Molecular Epidemiology and Antifungal Susceptibility Profile of Candidozyma Isolates From Argentina.

Background: Epidemiological surveillance of Candidozyma sp. has become important because many species of this new genus have been reported to be responsible for nosocomial outbreaks and to exhibit elevated minimal inhibitory concentrations (MIC) to one or more classes of antifungal drugs.

Objectives: To describe the genetic relationships among Argentinian clinical isolates belonging to the Candidozyma genus and to study the molecular mechanisms associated with antifungal resistance.

Correlation of zero echo time functional MRI with neuronal activity in rats.

Zero echo time (zero-TE) pulse sequences provide a quiet and artifact-free alternative to conventional functional magnetic resonance imaging (fMRI) pulse sequences. The fast readouts (<1 ms) utilized in zero-TE fMRI produce an image contrast with negligible contributions from blood oxygenation level-dependent (BOLD) mechanisms, yet the zero-TE contrast is highly sensitive to brain function. However, the precise relationship between the zero-TE contrast and neuronal activity has not been determined.

Examining the Utility of Lateral Neck X-Rays in Pediatric Otolaryngology.

Objective: The utility of lateral neck X-rays is unclear in pediatric otolaryngology. Past research showed that lateral neck X-ray did not change treatment decisions for children with suspected foreign body aspiration. This study examines the utility of lateral neck X-ray for patients also receiving otolaryngology consults for any indication.

Multimodal data integration to predict atrial fibrillation.

Aims: Many studies have utilized data sources such as clinical variables, polygenic risk scores, electrocardiogram (ECG), and plasma proteins to predict the risk of atrial fibrillation (AF). However, few studies have integrated all four sources from a single study to comprehensively assess AF prediction.

Methods And Results: We included 8374 (Visit 3, 1993-95) and 3730 (Visit 5, 2011-13) participants from the Atherosclerosis Risk in Communities Study to predict incident AF and prevalent (but covert) AF.

Diagnosis and management of inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series.

Introduction: The clinical characteristics of inflammatory bowel disease (dnIBD) diagnosed after solid organ transplant (SOT) are not well-described, particularly since the advent of biologic therapy for treatment of IBD.

Methods: We conducted a single-center, retrospective review of SOT recipients between 2010 and 2022 at the University of Minnesota Medical Center who were diagnosed with IBD after transplant.

Results: Of 89 patients at our center with IBD and a history of SOT, five (5.

Predicting in-hospital mortality using Elixhauser comorbidity in patients underwent single and multiple coronary artery bypass surgery.

Background: Coronary Artery Bypass Grafting (CABG) is a high-risk surgery. Cardiovascular diseases are strongly associated with comorbidities. This study aimed to assess the prediction of in-hospital mortality by comorbidities in patients who underwent CABG.

Identification of the Skip Phenomenon Among Patients With Infective Endocarditis: A Retrospective Review.

The skip phenomenon (SP) is a pattern where blood cultures are intermittently positive before final clearance. We report that one-third of patients with infective endocarditis experienced the SP. Patients with the SP experienced both a longer duration of bacteremia and hospital stay, with a higher 1-year mortality rate.

Sodium-glucose co-transporter-2 inhibitor treatment-associated changes in hemoglobin level in anemic patients with myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms.

Not available.

Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.

Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.

Canopy complexity drives positive effects of tree diversity on productivity in two tree diversity experiments.

Forest canopy complexity (i.e., the three-dimensional structure of the canopy) is often associated with increased species diversity as well as high primary productivity across natural forests.

Imaging dose and image quality of kilovoltage imaging implemented on a helical tomotherapy unit.

The purpose of this work was to evaluate the imaging dose for the Accuray Radixact ClearRT system. Low-contrast resolution and CT number consistency was evaluated as well. CTDI measurements were compared to vendor supplied values, and similar measurements were done on a Varian TrueBeam kV cone-beam CT (CBCT) and a Philips Big Bore CT scanner.

The PRO-AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department.

Background: Existing risk scores assessing geriatric vulnerability in the emergency department (ED) have shown limited predictive power, especially in diverse populations. We investigated the relationship of a quick and easy-to-administer geriatric vulnerability scoring system with functional decline and mortality in older patients admitted to multiple hospitals through the ED in the United States (US) and Brazil (BR).

Method: Federated, international, multicenter observational study of hospitalized ED patients aged ≥ 65 from US and BR.

Development and validation of machine-learning models for predicting the risk of hypertriglyceridemia in critically ill patients receiving propofol sedation using retrospective data: a protocol.

Introduction: Propofol is a widely used sedative-hypnotic agent for critically ill patients requiring invasive mechanical ventilation (IMV). Despite its clinical benefits, propofol is associated with increased risks of hypertriglyceridemia. Early identification of patients at risk for propofol-associated hypertriglyceridemia is crucial for optimising sedation strategies and preventing adverse outcomes.

