Impact of Scleroderma-Associated Autoantibodies on Clinical Outcome Assessments: Post Hoc Analysis From a Randomised, Double-blind, Placebo-controlled, Phase 3 Trial of Tocilizumab in Scleroderma.

Objective: Scleroderma-associated autoantibodies (SSc-Abs) are specific in participants (pts) with systemic sclerosis and are associated with organ involvement. Our objective was to assess the influence of baseline SSc-Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial.

Methods: We used data on both the groups who received placebo (Pbo) and tocilizumab from the focuSSced trial.

Developing : A Virtual Peer-Support Wellness Intervention by and for Trans/Gender Diverse Michiganders.

The U.S. trans/gender diverse (TGD) community experiences considerable mental health disparities and barriers to health care.

Bayesian Sample Size Calculation in Small n, Sequential Multiple Assignment Randomized Trials (snSMART).

A recent study design for clinical trials with small sample sizes is the small n, sequential, multiple assignment, randomized trial (snSMART). An snSMART design has been previously proposed to compare the efficacy of two dose levels versus placebo. In such a trial, participants are initially randomized to receive either low dose, high dose or placebo in stage 1.

Re-defining the interpretation of 24-h urine studies for stone formers.

Objectives: To identify associations between 24-h urine abnormalities and clinical risk factors for recurrent stone formers.

Patients And Methods: The Registry for Stones of the Kidney and Ureter was queried for all patients who underwent 24-h urine studies. Patients were categorised by the number of clinical risk factors for recurrent stone disease.

Magnetophononics and the chiral phonon misnomer.

The direct, ultrafast excitation of polar phonons with electromagnetic radiation is a potent strategy for controlling the properties of a wide range of materials, particularly in the context of influencing their magnetic behavior. Here, we show that, contrary to common perception, the origin of phonon-induced magnetic activity does not stem from the Maxwellian fields resulting from the motion of the ions themselves or the effect their motion exerts on the electron subsystem. Through the mechanism of electron-phonon coupling, a coherent state of circularly polarized phonons generates substantial non-Maxwellian fields that disrupt time-reversal symmetry, effectively emulating the behavior of authentic magnetic fields.

Evidence for a case-based module in the low-resource setting to teach ectopic pregnancy management.

Introduction: Case-based learning (CBL) utilizes authentic clinical cases that connect theory to practice. CBL has been shown to result in deeper learning and high engagement of adult learners. An open-source, web-based CBL module was created to help learners develop the cognitive foundation of ectopic pregnancy management in the low-resource setting.

Comorbidity between internalizing symptoms and disordered eating is primarily driven by genetic influences on emotion regulation in adult female twins.

Internalizing (e.g., anxiety, depression) and disordered eating (DE; e.

Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey.

Purpose: In prostate cancer patients, high radiation doses to the urethra have been associated with an increased risk of severe genitourinary toxicity following dose-escalated radiotherapy. Urethra-sparing techniques have emerged as a promising approach to reduce urinary toxicity. This international survey aims to evaluate current global practices in urethra-sparing and explore future directions for the implementation of this technique in external beam radiotherapy (EBRT) for prostate cancer.

Post-training breakdown: acute effects of different training types on body hydration status and performance.

Objective: Wrestling is a complex sport that requires a combination of strength, endurance, and wrestling-specific technical training. Endurance activities, such as running, are commonly performed for rapid weight reduction before competition. However, these activities can severely disrupt recovery and lead to significant declines in performance.

Where do "chemical imbalance" beliefs come from? Evaluating the impact of different sources.

Introduction: Although the etiology of depression is incredibly complex, the narrative that it is caused by a simple "chemical imbalance" persists in lay settings. We sought to understand where people are exposed to this explanation (i.e.

Assessing self-determined motivation for drinking alcohol via the Comprehensive Relative Autonomy Index for Drinking.

Introduction: Self-Determination Theory (SDT) examines human motivation in multiple domains; however, the only existing measure assessing SDT-informed behavioral regulations for drinking focuses on responsible drinker behaviors, rather than drinking , which is important given the alignment between SDT and harm reduction approaches to alcohol use. The aim of this study was to test the structural validity of the SDT-informed Comprehensive Relative Autonomy Index for Drinking (CRAI-Drinking) among college students.

Methods: Participants included two convenience samples with a total of 630 adult drinkers (M = 21.

Psychosocial moderators of the association between pain intensity and physical function in people with systemic sclerosis.

Background: Pain is a prevalent symptom of systemic sclerosis. While previous studies have demonstrated a correlation between higher pain intensity and lower physical function in individuals with systemic sclerosis, the potentially moderating effect of psychosocial factors on the association has yet to be explored.

Methods: This cross-sectional study used data from a fatigue self-management trial for adults with systemic sclerosis.

Variation in approach for midsize (4-6cm) ventral hernias across a statewide quality improvement collaborative.

Introduction: Repair of midsize (4-6 cm) ventral hernias is challenging given lack of guidelines. Within this context, we sought to characterize surgical approach among patients undergoing repair of midsize ventral hernias within the only population-level, clinically-nuanced hernia registry in the US.

Methods: Retrospective cohort study of patients undergoing ventral hernia repair in the Michigan Surgical Quality Collaborative Core Optimization Hernia Registry (MSQC-COHR).

