

Accurate statistical modeling of wind speed variability is crucial for assessing wind energy potential, particularly in regions with low wind speeds and significant calm hours. This study evaluates the Champernowne distribution as a novel model for wind speed analysis, comparing its performance with the two-parameter Weibull, three-parameter Weibull, and Rayleigh-Rice distributions. Wind speed data at 10 m hub height over three years (2021-2023) from Ben Guerir, Morocco, were analyzed using statistical metrics such as Root Mean Square Error (RMSE), Mean Absolute Error (MAE), Mean Bias Error (MBE), Coefficient of Determination (R2), Akaike Information Criterion (AIC), and Bayesian Information Criterion (BIC).

Comparative assessment of empirical and hybrid machine learning models for estimating daily reference evapotranspiration in sub-humid and semi-arid climates.

Improving the accuracy of reference evapotranspiration (RET) estimation is essential for effective water resource management, irrigation planning, and climate change assessments in agricultural systems. The FAO-56 Penman-Monteith (PM-FAO56) model, a widely endorsed approach for RET estimation, often encounters limitations due to the lack of complete meteorological data. This study evaluates the performance of eight empirical models and four machine learning (ML) models, along with their hybrid counterparts, in estimating daily RET within the Gharb and Loukkos irrigated perimeters in Morocco.

Pushing the limits of electron donation for -chelating ligands an alliance of phosphonium ylide and anionic abnormal NHC.

The grafting of a -(CH)PR moiety on an NHC ligand backbone in the Mn(I) complex [Cp(CO)Mn(IMes)] followed by double deprotonation opens a route to bidentate ligands with extreme electron-donating character. Such remarkable electronic properties can even allow intramolecular sp C-H functionalization in typically inert square-planar Rh(I) dicarbonyl complexes.

Impact of water stress to plant epigenetic mechanisms in stress and adaptation.

Water is the basic molecule in living beings, and it has a major impact on vital processes. Plants are sessile organisms with a sophisticated regulatory network that regulates how resources are distributed between developmental and adaptation processes. Drought-stressed plants can change their survival strategies to adapt to this unfavorable situation.

Three-dimensional ordered macro-microporous ZIF-8-α-Glu microreactors for α-glucosidase inhibitors screening from green tea.

Due to the larger pore structure, the macroporous material can be used as the immobilized carrier to not only increase the enzyme loading capacity, but also facilitate the transfer of reactants and substrates. Based on this, a three-dimensional ordered macro-microporous ZIF-8 (SOM-ZIF-8) was prepared using three-dimensional ordered stacked polystyrene spheres as the hard template. The morphology and structure of SOM-ZIF-8 were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR) and so on.

Territorial obstacles causing early school dropout in Morocco: Multivariate spatial analysis.

Early school dropout rates in Morocco exhibit widespread spatial imbalances leading to adverse consequences. Indeed, there is thus a pressing need to investigate the factors contributing to the phenomenon. To this end, this study conducts a multivariate spatial analysis of 75 provinces in Morocco.

Prevalence and predictors of overweight and obesity among women of childbearing age in the province of Essaouira, Morocco.

Low- and middle-income countries are facing a rapid increase in nutritional problems, particularly in Africa, where undernutrition, overweight and micronutrient deficiencies coexist, creating a double burden of malnutrition and a challenge to public health policies. In this context, Morocco stands out for its early nutritional transition, characterized by a moderate prevalence of overweight and undernutrition and elevated levels of micronutrient deficiencies. The aim of this study was to assess the weight status of women of childbearing age and identify its determinants to suggest ways to improve it.

Effect of crude extract and polysaccharides derived from Fucus spiralis on radish plants Raphanus sativus L. agrophysiological traits under drought stress.

