Phenotypic and genetic analysis of a large family with migraine-associated vertigo.

Objectives: To describe a large multigenerational family with migraine-associated vertigo (MAV) combining a detailed phenotypic and genetic analysis.

Background: Migraine-associated vertigo is said to be highly prevalent in the general population and, like other migraine syndromes, its etiology is felt to have a strong genetic component. However, so far, there have been no reports of large families with MAV.

Migraine associated vertigo.

The interrelations of migraine and vertigo are complex, eluding a simple localization either centrally or peripherally. Spontaneous episodic vertigo, benign paroxysmal positional vertigo, and Meniere's disease all occur more frequently in patients with migraine than in those without. Family studies support a hereditary predisposition to migraine associated vertigo.

Association of progesterone receptor with migraine-associated vertigo.

While migraine has been demonstrated to be familial and have genetic contributions, genome-wide linkage analyses and candidate gene studies have highlighted that migraine is genetically complex. Despite substantial efforts, no consistent replication of linkage or association has been reported for common migraine syndromes. Among the candidate genes tested for association with migraine by several groups were female sex hormone genes based on the observation of a much higher incidence of migraine in females.

Evaluation of vertiginous children.

Our objective was to evaluate, using a structured approach method, the history and findings in vertiginous children as compared with a group of healthy children. We evaluated 24 vertiginous children (15 girls, 9 boys) with episodes of true vertigo of unknown etiology and 12 healthy age- and gender-matched controls. A detailed medical history was obtained using a structured approach technique.

[Migraine and vertigo].

Introduction: Headache and dizziness are two of the most frequent symptoms that lead patients to visit neurology outpatient services. One of the most interesting associations is the one existing between migraine and vertigo. Different terms have been used in the literature to refer to this clinical picture, but perhaps the one that best defines this relation is that of recurring migraine-associated vertigo, which should be considered an entity in its own right.

Serotonin-induced plasma extravasation in the murine inner ear: possible mechanism of migraine-associated inner ear dysfunction.

Sensitivity to sound and vertigo are often components of migraine. Recent studies suggest that plasma extravasation from intradural blood vessels may contribute to migraine pain. This study documented plasma extravasation in the mouse inner ear after intravenous administration of serotonin (5-HT).

Vestibular rehabilitation for migraine-associated dizziness.

The purpose of this study was to investigate the effects of a vestibular rehabilitation program on patients with the diagnosis of migraine-associated dizziness. Subjects were placed in four groups as follows: idiopathic migraine-associated dizziness; idiopathic migraine-associated dizziness and associated benign positional vertigo; posttraumatic migraine-associated dizziness; and posttraumatic migraine-associated dizziness and benign positional vertigo. Vestibular rehabilitation therapy was administered to all patients.

Vertigo and imbalance in children: a retrospective study in a Helsinki University otorhinolaryngology clinic.

Objective: To determine medical characteristics of children with vertigo who visited an otorhinolaryngology (ENT) clinic during a 5-year period.

Design: A retrospective chart review carried out between 2000 and 2004.

Setting: Helsinki University Central Hospital tertiary referral center ENT clinic.

Migraine-associated vertigo.

Conclusions: It is probably not wise to demand a temporal relationship between migraine symptoms and vertigo for the definition of migrainous vertigo. When recurrent vertigo attacks begin at an early age in a patient with normal hearing and migraine, there are few diagnoses other than migraine that need to be considered.

Objective: The clinical association between migraine and vestibular symptoms, such as dizziness, motion intolerance and spontaneous attacks of vertigo, is well documented.

Audiometric findings of patients with migraine-associated dizziness.

Objective: The objective of this study was to determine whether the audiometric findings of migraine-associated dizziness could be used to better distinguish migraine-associated dizziness from Meniere's disease.

Study Design: A retrospective chart review.

Setting: Tertiary, otology/neurotology practice.

Benign paroxysmal positional vertigo: how to diagnose and quickly treat it.

Benign paroxysmal positional vertigo, the most common cause of vertigo, can be diagnosed and treated with a simple maneuver that can quickly be performed in the primary care physician's office. How to diagnose and manage other causes of dizziness, including Meniere disease, acute vestibular syndrome, migraine-associated vertigo, and motion sickness, is also covered in this article.

Neuroradiological features of vertigo.

The diagnostic pathway in a patient with vertigo starts with the accurate evaluation of medical history followed by a general physical and neurological examination. This step can often lead to the identification of the correct cause of the disease or, at least, to a distinction between peripheral and central vertigo. Neuroradiological investigations have to be considered as elective diagnostic procedures and include: computed tomography (CT), magnetic resonance (MR), MR angiography (MRA), angiography.

Dizziness and migraine: a causal relationship?

Both migraine and dizziness are very frequent complaints, but the comorbidity of the two disorders is higher than it might be expected to be on the basis of chance alone. This implies a possible causal relationship, but definite diagnostic criteria for migraine-related vertigo are still lacking. Very recent attempts in this direction have shown that migraine may be the third leading cause of vertigo and that migraine-related vertigo may be effectively treated.

Hearing symptoms in migrainous infarction.

Background: In case reports, migraine headaches have been associated with fluctuating low-frequency hearing loss and sudden, unilateral hearing loss. Auditory symptoms associated with migrainous infarction have not previously been emphasized.

Objective: To describe migrainous infarction presenting with acute auditory symptoms.

Pharmacological treatment of vertigo.

This review discusses the physiology and pharmacological treatment of vertigo and related disorders. Classes of medications useful in the treatment of vertigo include anticholinergics, antihistamines, benzodiazepines, calcium channel antagonists and dopamine receptor antagonists. These medications often have multiple actions.

Migraine-associated dizziness: patient characteristics and management options.

Objective: To determine patient characteristics and effectiveness of therapy for migraine-associated dizziness.

Study Design: Retrospective chart review.

Setting: Tertiary referral center.

[Vertigo as a symptom of migraine].

Epidemiology: Since both migraine and vertigo are common complaints in clinical practice they may coincide in an individual patient just by chance. There are, however, numerous patients with vestibular symptoms caused by migraine, accounting for 6-8% of diagnoses in specialized dizziness clinics. CLINICAL MANIFESTATION: Migraine-associated vertigo is a vestibular disorder which manifests itself with spontaneous or positional rotational vertigo or dizziness induced by head motion.

Migraine-associated vertigo.

A retrospective analysis was performed on a consecutive series of 363 patients presenting with vertigo; 32% had migraine. Of the 224 patients with no pathology other than migraine or vestibular dysfunction, migraineurs had a significantly higher prevalence of normal, central, and combined central and peripheral vestibular dysfunction compared to non-migraineurs. The combination of central and peripheral vestibular signs was a feature of migraine with aura.

Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness.

Objective: To assess the effects of antimigrainous therapy on migraine-associated dizziness/vertigo. We hypothesized that a medication's ability to ameliorate dizziness/vertigo in this patient population would be directly correlated with its efficacy in improving headache symptoms.

Study Design: Patient survey.

Migraine-associated dizziness.

We reviewed the clinical histories, examinations and results of quantitative vestibular testing in 91 patients with migraine-associated dizziness. Nausea and vomiting, hypersensitivity to motion and postural instability accompanied the dizziness. In the majority of patients, the temporal profile of the dizziness was more typical of the headache phase of migraine than of the aura phase.

[Basilar artery migraine associated with transient global amnesia].

Transient global amnesia (TGA) is an unusual form of the amnestic syndrome, clinically characterized by profound disturbance of short-term memory with preservation of immediate recall and long-term memory. Spontaneous recovery is the rule and is usually complete within several hours. The etiology of TGA is not clear.