321 results match your criteria: "Mitsubishi Kyoto Hospital.[Affiliation]"
Investigation of Whole Blood Thiamine Concentration in Independently Ambulatory Residents of a Provincial Town in Japan: A Cross-Sectional Study.
Cureus
May 2023
Department of Clinical Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JPN.
Article Synopsis
- Thiamine deficiency (TD) is a public health issue affecting 2-6% of people in Europe and the US, with significant reductions reported in East Asia, but little research has been done in Japan, where the aging population is particularly notable.
- A study investigated TD among 270 independent ambulatory individuals aged 25-97 in a Japanese town, finding a mean blood thiamine concentration of 47.6 ng/ml, with no cases of TD or borderline values detected.
- The results indicate that TD might be rare among active citizens, and the study suggests the importance of exploring TD prevalence across a broader demographic in the future.
Difficulty swallowing and food bolus obstruction in advanced cancer: association with the cachexia-related quality of life.
Ann Palliat Med
July 2023
Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Background: Swallowing disorders including difficulty swallowing and food bolus obstruction, result in reduced dietary intake-a common occurrence that leads to cachexia in patients with advanced cancer. This study examined the effects of swallowing difficulty and food bolus obstruction on cachexia-related quality of life (QOL).
Methods: This study secondarily analyzed data from a self-reported questionnaire survey of adult patients with advanced cancer at 11 palliative care services.
Thiamine Deficiency in a Patient With Schizophrenia: Precautions and Countermeasures for Subclinical Thiamine Deficiency.
Cureus
May 2023
Department of Psycho-oncology, Saitama Medical University International Medical Center, Hidaka, JPN.
Patients with schizophrenia often experience problems associated with ordinary exercises of life due to their mental symptoms. Those experiencing problems related to feeding behavior, in particular, are considered to be susceptible to developing Wernicke encephalopathy due to a deficiency in thiamine, the physiological stores of which are limited; however, there are few reported cases, and most of them were accompanied by the classical triad of signs. We report our experience with asymptomatic thiamine deficiency (TD) in a schizophrenia patient.
View Article and Find Full Text PDFBackground: Although thiamine deficiency (TD) can lead to Wernicke encephalopathy, the characteristics associated with TD in the elderly have not yet been clarified. We sought to clarify the frequency of TD among an institutionalized elderly population with a controlled dietary intake and to identify possible factors related to TD.
Method: We undertook a cross-sectional study of residents in three nursing homes for the elderly as of June 2020.
Effects of Long-Term Carvedilol Therapy in Patients With ST-Segment Elevation Myocardial Infarction and Mildly Reduced Left Ventricular Ejection Fraction.
Am J Cardiol
July 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Article Synopsis
- The study investigates the effects of long-term β-blocker therapy, specifically carvedilol, in patients with ST-segment elevation myocardial infarction (STEMI) and mildly reduced left ventricular ejection fraction (LVEF, ≥40%).
- Conducted as part of the CAPITAL-RCT trial, researchers analyzed 794 patients, splitting them into two LVEF groups to evaluate the outcomes of β-blocker therapy versus no therapy.
- Results indicated that while there was no significant impact on overall mortality and major adverse cardiac events, patients with mildly reduced LVEF did experience a statistically significant lower rate of cardiac-related events when treated with carvedilol, suggesting potential benefits for this specific group.
Dual Antiplatelet Therapy Duration After Multivessel Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention.
Circ J
October 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
Background: There is a scarcity of data evaluating contemporary real-world dual antiplatelet therapy (DAPT) strategies after percutaneous coronary intervention (PCI).
Methods and results: In the OPTIVUS-Complex PCI study multivessel cohort enrolling 982 patients undergoing multivessel PCI, including left anterior descending coronary artery using intravascular ultrasound (IVUS), we conducted 90-day landmark analyses to compare shorter and longer DAPT. DAPT discontinuation was defined as withdrawal of P2Yinhibitors or aspirin for at least 2 months.
