127,307 results match your criteria: "Missouri; Harry S. Truman Memorial Veterans Affairs Hospital-Research Service[Affiliation]"

Purpose: The etiology of early-onset scoliosis (EOS) has been shown to significantly influence baseline parent-reported health-related quality of life (HrQOL). In combining these etiology groups, we obligatorily lump together many disparate diagnoses, particularly true in the neuromuscular (NM) cohort. We sought to evaluate the influence of underlying neuromuscular diagnosis on the HrQOL at 5 years following surgery for EOS.

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Objective: Identify changes in general surgery resident autonomy and resident postgraduate year (PGY) level in Entrustable Professional Activity (EPA) cases over time.

Design: Retrospective cohort study.

Setting: United States Veterans Affairs (VA) hospital system, 2004 to 2020.

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The first five years of implementing Missouri's medication first approach to opioid use disorder treatment: Plateaus, regressions, and underbellies of progress.

J Subst Use Addict Treat

January 2025

University of Missouri-St. Louis, Addiction Science, Missouri Institute of Mental Health, 1 University Blvd., Benton Hall, Room 206, St. Louis, MO 63121, USA.

Introduction: Missouri's Medication First ("MedFirst") approach promotes same-day and long-term low-threshold access to medications for opioid use disorder (MOUD). Since 2017, Missouri's SAMHSA-funded State Targeted and State Opioid Response (STR/SOR) grants have supported MedFirst services (both medical and psychosocial) for uninsured individuals with opioid use disorder at state-contracted treatment programs. Though MedFirst demonstrated early success, results - with attention to possible racial disparities - must be revisited after five years of implementation.

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Machine learning in public health informatics: Evidence that complex sampling structures may not be needed for prediction models with imbalanced outcomes.

Ann Epidemiol

January 2025

Department of Orthopaedic Surgery, Thompson Laboratory for Regenerative Orthopaedics, School of Medicine, University of Missouri, 1100 Virginia Avenue, Columbia , MO 65211, USA. Electronic address:

Purpose: The objective of this study is to investigate the predictive ability of machine learning models for imbalanced outcomes from national survey data without the use of sampling weights.

Methods: We evaluated the predictive performance of machine learning models on imbalanced outcomes from the US National Health and Nutrition Examination Survey (USNHANES) without using sampling weights. Four machine learning models (support vector machine, random forest, least absolute shrinkage and selection operator regression, and deep neural network) were compared with a logistic model that incorporates the survey's complex sampling design.

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Objective: Alcohol and cannabis are two of the most widely used substances in the United States, where sleep problems are also prominent. Although poor sleep is linked to substance use, little is known about how prior-night sleep contributes to next-day decisions to use substances in daily life. This study tested the impact of prior-night sleep duration and quality on momentary motives for alcohol (Aim 1) and cannabis use (Aim 2).

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Assessing Mitigation Translocation as a Tool to Reduce Human-great Horned owl Conflicts.

Environ Manage

January 2025

United States Department of Agriculture, Animal Plant Health Inspection Service, Wildlife Services, Fort Collins, CO, USA.

The great horned owl (Bubo virginianus) is a generalist predator that inhabits wide-ranging territories that are relatively stable throughout the year. These owls are also involved in a variety of human-owl conflicts, including killing of domestic poultry, predating colonially nesting seabirds and shorebirds, and pose a hazard to safe aircraft operations. Managing these conflict situations presents unique challenges as great horned owls are nocturnally active and occupy a wide range of habitats.

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Riverine flooding is increasing in frequency and intensity, requiring river management agencies to consider new approaches to working with communities on flood mitigation planning. Communication and information sharing between agencies and communities is complex, and mistrust and misinformation arise quickly when communities perceive that they are excluded from planning. Subsequently, riverfront community members create narratives that can be examined as truth regimes-truths created and repeated that indicate how flooding and its causes are understood, represented, and discussed within their communities-to explain why flooding occurs in their area.

