Draw+: network-based computational drug repositioning with attention walking and noise filtering.

Purpose: Drug repositioning, a strategy that repurposes already-approved drugs for novel therapeutic applications, provides a faster and more cost-effective alternative to traditional drug discovery. Network-based models have been adopted by many computational methodologies, especially those that use graph neural networks to predict drug-disease associations. However, these techniques frequently overlook the quality of the input network, which is a critical factor for achieving accurate predictions.

Nanoceria as a non-steroidal anti-inflammatory drug for endometriosis theranostics.

Endometriosis, the growth of endometrial-like tissue outside the uterus, causes chronic pain and infertility in 10 % of reproductive-aged women worldwide. Unfortunately, no permanent cure exists, and current medical and surgical treatments offer only temporary relief. Endometriosis is a chronic inflammatory disease characterized by immune system dysfunction.

Identifying potential medical aid beneficiaries using machine learning: A Korean Nationwide cohort study.

Objective: To identify potential medical aid beneficiaries using demographic and medical history of individuals and analyzing important features qualitatively.

Methods: This retrospective, national cohort, case-control study included data from the National Health Insurance Service (NHIS) in Korea between January 1, 2002 and December 31, 2019. Potential medical aid beneficiaries were classified using several machine learning models (linear models and tree-based models).

A Lucknolide Derivative Induces Mitochondrial ROS-Mediated G2/M Arrest and Apoptotic Cell Death in B16F10 Mouse Melanoma Cells.

Melanoma is an aggressive skin cancer with a high risk of cancer-related deaths, and inducing apoptosis in melanoma cells is a promising therapeutic strategy. This study investigates the anti-tumor potential of a novel lucknolide derivative LA-UC as a therapeutic candidate for melanoma. Lucknolide A (LA), a tricyclic ketal-lactone metabolite isolated from marine-derived sp.

Association Between Obesity and Intra-Abdominal Solid Organ Damage in Patients with Blunt Abdominal Trauma: A Cross-Sectional Study.

The global prevalence of obesity continues to rise. However, whether obesity affects the degree of intra-abdominal solid organ damage following blunt trauma remains unclear. This study aimed to investigate the correlation between obesity and intra-abdominal solid organ damage.

Improving Recovery of Diatoms Bio-Silica Using Chemical Treatment with VAUS.

High-temperature baking is a typical method to remove organic matter from diatoms, but it is not suitable for bio-silica because of the high crystallinity. This study provides a method using the VAUS to remove organic matter from diatoms more quickly and biocompatibly. The optimal frequency for organic matter removal was investigated for domestically produced .

Development of Machine Learning Models to Categorize Life Satisfaction in Older Adults Living Alone.

Objectives: This study aimed to identify factors associated with life satisfaction by developing machine learning (ML) models to predict life satisfaction in older adults living alone.

Methods: Data were extracted from 3,112 older adults participating in the 2020 Korea Senior Survey. We employed 5 ML models to classify the life satisfaction of older adults living alone: logistic Lasso regression, decision tree-based classification and regression tree (CART), C5.

Deubiquitinase inhibitor bAP-15 suppresses renal epithelial to mesenchymal transition via inhibition of p300 stability.

Renal fibrosis is an irreversible disease that is common in patients with chronic kidney disease. Elevated levels of the histone acetyltransferase p300 have been reported in various fibrotic diseases, including renal fibrosis, suggesting that p300 may be a promising therapeutic target. To investigate the specific deubiquitinase (DUB) involved in the regulation of p300 protein stability in renal epithelial cells, we tested 13 DUB inhibitors using a kidney tubular epithelial cell line.

Association Between Toothbrushing Habits and Self-Rated Oral Health: Re-Consideration of the 3-3-3 Toothbrushing Campaign.

Objectives: This study investigates the association between toothbrushing frequency and self-rated oral health to evaluate the effectiveness of the 3-3-3 toothbrushing campaign.

Methods: Employing a cross-sectional study design, we analysed responses from 13,199 adults using structured questionnaires. The dependent variable was self-rated oral health.

Development of a Predictive Model for Chewing Difficulty Using EuroQol-5 Dimension Among Korean Older Adults.

Objectives: We aimed to develop a predictive model for chewing difficulty using the EuroQol-5 dimension measure (EQ-5D).

Methods: We included 6643 individuals aged ≥ 65 years (mean age: 72.6 ± 4.

Conversion of N-doped biochar from carotenoid-extracted Tetraselmis suecica and its application to produce supercapacitors.

