38,895 results match your criteria: "Migraine Variants"
Cephalalgia
November 2024
Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
Eur J Neurol
January 2025
Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Objective: This study aimed to analyze the microcirculation of the macula, the optic nerve, and the choroid in patients with migraine by optical coherence tomography angiography (OCTA) during spontaneous migraine attacks, comparing the findings with scans performed in the interictal period in the same subjects and healthy controls (HCs).
Methods: In this case-crossover design study, patients diagnosed with migraine who underwent an OCTA during a migraine attack were enrolled. A cohort of HCs was recruited for comparison.
J Headache Pain
November 2024
Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
J Headache Pain
November 2024
Department of Pain Medicine, China-Japan Friendship Hospital, 100029, Beijing, China.
Background: Triptans selectively agoniste 5-Hydroxytryptamine(5-HT) receptors and are widely used in the treatment of migraine. Nevertheless, there is a dearth of comprehensive real-world clinical research on the safety of triptans. In light of the growing prevalence of migraine, it is imperative to gain a deeper understanding of the true extent of adverse events (AEs) associated with triptans in the clinical management of migraine.
View Article and Find Full Text PDFNeurol Int
October 2024
Department of Pediatrics, Hyogo Medical University School of Medicine, Nishinomiya 663-8501, Japan.
Objective: Evidence on prophylactic drugs for pediatric migraine is limited, especially when comorbid conditions contribute to treatment resistance. This study evaluated the efficacy of cyproheptadine in children with migraine and explored the impact of comorbid neurodevelopmental disorders and orthostatic intolerance (OI).
Methods: We retrospectively analyzed pediatric migraine patients treated with cyproheptadine.
Front Neurol
November 2024
Headache and Facial Pain Group, University College London (UCL), Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Extra-articular symptoms, including headaches, are frequently encountered in patients with Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders (HSD), and may be the presenting complaint. Migraine is reported in up to three quarters of patients with symptomatic joint hypermobility, have a higher headache frequency, and an earlier age of onset compared to the general population. Orthostatic headache is an important presentation, and should raise suspicion of an underlying spinal cerebrospinal fluid leak, dysautonomia, and craniocervical pathology, which are all associated with heritable connective tissue disorders (HCTD) including EDS.
View Article and Find Full Text PDFJ Headache Pain
November 2024
Headache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Objective: To delineate the structural connectome alterations in patients with chronic migraine (CM), episodic migraine (EM), and healthy controls (HCs).
Background: The pathogenesis of migraine chronification remains elusive, with structural brain network changes potentially playing a key role. However, there is a paucity of research employing graph theory analysis to explore changes in the whole brain structural networks in patients with CM and EM.
Clin Psychol Psychother
November 2024
Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
Eur J Pain
January 2025
Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Functional neuroimaging studies indicate that central transmission of trigeminal pain may commence up to 48 h prior to the onset of headache. Whether these cyclic changes are associated with somatosensory alteration remains incompletely understood.
Methods: The present study aimed to investigate the temporal progression of somatosensory alterations preceding the onset of a migraine attack.
J Headache Pain
November 2024
Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Background: Migraine is a prevalent neurological disorder affecting 14.1% of the global population. Despite advances in genetic research, further investigation is needed to identify therapeutic targets and better understand its mechanisms.
View Article and Find Full Text PDFMMW Fortschr Med
November 2024
Klinik und Poliklinik für Neurologie, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Germany.
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Pirogov Russian National Research Medical University, Moscow, Russia.
Front Genet
November 2024
Department of Basic Medical Sciences, College of Medicine, Taibah University Medina, Medina, Saudi Arabia.
Mol Brain
November 2024
Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
P/Q-type (Ca2.1) calcium channels mediate Ca influx essential for neuronal excitability and synaptic transmission. The CACNA1A gene, encoding the Ca2.
View Article and Find Full Text PDFJ Headache Pain
November 2024
Department of Neurology, Oslo University Hospital, Oslo, Norway.
Background: There is a lack of up-to-date information on the prevalence and burden of headache in Norway. Here we describe the methods and validation of the diagnostic tool of the PopHEAD study, a study designed to determine the prevalence and burden of migraine, tension-type headache, and medication-overuse headache.
Method: PopHEAD is a Norwegian population-based cross-sectional study conducted in Vestfold and Telemark County in 2023.
Synapse
November 2024
H. Lundbeck A/S, Neuroscience Research, Circuit Biology, Valby, Denmark.
Migraine is a debilitating neurological disorder that affects millions worldwide. Elucidating its underlying mechanisms is crucial for developing effective therapeutic interventions. In this editorial, we discuss the potential applications of one-photon miniscopes, which enable minimally invasive, high spatiotemporal resolution fluorescence imaging in freely moving animals.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA.
Migraine is one of the most common neurological disorders in the US. Currently, the diagnosis and management of migraine are based primarily on subjective self-reported measures, which compromises the reliability of clinical diagnosis and the ability to robustly discern candidacy for available therapies and track treatment response. In this study, we used a computational pipeline for the automated, rapid, high-throughput, and objective analysis of encephalography (EEG) data at Cleveland Clinic to identify signatures that correlate with migraine.
View Article and Find Full Text PDFMigraines make up a significant number of office visits every year, yet their pathophysiology and etiology remain largely elusive. This case report presents a 33-year-old patient who originally presented to the emergency department (ED) as a stroke alert and was later determined to have migraine with aura. The patient experienced an acute onset of headache, dizziness, and new-onset expressive aphasia.
View Article and Find Full Text PDFCephalalgia
November 2024
Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain.
Background: To evaluate the benefit-risk assessment of atogepant and calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) vs. placebo based on the number needed to treat (NNT) and the number needed to harm (NNH) in a blended episodic migraine and chronic migraine (EM + CM) population.
Methods: The NNT was calculated based on achievement of a ≥ 50% reduction in mean monthly migraine days (MMDs) from baseline across 12 weeks.
Cephalalgia
November 2024
Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
J Headache Pain
November 2024
Department of Internal Medicine, VNU University of Medicine and Pharmacy, Hanoi, Vietnam.
J Vis Exp
November 2024
Department of Molecular Physiology & Biophysics, University of Iowa; Department of Psychiatry, University of Iowa;
Spontaneous pain has been challenging to track in real time and quantify in a way that prevents human bias. This is especially true for metrics of head pain, as in disorders such as migraine. Eye squint has emerged as a continuous variable metric that can be measured over time and is effective for predicting pain states in such assays.
View Article and Find Full Text PDFCephalalgia
November 2024
Dept. of Systems Neuroscience, University Clinic Hamburg Eppendorf, Hamburg, Germany.
Background: In this study, we aimed to evaluate the differing global access to acute and preventive medications for migraine and tension-type headache.
Methods: A custom-built questionnaire created by members of the International Headache Society Juniors Group was sent to International Headache Society members worldwide, including a list of acute and preventive treatments for migraine and tension-type headache. This list was based on evidence-based medicine guidelines.
Cephalalgia
November 2024
Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Immun Inflamm Dis
November 2024
Health Center of Screening and Prevention of Diseases, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Objective: To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies.
Methods: A total of 129 migraine patients were enrolled. Seven questionnaires were used to gather information regarding the symptoms of migraine, gastrointestinal, depression, anxiety, and sleep.