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Background: A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine.

Methods: The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently.

Results: Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76.

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