3D Printing of Silicone Organogel Elastomers for Structured Soft Biomaterials.

Creating customizable soft medical implants and devices tailored to patient-specific anatomy represents a significant challenge in healthcare, requiring 3D-printable materials with viscoelastic properties similar to those of natural tissue, high adaptability, and biocompatibility. Here, we develop a family of silicone organogel inks for 3D printing of tunable soft biomaterials via direct ink writing (DIW). We have developed a set of ink formulations comprising photo-cross-linkable silicone polymers, silicone oil, and fumed silica nanoparticles to modify the rheological behavior of the inks, optimize their printability, and control the viscoelastic properties of the printed organogel materials.

The Moderating Effect of Social Skills and Social Support on the Association Between Poverty Ratio and Health Promotion Behaviors in Adolescence.

Eating and exercise habits established in adolescence are associated with immediate and long-term health outcomes. These habits may be influenced by adolescents' socioeconomic status (SES), such that low SES households often experience inequitable access to nutritious foods and opportunities for exercise. Emerging evidence suggests that social factors, such as social skills and social support may support adolescents' health behavior engagement.

Perceived barriers to neurodevelopmental follow-up among cardiac neurodevelopmental outcome collaborative institutional and affiliated members.

Objective: Neurodevelopmental follow-up programmes for children with CHD help identify neurodevelopmental impairments and support the delivery of recommended interventions. The Cardiac Neurodevelopmental Outcome Collaborative, Diversity, Equity, and Inclusion Special Interest Group surveyed members to assess perceived patient barriers to neurodevelopmental follow-up, previous diversity and inclusion education, and confidence in caring for historically marginalised populations.

Methods: A link to a Redcap online survey was emailed to Cardiac Neurodevelopmental Outcome Collaborative members on 23 April 2022, with 4 weeks given to complete.

Database of Nonaqueous Proton-Conducting Materials.

This work presents the assembly of 48 papers, representing 74 different compounds and blends, into a machine-readable database of nonaqueous proton-conducting materials. SMILES was used to encode the chemical structures of the molecules, and we tabulated the reported proton conductivity, proton diffusion coefficient, and material composition for a total of 3152 data points. The data spans a broad range of temperatures ranging from -70 to 260 °C.

Real-world insights from a cohort of approximately 2000 individuals who were analysed using a freely available next-generation sequencing anaemia screening programme.

Data from a large cohort of individuals referred for NGS testing evaluate the utility of next-generation sequencing in clinical practice for diagnosing hereditary haemolytic anaemias.

Real-World Effectiveness and Safety of Upadacitinib in Crohn's disease: A Multi-Centre Study.

Background: We aimed to describe the real-world effectiveness and safety of upadacitinib (UPA), an oral Janus kinase 1 inhibitor (JAKi) in patients with Crohn's disease (CD).

Methods: A retrospective analysis was conducted across nine centers in the United States, focusing on adults with CD treated with UPA 45 mg as induction therapy for active luminal disease. The co-primary endpoints were clinical remission at 12 weeks (Harvey Bradshaw Index ≤ 4 or absence of symptoms on physician's global assessment) and endoscopic remission at 6 months (SEMA-CD score of 0-1 or absence of ulcers).

A phase II study of multiparametric MR-guided high-dose response-adaptive radiotherapy with concurrent temozolomide in patients with newly diagnosed glioblastoma: Results from an interim analysis.

Background: Biologically-informed radiotherapy (RT) targeting an adversely prognostic hypercellular/hyperperfused imaging phenotype in patients with newly diagnosed glioblastoma (GBM) may improve outcomes by identifying emerging regions of treatment resistance associated with survival (OS), and is under investigation in an ongoing Phase II trial (XXX) of individualized, response-adaptive RT.

Methods: In this single-arm phase II study, patients with newly diagnosed GBM following resection undergo dose-intensified chemoradiation (chemoRT) targeting the residual hypercellular (TV, 2 SD above mean intensity contralateral normal brain) and hyperperfused tumor volume (TV, 1 SD above contralateral normal frontal lobe grey matter) identified using high b-value diffusion-weighted and dynamic contrast-enhanced perfusion MRI. The combination of TV and TV (TV/TV) is treated to 50 Gy in 20 fractions (2.

The Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Atrial Fibrillation Burden In Diabetic Patients.

Atrial Fibrillation (AF) and Type 2 Diabetes Mellitus (T2DM) are comorbid conditions associated with increased adverse outcomes. Recent evidence suggests that antidiabetic therapies such as sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 agonists (GLP1a) may influence the risk of AF and stroke differently. This study aims to compare the risk of new-onset AF and stroke in T2DM patients treated with SGLT2i versus GLP1a.

Cost as a barrier to eyeglasses in pediatric population: a cross-sectional survey analysis.

Eyeglasses are an essential medical device to maximize visual potential and learning in children. We surveyed parents and pediatric ophthalmologists regarding their perspectives on the cost of pediatric eyeglasses. Parents and ophthalmologists identified cost as a barrier to obtaining eyeglasses.

Orphan discipline and child neglect: An analysis from 48 countries.

Background: Orphans comprise a sizable sub-population of all children, and their status as orphans exposes them to many risk factors. Orphan exposure to violent discipline is poorly understood, as research on parents' disciplinary practices largely focuses on biological families. The little research that exists has found that orphans are at reduced risk of harsh discipline but fails to explain why.

