322 results match your criteria: "Mitsubishi Kyoto Hospital.[Affiliation]"

Associations of nutrition impact symptoms with dietary intake and eating-related distress in patients with advanced cancer.

Clin Nutr ESPEN

April 2024

Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai City, Miyagi 980-8575, Japan. Electronic address:

Background & Aims: There is no definition of nutrition impact symptoms (NISs) in cancer care. Moreover, there is a lack of evidence on the associations of NISs with dietary intake and eating-related distress (ERD) in advanced cancer. Therefore, this study aimed to determine the associations of NISs with dietary intake and ERD in patients with advanced cancer.

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  • * Out of 178 patients, 37% received home treatment, with low rates of serious complications: 4.6% had major bleeding, but there were no deaths or recurrent PE in this group.
  • * The findings suggest that certain cancer patients with low-risk PE could safely manage their treatment at home instead of in a hospital setting.
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  • - The study aimed to develop a systematic method for diagnosing atrioventricular nodal reentrant tachycardia (AVNRT) that has a concealed nodoventricular pathway (cNVP).
  • - Researchers analyzed 13 cases of AVNRT involving cNVP, focusing on how the pathway connected to either the slow or fast pathways, and also looked at cases of orthodromic reciprocating tachycardia related to cNVP.
  • - The diagnostic process involves three key steps: identifying accessory pathways via His-refractory PVCs, excluding orthodromic reciprocating tachycardia, and confirming the AVN as the cNVP insertion site, with specific criteria for tachy
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  • The study focused on how different settings of cryoballoon ablation affect the size of frozen lesions in porcine hearts, particularly examining application duration and push-up technique.
  • Results showed that longer application durations (at least 150 seconds) and the push-up technique (especially at 20 seconds post-freezing) significantly increase lesion size.
  • Interestingly, the absence of laminar flow didn't lead to larger lesions, even though it resulted in lower balloon temperatures.
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  • The text discusses patients with BRCA1/2 pathogenic variants and metastatic breast cancer, highlighting their treatment experiences.* -
  • Of the patients, three had recurrences after chemotherapy, while one with advanced disease needed chemotherapy before starting olaparib.* -
  • There is ongoing debate about whether prior treatments with anthracycline or taxane are beneficial before using PARP inhibitors like olaparib.*
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Aims: Atrial fibrillation (AF) type (paroxysmal, persistent, or permanent) is important in determining therapeutic management; however, clinical outcomes by AF type are largely unknown for hospitalized patients with heart failure (HF).

Methods And Results: The Japanese Registry Of Acute Decompensated Heart Failure is a retrospective, multicenter, and nationwide registry of patients hospitalized for acute HF in Japan. Follow-up data were collected up to 5 years after hospitalization.

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  • Acute coronary syndrome (ACS) includes conditions like myocardial infarction (MI) and unstable angina (UA), but diagnosing them early remains challenging due to delayed elevation of cardiac markers like troponin.
  • A study analyzed the potential of serum nardilysin (NRDC) as a biomarker for early ACS detection by involving two patient cohorts, finding that NRDC levels were significantly higher in ACS patients compared to those without.
  • The study showed that NRDC had better sensitivity for ACS diagnosis within 6 hours of symptom onset than traditional markers and could aid in diagnosing patients who test negative for troponin, strengthening its role when used alongside hsTnI.
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  • Prophylactic embolization of the inferior mesenteric artery (IMA) during endovascular aneurysm repair (EVAR) aims to prevent type 2 endoleaks (T2ELs), but the effect of patent lumbar arteries (LAs) on these complications and aneurysm size is unclear.
  • In a study of 57 patients undergoing EVAR, T2ELs occurred in 22.8% of cases, with 64.6% experiencing aneurysm sac shrinkage over four years.
  • The number of postoperative patent LAs was identified as a significant risk factor for T2ELs and a predictor for both aneurysm enlargement and shrinkage, suggesting their importance in post-E
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  • A study analyzed long-term mortality in patients with severe coronary artery disease who underwent either PCI or CABG, focusing on those with peripheral artery disease (PAD).
  • Out of 14,867 patients, 3,380 were assessed, revealing a higher cumulative 5-year mortality rate of 31.2% for patients with PAD compared to 16.2% for those without.
  • The findings indicated that while both procedures carried a higher risk of all-cause death for PCI versus CABG, there was no significant difference in cardiovascular deaths based on PAD status.
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  • * OctaRay identified more focal and rotational activation sites than PentaRay, but had lower reproducibility and stability rates for these activations after pulmonary vein isolation in persistent AF patients.
  • * Ultimately, the OctaRay catheter was found to provide high-resolution and reliable identification of focal and rotational activations, which are associated with shorter AF-cycle lengths and increased activation frequency.
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Background: The definition of progressive pulmonary fibrosis is based on a 1-year lung function decline.

