Orexin concentrations and diurnal variation in the cerebrospinal fluid of intensive care unit patients undergoing aortic surgery with spinal drainage.

Background: Cerebrospinal fluid (CSF) levels of orexin show a cyclic diurnal variation in healthy subjects, which is diminished in patients with certain diseases. However, possible circadian variations in orexin levels in critically ill patients remain unknown. In this study, we evaluated the orexin concentrations in the CSF and their diurnal variation in patients undergoing thoracic aortic aneurysm repair with lumbar intrathecal catheterization for CSF drainage after non-neurosurgery.

Cytokine Storms and Anaphylaxis Following COVID-19 mRNA-LNP Vaccination: Mechanisms and Therapeutic Approaches.

Acute adverse reactions to COVID-19 mRNA vaccines are a major concern, as autopsy reports indicate that deaths most commonly occur on the same day of or one day following vaccination. These acute reactions may be due to cytokine storms triggered by lipid nanoparticles (LNPs) and anaphylaxis induced by polyethene glycol (PEG), both of which are vital constituents of the mRNA-LNP vaccines. Kounis syndrome, in which anaphylaxis triggers acute coronary syndrome (ACS), may also be responsible for these cardiovascular events.

Fungemia With Wickerhamomyces anomalus: A Case Report and Literature Review.

We report the case of an 84-year-old man with a history of IgG4-related sclerosing cholangitis who was diagnosed with advanced esophageal cancer and underwent radiation and chemotherapy. An implantable central venous access port was placed for chemotherapy and total parenteral nutrition. The patient presented with a fever and received antimicrobial therapy for acute cholangitis but remained febrile, and subsequently, yeast was detected in the aerobic bottle of blood culture obtained from the central venous line.

Higher Cardio-Ankle Vascular Index Values in Patients With Vestibular Neuritis May Indicate a Better Prognosis.

Background: The presumed etiology of vestibular neuritis (VN), a sudden onset of spontaneous vertigo without auditory or cranial nerve symptoms, includes viral infections and vascular disorders. However, no clinical test for estimating vascular disorders in VN has been reported. Moreover, estimating the etiology of VN is important to predict the prognosis and select appropriate treatment.

Is High Score of Preoperative Lactate Dehydrogenase to Albumin Ratio Predicting Poor Survivals in Esophageal Carcinoma Patients?

Purpose: The lactate dehydrogenase-to-albumin ratio (LAR) has been reported as a potential prognostic biomarker in various cancers; however, only a few pieces of information have been reported on esophageal cancer. Therefore, this study aimed to evaluate the prognostic significance of preoperative LAR in patients with esophageal cancer.

Methods: This study included 236 patients (193 men and 43 women; mean age of 66 years [range, 41-83 years]) with esophageal cancer who underwent curative surgery between September 2008 and March 2020.

Effects of flat-flexible shoes on lower limb joint kinetics and kinematics in gait.

Flat-flexible shoes with unique characteristics, such as low pitch and flexibility, can increase the efficiency of ankle energy and running performance. If flat-flexible shoes have the same effect during walking, they could be used for gait training. This study aimed to investigate the effects of flat-flexible shoes on the kinematics and kinetics of the lower limb.

Association between the Effects of Positive Social-Comparative Feedback and Learners' Competitiveness.

This study examined the effects of positive social-comparative feedback on learners' intrinsic motivation on a motor learning task, as well as its association with learners' competitiveness. The participants, who performed a balance task in a positive social-comparative feedback and a control group, were assessed for performance outcome, perceived competence, and competitiveness. The positive social-comparative feedback group demonstrated more effective balance performance than the control group on the retention test.

Relationship between correcting error and smoothness of movement in the process of motor learning.

[Purpose] Improvement in the smoothness of movement is a motor learning outcome. This study sought to clarify the relationship between motor skills and smoothness of movement in motor learning. [Participants and Methods] We subjected 12 healthy adults to a task in which they had to learn the sensation of a load while standing up and sitting down.

How does physical guidance affect motor learning and learner's workload?

[Purpose] Physical guidance is routinely used in clinical practices such as rehabilitation to facilitate motor learning. Physical guidance would facilitate motor learning and reduce the workload; however, this relationship is unknown. Thus, we aimed to investigate this relationship using a physical guidance device.

Recurrent massive myxoid liposarcoma in retroperitoneum 10 years post initial operation.

Introduction: Myxoid liposarcoma tends to be a relatively good prognosis. Follow-up is recommended once a year from the 5th year after surgery.

Case Presentation: A 48-year-old man had a massive retroperitoneal tumor, measuring approximately 20 cm.

The prognostic impact of the controlling nutritional status (CONUT) score in patients undergoing cardiovascular surgery.

Background: Various postoperative predictive markers following cardiovascular surgery have been examined for use in the current aging population. The controlling nutritional status (CONUT) score, which is advocated not only as a screening tool for poor nutritional status, but also as an immunonutritional assessment, has started to attract attention in several clinical settings, such as in cancer and heart failure patients. The aim of this study was to evaluate the value of the CONUT score as a postoperative prognostic marker in patients who underwent cardiovascular surgery.

