Sugammadex - indications and clinical use.

Neuromuscular blocking agents are a substantial element of anaesthesia in almost every surgical field. Nevertheless, their use has been associated with rises in mortality and morbidity. Of importance are: the general health state of the patient, liver and renal function, metabolism and excretion, active metabolites, side effects of muscle relaxants and, above all, residual paralysis.

The morphology of myeloma cells changes with progression of the disease.

Aim Of The Study: Multiple myeloma is a heterogeneous entity with variable course. Plasma cells found in bone marrow smears are characterised by extremely high diversity of morphology. We have attempted to determine whether the morphological characteristics of myeloma cells vary with the natural course of the disease.

Effectiveness evaluation for short-term group pre-deployment VR computer-assisted stress inoculation training provided to Polish ISAF soldiers.

The goal of this study was to assess effectiveness of a short collective stress inoculation training (SIT) conducted according to the methodology of the Virtual Reality Medical Center of San Diego (Training of Physiological Control Exposure to Virtual Stressor while Maintaining Physiological Control). The results obtained indicate a short-term effectiveness of the training as a method of tension reduction. However, in the long-term perspective these results are ambiguous and they suggest a need of further research.

Phacoemulsification with corneal astigmatism correction with the use of a toric intraocular lens in a case of megalocornea.

We report the case of a 49-year-old patient with megalocornea and coexisting corneal astigmatism. The corneal diameter in the right eye was 15.0 mm and in the left eye, 14.

Severe decrease in visual acuity with choroidal hypoperfusion after photodynamic therapy.

Background: Photodynamic therapy (PDT) is considered a selective method of treatment which works in areas of choroidal neovascularization (CNV); however, there are reports of choroidal hypoperfusion after PDT. This paper presents a clinical case of choroidal circulation disturbances caused by PDT, accompanied by CNV progression.

Case Report: The patient, a 75-year-old woman, was qualified for PDT in the right eye--first treatment due to progression of occult CNV.

Translumbar inferior vena cava cannulation.

Background: The aim of the study was to review our three year experience with translumbar insertion of dialysis catheters.

Methods: In five adult patients (4 males and one female, mean age 45 yr), requiring dialysis due to end-stage chronic renal failure, the inferior vena cava was cannulated because of the impossibility of using any other approach. All procedures were performed under fluoroscopy.

Future possibilities in glaucoma therapy.

Glaucoma is a group of eye diseases causing irreversible optic nerve damage. This review presents 4 elements of future glaucoma treatment strategies: baroprotection, vasoprotection, neuroprotection and gene therapy. New baroprotection includes compounds that alter the actin cytoskeleton (rho-kinase inhibitors, latrunculin, cytochalasin), new drugs that enhance aqueous outflow via the trabecular meshwork (statins, steroid antagonists) and via the uveoscleral route (EP2 agonists, 5-HT2 agonists), as well as new classes of components that suppress aqueous humor formation (cannabinoids).

Safety of ranibizumab therapy in wet AMD and the role of vascular endothelial growth factors in physiological angiogenesis.

Vascular endothelial growth factor - A (VEGF-A), is a major factor implicated in choroidal neovascularisation (CNV) and therefore a target for therapeutic agents in wet age related macular degeneration (AMD). Ranibiuzumab (Lucentis) blocks all active isoforms of VEGF-A and the products of their degradation. It penetrates through all layers of the retina in order to reach the target tissue.

Optical coherence tomography in imaging of macular diseases.

OCT (opitcal coherence tomography), is a diagnostic method that enables the analysis of the retinal structures by means of high-resolution tomographic cross-sections of the retina. Whereas fluorescein and indocyanine angiography allow visualization of the retinal epithelium layer and chorioretinal vessels, OCT may help in diagnosing and monitoring the condition of many internal retinal layers. Ultrasound B-mode examinations have a resolution of about 150 microm while OCT provides a resolution of 10 microm.

Intravenous insulin therapy in the maintenance of strict glycemic control in nondiabetic acute stroke patients with mild hyperglycemia.

Several reports indicate that mild hyperglycemia (plasma glucose level [PGL] ≥7.0 and ≤10.0 mmol/L [≥126 and ≤180 mg/dL]) is associated with poor prognosis in nondiabetic patients who sustain acute ischemic stroke (AIS).

Artrofoon as alternative preparation in the treatment of uncomplicated forms of nonspecific ulcerative colitis.

Therapy of uncomplicated nonspecific ulcerative colitis with artrofoon effectively reduces the duration and number of relapses. During remissions, the count of apudocytes, serotonin-, melatonin-, vasointestinal peptide-producing, and mast cells and the parameters of cell homeostasis against the background of artrofoon therapy were much closer to the normal than during treatment with salofalk.

Degenerative pontine lesions in patients with familial narcolepsy.

