4,934 results match your criteria: "Miliary Tuberculosis"

A Challenging Case of Miliary Tuberculosis in Pregnancy.

Int J Mycobacteriol

October 2024

Department of Anaesthesiology, AIIMS, Bhopal, Madhya Pradesh, India.

Miliary tuberculosis (TB) is an uncommon yet severe condition that can pose substantial risks to pregnant women and their unborn child. This case study describes a 22-year-old pregnant female at 23 weeks of gestation presented with breathlessness, fever accompanied by chills, dry cough, and loss of appetite. With no significant comorbidities, her initial symptoms were inconclusive, leading to her initial diagnosis as a case of pyrexia of unknown origin.

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Hemophagocytic lymphohistiocytosis is a rare life-threatening condition, with a high mortality rate, characterized by a dysfunctional immune response resulting in multi-organ damage. The secondary or sporadic form of the disease can be triggered by a multitude of infections, malignancies, and autoimmune disorders. Tuberculosis is commonly involved as a trigger for hemophagocytic lymphohistiocytosis.

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Introduction: Candida albicans infection shows a wide range of patterns on chest computed tomography, including ground glass opacities and consolidation, with the miliary pattern being the least frequent. The miliary pattern is not exclusive to tuberculosis. Fungal lung infections are rare and potentially fatal.

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Background: The infection caused by Mycobacterium tuberculosis arises from a complex interplay between the host immune system and the bacteria. Early and effective treatment of this disease is of great importance in order to prevent the emergence of drug-resistant strains. This necessitates the availability of fast and reliable diagnostic methods for managing affected cases.

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Article Synopsis
  • - Military tuberculosis (MT) is a severe and potentially life-threatening form of tuberculosis characterized by widespread infection throughout the body caused by Mycobacterium tuberculosis entering the bloodstream or lymphatics.
  • - Diagnosing MT is challenging because it often presents with vague symptoms and physical examination findings that can confuse even experienced doctors, while bacteriological evidence is frequently absent.
  • - The prognosis for MT depends heavily on how early the disease is diagnosed and treated, emphasizing the importance of prompt medical intervention, especially in vulnerable populations like children, young adults, and those with HIV.
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Disseminated histoplasmosis from western Mexico-rethinking our geographic distribution of endemic fungal species: a case report and review of literature.

J Med Case Rep

November 2024

Division of Pediatric Infectious Diseases, Memorial Care Miller Children's & Women's Hospital Long Beach, Clinical Professor of Pediatrics, University of California Irvine Department of Pediatrics, Irvine, CA, USA.

Background: Histoplasma is a fungal pathogen found in many parts of the world. In North America, its distribution is traditionally thought to be endemic to the Ohio and Mississippi River valleys. Development of histoplasmosis after Histoplasma exposure is related to degree of inoculum exposure and susceptibility, for example, immunocompromised status.

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Tumour necrosis factor-alpha (TNF-α) inhibitors are commonly used in the treatment of ankylosing spondylitis (AS) due to their effectiveness in reducing inflammation and slowing disease progression. However, their use is associated with an increased risk of opportunistic infections, particularly tuberculosis (TB). This case report presents a young male patient in the United Kingdom (UK) with AS, who had been on long-term biological therapy with adalimumab, a TNF-α inhibitor.

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Tuberculosis, caused by , is a widely spread disease complex affecting multiple organs. It is a type of communicable disease disproportionately affecting low and middle-income countries. The imaging modality of choice for pulmonary tuberculosis is computed tomography, and for brain lesions, it is a contrast-enhanced magnetic resonance imaging study.

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Clinical analysis of 20 cases of perinatal tuberculosis.

BMC Infect Dis

October 2024

Second Department of Infectious Disease, Kunming Children's Hospital, Kunming, 650000, Yunnan, China.

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Article Synopsis
  • * A case study describes a 71-year-old man from Mexico with a history of smoking, diabetes, and hypertension, who developed a widespread skin condition that was later diagnosed as miliary cutaneous tuberculosis.
  • * Diagnosis was confirmed through histopathological exam showing specific cells and bacteria, and the patient began treatment, highlighting the need for quick and accurate diagnosis in those with weakened immune systems.
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Disseminated Tuberculosis: Rare Presentation.