CEP44 and CCDC15 label the spermatozoa proximal and atypical distal centrioles.

The centrosome is a conserved characteristic of eukaryotic and human cells but is highly specialized in reproductive cells. The spermatozoan centrosome includes a slightly modified proximal centriole, an atypical distal centriole, and specialized pericentriolar material, including striated columns and capitellum. We investigated the localization of canonical centriolar proteins CEP44 and CCDC15 in human spermatozoa.

The 2022 ADEA Climate Study in U.S. and Canadian Dental Schools and Allied Dental Programs: Methodological Considerations.

Objectives: From January 2020 to the end of August 2020, preliminary research gathered data about the need for and the feasibility of an ADEA-led joint Climate Study of dental schools and allied dental programs in the United States and Canada. Informed by these findings, the first ever ADEA-led joint Climate Study took place in 2022. The objectives of this manuscript were to describe the timeline of this climate study and provide information about its methodology, specifically about (a) who participated in this research, (b) what was assessed, (c) how the study was conducted, and (d) how the results were communicated.

Comparative Foliar Atmospheric Mercury Accumulation across Functional Types in Temperate Trees.

Vegetation assimilation of atmospheric gaseous elemental mercury (GEM) represents the largest dry deposition pathway in global terrestrial ecosystems. This study investigated Hg accumulation mechanisms in deciduous broadleaves and evergreen needles, focusing on how ecophysiological strategies─reflected by δC, δO, leaf mass per area, and leaf dry matter content-mediated Hg accumulation. Results showed that deciduous leaves exhibited higher total Hg (THg) concentrations and accumulation rates (THg), which were 85.

Whole Brain MRI Assessment of Age and Sex-Related R2* Changes in the Human Fetal Brain.

Iron in the brain is essential to neurodevelopmental processes, as it supports neural functions, including processes of oxygen delivery, electron transport, and enzymatic activity. However, the development of brain iron before birth is scarcely understood. By estimating R2* (1/T2*) relaxometry from a sizable sample of fetal multiecho echo-planar imaging (EPI) scans, which is the standard sequence for functional magnetic resonance imaging (fMRI), across gestation, this study investigates age and sex-related changes in iron, across regions and tissue segments.

Impact of Implant Mesiodistal Distance on Peri-Implant Bone Loss: A Cross-Sectional Retrospective Study.

Purpose: The purpose of this study was to verify the effect of our previously proposed mesiodistal distance for multiple posterior implants on preserving peri-implant bone, and to provide a measurable criterion for predicting implant prognosis.

Methods: One hundred and two patients with dental implants placed in the posterior free-end edentulous arches were recruited in this cross-sectional study. Calibrated X-rays (peri-apical [PA] or bite-wing x-ray) were collected to measure the mesiodistal space as well as the corresponding bone resorption of implants after prosthesis placement.

Long-Term Care Insurance and Health Inequality: Evidence From China.

This study examined the relationship between the Chinese Long-Term Care Insurance (LTCI) programme and health inequality among older adults in China and explored potential explanatory factors. Overall, the LTCI was found to improve the health of Chinese older adults. However, it was also associated with widening health inequality among older residents across income classes and between urban and rural areas.

Transgressive hybrids as hopeful holobionts.

Background: Hybridization between evolutionary lineages has profound impacts on the fitness and ecology of hybrid progeny. In extreme cases, the effects of hybridization can transcend ecological timescales by introducing trait novelty upon which evolution can act. Indeed, hybridization can even have macroevolutionary consequences, for example, as a driver of adaptive radiations and evolutionary innovations.

South to south collaboration: advancing quality of abortion care through health care professionals exchange program.

Background: South-South Cooperation (SSC) is recognized as a vital component of goal 17 - 'Partnerships for the goals' within the SDGs and countries in the global south has been utilizing this cooperation mainly in research. We report the first health care professional exchange program through this south-to-south collaboration focusing on advancing quality of abortion care in the Sub-Saharan region.

Methods: We conducted a comprehensive mixed method study, incorporating both quantitative and qualitative approaches, to assess the impact of health care professionals' exchange program within the obstetrics and gynecology departments of two teaching institutions in Ethiopia and Rwanda over the course of a year (February 1, 2023-January 31,2024).

When We Make Errors and Do Harm: A Narrative Review of Second Victim Syndrome and Implications for Neuro-Ophthalmologists.

Background: In the aftermath of an adverse event, the first priority is to provide care for the patient, known as the first victim. However, the experiences of healthcare professionals (HCPs) involved in these events, known as "second victims", have been largely overlooked. This review aims to consolidate existing knowledge on second victim syndrome (SVS), explore its unique implications for neuro-ophthalmologists, and suggest support strategies to increase awareness and meet the needs of affected colleagues.

From node to network: weaving a global perspective on efficacy and costs of non-pharmaceutical interventions.

Non-pharmaceutical intervention (NPI) policies, ranging from mild measures to total isolation, were implemented worldwide during the COVID-19 pandemic. We adopt a systematic approach to guide policymakers in deploying NPI policies to mitigate the pandemic's effects while balancing their social and economic impacts. Our results show that each NPI has an optimal duration, beyond which its effectiveness plateaus.

Genomics yields biological and phenotypic insights into bipolar disorder.

Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.