Humans, Animals, Food and Environment: One Health Approach against Global Antimicrobial Resistance.

Antimicrobial resistance represents one of the most relevant threats to global public health and food security, affecting anyone, of any age, in any country and is responsible for longer hospital stays, higher medical costs and increased mortality. Resistant microorganisms are present in humans, animals, food and the environment, and, therefore, the One Health approach is very promising to counteract antimicrobial resistance, since human health and animal health are connected to each other and with the environment and the latter a potential source of resistant microorganisms. In this context, the need for novel antimicrobial drugs has stimulated the exploration of plant products as a source of novel phytotherapeutics able to reverse antimicrobial resistance when used in combination with conventional antibiotic drugs.

Relaxant Effect of Monoterpene (-)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels.

Carveol is a monoterpene present in the structure of many plant products. It has a variety of biological activities: antioxidant, anticancer and vasorelaxation. However, studies investigating the effect of monoterpenoids on human vessels have not yet been described.

Anti-Inflammatory and Physicochemical Characterization of the Essential Oil Inclusion Complex in β-Cyclodextrin.

is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed using different physical methods.

Application of Super Absorbent Polymer and Plant Mucilage Improved Essential Oil Quantity and Quality of var. Keshkeni Luvelou.

One of the major factors limiting the production of medicinal plants in arid and semi-arid areas is water deficit or drought stress. One-third of the land in the world is arid and semi-arid and is inhabited by nearly 4 × 10 people. (sweet basil) is a valuable medicinal plant that is sensitive to water deficit, and water shortage negatively affects sweet basil yield and quality.

Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its β-Cyclodextrin (β-CD) Inclusion Complex in Animal Inflammation Models.

Isopulegol (ISO) is an alcoholic monoterpene widely found in different plant species, such as Melissa officinalis, and has already been reported to have a number of pharmacological properties. Like other terpenes, ISO is a highly volatile compound that is slightly soluble in water, so its inclusion into cyclodextrins (CDs) is an interesting approach to increase its solubility and bioavailability. Thus, our aim was to evaluate the antiedematogenic and anti-inflammatory activity of isopulegol and a β-cyclodextrin-isopulegol inclusion complex (ISO/β-CD) in rodent models.

GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of and Safrole: Inhibition of Efflux Pumps.

Considering the evidence that essential oils, as well as safrole, could modulate bacterial growth in different resistant strains, this study aims to characterize the phytochemical profile and evaluate the antibacterial and antibiotic-modulating properties of the essential oil (EOOO) and safrole against efflux pump (EP)-carrying strains. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed by gas chromatography coupled to mass spectrometry (GC-MS). The antibacterial and antibiotic-modulating activities of the EOOO and safrole against resistant strains of and were analyzed through the broth microdilution method.

Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice.

Nootkatone (NTK) is a sesquiterpenoid found in essential oils of many species of (Rutaceae). Considering previous reports demonstrating that NTK inhibited inflammatory signaling pathways, this study aimed to investigate the effects of this compound in mice models of acute and chronic inflammation. Murine models of paw edema induced by carrageenan, dextran, histamine, and arachidonic acid, as well as carrageenan-induced peritonitis and pleurisy, were used to evaluate the effects of NTK on acute inflammation.

A Comparative Study of the in Vitro Antimicrobial and Synergistic Effect of Essential Oils from L. and L. from Morocco with Antimicrobial Drugs: New Approach for Health Promoting Products.

L. (laurel, Lauraceae) and L. (apricot, Rosaceae) are important industrial crops and display significant biological properties, including antimicrobial activity.

Chemical composition, antitumor and antioxidant effects of four lebanese plants extracts on human pulmonary adenocarcinoma.

Lung cancer leading cause of humans' cancer-related death remains incurable with current drug therapies having many side-effects. Finding new natural cancer remedies would help design better therapies. This study aims to investigate the anticancer and antioxidant effects of the Levant endemic plants , , and on human pulmonary adenocarcinoma.

Anticancer Effects of Wild Mountain Extract in Adrenocortical Tumor Cell Models.

Mint [ (L.) Hudson] is an aromatic plant that belongs to Lamiaceae family. It is traditionally used as herbal tea in Europe, Australia and North Africa and shows numerous pharmacological effects, such as spasmolytic, antioxidant, antimicrobial and anti-hemolytic.

LncRNAs as Potential Therapeutic Targets in Thyroid Cancer.

Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis.

Analysis of the essential oil composition of three cultivated Nepeta species from Iran.

Essential oils (EOs) of three Iranian cultivated Nepeta species were investigated. The oils were obtained by hydrodistillation of air-dried plant materials at full flowering stage and analyzed by gas chromatography (GC) and gas chromatography coupled to mass spectroscopy (GC/MS). In total, 89 compounds were detected.