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Background: Left ventricular (LV) dilatation and extensive scar portend a poor prognosis in heart failure (HF). The Revivent TC system (BioVentrix Inc) is used either during a hybrid transcatheter-surgical or a surgical-only procedure to exclude transmural scar and reduce LV dimensions.

Objectives: The purpose of this study was to examine the safety and efficacy of the Revivent TC® anchor system in patients with HF.

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Background And Purpose: Pituitary adenylate cyclase activating polypeptide (PACAP) is a human migraine trigger that is being targeted for migraine. The δ-opioid receptor (δ-receptor) is a novel target for the treatment of migraine, but its mechanism remains unclear. The goals of this study were to develop a mouse PACAP-headache model using clinically significant doses of PACAP; determine the effects of δ-receptor activation in this model; and investigate the co-expression of δ-receptors, PACAP and PACAP-PAC1 receptor.

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NAFLD and NAFLD Related HCC: Emerging Treatments and Clinical Trials.

Int J Mol Sci

January 2025

Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO 65212, USA.

Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver disease (MAFLD), is the most prevalent liver disease worldwide. It is associated with an increased risk of developing hepatocellular carcinoma (HCC) in the background of cirrhosis or without cirrhosis. The prevalence of NAFLD-related HCC is increasing all over the globe, and HCC surveillance in NAFLD cases is not that common.

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Improving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT.

AJNR Am J Neuroradiol

January 2025

From the Department of Radiology (A.T.T., D.Z., D.K., S. Payabvash) and Neurology (S. Park), NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York, NY; Department of Radiology and Biomedical Imaging (G.A., A.M.) and Neurology (G.J.F., K.N.S.), Yale School of Medicine, New Haven, CT; Zeenat Qureshi Stroke Institute and Department of Neurology (A.I.Q.), University of Missouri, Columbia, MO; Department of Neurosurgery (S.M.), Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, NY; and Department of Neurology (S.B.M.), Weill Cornell Medical College, Cornell University, New York, NY.

Background And Purpose: Robustness against input data perturbations is essential for deploying deep-learning models in clinical practice. Adversarial attacks involve subtle, voxel-level manipulations of scans to increase deep-learning models' prediction errors. Testing deep-learning model performance on examples of adversarial images provides a measure of robustness, and including adversarial images in the training set can improve the model's robustness.

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Dose-related effects of eugenol: Exploring renal functionality and morphology in healthy Wistar rats.

Food Chem Toxicol

January 2025

Laboratory of Structural Biology, Department of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais Brazil; Department of Veterinary, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address:

Eugenol has pharmacological properties, but its impact on renal function is limitedly studied. Thus, this study evaluated the effects of eugenol at 10, 20, and 40 mg kg, administered via gavage for 60 days, on histological, biochemical, oxidative, and proteomic parameters in rat kidneys. Adult Wistar rats treated with 10 mg kg of eugenol had kidneys with low total antioxidant capacity, high nitric oxide content, and high percentual of blood vessels, with no damage to renal function or morphology.

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Knee osteoarthritis significantly impacts mobility and quality of life. This condition is a leading cause of disability in aging populations, with total knee replacement commonly sought in advanced cases. Traditional nonoperative management strategies, including anti-inflammatories, corticosteroid injections, and hyaluronic acid, often provide limited relief, especially in severe cases.

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Implementing accelerometer technologies in beef operations is an alternative to increase precision in estrous detection. We hypothesized that (1) the accelerometer algorithm has similar accuracy in detecting behavioral estrus as does visual observation of pressure-sensitive sensors (estrus patches) in grazing beef cows; (2) variables measured by the accelerometer, such as estrus intensity, are associated with hormonal, ovarian, and uterine variables monitored before, during, and after estrus; and (3) the accelerometer variables are associated with the probability of pregnancy in grazing beef cows submitted to embryo transfer (ET). Fifty cows were fitted with accelerometer and patches to detect estrus after a synchronization protocol in eight subsequent rounds.