Target Lesion Revascularization After Intravascular Ultrasound-Guided Percutaneous Coronary Intervention.
Circ Cardiovasc Interv
May 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan (K.Y., H.S., H.W., K.Y., K.O., T.K.).
Background: Several stent expansion criteria derived from the intravascular ultrasound (IVUS) evaluation have been proposed to predict future clinical outcomes, but optimal stent expansion criteria as a guide during percutaneous coronary intervention (PCI) are still controversial. There are no studies evaluating the utility of stent expansion criteria along with the clinical and procedural factors in predicting target lesion revascularization (TLR) after contemporary IVUS-guided PCI.
Methods: OPTIVUS-Complex PCI study (Optimal Intravascular Ultrasound Guided Complex Percutaneous Coronary Intervention) multivessel cohort was a prospective multicenter study enrolling 961 patients undergoing multivessel PCI including left anterior descending coronary artery using IVUS with an intention to meet the prespecified criteria for optimal stent expansion.
Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in Patients With Multivessel Disease.
JACC Asia
April 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Article Synopsis
- The study explored the impact of intravascular ultrasound (IVUS) on patient outcomes in those with multivessel disease undergoing percutaneous coronary intervention (PCI), showing it was infrequently used in past trials.
- The OPTIVUS-Complex PCI study enrolled 1,021 patients to evaluate the effectiveness of IVUS-guided PCI, aiming to achieve optimal stent expansion based on specific criteria.
- Results indicated a 1-year major adverse cardiac and cerebrovascular events (MACCE) rate of 10.3%, which was significantly lower than the predefined PCI goal of 27.5%, suggesting that contemporary PCI practices may lead to better outcomes in this patient group.
Effectiveness and safety of morphine administration for refractory dyspnoea among hospitalised patients with advanced heart failure: the Morphine-HF study.
BMJ Support Palliat Care
January 2024
Cardiology, National Hospital Organisation Kyoto Medical Center, Kyoto, Japan.
Objectives: Morphine is effective in alleviating dyspnoea in patients with cancer. We aimed to investigate the effectiveness and safety of morphine administration for refractory dyspnoea in patients with advanced heart failure (HF).
Methods: We conducted a multicentre, prospective, observational study of hospitalised patients with advanced HF in whom morphine was administered for refractory dyspnoea.
Heterogeneity in Characteristics and Outcomes of Patients who met the Indications for Vericiguat Approved by the Japanese Agency: From the KCHF Registry.
J Card Fail
June 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis.
Sci Rep
April 2023
Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Despite standard treatment with systemic corticosteroids and/or antifungal triazoles, a substantial proportion of patients with allergic bronchopulmonary aspergillosis (ABPA) experience frequent relapses and require long-term treatment despite unfavorable adverse effects. We investigated the efficacy and safety of anti-interleukin (IL)-5/IL-5 receptor α chain (Rα) monoclonal antibodies (mAbs) in patients with ABPA complicated by asthma. ABPA cases treated with anti-IL-5/IL-5Rα mAbs were collected from 132 medical institutes in 2018 and published case reports in Japan.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the link between tricuspid regurgitation (TR) and outcomes in patients with acute heart failure (AHF) using data from a large Japanese registry.
- A total of 3,735 AHF patients were analyzed, revealing a direct correlation where increased severity of TR led to higher risks of all-cause mortality and hospital readmissions for heart failure.
- Despite the high prevalence of moderate to severe TR, very few patients underwent surgical intervention, highlighting a potential gap in treatment options for these individuals.
Comparison of the OPTIVUS-Complex PCI Multivessel Cohort With the Historical CREDO-Kyoto Registry Cohort-3.
Circ J
October 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
Article Synopsis
- The OPTIVUS-Complex PCI study investigated the effectiveness of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) compared to standard PCI and coronary artery bypass grafting (CABG) in patients with multivessel coronary disease.