Effect of geographical origin on yield and composition of cone essential oils of Cedrus libani A. Rich. growing in Lebanese protected areas and variability assessment in comparison with literature survey.

Gas chromatography-mass spectrometry analysis together with principal component analysis revealed that geographical origin influenced the yield and composition of the essential oils (EOs) extracted by hydrodistillation performed for 3 h using a Clevenger-type apparatus, from the cones of Cedrus libani A. Rich., growing wild at four Lebanese natural reserves and protected areas: Bsharri, Chouf, Ehden, and Tannourine, and from a cultivated cedar growing in Qartaba.

Monthly changes in contents and compositions of oil of : a comparison study.

The essential oil components of fresh and dry aerial parts of , monthly harvested from Iran during a year, were compared. The EO contents of dry plant samples were dramatically higher than the fresh materials. The dry sample collected in March with 1.

Curcumin's Nanomedicine Formulations for Therapeutic Application in Neurological Diseases.

The brain is the body's control center, so when a disease affects it, the outcomes are devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion.

In vitro Antibiotic and Modulatory Activity of (L.) Kuntze against strains.

The emergence of fungal resistance to commercial drugs has been a major problem for the WHO. In this context, research with natural products is promising in the discovery of new active substances. Thus, this work evaluated the antifungal effect of a medicinal plant (i.

Sustainable Crop Protection, Global Climate Change, Food Security and Safety-Plant Immunity at the Crossroads.

The development of novel strategies of plant disease management is crucial in view of the growing demand of sustainability in agri-food chains. The use of agrochemicals is not without risk for the consumer and environment in terms of their residues in food, feed, water bodies and harmful effects on nontarget organisms. However, because of the high global annual yield losses attributable to plant diseases and also due to global climate changes that have exacerbated some phytosanitary emergences, chemical input in agriculture is mandatory.

Monoterpenes: Essential Oil Components with Valuable Features.

Medicinal plants have a wide range of secondary metabolites including monoterpene. These volatile compounds are the main components of essential oils, belonging to the isoprenoid group and possessing valuable features for plants and humans. This review provides comprehensive information on chemical structures and classification of monoterpenes.

Essential Oil of Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria.

This study is a pioneer in reporting the antibacterial properties of the species Baill. The genus belongs to the family Euphorbiaceae composed of numerous species with documented biological activities. However, the pharmacological properties of remain poorly understood.

Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Strains.

Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. α-Bisabolol is a sesquiterpene isolated from several plants such as L.

Photoinduced Antibacterial Activity of the Essential Oils from Lam and C. DC. by Blue Led Light.

The objective of this work was to evaluate the phytochemical composition and the antibacterial and antibiotic-modulating activities of the essential oils of Lam (OEEb) and C. DC (OEPm) singly or in association with blue LED (Light-emitting diode) light. The antibacterial and antibiotic-modulatory activities of the essential oils on the activity of aminoglycosides were evaluated to determine the minimum inhibitory concentration (MIC, μg/mL) in the presence or absence of exposure to blue LED light.

UPLC-MS-ESI-QTOF Analysis and Antifungal Activity of the Arruda Leaf and Root Hydroalcoholic Extracts.

The aim of this study was to identify and evaluate the chemical compositions and effects of the leaf and root hydroalcoholic extracts (HELST and HERST) against different strains of . Chemical analysis was performed by Ultra-Performance Liquid Chromatography Coupled to Quadrupole/Time of Flight System (UPLC-MS-ESI-QTOF). The Inhibitory Concentration of 50% of the growth (IC as well as the intrinsic and combined action of the extracts with the antifungal fluconazole (FCZ) were determined by the microdilution method while the minimum fungicidal concentrations (MFCs) and the effect on fungal morphological transitions were analyzed by subculture and in humid chambers, respectively.

Antidiabetic Potential of Medicinal Plants and Their Active Components.

Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects.

-Derived Natural Products with Potential for Use in Health Maintenance.

genus (Euphorbiaceae family), which is the third largest genus of angiosperm plants comprising ca. 2000 recognized species, is used all over the world in traditional medicine, especially in the traditional Chinese medicine. Members of this taxa are promptly recognizable by their specialized inflorescences and latex.

Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans.

Melatonin is a widespread molecule among living organisms involved in multiple biological, hormonal, and physiological processes at cellular, tissue, and organic levels. It is well-known for its ability to cross the blood-brain barrier, and renowned antioxidant effects, acting as a free radical scavenger, up-regulating antioxidant enzymes, reducing mitochondrial electron leakage, and interfering with proinflammatory signaling pathways. Detected in various medicinal and food plants, its concentration is widely variable.