Microalgae are one of the promising feedstocks for biorefinery, contributing significantly to net-zero emissions through carbon capture and utilization. However, the disposal of microalgal byproducts from the manufacturing process causes additional environmental pollution, thus, a new application strategy is required. In this study, the Tetraselmis suecica byproduct from the carotenoid extraction process was carbonized and converted into biochar.

Mental health vulnerability in multicultural families: Risk factors among homogenous country.

We investigate the mental health of multicultural families (CFs) in South Korea, identify risk factors, and propose interventions to improve mental health. Adults over 19 years of age were analyzed using the Community Health Survey 2019 in South Korea, consisting of 228,952 individuals including 3,524 from multi-CFs. We employed chi-squared tests and multiple logistic regression to compare mental health between multi- and mono-CFs, exploring the influence of various factors.

Peripheral cranio-spinal nerve communication for trapezius muscle control using axonal profiling through immunostaining.

Accessory nerve (CNXI) has been known to be the primary conduit for motor control of the trapezius, while the supplementary cervical nerves (C3 and C4) are responsible for processing sensory information from muscle. However, the lack of substantial direct evidence has led to these conclusions being regarded as mere speculation. This study used immunostaining (using antibodies against neurofilament 200 for all axons, choline acetyltransferase for cholinergic axons, tyrosine hydroxylase for sympathetic axons, and alpha 3 sodium potassium ATPase for proprioceptive afferent axons) of human samples to verify the functional contributions of nerves.

Rapamycin treatment during prolonged maturation enhances the developmental competence of immature porcine oocytes.

Porcine oocytes undergo maturation (IVM) for 42-44 h. During this period, most oocytes proceed to metaphase and then to pro-metaphase if the nucleus has sufficiently matured. Forty-four hours is sufficient for oocyte nuclear maturation but not for full maturation of the oocyte cytoplasm.

Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic -Induced Colitis and Tumorigenesis.

The human colonic commensal enterotoxigenic (ETBF) is associated with chronic colitis and colon cancer. ETBF colonization induces colitis via the toxin (BFT). BFT secreted by ETBF cause colon inflammation via E-cadherin cleavage/NF-κB signaling.

Macrophage membrane coated discoidal polymeric particles for evading phagocytosis.

Unlabelled: The purpose of this study was to investigate the potential of discoidal polymeric particles (DPPs) coated with macrophage membranes as a novel drug delivery system. The study aimed to determine whether these coated particles could reduce phagocytosis, and target specific organs, thereby enhancing drug delivery efficacy. In this study, discoidal polymeric particles (DPPs) were synthesized by a top-down fabrication method serving as the core drug delivery platform.

Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations.

Introduction: Neurogenesis in the adult brain may play an important role in memory and cognition; however, knowledge of neurogenic markers in the human brain remains limited. We compared the single-nucleus transcriptome of the hippocampus with that of other cortical regions to identify hippocampus-specific neurogenic markers.

Methods: We analyzed 26,189 nuclei from four human brains collected within 16 h of death.

Religion, personality, or none of them? Exploratory evidence on their correlations with economic preference parameters.

Introduction: Previous empirical research in the social sciences suggests sizable differences across religious denominations for various outcomes of interest, such as educational attainment, marital stability, wealth, or fertility. A small body of previous experimental literature has investigated possible differences in economic preference parameters (including time preference and risk attitude) between religious denominations that might explain those differences.

Methods: This research adds to the extant literature on religion and preferences by including information on subjects' Big Five personality traits and analyzing potential correlations with loss aversion.

Improving Recovery of Diatoms Bio-Silica Using Chemical Treatment with VAUS TM.

High-temperature baking is a typical method to remove organic matter from diatoms, but it's not suitable for bio-silica because of the high crystallinity. This study provides a method using the VAUS to remove organic matter from diatoms more quickly and biocompatibly. Organic matter was removed by using VAUS, while NaOCl was utilized to remove the organic matter from the silicate frustule.

Socioeconomic disparities in alcohol-related depression: a national cohort study of low-income medical aid beneficiaries and national health insurance beneficiaries in Korea.

Objective: To examine the association between patterns of alcohol consumption in the past and the risk of depression among medical aid beneficiaries and National Health Insurance beneficiaries in Korea.

Methods: We used data from the National Health Information Database (NHID) of 1,292,618 participants who underwent health checkups in 2015-16 and 2017-18. We categorized alcohol consumption into four groups: continuous high, increased, decreased, and non-consumers.