The study aims to assess the safety and effectiveness of FOLFIRI combined with aflibercept (AFL) as a second-line chemotherapy for patients with metastatic colorectal cancer (mCRC) who are resistant to prior treatments involving anti-EGFR antibodies.
The main goal is to evaluate the 6-month progression-free survival (PFS) rate, with secondary goals including overall survival, response rates, and potential adverse effects, based on a sample size of 41 participants.
This research is necessary due to the lack of clinical trial data specifically for mCRC patients who have failed anti-EGFR therapy, highlighting the need for a prospective study to fill this knowledge gap.