328 results match your criteria: "Microcystic Adnexal Carcinoma"
Primary cutaneous adnexal adenocarcinoma not otherwise specified versus metastatic breast carcinoma: A case report and review of the literature.
JAAD Case Rep
September 2024
Department of Pathology, Stamford Hospital, Stamford, Connecticut.
Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal Carcinoma, and Porocarcinoma.
Mod Pathol
November 2024
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
Article Synopsis
- Squamoid eccrine ductal carcinoma is a rare tumor with characteristics that fall between squamous cell carcinoma (SCC) and certain sweat gland carcinomas, leading to debates on its classification.
- The study examined 15 cases of this carcinoma, revealing that most cases had UV signature mutations and TP53 mutations as the most common genetic alterations.
- Transcriptome analysis indicated that this carcinoma expresses 364 genes more and 525 genes less compared to SCC and sweat gland tumors, reinforcing the idea that it has an intermediate phenotype between these cancer types.
Pigmented Microcystic Adnexal Carcinoma with Melanocyte Colonization: A Case Report.
Acta Derm Venereol
July 2024
Division of Dermatology, Hitachi General Hospital, Ibaraki, Japan.
Article Synopsis
- * A recent case study involved a 58-year-old with a growing eyelid nodule, where histopathology showed small, mucin-filled tubules and significant microcysts, making it resemble myxoid microcystic adnexal carcinoma (MAC).
- * Diagnosis was confirmed through S100 protein expression and the presence of the MEF2C::SS18 fusion, highlighting MSA's distinct characteristics and complicating its differentiation from other tumors like
Equivalent Overall Survival for Microcystic Adnexal Carcinoma After Mohs Micrographic Surgery and Wide Local Excision: A Population-Based Analysis.
Dermatol Surg
December 2024
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Microcystic Adnexal Carcinoma. A Rare Entity.
J Clin Exp Dent
April 2024
Maxilofacial Surgery Department, Hospital Gregorio Marañon. Madrid, Spain.
Article Synopsis
- Microcystic adnexal carcinoma is a rare malignant tumor that affects sweat glands, primarily found in the deep dermis and known for being locally aggressive with a low chance of metastasis.
- A case study discussed a 46-year-old woman who had a slow-growing lesion on her upper lip, diagnosed as this type of carcinoma; she underwent surgery for removal and reconstruction.
- The tumor often presents as a solitary lesion on the central face of middle-aged Caucasian women, requires an incisional biopsy for accurate diagnosis, and has no established consensus on treatment or follow-up due to its rarity.
A Systematic Review of the Epidemiology, Clinical Characteristics, Treatment, and Outcomes for Desmoplastic Trichoepithelioma: Underscoring Mohs Micrographic Surgery in Management.
Dermatol Surg
August 2024
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Article Synopsis
- Desmoplastic trichoepithelioma (DTE) is a rare benign skin tumor that can look like malignant conditions, making diagnosis challenging.
- A systematic review of 338 DTE cases highlighted that Mohs micrographic surgery (MMS) showed a 0% recurrence rate, significantly outperforming other treatments like standard excision (13.1% recurrence) and electrosurgery (2.1%).
- The findings suggest that MMS is the best option for treating DTEs, especially since these tumors are often located in sensitive cosmetic areas.
Article Synopsis
- A 23-year-old South Asian man developed a darkly pigmented papule on his scalp, which grew within a pre-existing warty plaque present since birth.
- The papule showed characteristics indicative of basal cell carcinoma (BCC) when examined and biopsied, confirming it developed from a sebaceous naevus.
- Sebaceous naevi are benign skin lesions that can develop into malignancies like BCC in a small percentage of cases, especially in adults.
Multiple Keratoacanthoma-like Syndromes: Case Report and Literature Review.
Medicina (Kaunas)
February 2024
Department of Dermatology, University of Thessaly, University Hospital of Larissa, 41334 Larissa, Greece.
Article Synopsis
- - Keratoacanthoma (KA) is a rapidly growing skin tumor that can appear as single or multiple lesions, particularly in certain rare genetic syndromes like Ferguson-Smith syndrome and others.
- - Treatment of these syndromes is complex because of the presence of numerous lesions and other skin cancers, exemplified by a case involving a 40-year-old woman with multiple treatment-resistant keratoacanthomas and invasive squamous cell carcinoma.
- - The woman was successfully treated with a combination of oral acitretin and topical Fluorouracil for her keratoacanthomas, while surgical intervention was used for her ulcerated cancer, and the study included a review of literature on diagnosis and treatment of similar syndromes
Perineural Infiltration: A Comprehensive Review of Diagnostic, Prognostic, and Therapeutic Implications.
Am J Dermatopathol
May 2024
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Article Synopsis
- - Perineural infiltration is when cancer cells spread around and through nerves, playing a key role in the spread of certain skin cancers.
- - Recognizing perineural infiltration is important for predicting the outlook of aggressive skin cancers like squamous cell carcinoma and other localized tumors.
- - The review includes findings on both malignant and benign skin tumors that show perineural infiltration and highlights some histopathological features that can mimic this condition.
Distant Metastatic Microcystic Adnexal Carcinoma.
