[Successful results of total femoral resection and prosthetic replacement in two patients].

Resection of the whole femur, together with endoprosthetic replacement is a major limb-salvaging procedure. We performed total femoral resection and endoprosthetic replacement with TMTS (Turkish Musculoskeletal Tumor Society) prosthesis in two young (20 years old) male patients with stage-IIB osteosarcoma. Postoperative complications were only temporary sciatic nerve neuropraxia and minor skin necrosis around the surgical wound.

[The effects of surgical margins on local control and survival in extremity soft tissue sarcomas].

Objectives: We evaluated the effects of surgical margins and other prognostic factors on local control and survival in extremity soft tissue sarcomas.

Methods: The study included 40 patients (34 males, 6 females; mean age 45 years; range 13 to 77 years) who underwent treatment for extremity soft tissue sarcomas. Of these, 14 patients presented with recurrences following treatment elsewhere.

[The efficacy of local T-pa infusion in the treatment of axillary vein thrombosis].

Background: We evaluated the results of local tissue plasminogen activator (t-PA) infusion in the treatment of axillary vein thrombosis.

Methods: Fourteen male patients (mean age 23+/-2 years) who presented with pain and swelling in the arm were diagnosed as having axillary vein thrombosis. Besides physical examination, diagnoses were made with the use of venous Doppler ultrasound, duplex scanning or venography.

Cc-chemokine eotaxin as a marker of efficacy of specific immunotherapy in patients with intermittent IgE-mediated allergic rhinoconjunctivitis.

Background: Allergen-specific immunotherapy (SIT) is believed to be a valuable remedy in several allergic diseases; however, an accurate immunological marker of the efficacy of this treatment method has not been found yet. Cc-chemokine eotaxin, owing to its selective action on eosinophils, seems to play an important role in the pathophysiology of allergic response. The purpose of this study was to assess the usefulness of eotaxin in monitoring of SIT efficacy in patients with IgE-mediated allergic rhinoconjunctivitis.

Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.

Studies that researched the role of aminoguanidine and tolestat in the prevention of diabetic retinopathy and nephropathy resulted in conflicting data. We investigated the effects of these agents in the prevention of ocular and renal changes in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ in 30 rats.

Eotaxin in serum of patients with asthma or chronic obstructive pulmonary disease: relationship with eosinophil cationic protein and lung function.

This study was undertaken to investigate the correlation between the serum ECP and the serum eotaxin level, and disease activity as evaluated with pulmonary function in patients with asthma or chronic obstructive pulmonary disease (COPD). 20 patients with stable asthma and 15 patients with COPD, and 15 subjects of the control group took part in this study. The analysis of ECP was performed according to the manufacturer's directions (Pharmacia Diagnostics AB, Uppsala, Sweden).

Optically active aromatic amino acids. Part VI. Synthesis and properties of (Leu5)-enkephalin analogues containing O-methyl-L-tyrosine1 with ring substitution at position 3'.

Twelve new [Tyr(Me)1, Leu5]-enkephalin analogues with substituents at position 3' of the Tyr ring have been synthesized using traditional solution methods. The substituents were -CO2H, -CONH2, -CO2Me, -(E)-CH=NOH, -(E)-CH=NOMe and CH2OH. The analogues were C-terminated with methyl esters, amides or as free acids.

The usage of frozen allografts of the spongy bone in filling the loss of bone after loosening of the hip prosthesis.

The authors present the way of using allogenic, frozen, radio-sterilizated, spongy bone grafts in operational reconstructing the defects of bone stock caused by loosening of the hip prosthesis. The bone grafts were sterelizated by radiation, formed in cubes and it had the fat removed. The operational reconstruction of the spongy bone was performed according to the method described by E.

Frozen allogenic spongy bone grafts in filling the defects caused by fractures of proximal tibia.

The authors present the way of using the allogenic, frozen, radio-sterilized, spongy bone grafts in operational filling of defects after infra-articular fracture of proximal tibia. Fifteen patients (11 men and 4 women) classified between 30 and 66 years old were evaluated. These patients were operated from 1996 to 1998.

Fractures of thoracic and lumbar spine; treatment and follow up.

The number of posttraumatic spinal fractures is constantly growing. About 15-20% of patients injury need surgery after injury, as result of spinal instability or canal stenosis often leading to neurological complications. In 1987-97 56 patients (6 female and 50 male) were treated following serious spine trauma with fractures.

Fusion of spine in children scoliosis with frozen & radiation--sterilized bone allograft.

102 children have been treated at the Institute of Traumatology, Orthopaedics & Neurosurgery a result of scoliosis. In all of these multi-step treatment has been applied. Initially a telescopic rod was implanted into the spine.

Frozen and radiation-sterilized bone allografts in the treatment of post-traumatic malformation of bones.

Post-traumatical malformations of bone are often reconstructed with the use of preserved bone allografts. At the Institute of Traumatology, Orthopaedics and Neurosurgery 495 patients were treated with use of preserved (frozen and radiation-sterilized) bone allografts, following trauma, between 1981 and 1995. Non union of bone and osteomyelitis were main reasons for allotransplantation of bone.