Compound effects of drought and COVID-19 on soybean production in Brazil: Challenges and policy responses.

This study investigates the cumulative and interactive impacts of drought and COVID-19 on soybean production in Brazil, focusing on cascading economic and operational disruptions. The country has faced numerous drought events in recent years (1989 to 2022), culminating with one in 2022 that, together with the occurrence of COVID-19, led to the highest decline in soybean production since 1990 (10.5 % of the total national production).

Erasable hippocampal neural signatures predict memory discrimination.

Memories involving the hippocampus can take several days to consolidate, challenging efforts to uncover the neuronal signatures underlying this process. Here, we use calcium imaging in freely moving mice to track the hippocampal dynamics underlying memory consolidation across a 10-day contextual fear conditioning task. We find two neural signatures that emerge following learning and predict memory performance: context-specific place field remapping and coordinated neural activity prior to memory recall (freezing).

Early Childhood Nutrition-Related Policy, System, and Environmental-Focused Evaluation: A Qualitative Study Exploring Knowledge, Barriers, and Opportunities.

Objective: To explore stakeholders' perceptions of the barriers, facilitators, and existing needs associated with evaluating policy, system, and environmental (PSE) strategies focused on early childhood nutrition within Supplemental Nutrition Assistance Program-Education (SNAP-Ed) programming using the Capabilities, Opportunities, and Motivations of Behavior Model.

Methods: Stakeholders (n = 32) implementing and evaluating SNAP-Ed-approved PSE nutrition-related strategies across the US participated in virtual semistructured interviews. Audio transcripts were deidentified, coded, and analyzed manually by 2 research assistants using thematic analysis with a hybrid deductive and inductive coding approach.

Maternal epigenetic index links early neglect to later neglectful care and other psychopathological, cognitive, and bonding effects.

Background: Past experiences of maltreatment and life adversity induce DNA methylation changes in adults, but less is known about their impact on mothers' maladaptive neglectful parenting and its negative effects. We performed an epigenome-wide association study to investigate the role of DNA methylation levels in mothers with neglectful care, who were exposed to childhood maltreatment and neglect, and their current negative effects. Saliva DNA methylation was determined with the Illumina Human Methylation EPIC BeadChip v1.

Prenatal PFAS exposures and cardiometabolic health in middle childhood in the MIREC cohort.

Studies on prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and cardiometabolic health in childhood have produced inconsistent results. In this study, we evaluated associations between prenatal PFAS exposures, individually and as a mixture, and cardiometabolic outcomes including insulin resistance, beta cell function, blood lipids, blood pressure and central adiposity during middle childhood (7-9 years of age) in a Canadian maternal-child cohort (n = 281). We also explored effect measure modification based on child sex and physical activity.

Management Variation in Pediatric Labial Adhesions: A Retrospective Cohort Study.

Objective: To compare treatment and outcome differences between primary care providers (PCP), pediatric and adolescent gynecologists (PAG), and pediatric urologists (PUR) in management of labial adhesions (LA).

Study Design: This was a retrospective, cohort study of patients aged 0 through 21 presenting for a clinic visit from July 2022 to July 2023 at a single institution, identified by ICD-9/ICD-10 codes for LA. Management variation was analyzed via cross-tabs with chi-square, Fisher's exact, and two-sample t-tests.

A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue.

Lighting interventions can mitigate fatigue by promoting circadian rhythmicity. We test whether individualized, wearable-based lighting interventions delivered via a mobile app reduce cancer-related fatigue in a randomized controlled trial with 138 breast cancer, prostate cancer, and hematopoietic stem cell transplant patients. Participants are randomized to tailored lighting intervention or control.

A clinical study on the evaluation of rehabilitation outcomes in patients with deep hand burns using hand strength monitoring.

Background: To provide reference for hand function assessment and treatment effectiveness by measuring changes in muscle strength before and after rehabilitation in patients with deep hand burns.

Methods: Clinical data from 112 patients with deep right hand burns treated at the Third Affiliated Hospital of Inner Mongolia Medical University were collected. Passive Functional Training: hand training was conducted using the continuous passive motion system, once daily for 40 minutes each session.

The vaccine dosing effect overcomes the reduced immunogenic potential and in vivo efficacy of 33F pneumococcal serotype.

Serotype 33F is an emerging Streptococcus pneumoniae (Spn) serotype associated with asymptomatic nasopharyngeal (NP) colonization and invasive pneumococcal disease (IPD). Serotype 33F is a component in the advanced version of the pneumococcal conjugate vaccine 15 (PCV 15) formulation. However, in the murine vaccination model, serotype 33F exhibits reduced immunogenicity, correlating with reduced protection against 33F.

Association of opioid utilization in the intensive care unit and opioid prescriptions at hospital discharge in opioid-naïve non-surgical patients who received enhanced oxygen therapy.

Purpose: To evaluate the association between opioid utilization in community-based intensive care units and the continuation of opioid prescriptions at hospital discharge for non-surgical, opioid-naïve patients.

Materials And Methods: This nested case-control study included adults without opioid prescriptions 45 days before hospital admission who had intensive care unit stays of 48 h or longer and received enhanced oxygen therapy. Patients were excluded if they had opioid allergies, cancer, in-hospital death, palliative care, major surgery, or substance use disorders.