Background And Purpose: Narcolepsy is characterized by chronic excessive daytime sleepiness with episodic sleep attacks. There are several associated symptoms of narcolepsy: cataplexy (bilateral muscle weakness without loss of consciousness provoked by an emotional trigger, e.g.

Oral treatment of metastatic breast cancer with capecitabine: what influences the decision-making process?

The importance of selecting treatment for metastatic breast cancer (MBC) that best suits the needs of the patient while offering a good clinical outcome is becoming more prominent in the decision-making process. We designed a questionnaire-based study to identify factors influencing treatment choice. We prospectively surveyed 218 female MBC patients scheduled to receive chemotherapy who were eligible for capecitabine monotherapy.

Dynamic testing of bone grafts.

The influence of cycling loading force on the substrate made of frozen bone grafts was investigated. Three layers of bone grafts were compacted in a spherical model of hip joint acetabulum and then subjected to a sinusoidal loading force. For each layer a series of N = 30 loading cycles were performed.

Testing the stability of the polyethylene acetabulum cemented on a frozen bone graft substrate on a model of an artificial hip joint.

The stability of the polyethylene acetabulum cemented on a substrate made of frozen bone grafts was investigated. The force was applied to the edge of the acetabulum and the magnitude of the force and resulting displacement were recorded. These tests were preceded by stress testing, during which the acetabulum was subjected to loading forces of 1 or 3 kN through 100,000 cycles.

Strokes in paroxysmal atrial fibrillation have more favorable outcome than in permanent atrial fibrillation.

Objective: Our aim was to compare the course of IS due to ptAF and pxAF.

Methods: A prospective, single-center study was conducted in patients with AF and acute IS with 6-month follow-up.

Results: We included 178 patients: 70 (39%) with pxAF and 108 (61%) with ptAF.

Blood flow in the testes and epididymides of male rats with experimental blockade of testicular veins.

Blood flow in reproductive organs was studied during experimental cessation of blood outflow in the testicular vein. This pathological state was accompanied by disturbances of the complex pathogenesis. The major component was autoregulatory focal ischemia, which resulted from the venoarterial response to venous hypertension.

Energy and nutritional value of diets used in patients alimentation and their assessment by patients of selected clinical department in the Military Medical Institute in Warsaw.

The aim of the work was laboratory assessment of energy and nutritional value of general and light diets used in patients of selected clinical department in the Military Medical Institute in Warsaw alimentation. Using questionnaire method the assessment of diets was done by patients too. Meals given to patients in hospital not always fulfilled nutritional requirements.

Pure red cell aplasia due to parvovirus B19 infection transmitted probably through hematopoietic stem cell transplantation.

Human parvovirus B19 is a very common infectious pathogen in humans. In healthy subjects, B19 infection is the cause of a self-limiting subclinical erythroid aplasia, followed by rash or arthralgia. In immunocompromised patients B19 can cause chronic anemia.

Cardiac troponin I after external electrical cardioversion for atrial fibrillation as a marker of myocardial injury--a preliminary report.

Background: It is uncertain whether external electrical cardioversion (CV) of atrial fibrillation (AF) can cause myocardial injury identifiable by troponin I (cTnI).

Aim: To examine whether external CV of AF can cause cTnI rise as measured with high-sensitivity assay, and to identify factors determining this elevation.

Methods: Patients with non-valvular AF selected for CV were included.

Changes in distribution pattern of CD8 lymphocytes in the scalp in alopecia areata during treatment with diphencyprone.

For many years, the role of T lymphocytes was hypothesized as being a major factor responsible for hair loss in alopecia areata (a.a.).

[Expression and immunogenic analysis for the tandem-arranged multiple mimic epitope gene of infectious bursal disease virus].

Five mimic epitopes of Infectious bursal disease virus (IBDV) have been identified from a 12-mer phage-displayed peptide library by 5 monoclonal antibodies. Based on the sequences of the five epitopes, multiple epitope gene 5epis was constructed by the five epitopes being tandemly arranged and linked with 4-peptide GGGS. The expression plasmid pET-5epis was constructed and successfully expressed in E.

Antiradical effect of allopurinol at early stages of experimental acute pancreatitis.

Pretreatment with allopurinol partly prevented generation of free oxygen radicals in the pancreas of dogs with experimental acute pancreatitis. Allopurinol holds promise for the prevention of acute postoperative pancreatitis.

Correlation of B type natriuretic peptides with clinical and echocardiographic parameters in heterogeneous population of patients with symptoms suggestive of heart failure.

Purpose: NT-proBNP and BNP concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and BNP in heterogeneous group of CHF patients on the basis of these peptides' correlation with NYHA class, LVEF and WMI measured by echocardiography.

Material And Methods: Consecutive patients admitted for suspected of CHE Blood samples were drawn for NT-proBNP, BNP, creatinine and echocardiography was performed.