Application of frozen and radiation-sterilised bone allografts for treatment of bone cysts.

Between 1981 and 1998 frozen and radiation sterilized bone allografts were transplanted into 1376 patients at the Institute of Traumatology, Orthopaedic and Neurosurgery of the Military School of Medicine in Warsaw. Of these 179 (13%) required treatment due to benign tumours. Incidence of solitary cysts was highest (127 cases, 71%), mainly occurring in children (84%).

Multiple oligodendroglioma: case report.

An 18-year-old female patient was hospitalized with headache and disturbance of consciousness. Magnetic resonance imaging (MRI) revealed a tumor in the left parieto-occipital lobe. The tumor was totally removed, and postoperative radiation therapy was administered locally at 50 Gy.

The tanycytic ependymoma of the lateral ventricle: case report.

The tanycytic ependymoma is an extremely rare, primitive neuroectodermal tumor, arising from the ependymoglial cells or tanycytes. Such cells are generally seen in the primitive nervous system instead of the mature ependymal cells. The tanycytic ependymoma described in this report was found in a 42-year-old man.

Impaired skin microcirculation and blood rheology in patients with monoclonal gammapathy.

Hemorheological disturbances in patients with monoclonal gammapathies are widely known, but there is little information about microcirculation in these patients. The following study was performed to examine skin microcirculation and its relationship with blood rheology. We analysed both haematological and hemorheological parameters (blood and plasma viscosity, aggregation index and filterability of 1 ml of whole blood) and skin microcirculation in 46 patients with monoclonal gammapathy and 22 healthy controls.

Silicone rubber microangiography of injured acute spinal cord after treatment with methylprednisolone and vitamin E in rats.

Study Design: An experimental study of changes in the microvasculature of the injured spinal cord that occur with methylprednisolone and vitamin E treatment.

Objective: To determine the effect of treatment with the methylprednisolone and vitamin E on the microvasculature of the traumatized spinal cord.

Summary Of Background Data: Silicon rubber microangiography provided an excellent three-dimensional method for defining the distribution of vasculature in untreated and treated rats after injury.

Transient left vocal cord paralysis during laparoscopic surgery for an oesophageal hiatus hernia.

A 45-year-old male, with symptoms of many years standing of gastro-oesophageal reflux disease, was subjected, under general anaesthesia, to laparoscopic fundoplication. Tracheal intubation yielded no problems but great difficulties were encountered during tube insertion into the oesophagus. After surgery, aphonia developed.

Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl-5,6-substituted 2-thiouracil derivatives in mice.

Twenty four thiouracil derivatives, including N3-allyl- (19) and N1-allyl-2-thiouracil (20) were synthesized and their pharmacological effects [sedative-hypnotic activity (loss of righting reflex and spontaneous activity), convulsant activity, effect on pentobarbital (PB)-induced sleep and mortality] were evaluated in mice at doses of 320 mg/kg, i.p. and 2 mumol/mouse by intracerebroventricular (i.

The effect of chemo- and chemoimmunotherapy on the presence of circulating melanoma cells in peripheral blood. Preliminary results.

Reverse transcription and polymerase chain reaction (RT/PCR) with primers specific for tyrosinase allow for a new method of early detection of individual melanoma cells in peripheral blood. Using this test the effect of chemo- and chemoimmunotherapy on the spread of early micrometastatic cancer cells has been evaluated. No significant correlations have been found between RT/PCR results on the one hand and stage of disease, a kind of the therapy protocol used and usage of the therapy as an adjuvant or palliative on the other hand.

Monocyte chemotactic and activating factor/monocyte chemoattractant protein (MCAF/MCP-1) in bronchoalveolar lavage fluid from patients with atopic asthma and chronic bronchitis.

Monocyte chemotactic and activating factor/monocyte chemoattractant protein (MCAF/MCP-1) is a member of the beta (C-C) subfamily of chemokines. The biological roles played by MCAF/MCP-1 in a number of inflammatory and noninflammatory diseases states is not well known. Several studies have confirmed that inflammation is present in the airways of subjects with atopic asthma and with chronic bronchitis.

Monocyte chemotactic and activating factor/monocyte chemoattractant protein in bronchoalveolar lavage fluid from patients with atopic asthma and chronic bronchitis. Relationship to lung function tests, bronchial hyper-responsiveness and cytology of bronchoalveolar lavage fluid.

Monocyte chemotactic and activating factor/monocyte chemoattractant protein (MCAF/MCP1) is a member of beta (C-C) subfamily of chemokines. The biological roles played by MCAF/MCP1 in a number of inflammatory and non-inflammatory disease states is not well known. Several studies have confirmed that inflammation is present in the airways of subjects with atopic asthma (AA) and in chronic bronchitis (CHB).

The use of bone-marrow-derived fibroblastoid cells and fresh bone marrow in the treatment of bone defects: an experimental study.

Bone-marrow aspirate (containing bone progenitor cells), in vitro expanded autologous bone-marrow-derived stromal fibroblastoid cells, and a combination thereof were tested for the potential to fill bone defects. They were compared to grafts of fresh autologous bone or allogeneic devitalized bone. Mandibular defects in rabbits were chosen for this study.