Association between resting-state synaptic activity and overall performance in a cognitive visuoconstructive task as revealed by magnetoencephalography (MEG).

Performance of a task involves the engagement of various brain areas, as evidenced by the effects of lesions of particular brain areas and the results of functional neuroimaging and neurophysiological studies. Here we tested the hypothesis that overall task performance would depend on the level of ongoing, resting-state change in synaptic activity of participating areas, such that the degree of success of the outcome would be higher, the higher the resting-state activation. For that purpose, we used 248-sensor magnetoencephalography (MEG) in healthy people to obtain estimates of resting-state synaptic activity in various areas and then correlated those estimates to the average performance score in three visuospatial tasks assessed outside the MEG session using the Montreal Cognitive Assessment (MoCA), namely the Trails, Cube, and Clock Drawing (TCCD) tasks.

Intergenerational Impacts of Historical Trauma on Contemporary Depression Symptoms Among Indigenous Communities.

Introduction: Indigenous communities in the U.S. and Canada have endured generations of historical trauma.

Learning from the roundtable on obesity solutions experiences: A 10-year anniversary point of view.

The Roundtable on Obesity Solutions (ROOS), established in 2014, is a unique organization of multisectoral voices addressing the public health challenge of obesity. The ROOS brings together practitioners, researchers, funders, companies, health systems, government agencies, and the lived experience to dialogue and guide the national conversation about the multilevel challenges and opportunities related to obesity. This paper presents insights and key learnings from a symposium developed to celebrating the 10th Anniversary of the ROOS.

Elevating Clinical Informatics: Dynamic Resident Training to Enhance Subspecialty Appeal.

Objective:  This study aimed to bridge the educational gap in clinical informatics (CI) at the residency level and stimulate interest in CI as a rewarding career path.

Methods:  We developed an innovative CI and quality improvement (QI) resident rotation. This rotation replaced traditional QI blocks for Internal Medicine and several other residency programs, offering comprehensive exposure to core informatics and QI principles.

Echocardiogram utilization in hospitalized adults with isolated traumatic brain injury: Propensity-matched analysis of the national inpatient sample 2016-2020.

Background: Early left ventricular systolic dysfunction is common after moderate-severe traumatic brain injury (TBI). Echocardiography (Echo) can evaluate cardiac function across various clinical scenarios; however, its utilization in isolated TBI remains poorly understood. To address this gap, we aim to examine Echo utilization in hospitalized adults with isolated TBI.

Exposed digits increase weight bearing and alter sub-bandage pressures in dogs with forelimb splints.

Objective: The goal of this study was to evaluate the difference in weight bearing in a toes-in splint versus a toes-out forelimb splint and to determine the difference in sub-bandage pressures between the groups. We hypothesized that (1) weight bearing would not be different between the 2 splints and that (2) sub-bandage pressures would be distributed higher on the distal digits in the toes-out splint and pressures would be more evenly distributed across the paw in the toes-in splint.

Methods: In this controlled crossover trial, a random forelimb of 10 healthy dogs was bandaged with a splint that left the digits exposed and again with a splint that encompassed the digits.

Neoadjuvant Chemotherapy for Newly Diagnosed, Advanced Ovarian Cancer: ASCO Guideline Update.

Purpose: To provide updated guidance regarding neoadjuvant chemotherapy (NACT) and primary cytoreductive surgery (PCS) among patients with stage III-IV epithelial ovarian, fallopian tube, or primary peritoneal cancer (epithelial ovarian cancer [EOC]).

Methods: A multidisciplinary Expert Panel convened and updated the systematic review.

Results: Sixty-one studies form the evidence base.

New Directions For Women's Health: Expanding Understanding, Improving Research, Addressing Workforce Limitations.

In the United States, the field of women's health faces critical challenges. This article, part of the National Academy of Medicine's Vital Directions for Health and Health Care: Priorities for 2025 initiative, emphasizes the need for a holistic, lifespan approach to women's health that considers biological sex, gender, and intersecting social factors. We identify three key challenges: broadening the understanding of women's health beyond reproductive issues, improving the research ecosystem, and addressing workforce limitations.

Diagnosis of atrial cardiomyopathy: from the electrocardiogram to the new opportunities with multimodality imaging.

Atrial cardiomyopathy (AC) has been defined by the European Heart Rhythm Association as "Any complex of structural, architectural, contractile, or electrophysiologic changes in the atria with the potential to produce clinically relevant manifestations".1 The left atrium (LA) plays a key role in maintaining normal cardiac function; in fact atrial dysfunction has emerged as an essential determinant of outcomes in different clinical scenarios, such as valvular diseases, heart failure (HF), coronary artery disease (CAD) and atrial fibrillation (AF). A comprehensive evaluation, both anatomical and functional, is routinely performed in cardiac imaging laboratories.