1,441 results match your criteria: "Milia"

Background: The Italian Fund for Alzheimer's and other dementias approved in 2020 enabled the conducting of a survey in the Italian Centers for Cognitive Disorders and Dementias (CCDDs) to analyse the organization, the administrative features and the professionals' characteristics.

Aims: To investigate the current use of neuropsychological (NP) tests in Italian CCDDs and the association between the use of a basic set of tests for neuropsychological assessment (NPA) and organizational/structural characteristics of CCDDs.

Methods: A survey was conducted with an online questionnaire in all CCDDs between July 2022 and February 2023.

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Microbial electrochemical technologies (MET) can remove a variety of organic and inorganic pollutants from contaminated groundwater. However, despite significant laboratory-scale successes over the past decade, field-scale applications remain limited. We hypothesize that enhancing the electrochemical conductivity of the soil surrounding electrodes could be a groundbreaking and cost-effective alternative to deploying numerous high-surface-area electrodes in short distances.

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We present the case of a 36-year-old paraplegic woman with a history of spinal cord injury who developed a generalized blistering rash, later diagnosed as bullous pemphigoid (BP). During her hospitalization, she was treated with prednisone and rituximab infusions, transitioning to maintenance therapy with topical steroids, doxycycline, and nicotinamide. A year later, she presented with concerns about a BP flare on her feet.

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Cattle have been selectively bred for coat color, spotting, and depigmentation patterns. The assumed autosomal dominant inherited genetic variants underlying the characteristic white head of Fleckvieh, Simmental, and Hereford cattle have not been identified yet, although the contribution of structural variation upstream the gene has been proposed. Here, we construct a graph pangenome from 24 haplotype assemblies representing seven taurine cattle breeds to identify and characterize the white head-associated locus for the first time based on long-read sequencing data and pangenome analyses.

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Objective: We aimed to document the treatment outcomes of African patients treated with low-intensity electrodesiccation for DPN's. Other treatment options for DPN's include snip excision, light curettage, cryotherapy, and lasers devices such as PDL, Nd: YAG, KTP, and CO2, which are generally unsafe for darker skin types and come with high costs.

Methods: Nonprobability convenience sampling of patient records was used to extract retrospective data on demographics and treatment outcomes according to the inclusion criteria.

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Milia within resolving bullous pemphigoid lesions.

Dermatol Online J

August 2024

Department of Dermatology, King Abdullah Medical Complex, Jeddah, Saudi Arabia.

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eCyanation Using 5-Aminotetrazole As a Safer Electrophilic and Nucleophilic Cyanide Source.

JACS Au

November 2024

School of Science, Faculty of Engineering and Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, United Kingdom.

Article Synopsis
  • A new electrochemical method is introduced for safer cyanation reactions using 5-aminotetrazole as a cyanide source, avoiding toxic cyanide salts.
  • This method successfully generates both electrophilic and nucleophilic cyanide sources and allows for the synthesis of various compounds like cyanamides, heterocycles, and aromatic nitriles.
  • The process has been adapted for flow electrosynthesis, showcasing its scalability and potential for large-scale use.*
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  • - The study investigates the distribution of the synthetic cathinone MDPHP in post-mortem specimens of a 30-year-old man, highlighting high concentrations in urine and gastric content, suggesting potentially lethal levels.
  • - Various toxicological analyses, including gas chromatography and liquid chromatography, were used to measure MDPHP and other substances, with no evidence of recent cocaine injection found.
  • - Findings indicated that MDPHP levels were significantly higher compared to previously reported fatal cases, leading the researchers to conclude that the individual's death was likely due to MDPHP overdose.
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Background: Differentiating melanoma (MM) from seborrheic keratosis (SK) containing a blue-white veil (BWV) remains challenging.

Objective: Identify dermoscopic features that can improve upon the differentiation between MMs and SKs exhibiting BWV.

Methods: Images from 110 MMs and 121 SKs containing BWV were aggregated, and 91 MMs and 62 SKs from this data set had complete agreement on the presence of BWV according to 3 expert dermoscopists.

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Objectives: Chagas disease (CD), or American trypanosomiasis, is a parasitic disease caused by Trypanosoma cruzi, primarily transmitted by triatomine bugs. Increased travels and migrations introduced CD to non-endemic regions, including Europe. In Italy, the disease has raised public attention mainly in northern regions, where Latin American migrant population is larger.

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Multilayer patch functionalized microfibrillated cellulosic paper sensor for sweat glucose monitoring.

Sci Rep

October 2024

Department of Applied Sciences and Humanities, Faculty of Engineering and Technology, Jamia Milia Islamia, New Delhi, 110025, India.