Drought is a significant environmental stressor that induces changes in the physiological, morphological, biochemical, and molecular traits of plants, ultimately resulting in reduced plant growth and crop productivity. Seaweed extracts are thought to be effective in mitigating the effects of drought stress on plants. In this study, we investigated the impact of crude extract (CE), and polysaccharides (PS) derived from the brown macroalgae Fucus spiralis (Heterokontophyta, Phaeophyceae) applied at 5% (v/v) and 0.

Review of Recent Advances in Predictive Maintenance and Cybersecurity for Solar Plants.

This paper presents a systematic review that explores the latest advancements in predictive maintenance methods and cybersecurity for solar panel systems, shedding light on the advantages and challenges of the most recent developments in predictive maintenance techniques for solar plants. Numerous important research studies, reviews, and empirical studies published between 2018 and 2023 are examined. These technologies help in detecting defects, degradation, and anomalies in solar panels by facilitating early intervention and reducing the probability of inverter failures.

Phosphogypsum as Fertilizer: Impacts on Soil Fertility, Barley Yield Components, and Heavy Metals Contents.

According to the FAO, 828 million people were facing acute food insecurity in 2021. Fertilization is a critical input factor in crop production and food security achievement. Therefore, fertilization is a critical input factor in crop production and food security achievement.

Systematic review of computational techniques, dataset utilization, and feature extraction in electrocardiographic imaging.

This study aimed to analyze computational techniques in ECG imaging (ECGI) reconstruction, focusing on dataset identification, problem-solving, and feature extraction. We employed a PRISMA approach to review studies from Scopus and Web of Science, applying Cochrane principles to assess risk of bias. The selection was limited to English peer-reviewed papers published from 2010 to 2023, excluding studies that lacked computational technique descriptions.

Genetic Analysis of Days Open in Moroccan Holstein Using Different Models to Account for Censored Data.

Reproductive efficiency is a key element of profitability in dairy herds. However, the genetic evaluation of fertility traits is often challenged by the presence of high censorship rates due to various reasons. An easy approach to address this challenge is to remove the censored data from the dataset.

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Ultrasound, pulsed electric fields, and high-voltage electrical discharges assisted extraction of cellulose and lignin from walnut shells.

Extracting The extraction of cellulose and lignin from biomass is essential for the development of sustainable bio-based materials. This study examines the effects of physical pretreatment techniques-ultrasound (US), pulsed electric fields (PEF), and high-voltage electrical discharges (HVED)-on the efficiency of alkali treatment for cellulose and lignin extraction from walnut shells. The primary objective was to enhance extraction yields and improve extract quality while evaluating the effectiveness of these methods.

Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus.

Hepatitis C virus (HCV) presents a significant global health issue due to its widespread prevalence and the absence of a reliable vaccine for prevention. While significant progress has been achieved in therapeutic interventions since the disease was first identified, its resurgence underscores the need for innovative strategies to combat it. The nonstructural protein NS5A is crucial in the life cycle of the HCV, serving as a significant factor in both viral replication and assembly processes.

HLA Class I (A and B) Allele Polymorphism in a Moroccan Population Infected with Hepatitis C Virus.

Hepatitis C virus (HCV) infection is one of the major health burdens worldwide. Its course depends on the virus itself and the host's immune responses. The latter are conditioned by immunogenetic factors, in particular human leukocyte antigens (HLAs), whose role in determining the outcome of infection varies according to populations and ethnic groups.

Advances in structural modification of fucoidans, ulvans, and carrageenans to improve their biological functions for potential therapeutic application.

Marine sulfated polysaccharides constitute a class of bioactive polymers commonly found in cell walls of macroalgae. Among these macromolecular substances, fucoidans, ulvans, and carrageenans have attracted considerable attention providing interesting therapeutic properties affected by a combination of various structural factors, such as sulfation pattern, molecular weight, monosaccharide composition, and glycosidic linkages. Remarkably, chemical modification, enzymatic hydrolysis and crosslinking are promising approaches for developing the application of these polysaccharides through enhancement and/or addition of new biological properties.