Omega-3 index improves upon the pooled cohort equation in predicting risk for CVD.

Background: Accurate predictive tools are crucial for identifying patients at increased risk for atherosclerotic cardiovascular disease (ASCVD). The Pooled Cohort Equation (PCE) is commonly used to predict 10-year risk for ASCVD, but its accuracy remains imperfect.

Objective: This study examined the extent to which the omega-3 index (O3I; the proportion of eicosapentaenoic acid+docosahexaenoic acid in erythrocyte membranes) improved the predictive capability of PCE.

Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory.

This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR.

Black nursing faculty: Overcoming challenges on the road to earning tenure and promotion.

Background: Approximately 9 % of nursing faculty are Black (National League for Nursing, 2020). Black faculty seldom seek tenure and promotion. Tenure and promotion represent a professional and academic accomplishment, reflecting a scholar's ability to achieve success in research, teaching, and service.

Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels.

Inward rectifier Kir4.1 potassium channels are abundantly expressed in cells that are important for electrolyte homeostasis. Dysregulation of Kir4.

Foundations of Interprofessional Education in Dental Schools: A Narrative Review.

Interprofessional education (IPE) and interprofessional collaborative practice have gained significant recognition for their ability to enhance health care education and improve patient outcomes, particularly in dentistry. Given the close connection between oral and general health, incorporating IPE into dental curricula has become essential in preparing practitioners for collaborative patient-centered care. This review focuses on the foundations of IPE in dental schools, focusing on its role in preparing students for collaborative health care.

Overdose and overwork: First responder burnout and mental health help-seeking in Missouri's overdose crisis.

As the overdose crisis continues to spiral, high volume and intensity of drug poisoning calls are impacting first responders' mental health. This study examined burnout and attitudes towards mental health help-seeking among first responders in Missouri. The study included 3059 participants, of which 76.

Type A Aortic Dissection Following Abdominal Solid Organ Transplantation: Population-Level Outcomes in the United States.

Background: This study aims to analyze the patient characteristics, clinical outcomes, and contemporary trends concerning type A aortic dissection (TAAD) in previous recipients of abdominal solid organ transplantation (ASOT) in the United States.

Methods: The National Inpatient Sample was queried to identify all patients aged ≥18 with TAAD and a history of ASOT (TAAD-ASOT) between 2002 and 2015Q3 using ICD-9 diagnosis and procedure codes. Baseline characteristics and in-hospital outcomes were compared between TAAD-ASOT patients and TAAD patients without a history of ASOT (TAAD-non-ASOT).

Integrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility Study.

Background: Amyotrophic lateral sclerosis (ALS) leads to rapid physiological and functional decline before causing untimely death. Current best-practice approaches to interdisciplinary care are unable to provide adequate monitoring of patients' health. Passive in-home sensor systems enable 24×7 health monitoring.

Refugium amidst ruins: Unearthing the lost flora that escaped the end-Permian mass extinction.

Searching for land refugia becomes imperative for human survival during the hypothetical sixth mass extinction. Studying past comparable crises can offer insights, but there is no fossil evidence of diverse megafloral ecosystems surviving the largest Phanerozoic biodiversity crisis. Here, we investigated palynomorphs, plant, and tetrapod fossils from the Permian-Triassic South Taodonggou Section in Xinjiang, China.

Connecting Underrepresented Medical Students to Resources and Role Models in Orthopaedic Surgery: A Virtual Diversity, Equity, Inclusion, and Accessibility Summit.

Introduction: Limited access to resources and stereotypes about orthopaedic surgeons may contribute to the low percentage of women and people of underrepresented in medicine (URiM) backgrounds in orthopaedic surgery. Several organizations have created resources to address these barriers, but medical students are unlikely to be exposed to the initiatives through traditional curricula. The purpose of this study was to (1) evaluate the ability of a 1-day virtual Diversity, Equity, Inclusion, and Accessibility (DEIA) summit to effectively reach URiM medical students, (2) increase medical students' knowledge of DEIA resources, and (3) augment the perception of diverse backgrounds in orthopaedic surgery.

Cognitive Fluctuations in a Rare Disease Population: Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals with Phenylketonuria.

Background: Phenylketonuria (PKU) is a rare, hereditary disease that causes disruption in phenylalanine (Phe) metabolism. Despite early intervention, individuals with PKU may have difficulty in several different cognitive domains, including verbal fluency, processing speed, and executive functioning.

Objective: The overarching goal of the Evaluating Fluctuations in Cognitive and Speech Characteristics in Phenylketonuria study (CSP Study) is to characterize the relationships among cognition, speech, mood, and blood-based biomarkers (Phe, Tyr) in individuals with early treated PKU.

In memoriam: Carl J. Carrano : July 14, 1950-January 26, 2022.

This article is a celebration of the life and work of Carl J. Carrano who, from a childhood in Long Island, New York, built a career in bioinorganic chemistry, especially in the context of metal uptake and halogen metabolism in microbes and marine organisms.

Novel Controlled Metabolic Accelerator for Obesity-Related HFpEF: The HuMAIN-HFpEF Randomized Clinical Trial.

Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.

Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.

Polygenic Scores of Cardiometabolic Risk Factors in American Indian Adults.

