74 results match your criteria: "Ministry of Health Haydarpaşa Numune Training and Research Hospital[Affiliation]"
Disease Activity in Pregnant and Postpartum Women With Multiple Sclerosis Receiving Ocrelizumab or Other Disease-Modifying Therapies.
Neurol Neuroimmunol Neuroinflamm
November 2024
From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University; Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne; Department of Neurology (O.G.S., K.B.), Box Hill Hospital; Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill; Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital; CORe (T.K.), Department of Medicine, University of Melbourne, Australia; Amiri Hospital (R.A.), Sharq, Kuwait; Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands; Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth; Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands; University of Newcastle (J.L.-S.), Newcastle; Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia; Karadeniz Technical University (C.B.), Medical Faculty, Trabzon; Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey; University Hospital Center Zagreb (M.H.); University of Zagreb (M.H.), School of Medicine, Croatia; Monash Health (N.A.J.); Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia; CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada; Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran; University of New South Wales (Suzanne Hodgkinson), Sydney, Australia; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.); Universitary Hospital Ghent (G.L.); Department of Neurology (B.W.), Antwerp University Hospital, Edegem; Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada; Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy; Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy; Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands; Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic; Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania; UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy; University of Queensland (P.A.M.), Brisbane; Royal Brisbane and Women's Hospital (P.A.M.), Australia; Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy; Koc University (A.A.), Istanbul, Turkey; Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy; Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen; School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands; Centro Hospitalar Universitario de Sao Joao (M.J.S.); Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal; Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom; Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital; Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia; Austin Health (R.A.M.), Melbourne, Australia; Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey; Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy; Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman; Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey; St. Michael's Hospital (J.O.), Toronto, Canada; and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland.
Background And Objectives: Women with multiple sclerosis (MS) are at risk of disease reactivation in the early postpartum period. Ocrelizumab (OCR) is an anti-CD20 therapy highly effective at reducing MS disease activity. Data remain limited regarding use of disease-modifying therapies (DMTs), including OCR, and disease activity during peripregnancy periods.
View Article and Find Full Text PDFPredictors of relapse risk and treatment response in AQP4-IgG positive and seronegative NMOSD: A multicentre study.
J Neurol Neurosurg Psychiatry
September 2024
Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia
Background: Neuromyelitis optica spectrum disorder (NMOSD) can be categorised into aquaporin-4 antibody (AQP4-IgG) NMOSD or seronegative NMOSD. While our knowledge of AQP4-IgG NMOSD has evolved significantly in the past decade, seronegative NMOSD remains less understood. This study aimed to evaluate the predictors of relapses and treatment responses in AQP4-IgG NMOSD and seronegative NMOSD.
View Article and Find Full Text PDFLatent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot.
Thorac Res Pract
May 2024
Department of Infectious Diseases and Clinical Microbiology, Mersin University Faculty of Medicine, Mersin, Turkey.
Article Synopsis
- Latent tuberculosis infection (LTBI) screening is essential for solid organ transplant (SOT) recipients, but many centers in Turkey are not adequately performing these screenings.
- In a study involving 766 SOT patients, 46.9% tested positive for LTBI, but only about half of those treated were registered, and there was a low completion rate of treatment.
- The findings highlight the need for better TB risk assessment and adherence to national guidelines to improve pre-transplant care for SOT recipients in Turkey.
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group.
Ren Fail
December 2024
Department of Nephrology, Istanbul University Faculty of Medicine, Istanbul, Turkiye.
Background: Immunoglobulin A (IgA) nephropathy (IgAN) treatment consists of maximal supportive care and, for high-risk individuals, immunosuppressive treatment (IST). There are conflicting results regarding IST. Therefore, we aimed to investigate IST results among IgAN patients in Turkiye.
View Article and Find Full Text PDFReal-world treatment outcomes from nationwide Onco-colon Turkey registry in RAS wild-type patients treated with biologics second-line mCRC.
J Oncol Pharm Pract
April 2024
Department of Medical Oncology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Türkiye.
Article Synopsis
- Colorectal cancer is a major global health issue, and in Turkey, a study was conducted to assess the effectiveness of second-line treatments for patients with RAS wild-type metastatic colorectal cancer.
- The research involved a retrospective analysis of 588 patient records from 28 centers, categorizing them by the type of biological treatments received: anti-EGFR and anti-VEGF.
- Results showed no significant differences in overall survival or progression-free survival among the different treatment groups, indicating similar effectiveness of the biological agents in second-line treatments.
[Evaluation of In vitro Efficacy of Meropenem/Colistin and Meropenem/Fosfomycin Combinations on Multidrug Resistant Gram-Negative Bacilli].
Mikrobiyol Bul
July 2023
University of Health Sciences, Hamidiye Medical Faculty, Department of Medical Microbiology, İstanbul, Türkiye.
The rate of extensively drug-resistant and pan-resistant gram-negative rods isolated as infectious agents is increasing around the world and in Türkiye. One of the important options in the treatment of these infections is the combined use of antibiotics. Therefore, the aim of this study was to investigate the in vitro effect of meropenem/colistin and meropenem/fosfomycin combinations on carbapenem-resistant gram-negative bacilli isolated as infectious agents.