Objectives: To evaluate the epidemiology and clinical relevance of 1-year lung function decline in sarcoidosis.

Methods: A retrospective observational study at a general sarcoidosis clinic.

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Background: It remains unclear whether clopidogrel is better suited than aspirin as the long-term antiplatelet monotherapy following dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).

Objectives: This study compared clopidogrel monotherapy following 1 month of DAPT (clopidogrel group) with aspirin monotherapy following 12 months of DAPT (aspirin group) after PCI for 5 years.

Methods: STOPDAPT-2 (Short and Optimal Duration of Dual Antiplatelet Therapy 2) is a multicenter, open-label, adjudicator-blinded, randomized clinical trial conducted in Japan.

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  • There is a lack of research on why patients with coronary artery disease stop taking statins, but a study of over 11,000 patients found that about 21% discontinued them within 7 years, mainly due to nonadherence, side effects, and worsening health conditions.
  • Statin discontinuation was linked to a significantly higher risk of mortality, with different reasons for stopping having varying levels of risk associated with them.
  • Younger patients, men, those with acute coronary syndrome, and current smokers were more likely to discontinue due to nonadherence, while older patients with severe health issues were more likely to stop because of worsening co-morbidities.
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Background: This study assessed the prognostic importance of B-type natriuretic peptide (BNP) concentrations for clinical events after catheter ablation for atrial fibrillation (AF).

Methods and results: We enrolled 1,750 consecutive patients undergoing initial AF ablation whose baseline BNP data were available from a large-scale multicenter observational cohort (TRANQUILIZE-AF Registry). The prognostic impact of BNP concentration on clinical outcomes, including recurrent tachyarrhythmias and a composite of heart failure (HF) hospitalization or cardiac death, was evaluated.

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Marchiafava-Bignami disease (MBD) is a very rare disorder characterized by demyelination and necrosis of the corpus callosum. A 53-year-old male was transported to the emergency room with impaired consciousness. On his arrival, he was quite emaciated.

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Background: Polypharmacy was reported to be associated with major bleeding in various populations. However, there are no data on polypharmacy and its association with bleeding in patients undergoing percutaneous coronary intervention (PCI).

Methods and results: Among 12,291 patients in the CREDO-Kyoto PCI Registry Cohort-3, we evaluated the number of medications at discharge and compared major bleeding, defined as Bleeding Academic Research Consortium Type 3 or 5 bleeding, across tertiles (T1-3) of the number of medications.

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Background: There are no studies comparing single-session vs staged multivessel intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS) or non-ST-segment-elevation acute coronary syndrome (NSTE-ACS).

Objectives: The authors aimed to compare single-session vs staged multivessel IVUS-guided PCI in patients with CCS or NSTE-ACS.

Methods: The OPTIVUS-Complex PCI study multivessel cohort was a prospective multicenter single-arm trial enrolling 1,021 patients with CCS or NSTE-ACS undergoing multivessel PCI including left anterior descending coronary artery using IVUS aiming to meet the prespecified OPTIVUS criteria for optimal stent expansion.

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Aims: We aimed to explored the association between the use of optimal medical therapy (OMT) in patients with myocardial infarction (AMI) and diabetes mellitus (DM) and clinical outcomes.

Methods: Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome (BleeMACS) is an international registry that enrolled participants with acute coronary syndrome followed up for at least 1 year across 15 centers from 2003 to 2014. Baseline characteristics and endpoints were analyzed.

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  • * Among 10,822 patients, PC-AKI occurred significantly more in those undergoing emergent PCI (10.5%) compared to elective PCI (3.7%).
  • * Patients with PC-AKI had a higher risk of all-cause death, with the risk being greater for those who had emergent PCI, indicating the severity of PC-AKI's impact in urgent situations.
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  • The study aimed to investigate the link between ST-segment depression during atrial fibrillation (AF) and future heart failure (HF) events among patients.
  • It involved 2,718 AF patients, revealing that 25.4% exhibited ST-segment depression, which was linked to higher rates of cardiac death and hospitalization due to HF during a 6-year follow-up.
  • The type of ST-segment depression (e.g., horizontal or downsloping) significantly impacted this risk, with the findings suggesting that not all forms of ST-segment depression indicate the same level of future heart failure risk.
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Akathisia, an Easily Overlooked Side Effect.

J Clin Oncol

September 2023

Hideki Onishi, MD, PhD, Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan; Akira Yoshioka, MD, PhD, Department of Medical Oncology and Palliative Care, Mitsubishi Kyoto Hospital, Kyoto, Japan; Izumi Sato, MPH, PhD, Department of Clinical Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; Nozomu Uchida, MD, Department of General Medicine, Ogano Town Central Hospital, Saitama, Japan; and Mayumi Ishida, CP, PhD, Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.

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