J Assoc Physicians India

October 2024

Senior Consultant, Department of Pathology and Lab Medicine, Venkateshwar Hospital, Delhi, India.

Article Synopsis
  • India has a significant TB problem, accounting for 26% of global cases, with high death rates and serious health impacts.
  • Disseminated TB, which is found in <2% of immunocompromised patients and 20% of extrapulmonary cases, has a mortality rate close to 25-30%.
  • The case study highlights a young female patient who was diagnosed with disseminated TB exhibiting symptoms like nosebleeds and low platelet count.
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  • - The study analyzed 79 patients with severe tuberculosis-related ARDS who received ECMO treatment at 20 centers worldwide, focusing on their 90-day survival rates and related complications.
  • - Results showed that 51% of patients survived for 90 days, with significant complications including major bleeding and infections; miliary TB patients had a notably higher survival rate than those with cavitary TB.
  • - Factors like older age, drug-resistant TB, and higher pre-ECMO SOFA scores were identified as key predictors of mortality, suggesting that ECMO could be a valuable intervention for patients with TB-induced ARDS.
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  • Tuberculous meningitis (TBM) is a severe complication of miliary tuberculosis (MT) with a high mortality rate, but early diagnosis and treatment can greatly improve outcomes.
  • Currently, there is no reliable way to predict which MT patients will develop TBM, prompting the development of an early screening model using chest CT images.
  • The proposed model utilizes few-shot learning and a specialized feature extraction method to effectively identify potential TBM cases, demonstrating strong performance in experiments, and aims to aid clinicians in the early detection and prevention of TBM.
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  • * The report details a case of a 39-year-old woman who suffered from a seizure; her normal chest X-ray delayed the detection of MTB, ultimately leading to severe health consequences.
  • * It underscores the limitations of traditional chest X-rays in diagnosing MTB, recommending more advanced imaging techniques like chest CT or MRI, and stresses the importance of timely treatment, especially in developing countries affected by conflict and poverty.
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  • Tuberculosis is making a resurgence globally, and in Morocco, it can lead to rare but serious conditions like common iliac artery aneurysms, which pose high risks of infection and bleeding, necessitating careful treatment planning.
  • A case involving a 54-year-old man presented with skin necrosis and a pulsating groin mass was diagnosed with a false aneurysm caused by tuberculosis, leading to emergency surgery that successfully restored arterial function.
  • Although mycotic aneurysms are uncommon, they can result from direct infection or bloodborne spread, and while treatment success rates can be good, the mortality from complications like ruptures remains significant, highlighting the need for effective management strategies.
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  • A patient with miliary tuberculosis was diagnosed with drug-induced immune thrombocytopenia (DITP) caused by ceftriaxone, contrary to the initial assumption that it was due to the tuberculosis drugs.
  • Identifying the specific drug causing DITP is crucial to ensure continuation of essential tuberculosis treatment without unnecessary changes.
  • When multiple medications are involved, additional testing for drug-dependent platelet antibodies may be needed to make an informed decision about treatment adjustments.
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  • Pancytopenia is a condition characterized by decreased levels of red blood cells, white blood cells, and platelets, often resulting from various illnesses like bone marrow failure, infections, or nutritional deficiencies.
  • A study conducted over 12 months involved 70 pediatric patients, with a focus on their symptoms, demographics, and possible causes of pancytopenia, revealing that fever and arthralgias were the most common symptoms observed.
  • Findings indicated that a significant portion of pediatric pancytopenia cases could be preventable, highlighting the need for better awareness and diagnostic practices to ensure early detection and treatment.
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Amyloidosis is a misfolded protein deposition disorder within the extracellular matrix, leading to dysfunction in the affected organ. Primary amyloidosis manifests as AL and ATTR subtypes, wherein AL is associated with plasma cell dyscrasias. Herein we present a case of a patient who underwent investigation due to the presence of bilateral reticulonodular lung infiltrates, suggestive of miliary tuberculosis.

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