Propugnating Effect of Bark of Against Different Toxicants Viz Carbon Tetrachloride, Ethanol and Paracetamol on HepG Cell Lines.

Objective: The aim of the study was to evaluate the hepatoprotective activity of the bark extract (Ethanol: Water) in the ratio of (3:1) of (BERM) by intoxicating the HepG cell lines with different toxicants viz, CCL, Ethanol and Paracetamol with different concentrations of the extract were used. The HepG cell lines were subjected to MTT Assay for studying the cytotoxicity.

Methods: HepG cells were plated using 96 well plate in 10% bovine serum, exposed to different toxicants viz, 2% CCl, 60% Ethanol and 14 mM Paracetamol respectively.

Identification of glucosyl transferase inhibitors from against in dental caries.

Dental caries is a multi factorial disease that starts with microbiological shifts affected by salivary flow, composition, exposure to fluoride, consumption of dietary sugars, and preventive behaviours. The (. ) is an initiator of caries because there is a variety of a virulence factor unique to the bacterium that has been isolated and plays an important role in caries formation.

Crystal structure, optical properties, DFT analysis of new morpholine based Schiff base ligands and their copper(II) complexes: DNA, protein docking analyses, antibacterial study and anticancer evaluation.

New morpholine derived Schiff base ligands (HL and HL) and their Cu(II) complexes [Cu(L)] (1) and [Cu(L)] (2) have been synthesized and characterized by H NMR, IR, UV-Vis, EPR studies and cyclic voltammetric analyses. Single crystal X-ray crystallography studies confirm the structure of newly synthesized Schiff base ligands HLand HL. The ground state electronic structures of Cu(II) complexes 1 and 2 have been investigated by DFT/B3LYP theoretical analysis with 6-31G (d,p) and LANL2DZ basis set.

A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive chemotherapy.

In this work, a theranostic nanocage system was developed for the targeted delivery of the anti-cancer agents camptothecin (CPT) and luotonin A (LuA). The core of the nanocage system (FeO@OA-AD-SP NCs) was formed by biogenically synthesized FeO nanoparticles (NPs) decorated with a model anti-cancer drug (AD) and biosurfactant saponin (SP). The FeO@OA-AD-SP NCs showed a high lipophilic AD loading efficiency (>80%) and a controlled pH-responsive drug release in stimulated cancerous cells in pH 6.

Natural alkaloid Luotonin A and its affixed acceptor molecules: Serum albumin binding studies.

Effective interaction of natural alkaloid Luotonin A (L) and its affixed acceptor molecules 1 and 2 with donor molecule as Bovine serum albumin (BSA) at various pH (4.0, 7.4 and 10.

Isolation and Characterization of an Acyclic Isoprenoid from Linn. and its Antibacterial Potential : - Antimicrobial Activity of Linn. Seeds.

Objectives: Linn. is a plant well-known for its antimicrobial, antidiabetic and anti-arthritic properties in the Ayurvedic and Siddha system of medicine. This has prompted the screening of this plant for antibacterial activity.

Antioxidant, antiglycation and insulinotrophic properties of (L.) : Possible role in prevention of diabetic complications.

In an attempt to develop Complementary and Alternative Medicine (CAM) for the treatment of diabetes and related complications, the antidiabetic potential of the mature unripe fruits of (CGF) was evaluated. Oxidative stress and glycation plays an important role in manifesting of diabetes and vascular complications. Agents with antioxidant and antiglycation properties may retard these pathological alterations.

In vitro genotoxicity of pyridine in human lymphocytes.

This work was carried out to study the genotoxicity of pyridine in vitro on human leucocyte culture. Cyclophosphamide, a well-known carcinogen was used as positive control. The four different concentrations of pyridine and cyclophosphamide showed breaks and pulverization of chromosomes in dose dependent manner.

Protective effects of Emblica officinalis (Amla) on metal-induced lipid peroxidation in human erythrocytes.

The protective potential of Emblica officinalis (amla) was investigated on metal-induced lipid per oxidation in human erythrocytes. Increases in the levels of MDA and catalase activity were assessed as lipid per oxidation. In addition, glutathione peroxidase (GPX), glutathione (GSH), and ascorbic acid levels were assessed as antioxidant indices.

Immunomodulatory activity of geranial, geranial acetate, gingerol, and eugenol essential oils: evidence for humoral and cell-mediated responses.

Objective: The immunomodulatory effect of geranial, geranial acetate, gingerol, and eugenol essential oils were evaluated by studying humoral and cell-mediated immune responses.

Materials And Method: The essential oils were evaluated for immunomodulatory activity in in vivo studies, using rats as the animal model. The essential oils were tested for hypersensitivity and hemagglutination reactions, using sheep red blood cells (SRBC) as the antigen while sodium carboxy methyl cellulose (SCMC) served as the control in all the tests.

Lemon peels mediated synthesis of silver nanoparticles and its antidermatophytic activity.

There is an increasing commercial demand for nanoparticles due to their wide applicability in various areas. Metallic nanoparticles are traditionally synthesized by wet chemical techniques, where the chemicals used are quite often toxic and flammable. In this work, The extract of lemon peel was prepared and mixed with 1 mM AgNO3 solution .

Antimicrobial potential of Actinomycetes species isolated from marine environment.

Objective: To evaluate the antimicrobial activity of Actinomycetes species isolated from marine environment.

Methods: Twenty one strains of Actinomycetes were isolated from samples of Royapuram, Muttukadu, Mahabalipuram sea shores and Adyar estuary. Preliminary screening was done using cross-streak method against two gram-positive and eight gram-negative bacteria.

A biochemical study on variability of Superoxide dismutase, Catalase and Glutathione peroxidase in dry cleaners.

Several chemicals which induce cytotoxicity are broadly classified into three types and they are organophosphate, organochlorine and carbomate compounds. Perchloroethylene has been clearly identified as a carcinogen in experimental animals and it's a very common carcinogen used for dry clean purpose. Hence, in the present study, blood samples from dry cleaners were taken, Superoxide dismutase, Catalase and Glutathione peroxidase activity was estimated in blood samples of dry cleaners.