Pre-hospital blood pressure lowering in presumed hyperacute stroke: A systematic review and meta-analysis of randomized controlled trials.

Background: High blood pressure (BP) is common in acute stroke and a predictor of poor outcomes. Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. We aimed to assess whether patients with presumed acute stroke benefit from pre-hospital BP lowering.

Cefixime-Infused Green ZnO Nanoplatelets With Enhanced Biological Potential.

The escalating resistance to traditional antibiotics causes a significant hazard to public health, demanding innovative antimicrobial strategies. This study introduces cefixime-infused green-synthesized zinc oxide nanoplatelets (ZnO NPts) highlighting their enhanced biological potential. The successful formation of ZnO NPts and their subsequent infusion with cefixime were confirmed using various characterization techniques: UV-visible spectroscopy, Fourier transform infrared spectroscopy, x-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, and dynamic light scattering.

Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Predictor for Sepsis Mortality in Children Admitted to Pediatric Intensive Care Unit (PICU): A Comparison With Prothrombin Time/International Normalized Ratio (PT/INR) and Urea/Creatinine Ratio.

Background Sepsis is the primary cause of death in children, and it is crucial to identify patients at high risk of mortality early on in order to provide intensive monitoring and management in the Pediatric Intensive Care Unit (PICU). Objective The objective of this study was to assess the predictive value of routinely used sepsis indicators, including neutrophil gelatinase-associated lipocalin (NGAL), urea to creatinine ratio (urea/Cr), and prothrombin time and international normalized ratio (PT/INR), in predicting death in critically unwell children. Patients and methods A total of 75 children were included in the research conducted at the PICU of Minia University.

Clemastine mitigates sepsis-induced acute kidney injury in rats; the role of α-Klotho/TLR-4/MYD-88/NF-κB/ Caspase-3/ p-P38 MAPK signaling pathways.

Sepsis is a fatal condition, with an annual incidence of more than 48 million cases as well as 11 million deaths resulting from it. Moreover, sepsis continues to rank as the fifth most prevalent cause of mortality globally. The objective of this study is to investigate if Clemastine (CLM) pretreatment protects against acute kidney injury (AKI) caused by cecal ligation and puncture (CLP) via modulating Toll-like receptor-4 (TLR-4), Myeloid differentiation primary response 88 (MYD-88), nuclear factor kappa B (NF-κB), Bcl-2-associated X (Bax), B-cell lymphoma-2 (Bcl-2), and caspase-3 signaling pathways.

A global prevalence of electronic nicotine delivery systems (ENDS) use among students: a systematic review and meta-analysis of 4,189,145 subjects.

Background: The use of electronic nicotine delivery systems (ENDS), including e-cigarettes, vape pens, hookah pens, e-cigars, and e-pipes, has grown in popularity worldwide, particularly among young individuals. However, these products are not without risks, as their emissions may contain harmful substances such as diacetyl (a flavoring agent linked to specific pulmonary problems in high concentrations), tobacco-specific nitrosamines, and volatile organic compounds with unknown long-term effects on lung health.

Objective: This systematic review and meta-analysis aimed to assess the prevalence of ENDS use among school and college students on a global scale.

User-Friendliness Evaluation of Handling pMDI with Various Add-on Devices in Asthmatic Patients.

The objective of this study was to assess the use of pMDI alone and pMDI with different spacers in asthmatic patients and to identify any associations between errors in handling the device for the first time and the sessions needed to reach the correct handling method, considering patient demographics and clinical characteristics. A total of 150 Asthmatic patients were crossed over to handle pMDI alone and with add-on inhalable devices (Aerochamber plus, Tips Haler, Able, Dispozable and Aer-8) randomly, without receiving verbal or demonstrative instruction (baseline assessment). The assessment of the inhaler technique was performed using checklists that had been set beforehand.

Infection in Nile Tilapia (): A Review.

(Group B Lancefield) has emerged as a significant pathogen affecting both humans and animals, including aquatic species. Infections caused by are becoming a growing concern in aquaculture and have been reported globally in various freshwater and marine fish species, particularly those inhabiting warm water environments. This has led to numerous outbreaks with high morbidity and mortality in fish.