Ann Dermatol
November 2023
Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.
Article Synopsis
- Microcystic adnexal carcinoma (MAC) is a rare but aggressive skin cancer with a high chance of recurrence, although it rarely spreads to distant sites.
- A 55-year-old man on immunosuppressants after liver transplantation developed a growing skin nodule, which was diagnosed as MAC after a biopsy.
- Despite successful removal of the primary tumor, the patient returned 11 months later with new skin nodules elsewhere on his body, also confirmed to be MAC, highlighting the potential for distant spread in this rare cancer.
Plaquelike Syringoma Mimicking Microcystic Adnexal Carcinoma: A Potential Histologic Pitfall.
Cutis
October 2023
Dr. Michaelis is from the Department of Dermatology, Mayo Clinic, Jacksonville, Florida. Drs. Wieland and Brewer are from the Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Evaluating Rates of Positive Margins After Standard Excision of Cutaneous Adnexal Malignancies.
Dermatol Surg
October 2023
All authors are affiliated with the Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
Article Synopsis
- Adnexal neoplasms are typically excised using standard local excision or Mohs micrographic surgery, especially in high-risk areas like the head and neck, due to their tendency for subclinical extension.
- A study analyzed 4,402 cases of cutaneous adnexal malignancies from 2004 to 2019, finding that tumors in the head and neck were more likely to have positive surgical margins compared to those in the trunk and extremities.
- The research concluded that certain adnexal tumor types, especially those on the head and neck, show a higher rate of positive margins and poorer survival rates, indicating the potential benefit of Mohs micrographic surgery for better outcomes.
Magnetic resonance imaging findings of sclerosing microcystic adenocarcinoma: A case report and review of the literature.
Radiol Case Rep
October 2023
Department of Radiology, Jichi Medical University, Tochigi, Japan.
Article Synopsis
- Sclerosing microcystic adenocarcinoma (SMA) is a rare form of salivary gland cancer that resembles another tumor type called microcystic adnexal carcinoma (MAC) and has recently been classified in the WHO's latest edition of head and neck tumors.* -
- The case study involves a 61-year-old woman with masses in her mouth, which were analyzed using advanced imaging techniques showing distinctive MRI characteristics like low signal intensity and specific patterns of enhancement.* -
- The histopathological examination revealed that these tumors contained small strands of cells forming ducts and cysts within a dense fibrous structure, aligning with known features of SMA, highlighting the importance of MRI findings for diagnosis.*
Microcystic adnexal carcinoma of the eyelid and orbit: A case report and review of literature.
Medicine (Baltimore)
August 2023
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Article Synopsis
- Microcystic adnexal carcinoma (MAC) is a rare skin cancer that often gets misdiagnosed and tends to recur locally, especially in the eyelid and orbital regions where it can cause significant complications.
- The unique challenges of eyelid and orbital MAC include a high risk of misdiagnosis due to its ambiguous symptoms and the potential for severe consequences like disfigurement and even death if not properly treated.
- Effective management requires heightened awareness, early diagnosis, complete surgical removal, long-term monitoring, and collaboration among various medical specialists.
Article Synopsis
- * A case study reports a 61-year-old woman who underwent total excisional surgery and A-T flap surgery for a recurring MAC lesion on her right eyebrow, showing no recurrence after two years.
- * The study highlights the importance of considering MAC in medical diagnoses and emphasizes the need for complete surgical excision, long-term follow-up, and the potential of hair transplantation to address scarring from surgery.
Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review.
Ophthalmic Plast Reconstr Surg
November 2023
Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, U.S.A.
Article Synopsis
Hair repigmentation in microcystic adnexal carcinoma.
JAAD Case Rep
May 2023
Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia.
Solitary Vulvar Syringoma With Deep Extension; Potential for Misdiagnosis as the Microcystic Adnexal Carcinoma (MAC).
Am J Dermatopathol
March 2023
Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, IL; and.
Article Synopsis
- A 43-year-old woman was diagnosed with a painful, pruritic nodule on her right vulva, which was found to be about 2.0 cm in size during a physical examination.
- Histological analysis of the excised growth revealed a well-defined proliferation of unusual cuboidal cells organized in various shapes, indicating it was likely a syringoma, although it had deep extension characteristics similar to microcystic adnexal carcinoma.
- Misdiagnosis between these two conditions is common due to their morphological similarities, making it crucial for pathologists to accurately identify them; notably, this case is the first documented instance of a solitary and painful vulvar syringoma with deep extension.
Improved Margin Control of Microcystic Adnexal Carcinoma After Mohs Micrographic Surgery Compared With Wide Local Excision.
Dermatol Surg
April 2023
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- Microcystic adnexal carcinoma (MAC) is a skin tumor that is usually aggressive and infiltrative, commonly treated through surgical excision, though there's little research comparing surgical methods.* -
- This study analyzed 69 MAC cases over 27 years, comparing outcomes between two surgical techniques: Mohs micrographic surgery (MMS) and wide local excision (WLE).* -
- Results showed that all MAC treated with MMS had clear margins, while 60% of WLE cases had positive margins after the first operation, indicating MMS may be a more effective method for preventing recurrence.*