1 results match your criteria: "MichiganbIndiana University School of Medicine[Affiliation]"
Deregulation of the HOXA9/MEIS1 axis in acute leukemia.
Curr Opin Hematol
July 2016
aDepartment of Pathology, University of Michigan, Ann Arbor, MichiganbIndiana University School of Medicine, Indianapolis, Indiana, USA.
Purpose Of Review: HOXA9 is a homeodomain transcription factor that plays an essential role in normal hematopoiesis and acute leukemia, in which its overexpression is strongly correlated with poor prognosis. The present review highlights recent advances in the understanding of genetic alterations leading to deregulation of HOXA9 and the downstream mechanisms of HOXA9-mediated transformation.
Recent Findings: A variety of genetic alterations including MLL translocations, NUP98-fusions, NPM1 mutations, CDX deregulation, and MOZ-fusions lead to high-level HOXA9 expression in acute leukemias.