Dermatofibrosarcoma Protuberans, Version 1.2025, NCCN Clinical Practice Guidelines In Oncology.

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma and affects an estimated 1,500 people annually in the United States. DFSP frequently exhibits extensive local infiltration. Initial treatment is through surgical excision, and care should be taken to ensure that negative margins are achieved to minimize recurrence.

NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2025.

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria for selecting individuals for screening and offer recommendations for evaluating and managing lung nodules detected during initial and subsequent annual screening. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for Lung Cancer Screening.

Latent motor growth trajectories of term and preterm infants based on caregiver report.

Early motor development is a key predictor of development in other skill domains and specific neurodevelopmental disorders, but it is typically measured as achievement of milestones rather than rate of development. To explore the value of the latter approach, this study utilized a novel caregiver report method to examine differences in the developmental trajectory of motor development in term-born compared to preterm-born infants. Caregiver-infant dyads (331 term, 240 preterm) were followed from birth through 12 months (48% female; 6.

Implementation and sustainment of a clinical practice guideline in a physical therapy student-run pro bono clinic: a case report.

Background: The development of evidence-based practitioners is an expectation of entry-level physical therapist education. Knowledge translation is a process to enhance the uptake of evidence into clinical practice. Student run pro bono clinics provide an authentic learning environment in which knowledge translation activities can be used to implement clinical practice guidelines (CPGs).

Two-year outcomes using fast-acting sub-perception therapy for spinal cord stimulation: results of a real-world multicenter study in the United States.

Background: Fast-acting Sub-perception Therapy (FAST) is a novel spinal cord stimulation (SCS) modality delivering paresthesia-free pain relief. Our study evaluated the longer-term, real-world impact of FAST on chronic pain.

Research Design And Methods: As part of a multicenter, real-world, consecutive case series, we retrospectively identified patients who used FAST-SCS and analyzed their data.

A novel tool for assessing pediatric emergency care in low- and middle-income countries: a pilot study.

Background: Globally, most children seek emergency care at general rather than specialized pediatric emergency departments. There remains significant variation in the provision of pediatric emergency care, particularly in resource-constrained settings. The objective of this study is to pilot a self-assessment tool to evaluate pediatric emergency care capabilities in low- and middle-income country (LMIC) hospitals on the African Continent.

Fishhook Injuries and Antibiotic Prescribing Patterns: A Retrospective Analysis.

Introduction: Fishhook injuries are a common occurrence among anglers. There are no guidelines for prophylactic antibiotic use after fishhook removal. This study analyzed the management of embedded fishhooks, prophylactic antibiotic use, and complication rate at a Michigan county emergency department to observe whether antibiotic use changes patient outcome.

Hospital Involvement in Screening for and Addressing Patients' Health-Related Social Needs.

The number of hospitals screening patients for health-related social needs (HRSNs) has increased substantially in recent years, yet little is known about the extent to which hospitals invest in programs or strategies aimed at addressing identified needs. Using data from the 2022 American Hospital Association (AHA) Annual Survey for 2,468 non-federal general medical and surgical hospitals, this study explored screening rates and related interventions for eight HRSNs: housing, food insecurity, utilities, interpersonal violence, transportation, employment or income, education, and social isolation. Sample hospitals screened for an average of 6.

Cleft-Related Revision Procedures: Surgeon Perspectives on Shared Decision-Making and a Decision Aid Prototype.

Objective: Decision-making for elective cleft lip and nose revisions varies widely, from patient-led decisions to more paternalistic approaches. As these procedures incur additional scarring that may impact future interventions, patients should be equipped to participate in these surgical decisions. We thus developed a decision aid based on international standards, and to ensure methodologic rigor, we sought feedback from other surgeons regarding shared decision-making and potential barriers to adopting the decision aid.

Managing emotions in everyday life: Why a toolbox of strategies matters.

Emerging research indicates that people use multiple strategies to manage their emotions in everyday life. Yet, we know little about what these strategy combinations look like, how they function, or how individual differences influence these phenomena. We addressed these issues in two, 2-week daily diary studies performed during the height of the COVID-19 pandemic ( = 422; data collected April and September 2020).

Structural brain correlates of externalizing traits and symptoms in the IMAGEN sample.

The evidence supporting the presence of individual brain structure correlates of the externalizing spectrum (EXT) is sparse and mixed. To date, large-sample studies of brain-EXT relations have mainly found null to very small effects by focusing exclusively on either EXT-related personality traits (e.g.

Peer discrimination and diurnal cortisol output in a rural boarding school in China: Empirical findings and methodological considerations.

Adolescents' experiences of discrimination and their health consequences are understudied in non-Western cultures. Using data from 90 rural Chinese adolescents ( = 13.70; 49% female), this study examined cumulative and daily experiences of peer discrimination (based on socioeconomic status, gender, parental migration status, appearance, grades) and their associations with diurnal cortisol output.