- The study included 1,021 patients and analyzed outcomes through propensity score matching with historical PCI and CABG groups, focusing on major events like death and myocardial infarction.
- Results showed that the IVUS-guided approach significantly reduced the risk of major adverse events at one year compared to both historical PCI and CABG controls, indicating better clinical outcomes.
Intracardiac energy inefficiency during atrial fibrillation rhythm with heart failure: Assessment by echo-vector flow mapping.
Int J Cardiol
May 2023
Department of Cardiology, Mitsubishi Kyoto Hospital, Kyoto, Japan.
Article Synopsis
- The study aimed to investigate the relationship between intracardiac dynamics during atrial fibrillation (AF) in patients with heart failure (HF) using echo-vector flow mapping.
- 76 patients were categorized into high and low NT-proBNP groups based on their serum levels, which helped assess energy loss during AF and sinus rhythms.
- Results showed that the high NT-proBNP group had significantly greater energy loss during AF, but this improved after restoring sinus rhythm, indicating a link between energy inefficiency and serum NT-proBNP levels.
Symptomatic subdural hemorrhage following heart valve surgery: a retrospective cohort study.
J Neurosurg
September 2023
Departments of1Neurosurgery and.
Objective: Subdural hemorrhage (SDH) has been reported to be the most frequent intracranial hemorrhagic complication following open heart surgery; however, its clinical features and pathophysiology remain unclear. The aim of this retrospective study was to elucidate the incidence, clinical course, and factors associated with the development of symptomatic SDH following heart valve surgery.
Methods: A retrospective review of medical records on the development of symptomatic SDH after heart valve surgery involving cardiopulmonary bypass (CPB) from April 2011 to March 2016 was performed.
Life Expectancy of Patients With Severe Aortic Stenosis in Relation to Age and Surgical Risk Score.
Ann Thorac Surg
December 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:
Article Synopsis
- The study investigates life expectancy after aortic valve replacement (AVR) in patients with severe aortic stenosis (AS), highlighting a lack of existing data on this topic.
- Data from 3815 patients in the CURRENT AS registry revealed that those who underwent AVR had better survival rates than those using a conservative treatment strategy, especially among younger patients.
- The findings suggest that assessing surgical risk based on age and STS score can help estimate life expectancy post-AVR, which is crucial for deciding between surgical and transcatheter approaches.
Impact of taste/smell disturbances on dietary intakes and cachexia-related quality of life in patients with advanced cancer.
Support Care Cancer
January 2023
Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai City, Miyagi, 980-8575, Japan.
Purpose: Taste and smell are used to enjoy meals; however, impairments of these sensory perceptions seriously impact health and eating habits. This study is aimed at investigating the impact of taste and smell disturbances on dietary intakes and cachexia-related quality of life (QOL) in patients with advanced cancer.
Methods: Using a self-report questionnaire, we surveyed patients with advanced cancer undergoing treatment at 11 palliative care centers.
Prognostic Value of the Severity of Clinical Congestion in Patients Hospitalized for Decompensated Heart Failure: Findings From the Japanese KCHF Registry.
J Card Fail
August 2023
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Article Synopsis
- Congestion significantly impacts hospitalization outcomes in heart failure patients, with higher levels correlating to increased risk of death or readmission.
- A study of 3787 hospitalized heart failure patients in Japan revealed that those with higher Composite Congestion Scores (CCS) at admission were more likely to experience adverse outcomes.
- Even after achieving complete decongestion prior to discharge, residual congestion still indicated a higher risk for post-discharge complications, emphasizing the importance of monitoring congestion levels throughout treatment.
Can depressed cancer patients with a borderline thiamine concentration develop deficiency within a short time period?
Palliat Support Care
August 2023
Department of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Background: Despite increasing reports of thiamine deficiency (TD) among cancer patients, there remain some patients with borderline thiamine concentrations (BTC). However, it is unclear whether such patients subsequently develop TD.
