Identification of L. Methanolic-Leaf-Extract-Derived Metabolites Exhibiting Xanthine Oxidase Inhibitory Activities: In Vitro and In Silico Approaches.

There is a growing interest in the discovery of novel xanthine oxidase inhibitors for gout prevention and treatment with fewer side effects. This study aimed to identify the xanthine oxidase (XO) inhibitory potential and drug-likeness of the metabolites present in the methanolic leaf extract of L. using in vitro and in silico models.

Anticancer Activity of Leaves Extract on Sprague-Dawley Rats: Model.

Medicinal plants are now used to treat cancer due to the presence of bioactive compounds. Apart from the plants, mangroves also possess rich bioactive compounds with high medicinal activity. Based on the ethnobotanical attributes of , we are keen to work with its anticancer activity.

Synthesis, Structural, Spectroscopic, Fluorescence, and Dielectric Studies of Bis-(4-Aminopyridine)-Zinc(II) Acetate: A Metal-Organic Crystal.

The advancement of crystalline growth and characterization tools allows us to investigate novel nonlinear optical substances suitable for photonic applications. Bis-(4-aminopyridine)-zinc(II) acetate (B4AZA), a metal-organic crystal was produced in this study using the slow evaporation procedure at room temperature. Analytical studies such as X-ray crystallography, Fourier transform infrared (FT-IR), UV-visible (UV-Vis), fluorescence, second harmonic generation (SHG), and dielectric tests were used to characterize the as-grown B4AZA crystals.

Synthesis, Spectroscopic, Optical, and Thermal Characterizations of Zinc (Tris)-Thiourea Sulfate: A Metal-Organic Crystal.

In the current research, Zinc (tris)-thiourea sulfate (ZTTS), a metal-organic crystal, has been synthesized using the slow solvent evaporation technique. Powder-X-ray diffraction (PXRD) analysis, Fourier transform infrared (FT-IR) spectroscopy, UV-Vis spectroscopy, photoluminescence (PL) spectroscopy, and thermal, and second harmonic generation measurements have all been applied to describe the as-synthesized ZTTS crystals. The synthesized samples crystallized in an orthorhombic structure, based on XRD analysis.

Synthesis, Spectroscopic, and Antibacterial Characterizations of Cadmium-Based Nanoparticles.

In the current study, the co-precipitation technique was employed for the synthesis of Cadmium oxide (CdO) and Copper‒doped Cadmium oxide (Cu‒CdO) nanoparticles. The synthesized samples were subjected to powder X-Ray diffraction (P-XRD), Field emission scanning electron microscopy (FE-SEM), Energy-dispersive X-ray (EDX), Fourier transforms Infrared (FT-IR), UV-Vis spectroscopy, photoluminescence (PL), laser-induced fluorescence spectroscopy and antibacterial investigations. According to the P-XRD analysis, both the samples were simple cubic in structure and have average grain sizes of 54 and 28 nm, respectively.

Catalytic response and molecular simulation studies in the development of synthetic routes in trimeric triaryl pyridinium type ionic liquids.

Under conventional and silica-supported Muffle furnace methods, water-soluble substituted trimeric triaryl pyridinium cations with various inorganic counter anions are synthesized. The solvent-free synthesis method is superior to the conventional method in terms of non-toxicity, quicker reaction times, ease of workup, and higher yields. Trimeric substituted pyridinium salts acted as excellent catalytic responses for the preparation of Gem-bisamide derivatives compared with available literature.

Wound Healing Potential of Couroupita guianensis Aubl. Fruit Pulp Investigated on Excision Wound Model.

Wound care management aims at stimulating and improving healing process without scar formation. Although various plants have been reported to possess wound healing properties in tribal and folklore medicines, there is a lack of scientific data to validate the claim. In this aspect, it becomes inevitable to prove the efficacy of naturally derived products at pharmacological levels.

Lam. (Mangrove) Bark Extract Reduces Ethanol-Induced Liver Cell Death and Oxidative Stress in Swiss Albino Mice: In Vivo and In Silico Studies.

The bark extract of (BERM) was recently reported for its prominent in vitro protective effects against liver cell line toxicity caused by various toxicants, including ethanol. Here, we aimed to verify the in vivo hepatoprotective effects of BERM against ethanol intoxication with the prediction of potential targets employing in silico studies. An oral administration of different concentrations (100, 200 and 400 mg/kg body weight) of BERM before high-dose ethanol via intraperitoneal injection was performed in mice.

Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential.

World-wide antimicrobial resistant is biggest threat in global health. It requires the urgent need of multisectoral action for the scientific community to achieve the sustainable development Goals. Due to their antimicrobial properties, silver nanoparticles are potential activates to pathogens, which explains their potential for multiple applications in various fields.

Influence of extracellular protein isolated from fish gut associated bacteria as an enhancer of growth and innate immune system in Mugil cephalus.

The cultural microbiomes of 27 bacteria colonies were isolated from Mugil cephalus for analysis of the antibacterial and antagonistic activities. A potent probiotic bacterium was characterized using16S r RNA sequencing. The potent strain was added to fish diet to perform the challenge test and to study the growth and immunological parameter.