Importance: Numerous efforts have been made to include diverse populations in genetic studies, but American Indian populations are still severely underrepresented. Polygenic scores derived from genetic data have been proposed in clinical care, but how polygenic scores perform in American Indian individuals and whether they can predict disease risk in this population remains unknown.

Objective: To study the performance of polygenic scores for cardiometabolic risk factors of lipid traits and C-reactive protein in American Indian adults and to determine whether such scores are helpful in clinical prediction for cardiometabolic diseases.

Ankle range of motion following surgical correction of early relapse in clubfoot.

Surgical options for relapsed clubfoot include repeat heel cord lengthening or posterior release for recurrent equinus, and anterior tibialis tendon transfer (ATT) for residual dynamic supination deformity. Some studies have suggested that these procedures be performed in isolation to allow for early range of motion after intra-articular surgery. This study was performed to examine clinical and radiographic outcomes comparing two surgical methods, simultaneous ATT with posterior release (ATT/PR) vs ATT performed in isolation (ATT(i)), for the management of recurrent clubfoot deformity.

Ophthalmology Examinations in Children With Skull Fractures and Underlying Focal Hemorrhage.

Objectives: To assess the frequency and yield of retinal examination in children below 2 years old undergoing abuse evaluations in the setting of skull fracture(s) and small underlying intracranial hemorrhage.

Methods: This cross-sectional study used CAPNET, a multicenter child physical abuse network, to identify children below 2 years with a skull fracture(s) and intracranial injury limited to an underlying small focal intracranial hemorrhage undergoing subspeciality child abuse evaluations. Our outcomes of interest were (1) the performance of a retinal examination, (2) the identification of retinal hemorrhages, and (3) associations of clinical factors and CAPNET site with the performance of retinal examinations.

Effects of baclofen on swallow motor pattern.

Baclofen is a GABA receptor agonist used clinically to manage spasticity. It has also been associated with increased duration of mechanical ventilation and rates of aspiration pneumonitis. We hypothesized that baclofen would impair pharyngeal swallow, a vital airway protective reflex.

Enhancing poultry health and productivity through the liver-gut axis with integrated nutritional and immunological approaches: a mini-review.

The liver-gut axis plays a central role in maintaining the health and productivity of poultry. In addition, the liver-gut axis serves as a key regulator of digestion, metabolism, immunity, and detoxification. The gut, with its diverse microbiota, is the primary site for nutrient absorption and immune modulation, while the liver metabolizes nutrients, detoxifies harmful substances, and acts as a frontline defense against pathogens translocated from the gut.

Artificial intelligence versus radiologists in detecting early-stage breast cancer from mammograms: a meta-analysis of paradigm shifts.

Purpose: Early detection of breast cancer is crucial for improving patient outcomes. With advancements in artificial intelligence (AI), there is growing interest in its potential to assist radiologists in interpreting mammograms for early cancer detection. AI algorithms offer the promise of increased accuracy and efficiency in identifying subtle signs of breast cancer, potentially complementing the expertise of radiologists and enhancing the screening process for early-stage breast cancer detection.

International evidence-based recommendations for polycystic ovary syndrome in adolescents.

Background: During adolescence, accurate diagnostic criteria and/or identification of adolescents "at risk" of polycystic ovary syndrome (PCOS) are critical to establish appropriate screening, treatment, and lifelong health plans. The 2023 International Evidence-Based Guideline for PCOS aimed to provide the most up-to-date evidence-based recommendations to improve health outcomes for individuals with PCOS, emphasizing accurate and timely diagnosis of PCOS from adolescence.

Methods: The best practice methods following the Appraisal of Guidelines for Research and Evaluation (AGREE-II) criteria were applied.

Media advocacy for farm safety and health: current landscape and future directions.

Background: Within public health, media advocacy embraces the influence of new media and journalists in setting public agendas and promoting important public health programming and policies. Though occupational health and safety (OSH) is an important component of public health, few studies have examined the use of media advocacy within this specific field. This study aims to examine how media is currently used to support OSH efforts as well as opportunities for engaging with this strategy.

Forty Years of Couple Therapy Process Research and We Are Still Just Getting Started: A Review of Quantitative Research.

Can empirical research guide clinicians in how to conduct effective couple therapy? While we know that couple therapy works, understanding the mechanisms of action-how and why it works-has been the focus of research for several decades. Using Doss's framework for understanding the key components of the change process-therapy change processes, client change processes, mediators, and outcomes-we reviewed 48 quantitative couple therapy process studies over a 40-year period. The results reveal a fragmented knowledge base.

Functional Assessment of Meniscus Extrusion, Excursion and Hoop Strain UnderClinicallyRelevantLoadedRangeofMotionConditions inMeniscus-IntactandMeniscusRoot-DeficientKneesUsingaNovelBiomechanicalModel.

The knee is meniscus-dependent, relying on the tissue's biomechanical properties to maintain joint health and function. Meniscus dysfunction has primarily been assessed by measuring tibiofemoral articular contact areas and pressures, which entail important limitations. Meniscus extrusion, excursion, and hoop strain are dynamic measures of meniscal function, which have potential advantages for clinically applicable biomechanical testing of meniscus.

Whole plant transpiration responses of common bean (Phaseolus vulgaris L.) to drying soil: Water channels and transcription factors.

Common bean (Phaseolus vulgaris L.) is the main legume crop for direct human consumption worldwide. Among abiotic factors affecting common bean, drought is the most limiting.