A Clinical Association between an Increasing Renal Resistive Index and the Atherosclerotic Burden in Patients with a Preserved Renal Function.

Objective A positive correlation is observed between the progression of renal impairment and the increasing risk of cardiovascular disease. Our aim was to examine the relationship between the renal resistive index (RRI) assessed by duplex sonography and the extent of atherosclerosis in patients without renal impairment undergoing vascular imaging studies. Methods The RRI was evaluated pre-procedurally among 106 outpatients with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.

Extrinsic feedback from a feedback device promotes the learning of range of motion measurements.

[Purpose] Although it is widely recognized that feedback is important for skill acquisition or improvement, feedback is not completely utilized in physical therapy education. Therefore, we aimed to verify the effect of extrinsic feedback from a feedback device on proficiency in range of motion measurements by a universal goniometer. [Participants and Methods] The participants included 22 physical therapy students who were randomly assigned to feedback (n=11) and non-feedback groups (n=11).

The effects of feedback timing and frequency on the acquisition of cardiopulmonary resuscitation skills of health sciences undergraduate students: A 2 x 2 factorial quasi randomized study.

Background: High-quality training is required to improve the cardiopulmonary resuscitation (CPR) skills. Although it has been reported that the use of a feedback device is effective, the effects of feedback timing and frequency on CPR training have not been investigated. The aim of this study was to clarify the influence of feedback frequency and timing on the acquisition of CPR skills.

Endovascular Treatment for Kommerell's Diverticulum with a Right-Sided Aortic Arch.

We report a rare case of type A dissection involving a right-sided aortic arch with an aberrant left subclavian artery originating from Kommerell's diverticulum in a 76-year-old woman. Endovascular treatment for Kommerell's diverticulum including intimal tear of the dissection was performed. At the 5-year follow-up, the patient was doing well, with no endoleak or dilatation of the Kommerell's diverticulum.

The effect of proficiency level on measurement error of range of motion.

[Purpose] The aims of this study were to evaluate the type and extent of error in the measurement of range of motion and to evaluate the effect of evaluators' proficiency level on measurement error. [Subjects and Methods] The participants were 45 university students, in different years of their physical therapy education, and 21 physical therapists, with up to three years of clinical experience in a general hospital. Range of motion of right knee flexion was measured using a universal goniometer.

Validity of a food frequency questionnaire in a population with high alcohol consumption in Japan.

Background And Objectives: Alcohol consumption has a relatively large impact on energy intake in drinkers, and several studies reported different dietary habits from non-drinkers. However, few studies have investigated the influence of alcohol consumption on the validity of the Food Frequency Questionnaire (FFQ). To investigate its influence, we conducted a validity test in a population with high alcohol consumption.

Addition of a renin-angiotensin-aldosterone system inhibitor to a calcium channel blocker ameliorates arterial stiffness.

Background: The aim of controlling hypertension is to protect against arteriosclerosis. Calcium channel blockers (CCBs) and renin-angiotensin-aldosterone system (RAAS) inhibitors have been reported to have antihypertensive effects, but their effect on the progression of arteriosclerosis is not fully understood. The cardio-ankle vascular index (CAVI) was developed to estimate arterial stiffness, which reflects arteriosclerosis.

[Surgical Repair of Coarctation of the Aorta in an Adult;Report of a Case].

We present a case of 30-year-old man with successful bypass grafting for coarctation of the aorta. Hypertension was identified during a health examination. Blood pressure difference between the upper and lower limbs was about 60 mmHg.

Anaerobic Threshold and Salivary α-amylase during Incremental Exercise.

[Purpose] The purpose of this study was to clarify the validity of salivary α-amylase as a method of quickly estimating anaerobic threshold and to establish the relationship between salivary α-amylase and double-product breakpoint in order to create a way to adjust exercise intensity to a safe and effective range. [Subjects and Methods] Eleven healthy young adults performed an incremental exercise test using a cycle ergometer. During the incremental exercise test, oxygen consumption, carbon dioxide production, and ventilatory equivalent were measured using a breath-by-breath gas analyzer.

Morphological Evaluation of Proximal Anastomosis by PAS-Port(®) System in Patients with Long-Term Patent Grafts.

Purpose: We examined grafts employing for morphological analysis of early and long-term results on proximal anastomosis with the PAS-Port(®).

Methods: One hundred and four patients treated by OPCAB with PAS-Port(®) were performed postoperative MDCT. Morphological evaluation of the proximal anastomotic region was classified into three groups (A; graft was anastomosed almost perpendicularly to the aortic wall, B; graft was same type A, but subsequently curved to form an acute angle with the aortic wall, C; graft take off acute angle with the aortic wall) evaluated on planar and sagittal sections.

[A clinical investigation of seven patients with pulmonary tuberculosis who developed mixed liver injury during oral anti-tuberculosis treatment].

Background: Liver injury is the most common and clinically significant adverse reaction to anti-tuberculosis drugs, sometimes resulting in a fatal outcome. It has been reported that liver injury induced by isoniazid and pyrazinamide, which has the potential to cause hepatocellular injury, has a risk of becoming severe; while an injury induced by rifampicin, which has the potential to cause cholestatic injury, rarely becomes severe. However, mixed liver injury has not been studied thoroughly.