Purple Ink Secretion Concentrate Exerts Cytotoxic Properties against Human Hepatocarcinoma Cell Line (HepG2): In Vitro and In Silico Studies.

Liver cancer is a leading cause of cancer death globally. Marine mollusc-derived drugs have gained attention as potential natural-based anti-cancer agents to overcome the side effects caused by conventional chemotherapeutic drugs during cancer therapy. Using liquid chromatography-mass spectrometry, the main biomolecules in the purple ink secretion released by the sea hare, named (), were identified as hectochlorin, malyngamide X, malyngolide S, bursatellin and lyngbyatoxin A.

The COVID-19 pandemic face mask waste: A blooming threat to the marine environment.

Recently, the COVID-19 disease spread has emerged as a worldwide pandemic and cause severe threats to humanity. The World Health Organisation (WHO) releases guidelines to help the countries to reduce the spread of this virus to the public, like wearing masks, hand hygiene, social distancing, shutting down all types of public transports, etc. These conditions led to a worldwide economic fall drastically, and on the other hand, indirect environmental benefits like global air quality improvement and decreased water pollution are also pictured.

Antigenotoxic and Antimutagenic Effects of , a Traditional Medicinal Herb against Genotoxicity of Cyclophosphamide: An Study on Human Peripheral Lymphocytes.

(family: Acanthaceae) is a medicinal herb-used in Indian system of medicine (Ayurveda, Siddha, and Unani), traditional and folk systems to treat various illnesses. This study examined the phytochemical constituents of ethanol extract from and its protective effect against genotoxicity caused by cyclophosphamide (CPA). Phytochemical screening and estimation of total phenolic content were analyzed using standard methods.

(L.) methanolic and aqueous extracts exert antiproliferative effects through the induction of apoptosis in MCF-7 breast cancer cells.

Breast cancer therapy using anticancer bioactive compounds derived from natural products as adjuvant treatment has gained recognition due to expensive and toxic conventional chemotherapeutic drugs. The whole plant of (L.) () has been investigated for its pharmacologically important anticancer properties but without categorizing the biological activities of the plant parts.

ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy.

Background And Objective: Cancer cells accumulate high concentrations of reactive oxygen species as a result of their faster and uninhibited metabolic activity. Cancer chemotherapeutic agents release an excess of severe adverse reactions as a result of targeting normal cells. This demands an improvement in targeted drug-delivery systems to selectively discharge anticancer drugs in the vicinity of such highly metabolically and mitotically active cells.

Bidentate Schiff Base Ligands Appended Metal(II) Complexes as Probes of DNA and Plasma Protein: In Silico Molecular Modelling Studies.

HL1 and HL2 (HL1 = 5-diethylamino-2-({[4-(diethylamino)phenyl]imino}methyl)-phenol; HL2 = 5-diethylamino-2-({[4-(dimethylamino)phenyl]imino}methyl)-phenol) are new Schiff base ligands which were prepared along with their metal(II) complexes of [Cu(L1)] (1), [Cu(L1)] (2), [Ni(L2)] (3) and [Ni(L2)] (4) and characterized by different analytical as well as spectroscopic analyses. The single crystal XRD analysis confirms the proposed structure of ligands such as HL1 and HL2. EPR spectral analysis gives evidence about the tetrahedrally coordinated geometry of complexes 1 and 2.

Effect of β-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of PPRγ and glucose transporter 4 in high fat diet and streptozotocin-induced diabetic rats.

Ethnopharmacological Relevance: β-Sitosterol is a plant derived compound similar to cholesterol structure and used in the treatment of hypercholesterolemia, prostate cancer, breast cancer and coronary artery disease. But no studies have been reported the effect of β-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and glucose transporter 4 (GLUT4) in insulin dependent tissues of high fat diet and streptozotocin-induced diabetic rats.

Materials And Methods: Type 2 diabetes was induced in male albino Wistar rats by feeding them with high fat diet comprising of 84.

HPLC characterization, acute and sub-acute toxicity evaluation of bark extract of in Swiss Albino mice.

Aim: , commonly called as 'red mangrove' grows in the tropical and sub-tropical regions and on the sheltered shores. The bioactive compounds from the plant have been used in the treatment of wide range of diseases. Though the beneficial effects have been reported, the safety and toxicological studies are not carried out.

Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery.

This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (FeO NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (FeO@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an HO environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of FeO@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively.

Biological Impacts of Metal(II) Complex-Based DNA Probes Derived from Bidentate N,O Donor Schiff Base Ligand.

In this article, we have reported the preparation and structural characterization of a new Schiff base ligand (E)-2-(((2,6-difluorophenyl)imino)methyl)phenol (HSBL) and its derived metal(II) complexes [Cu(SBL)] (1), [Ni(SBL)] (2) and [Pd(SBL)] (3). Using various analytical and spectroscopic techniques, their structural properties have been appraised. The proposed chemical structure of HSBL has been confirmed by Single crystal XRD studies.