View Article and Find Full Text PDFComparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis.
JAMA Neurol
July 2023
Perron Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Article Synopsis
- AHSCT is evaluated as a treatment for relapsing-remitting MS, comparing its effectiveness with medications like fingolimod, natalizumab, and ocrelizumab.
- The study utilized data from 6 MS centers and tracked 4915 patients over time, ensuring they were matched on similar characteristics for a fair comparison.
- Results showed that AHSCT had a lower annual relapse rate than fingolimod, with similar risks for disability worsening, suggesting it may be a more effective option for managing MS.
The risk of secondary progressive multiple sclerosis is geographically determined but modifiable.
Brain
November 2023
CORe, Department of Medicine, University of Melbourne, Melbourne 3050, Australia.
Article Synopsis
- The study investigates geographical differences in the risk of secondary progressive multiple sclerosis (SPMS) and how these may be influenced by factors like latitude and treatment types.
- It utilizes data from a global patient registry, focusing on relapsing-remitting multiple sclerosis patients and factors such as age, sex, and treatment efficacy.
- The research analyzes data from over 51,000 patients across 27 countries to establish patterns in the progression from relapsing-remitting to secondary progressive phases of the disease.
Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?
Medicine (Baltimore)
June 2023
Department of Oncology, Faculty of Medicine, Tekirdag Namik Kemal University, Turkey.
In the present study, we aimed to assess the association between the serum survivin level and overall survival and treatment response rates in metastatic pancreatic cancer (MPC). Serum samples were prospectively collected from 41 patients with newly diagnosed MPC patients and 41 healthy individuals (control group) to assess the survivin levels. The median survivin level was 136.
View Article and Find Full Text PDFDisability accrual in primary and secondary progressive multiple sclerosis.
J Neurol Neurosurg Psychiatry
September 2023
CORe, Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Article Synopsis
- The study compares disability progression in primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS), revealing that SPMS has a later onset and slower disability accrual compared to PPMS.* -
- Analysis utilized data from the MSBase cohort, adjusting for factors like age, sex, and drug therapies, and included 1,872 PPMS patients and 2,575 SPMS patients.* -
- Findings suggest that although SPMS patients start with greater baseline disability, their slower progression may lead to similar disability levels over time, indicating the need for careful consideration when combining these groups in clinical trials.*
Mortality in psoriatic arthritis patients, changes over time, and the impact of COVID-19: results from a multicenter Psoriatic Arthritis Registry (PsART-ID).
Clin Rheumatol
February 2023
Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University Medical School, Sihhiye, Ankara, 06100, Turkey.
Article Synopsis
- The study evaluated the mortality rates of patients with Psoriatic Arthritis (PsA) before and during the COVID-19 pandemic by analyzing data from a Turkish registry linked to the Cause of Death Registry.
- Findings revealed that the crude mortality rate in PsA patients doubled during the pandemic, with noticeable increases in both genders but more significant in females.
- The research concluded that pre-pandemic mortality rates for PsA were similar to the general population, but the pandemic has raised concerns about a potential increased mortality risk for PsA patients due to COVID-19, warranting further investigation.
Early predictors of disability in paediatric multiple sclerosis: evidence from a multi-national registry.
J Neurol Neurosurg Psychiatry
September 2022
CORe, Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Background: Early recognition of markers of faster disability worsening in paediatric-onset multiple sclerosis (MS) is a key requisite of personalised therapy for children with MS at the earliest possible time.
Objective: To identify early predictors of rapid disability accrual in patients with paediatric-onset MS.
Methods: Using the global MSBase registry, we identified patients who were <18 years old at the onset of MS symptoms.
Comparison of pramipexole versus ropinirole in the treatment of Parkinson's disease.
Ideggyogy Sz
January 2022
Department of Neurology, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Background And Purpose: Parkinson's disease is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. Levodopa is the most effective drug in the symptomatic treatment of the disease. Dopamine receptor agonists provide sustained dopamin-ergic stimulation and have been found to delay the initiation of levodopa treatment and reduce the frequency of various motor complications due to the long-term use of levodopa.
View Article and Find Full Text PDFCharacteristics and outcomes of 974 COVID-19 patients in intensive care units in Turkey.
Ann Saudi Med
December 2021
From the Department of Anesthesiology and Reanimation, Pamukkale University, Denizli, Turkey.
Background: In our previous report on Turkish COVID-19 patients requiring intensive care, the 24 patients in a single ICU were elderly and mortality was high. We extended our analysis to include patients admitted to ten ICUs.
Objectives: Report the demographics, clinical features, imaging findings, comorbidities, and outcomes in COVID-19 patients.
Clinical Efficacy of Hormonal and Nonhormonal Agents in the Treatment of Vulvovaginal Atrophy.
J Menopausal Med
April 2021
Department of Biostatistics, Sakarya University School of Medicine, Sakarya, Turkey.
