Inflammatory Markers Significantly Increased in Patients Treated with Obinotuzumab for Lymphoproliferative Diseases.

: The purpose of this study was to analyze the behaviors of inflammatory markers, such as procalcitonin and C-reactive protein (CRP), during treatment with obinotuzumab (an anti-CD20 antibody). : Our non-randomized observational study prospectively evaluated a cohort of 22 adult patients with lymphoproliferative neoplasms, chronic lymphocytic leukemia (CLL), and follicular lymphoma (FL) with indications for obinotuzumab therapy. : All patients had their blood drawn to determine blood counts, CRP, and procalcitonin, as well as body temperature measurements and blood cultures performed for bacterial infections on day 0 before administration of the anti-CD20 antibody.

The Glasgow Benefit Inventory-Assessment of Patients Who Underwent Laser-Assisted Dacryocystorhinostomy (LDCR).

Disruptions in lacrimal function can lead to various conditions, including chronic nasolacrimal duct obstruction and dacryocystitis, which may cause symptoms like excessive tearing, pain, and recurrent infections. In cases where pharmacological treatments are insufficient, surgical intervention becomes essential, which is widely used to restore effective tear drainage. This study evaluated postoperative outcomes of laser-assisted dacryocystorhinostomy (LDCR) in 48 patients, totaling 56 treated eyes, over a follow-up period of 6 months to 3.

A Meta-Analysis of Timing of Complete Revascularization in Patients with ST-Elevation Myocardial Infarction.

Recent randomized clinical trials (RCTs) of STEMI patients with multi-vessel disease (MVD) reported potential superiority of immediate (ICR) vs. staged complete revascularization (SCR). Inherently, the risk of procedural MI is less likely to be detected in ICR patients, and this may have influenced the results.

Tailoring capsid directed evolution technology for improved AAV-mediated CAR-T generation.

Chimeric antigen receptor (CAR) T-cell (CAR-T) therapies present options for patients diagnosed with certain leukemias. Recent advances of the technology included a method to integrate the CAR into the T-cell receptor alpha constant (TRAC) locus to take advantage of the endogenous promoter and regulatory elements for CAR expression. This method used adeno-associated viral (AAV) vectors based on AAV6 to deliver the donor template encoding the CAR construct.

A rapid parallel increase in the incidence and mortality of head and neck cancer among the Polish elderly over the last two decades and upward trends until 2035.

<b>Introduction:</b> Head and neck cancer (HNC) incidence and mortality have increased significantly among the elderly in Poland over the last two decades. This trend reflects the challenges of an aging population and underscores the need for specialized cancer care for seniors.<b>Aim:</b> The study aimed to analyze the morbidity and mortality of HNC among the elderly (ages 60-69, 70-79, and 80+) in Poland between 1999 and 2021, and predict trends until 2035, emphasizing the dynamics in the 80+ age group.

Non-infectious mixed cryoglobulinemia as a new clinical presentation of mutation in the gene encoding coatomer subunit alpha: a case report of two adult sisters.

Cryoglobulinemia is a rare disease characterized by the presence of cryoglobulins in the blood serum. It is usually caused by autoimmune, lymphoproliferative, or infectious factors. The pathogenesis of cryoglobulinemia is not well understood, therefore, genetic testing is very important.

Patient Satisfaction after Open Rhinoseptoplasty: What Do the Statistics Say?

<b>Introduction:</b> In its assumptions, rhinoplasty is intended to improve the aesthetics and restore normal function of the nose. In the Polish literature, a new tool has recently emerged for simultaneous assessment of the impact of rhinoseptoplasty on the external appearance and functionality of the nose.<b>Aim:</b> The aim of this study consisted in the surveying of patients having undergone rhinoplasty procedures using a validated and translated Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) questionnaire and the Rhinoplasty Outcome Evaluation (ROE) questionnaire to assess the functional and aesthetic outcomes of rhinoplasty.

Intestinal Parasites and Hematological Parameters in Children Living in Ambatoboeny District, Madagascar.

Madagascar is one of the poorest countries in the world. The country's extreme weather conditions, poor sanitation, and weak economy facilitate the spread of parasitic diseases. Infections with intestinal parasites are particularly dangerous for children because they can cause malnutrition and anemia, which, in turn, have a negative effect on children's cognitive functions and physical development.

Echocardiographic and Impedance Cardiography Analysis of Left Ventricular Diastolic Function in Acromegaly Patients.

BACKGROUND Due to the chronic effects of excess growth hormone (GH) and insulin-like growth factor-1 (IGF-1), patients with acromegaly (AC) may develop acromegalic cardiomyopathy with biventricular hypertrophy, systolic and diastolic dysfunction, resulting in congestive heart failure. This study aimed to evaluate the echocardiographic parameters of left ventricular (LV) diastolic function and impedance cardiography (ICG) parameters of cardiovascular hemodynamics in patients with AC. MATERIAL AND METHODS A total of 33 patients (male to female ratio: 1.

Senolysis potentiates endothelial progenitor cell adhesion to and integration into the brain vasculature.

Background: One of the most severe consequences of ageing is cognitive decline, which is associated with dysfunction of the brain microvasculature. Thus, repairing the brain vasculature could result in healthier brain function.

Methods: To better understand the potential beneficial effect of endothelial progenitor cells (EPCs) in vascular repair, we studied the adhesion and integration of EPCs using the early embryonic mouse aorta-gonad-mesonephros - MAgEC 10.

Expression of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs () Gene and Its Regulation by miR200b in Ovarian Endometriosis.

Endometriosis is a common chronic disorder characterized by the growth of endometrium-like tissue outside the uterine cavity. The disease is associated with chronic inflammation and pelvic pain and may have an impact on the patient's fertility. The causative factors and pathophysiology of the disease are still poorly recognized.

Hospitalizations of Patients with Atrial Fibrillation (AF) in Poland: A Nationwide Study Based on over One Million AF Hospitalizations in 2017-2021.

Atrial fibrillation (AF) is one of the most common forms of persistent arrhythmia in adults worldwide. The aim of this study was to present recent data on the epidemiology of patients hospitalized with AF in Poland. This is a retrospective, population-based study conducted using hospital discharge records.

The utility of the 21-gene Oncotype DX Breast Recurrence Score assay in node-negative breast cancer patients - the final analysis of the Polish real-life survey PONDx.

Introduction: Breast cancer (BC) is among the most frequently diagnosed malignant tumours in females. The optimal treatment of early HR+, HER2-, and lymph node-negative (N0) BC remains challenging. Since individual assessment of recurrence risk and expected benefits from adjuvant chemotherapy (CT) based on clinicopathological features alone appear inadequate, gene expression profiling tests have been developed.

Endometriosis development in relation to hypoxia: a murine model study.

Background: Endometriosis, due to its ambiguous symptoms, still remains one of the most difficult female diseases to treat, with an average diagnosis time of 7-9 years. The changing level of hypoxia plays an important role in a healthy endometrium during menstruation and an elevated expression of the hypoxia-inducible factor 1-alpha (HIF-1α) has been demonstrated in ectopic endometria. HIF-1α mediates the induction of proangiogenic factors and the development of angiogenesis is a critical step in the establishment and pathogenesis of endometriosis.