Methods: Here, we report cases of cancer patients progressing to TD within a short time period after presentation with BTC (24-28 ng/ml).
Impact of the Intermittent Pringle Maneuver for Predicting Post-hepatectomy Liver Failure: A Cohort Study of 597 Consecutive Patients.
World J Surg
April 2023
Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Background: Intermittent Pringle maneuver (PM) is widely performed to reduce blood loss during hepatectomy; however, its impact on clinically relevant post-hepatectomy liver failure (PHLF) remains controversial. This study aimed to assess the impact of PM on PHLF and explore whether PM provides additional value for predicting PHLF.
Methods: Consecutive patients, who underwent hepatectomy without biliary and/or vascular reconstruction between 2011 and 2018 in a single institution, were retrospectively analyzed.
Displacement of submacular hemorrhage secondary to age-related macular degeneration with subretinal injection of air and tissue plasminogen activator.
Sci Rep
December 2022
Department of Ophthalmology, Hyogo Prefectural Amagasaki General Medical Center, Higashinaniwa-Cho 2-17-77, Amagasaki, Hyogo, 660-8550, Japan.
Article Synopsis
- Submacular hemorrhage (SMH) in age-related macular degeneration can cause major vision loss, and this study looked at surgical outcomes from vitrectomy combined with a subretinal injection in 13 cases.
- The results showed that 12 out of 13 eyes had complete displacement of SMH, with significant improvements in best-corrected visual acuity (BCVA) and SMH height three months after surgery.
- Preoperative conditions, particularly the height of SMH and the status of the ellipsoid zone line, were linked to how quickly and effectively patients’ vision improved post-surgery.
Prognostic impact of catheter ablation in patients with asymptomatic atrial fibrillation.
PLoS One
December 2022
Department of Cardiovascular Medicine, Hirakata Kohsai Hospital, Osaka, Japan.
Article Synopsis
- This study investigates the long-term effects of catheter ablation compared to conservative management in asymptomatic atrial fibrillation (AF) patients to determine the procedure's effectiveness.
- Out of 537 matched pairs of patients, catheter ablation showed significantly fewer major cardiovascular issues among asymptomatic patients with previous AF-related complications, while the benefits were less clear for those without such complications.
- In contrast, symptomatic AF patients consistently benefited from catheter ablation regardless of their history with AF-related complications, suggesting different treatment efficacy based on symptom presence.
Impact of catheter ablation on functional tricuspid regurgitation in patients with atrial fibrillation.
J Interv Card Electrophysiol
September 2023
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-Cho, Sakyo-Ku, Kyoto, Japan.
Article Synopsis
- Atrial fibrillation (AF) significantly contributes to functional tricuspid regurgitation (TR), and the effectiveness of catheter ablation (CA) on this condition has been studied in a cohort of 2331 patients with available echocardiographic data.
- Among patients with functional TR, 64 underwent follow-up echocardiography 6-18 months after CA, showing a notable reduction in TR severity and jet area, indicating effective treatment outcomes.
- The findings suggest that the improvement in TR is related to changes in the structure and function of the right heart following ablation for AF.
Modifiers of the Risk of Diabetes for Long-Term Outcomes After Coronary Revascularization: CREDO-Kyoto PCI/CABG Registry.
JACC Asia
June 2022
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: Diabetes is a well-known risk factor for adverse outcomes after coronary revascularization.
Objectives: This study sought to determine high-risk subgroups in whom the excess risks of diabetes relative to nondiabetes are particularly prominent and thus may benefit from more aggressive interventions.
Methods: The study population consisted of 39,427 patients (diabetes: n = 15,561; nondiabetes: n = 23,866) who underwent first percutaneous coronary intervention (n = 33,144) or coronary artery bypass graft (n = 6,283) in the pooled CREDO-Kyoto PCI/CABG (Coronary Revascularization Demonstrating Outcome Study in Kyoto Percutaneous Coronary Intervention/Coronary Artery Bypass Graft) registry.