Objectives: Symptomatic local treatment of vaginal atrophy (VA) in menopausal women includes hormonal and nonhormonal preparations. Some women may be reluctant to use vaginal estradiol preparations because of the concern for developing breast cancer and endometrial hyperplasia. Therefore, it is necessary to compare the therapeutic effectiveness of alternative vaginal drugs, such as promestriene, an estrogen agonist, and sodium hyaluronate (NaH), a nonhormonal, water-based agent.
View Article and Find Full Text PDFThe relationship between premature ejaculation and the timing of pre-adult circumcision.
Andrologia
July 2021
Department of Urology, Istanbul University Cerrahpasa Faculty of Medicine, Fatih, Turkey.
We aimed to investigate the relationship between premature ejaculation and the age when men had been circumcised before adulthood. A total of 2,768 sexually active male patients aged between 18 and 65 years were included in this study. A multicentre study was conducted prospectively with the participation of 20 centres.
View Article and Find Full Text PDFEvaluation of the pregnant women's approaches regarding drug utilization.
North Clin Istanb
November 2020
Department of Medical Pharmacology, Marmara University Faculty of Medicine, Istanbul, Turkey.
Objective: Drug utilization habits of the pregnant are a critical aspect of rational use of the medicine (RUM). This study aimed to analyze the RUM related attitudes and the behaviors of women during their pregnancies.
Methods: The data were collected between May 2016-October 2016 by conducting surveys to 71 pregnant women admitted to the private and governmental hospitals in five districts of Northern Cyprus.
Utilization of biotechnological drugs in rare diseases requiring the use of off-label drugs in children in Turkey.
Turk J Med Sci
August 2021
Department of Medical Pharmacology, School of Medicine, Marmara University, İstanbul, Turkey
Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards off- label drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU.
Materials And Methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (<18- year) in Turkey.
Off-label drug use in pediatric patients: a comparative analysis with nationwide routine prescription data.
Turk J Pediatr
August 2021
Department of Medical Pharmacology, Marmara University Faculty of Medicine, İstanbul, Turkey.
Background: Children constitute a special population for off-label drug use (OLDU), yet limited drug-focused data exist regarding pediatric OLDU in clinical practice. This study aimed to investigate pediatric OLDU practice and compare it with pediatric drug utilization patterns of routine prescribing data.
Methods: This cross-sectional study examined all approved pediatric OLDU applications, compared with electronic prescription data on national Prescription Information System of Turkish Medicines and Medical Devices Agency in 2015.
Investigation of injectable drug utilization in primary care: A focus on different age groups in pediatric population.
Arch Pediatr
May 2020
Department of Medical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey. Electronic address:
Objective: The suitability of the injectables may vary across different age groups especially for children; therefore, knowledge on their usage patterns is critical in terms of rational pharmacotherapy. This study aimed to investigate pediatric injectable drug utilization in primary care with a focus on different age groups.
Method: By simple sampling method, 100 prescriptions that contained at least one injectable drug were randomly selected for each month of the year in 32 provinces of Turkey (n=38.
Needling with 5-fluorouracil for encapsulated blebs after Ahmed glaucoma valve implantation.
Cutan Ocul Toxicol
December 2019
Ministry of Health, Haydarpasa Numune Training and Research Hospital, İstanbul , Turkey.
To evaluate the efficacy of 5-fluorouracil (5-FU) needling of encapsulated blebs (EBs) after Ahmed glaucoma valve (AGV) implantation in patients with medically uncontrolled secondary glaucoma. Thirty-eight eyes of 37 patients who underwent AGV implantation due to secondary glaucoma with EB were recruited in this retrospective non-randomized study. 5-FU needling (0.
View Article and Find Full Text PDFA Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience.
Turk J Haematol
November 2019
İstanbul University Science Faculty, Department of Molecular Biology and Genetics, İstanbul, Turkey
Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP).
Materials And Methods: A total of 285 chronic ITP patients (187 women, 65.6%; 98 men, 34.
Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis.
J Neurol Neurosurg Psychiatry
April 2019
Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Objective: Oral immunotherapies have become a standard treatment in relapsing-remitting multiple sclerosis. Direct comparison of their effect on relapse and disability is needed.
Methods: We identified all patients with relapsing-remitting multiple sclerosis treated with teriflunomide, dimethyl fumarate or fingolimod, with minimum 3-month treatment persistence and disability follow-up in the global MSBase cohort study.
Re-evaluating pyoderma gangrenosum patients for Behçet disease before initiating any invasive procedures is essential.
J Am Acad Dermatol
August 2018
Department of Dermatology, Ankara Numune Training and Research Hospital, Turkish Ministry of Health, Ankara, Turkey. Electronic address:
Descemet membrane endothelial keratoplasty (DMEK): intraoperative and postoperative complications and clinical results.
Arq Bras Oftalmol
June 2018
Department of Ophthalmology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
Purpose: To evaluate the complications and clinical results of Descemet membrane endothelial keratoplasty (DMEK) in patients with endothelial failure that occurred during the learning curve of a surgeon.
Methods: Fifty eyes of 50 patients with DMEK and ≥6 months of follow-up were included. The patients were divided into the first 25 (group 1) and the second 25 (group 2) procedures performed by the surgeon.