The Thematic Analysis of Barriers to Immediate Post-Partum Long-Acting Reversible Contraception.

Background: Globally, many women express the desire to avoid immediate pregnancy for 24 months postdelivery, and only forty percent use contraceptives during this period. There is an enormous demand for postpartum family planning, particularly in developing countries with low- or middle-income grades. Postpartum intrauterine devices such as long-acting reversible contraceptives (LARCs) are among the most effective methods of family planning in the immediate postpartum period, yet their effectiveness is hindered because of a lack of availability and training.

Is there a link between peripheral inflammation and blood brain barrier integrity in children with attention-deficit/hyperactivity disorder? A case-control study.

Background: Claudin-5 is a vital constituent of tight junctions, which are critical elements of the blood-brain barrier. In people with neuropsychiatric disorders, peripheral inflammation is often found, although it is less common in healthy populations. The objective of this study was to examine the relationship between Claudin-5, peripheral immune cells, and the severity of symptoms in children with attention deficit hyperactivity disorder (ADHD).

Atrophic facial acne scars; bilateral comparison of two microneedle devices.

Microneedling is a minimally invasive procedure using fine needles to puncture the skin.The aim of this study is to compare the clinical efficacy as well as the histological effects of dermaroller versus dermapen in the management of post-acne atrophic scars.The study was conducted on 10 patients with post-acne atrophic scars.

Impact of Fingolimod Discontinuation Strategy on Recurrence of Disease Activity in Individuals With Multiple Sclerosis.

Background: For individuals with multiple sclerosis (MS), treatment interruption can result in relapse/recurrence of the disease activity. Currently, there are no consensus guidelines about whether an abrupt stop with a short washout period or gradual tapering is better for fingolimod (Gilenya) cessation. We investigated the impact of the fingolimod discontinuation strategy on the recurrence of disease activity and the rebound occurrence of symptoms during washout.

Benzothiazinone analogs as Anti-Mycobacterium tuberculosis DprE1 irreversible inhibitors: Covalent docking, validation, and molecular dynamics simulations.

Mycobacterium tuberculosis is a lethal human pathogen, with the key flavoenzyme for catalyzing bacterial cell-wall biosynthesis, decaprenylphosphoryl-D-ribose oxidase (DprE1), considered an Achilles heal for tuberculosis (TB) progression. Inhibition of DprE1 blocks cell wall biosynthesis and is a highly promising antitubercular target. Macozinone (PBTZ169, a benzothiazinone (BTZ) derivative) is an irreversible DprE1 inhibitor that has attracted considerable attention because it exhibits an additive activity when combined with other anti-TB drugs.

Nursing Students, Faculty, and Preceptors Perception of Effective Characteristics of Clinical Instructor: A Cross-Sectional Study.

Background: Nursing instructors play an important role in improving the clinical experience of nursing students. Despite this, little is known about the characteristics of effective clinical instructors.

Objective: Identifying the perceptions of nursing students, faculty, and preceptors of effective clinical instructors.

Unravelling the Interplay Between Primigravida Pregnant Women Health Profile, Catastrophic Thinking, Tokophobia and Childbirth Preferences in a Rural Area.

Aims: To assess the prevalence of tokophobia (fear of childbirth) and evaluate the relationship between catastrophic thinking, tokophobia, childbirth preferences and the health profile of primigravida (first-time pregnant women in rural areas).

Design: A descriptive correlational study.

Method: This study, implemented from January 2024 to March 2024, involved 300 primigravidae.

Rosuvastatin/calcium carbonate co-precipitated nanoparticles: A novel synergistic approach enhancing local bone regeneration in osteoporotic rat model.

This study aimed at preparing sustained release rosuvastatin (Ru) calcium carbonate (CC) co-precipitate nano-formulation for local intra-osseous application in osteoporotic rats. Nano-formulations were prepared by the co-precipitation method using different concentrations of polyvinyl alcohol (PVA) (0.2, 0.

Corrigendum: Camel proteins and enzymes: a growing resource for functional evolution and environmental adaptation.

[This corrects the article DOI: 10.3389/fvets.2022.