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Objective: To describe the clinical characteristics, treatments, complications, and outcomes in dogs with nasal planum squamous cell carcinoma (SCC) undergoing local treatment.

Methods: A retrospective, multi-institutional study was performed. Medical records were searched to identify dogs diagnosed with nasal planum SCC.

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Objective: Orthopedic residents are tasked with rapidly acquiring clinical and surgical skills, especially during their PGY-1 year. However, resource constraints and other factors frequently cause skills training to fall short of established guidelines. We aimed to design and evaluate a cross-institutional, month-long curriculum aimed at pooling resources to optimize training.

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Investigation of Transformation Pathways of Polyfluoroalkyl Substances during Chlorine Disinfection.

Environ Sci Technol

January 2025

Department of Civil and Environmental Engineering, University of Missouri, Columbia, Missouri 65211, United States.

Recent regulations on perfluorinated compounds in drinking water underscore the need for a deeper understanding of the formation of perfluorinated compounds from polyfluoroalkyl substances during chlorine disinfection. Among the compounds investigated in this study, N-(3-(dimethylaminopropan-1-yl)perfluoro-1-hexanesulfonamide (N-AP-FHxSA) underwent rapid transformation during chlorination. Within an hour, it produced quantitative yields of various poly- and per-fluorinated products, including perfluorohexanoic acid (PFHxA).

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Paramyxoviruses are significant human and animal pathogens that include mumps virus (MuV), Newcastle disease virus (NDV) and the murine parainfluenza virus Sendai (SeV). Despite their importance, few host factors implicated in paramyxovirus infection are known. Using a recombinant SeV expressing destabilized eGFP (rSeVCdseGFP) in a loss-of-function CRISPR screen, we identified the CMP-sialic acid transporter (CST) gene SLC35A1 and the UDP-galactose transporter (UGT) gene SLC35A2 as essential for paramyxovirus infection.

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Purpose: Sulfur mustard gas (SM) exposure to eyes causes multiple corneal injuries including stromal cell loss in vivo. However, mechanisms mediating stromal cell loss/death remains elusive. This study sought to test the novel hypothesis that SM-induced toxicity to human corneal stromal fibroblasts involves ferroptosis mechanism via p38 MAPK signaling.

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Objectives: The 22-modifier in the Current Procedural Terminology (CPT) system indicates increased surgical procedure complexity, aiming to secure greater reimbursement for surgeons. This study investigated the 22-modifier on reimbursement amounts after acetabular fracture fixation.

Methods: Design: Retrospective cohort study.

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Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease primarily affecting motor neurons, leading to progressive muscle atrophy and paralysis. This review explores the role of Schwann cells in ALS pathogenesis, highlighting their influence on disease progression through mechanisms involving demyelination, neuroinflammation, and impaired synaptic function. While Schwann cells have been traditionally viewed as peripheral supportive cells, especially in motor neuron disease, recent evidence indicates that they play a significant role in ALS by impacting motor neuron survival and plasticity, influencing inflammatory responses, and altering myelination processes.

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Background: Hypertension control and related cardiovascular outcomes among Americans remain suboptimal, and differ by race, ethnicity, and geography. Healthcare access is one of multiple critical factors in hypertension control. Understanding the degree to which healthcare access, versus other factors, produce these outcomes can inform policies and interventions to improve cardiovascular outcomes and reduce disparities.

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Background: Refluxate volume and pH drop following gastroesophageal reflux are mostly cleared by peristalsis. We evaluated the roles of primary volume clearing peristaltic wave (VCPW), secondary VCPW, post-reflux swallow-induced peristaltic wave (PSPW), and late primary peristaltic wave (LPPW) in refluxate clearance.

Methods: We retrospectively analyzed pH-impedance studies performed off therapy in 40 patients with typical esophageal symptoms.

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