Article Synopsis
  • A new noninvasive glucose monitoring sensor has been developed using biobased cellulosic papers that are functionalized for improved hydrophilicity, allowing them to efficiently collect and analyze sweat samples for glucose levels.
  • The sensor’s design incorporates a multilayer patch that enhances sweat absorption and miniaturization for better efficiency, while a “switch system” integrates accurate drug delivery with the glucose monitoring process.
  • This innovative approach offers a closed-loop solution for managing diabetes mellitus through sweat analysis, minimizing the need for painful blood collection.
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  • Epidermolysis bullosa (EB) is a genetic condition that causes blisters to form easily on the skin, either spontaneously or due to injury, leading to scarring and color changes in the skin.
  • A child with this condition exhibited extensive areas of lighter skin, frequent blistering in vulnerable spots, and issues with nail growth.
  • The case highlights the difficulty in differentiating between epidermolysis bullosa and another skin disorder called bullous extragenital lichen sclerosus et atrophicus.
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  • Two patients developed severe hypophosphatemia requiring hospitalization after denosumab treatment for osteoporosis, despite having normal kidney function and no known risk factors.
  • Both patients experienced neurological symptoms and severe fatigue, which improved with intravenous phosphate treatment, and they left the hospital with oral phosphate and vitamin D supplements.
  • As denosumab use increases, it's important to monitor serum phosphate and related levels regularly, and to consider hypophosphatemia as a potential issue when patients report unexplained fatigue or muscle problems.
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Reagent-free phosphorus precipitation from a denitrified swine effluent in a batch electrochemical system.

Heliyon

September 2024

Laboratory of Chemical and Environmental Engineering (LEQUIA), Institute of the Environment, University of Girona, Girona, Spain.

Article Synopsis
  • * This research explores a new method using electrochemical mediated precipitation without chemical additives, achieving over 90% phosphorus removal at a controlled pH of 11.5 in a two-chamber system treating swine effluent.
  • * The process demonstrated limited chlorine production and solid scaling, presenting a promising alternative to conventional pH adjustment methods for crystallizing phosphate salts.
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HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma.

J Exp Clin Cancer Res

September 2024

Department of Medicine, Surgery, and Pharmacy, University of Sassari, via P. Manzella 4, Sassari, 07100, Italy.

Article Synopsis
  • Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive liver cancer with poor treatment options, prompting research into new therapies targeting the Heat Shock Factor 1 (HSF1) transcription factor.
  • Studies showed that HSF1 levels are significantly elevated in various stages of iCCA and correlate with worse patient outcomes, while inhibiting HSF1 delayed tumor development in mouse models.
  • The HSF1 inhibitor KRIBB-11 was effective in slowing iCCA cell growth, inducing cell death, and reducing key metabolic functions in cancer cells, highlighting its potential as a therapeutic avenue.
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  • The paper evaluates how treating nasal vestibule tumors with interventional radiotherapy (IRT-brachytherapy) affects patients' quality of life using a patient-reported questionnaire.
  • Data was collected from 10 patients, monitoring acute side effects and quality of life at various time points after treatment, using the SNOT-22 questionnaire.
  • Results showed a significant improvement in quality of life scores from baseline to 6 months after treatment, suggesting benefits even when some patients experienced mild to moderate side effects.
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  • The study examines how microplastic (MP) content in urban sewage sludge at wastewater treatment plants varies seasonally due to changes in rain and human activity, with samples collected over a year in two cities along India's River Ganga.
  • It finds that MP concentration is highest during the monsoon season, with the majority of microplastics ranging from 50-200 µm in size, and identifies common types of microplastics such as polypropylene and nylon.
  • The research underscores the need for ongoing monitoring of microplastics in sewage sludge to better understand contamination levels and develop strategies for environmental protection.
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The relationship between shift work, sleep, and work hours on wellbeing.

Ind Health

August 2024

Department of Global Public Health and Primary Care, University of Bergen, Norway.

Article Synopsis
  • The study explored how sleep and work hours influence the wellbeing of day and shift workers, examining specific relationships between these factors.
  • It found that sleep acts as a mediator in how work schedules affect the impact of sleep and sleepiness on overall wellbeing, with significant negative effects for shift workers.
  • Additionally, work hours moderated this relationship, indicating that fewer work hours can lead to a stronger negative impact of sleep issues on wellbeing for shift workers.
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  • - This article discusses two 2022 mpox virus cases, highlighting a unique description of mpox pseudotumor in the perianal area, which had not been documented before.
  • - The first case involved a 42-year-old man with specific skin lesions, and histopathological analysis revealed several significant skin cell changes.
  • - The second case featured a 51-year-old man with a perianal mass, showing different histopathological findings, adding to the scarce literature on the histopathology related to the 2022 mpox outbreak.
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  • - Breast cancer, a common disease in women, is often caused by mutations in hormone receptors, and traditional treatments have limitations like side effects and low effectiveness.
  • - Nanotechnology presents a new avenue for treatment with targeted delivery and controlled drug release, but faces issues like poor size distribution and environmental impact.
  • - Biogenic nanotechnology, utilizing natural materials, has emerged as a safe and effective alternative, with plant-based nanoparticles showing promise in selectively targeting cancer cells while minimizing harm to healthy ones.
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