Adolescent health and the intersectionality of ethnicity/race, sex, and sexual orientation: A national probability sample from the Adolescent Brain Cognitive Development study.

Although children with marginalized sociodemographic characteristics are exposed to increased health risk and disparities, there is a paucity of population-based research on health status of children occupying multiple social marginalities. The present study investigated implications of children's intersectional sociodemographic characteristics on health risk indicators. In this longitudinal cohort study, we used longitudinal data from the ongoing Adolescent Brain Cognitive Development study.

University of Michigan ends joint effort in China.

Republican lawmakers had criticized decades-old ties with Shanghai Jiao Tong University.

Self-Collected Testing for Sexually Transmitted Infections: A National Text Message Survey of Adolescents and Young Adults.

Purpose: We aimed to analyze adolescent and young adults' (AYAs) perspectives on using sexually transmitted infection (STI) self-collection kits to help guide the provision and implementation of accessible and confidential reproductive health-care services for those who experience the burden of STIs and STI-related morbidity.

Methods: We utilized MyVoice, a nationwide text message survey of AYAs, to pose 6 open-ended questions on their perceptions and use of STI self-collection kits. Two independent reviewers used inductive content analysis to develop a codebook and analyze responses, and a third settled any coding discrepancies through discussion to reach consensus.

Identification of novel phenolic inhibitors from traditional Chinese medicine against toxic α-synuclein aggregation via regulating phase separation.

Parkinson's disease (PD), a neurodegenerative disorder without cure, is characterized by the pathological aggregation of α-synuclein (α-Syn) in Lewy bodies. Classic deposition pathway and condensation pathway contribute to α-Syn aggregation, and liquid-liquid phase separation is the driving force for condensate formation, which subsequently undergo liquid-solid phase separation to form toxic fibrils. Traditional Chinese Medicine (TCM) has a long history in treating neurodegenerative disease, herein; we identified chemicals from herbs that inhibit α-Syn aggregation.

Dietary Inflammatory Score and Incident Heart Failure in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

Background: Inflammation plays a key role in the development of heart failure (HF), and diet is a known modifiable factor that modulates systemic inflammation. The dietary inflammatory score (DIS) is a tool to quantify the inflammatory components of diet. We sought to determine whether the DIS is associated with incident HF events.

Finerenone and new-onset diabetes in heart failure: a prespecified analysis of the FINEARTS-HF trial.

Background: Data on the effect of mineralocorticoid receptor antagonist therapy on HbA levels and new-onset diabetes are conflicting. We aimed to examine the effect of oral finerenone, compared with placebo, on incident diabetes in the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure (FINEARTS-HF) trial.

Methods: In this randomised, double-blind, placebo-controlled trial, 6001 participants with heart failure with New York Heart Association functional class II-IV, left ventricular ejection fraction 40% or higher, evidence of structural heart disease, and elevated N-terminal pro-B-type natriuretic peptide levels were randomly assigned to finerenone or placebo, administered orally.

Effects of warning information at medication initiation on deprescribing intentions in older adults: A hypothetical vignette.

Objectives: To explore to what degree providing patients warning information about the long-term risks of a medication would affect their subsequent desire to discontinue it.

Methods: We conducted a vignette-based online experiment in which participants aged ≥ 65 years from the United States were asked to imagine starting and subsequently stopping omeprazole. Participants were randomized to one of four vignettes about starting omeprazole (potential long-term harms or no harm information; OTC vs.

Opening the black box: Think Aloud as a method to study the spontaneous stream of consciousness.

Asking participants to Think Aloud is a common method for studying conscious experience, but it remains unclear whether this approach alters thought qualities-such as meta-awareness, rate of topic shifts, or the content of thoughts in task-absent conditions. To investigate this, we conducted two studies comparing thinking aloud to thinking silently. In Study 1, 111 participants alternated between 15-minute intervals of verbalizing and silently reflecting on their stream of consciousness in a counterbalanced design.

Mental illness and personal recovery: A narrative identity framework.

This article presents a metamorphic model to describe the manifold role of narrative identity, a person's internal life story, across the course of mental illness and personal recovery. First, early adversity and negative co-authoring may contribute to the development of a fragile life story, which itself may combine with life stressors to increase the likelihood of mental illness. Second, mental illness may negatively impact the development of narrative identity, which in turn may exacerbate the devastating effects of mental illness on daily functioning.

Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex.

Chromatin regulatory proteins are expressed broadly and assumed to exert the same intrinsic function across cell types. Here, we report that 14 chromatin regulators undergo evolutionary-conserved neuron-specific splicing events involving microexons. Among them are two components of a histone demethylase complex: LSD1 H3K4 demethylase and the H3K4me0-reader PHF21A.