L. modulates altered metabolic pathways involved in key metabolisms in human breast cancer (MCF-7) cells: A metabolomics study.

The present study investigated the ability of leaves infusion (CSI) to modulate major metabolisms implicated in cancer cells survival, as well as to induce cell death in human breast cancer (MCF-7) cells. MCF-7 cell lines were treated with CSI for 48 h, doxorubicin served as the standard anticancer drug, while untreated MCF-7 cells served as the control. CSI caused 21.

Application of neural networks and neuro-fuzzy models in construction scheduling.

Construction scheduling is a complex process that involves a large number of variables, making it difficult to develop accurate and efficient schedules. Traditional scheduling techniques rely on manual analysis and intuition, which are prone to errors and often fail to account for all the variables involved. This results in project delays, cost overruns, and poor project performance.

Big Things, Small Packages: An Update on Microalgae as Sustainable Sources of Nutraceutical Peptides for Promoting Cardiovascular Health.

In 2017, a review of microalgae protein-derived bioactive peptides relevant in cardiovascular disease (CVD) management was published. Given the rapid evolution of the field, an update is needed to illumininate recent developments and proffer future suggestions. In this review, the scientific literature (2018-2022) is mined for that purpose and the relevant properties of the identified peptides related to CVD are discussed.

Flour nutritional profile, and soxhlet-extracted oil physicochemical breakdown-storage performance of white melon (Cucumeropsis mannii Naudin) seed varieties from Southeast Nigeria.

White melon (Cucumeropsis mannii Naudin), is among common and yet underutilized oil seed crop within the West African region, does not have sufficient information specific to its nutrient composition for foreign consumers. To supplement existing information, therefore, we investigated the nutritional profile of defatted and full-fat flour, alongside physicochemical breakdown and storage performance of soxhlet-extracted oil from two white melon (C. mannii) seed varieties found in Southeast Nigeria.

Zinc oxide nanoparticles adsorb emerging pollutants (glyphosate pesticide) from aqueous solutions.

The present study captures the precipitation synthesis of zinc nanoparticles and modification with alumina and oleic acid. The crystalline size evaluated from the XRD profile of the zinc oxide nanoparticles was 18.05 nm but was reduced to 14.

Haematological and biochemical toxicity in freshwater fish Clarias gariepinus and Oreochromis niloticus following pulse exposure to atrazine, mancozeb, chlorpyrifos, lambda-cyhalothrin, and their combination.

Transient exposures to high or low concentrations of a single or mixture of pesticides are common in aquatic organisms. Routine toxicity tests disregard transient exposures and the influence of time when examining the toxicity of contaminants. This study investigated the haematological and biochemical responses of juvenile C.

Germinated Bambara groundnut (Vigna subterranea) flour as an ingredient in wheat bread: Physicochemical, nutritional, and sensory properties of bread.

Wheat flour (WF) was substituted with germinated Bambara groundnut (Vigna subterranea) flour (GBF) at different proportions (5%, 10%, 15%, 20%, 25%, and 30%) and used in the preparation of bread. The dough mixing, pasting, and gelatinization properties of the blends were evaluated as well as the nutritional quality, in vitro starch digestibility, phytochemical constituents, antioxidant potential, color, texture, and sensory properties of breads. All the wheat dough containing GBF had higher water absorption capacity, gelatinization temperatures, dough development time, low peak, and setback viscosities.

Quantum and experimental investigation of the application of Crassostrea gasar (mangrove oyster) shell-based CaO nanoparticles as adsorbent and photocatalyst for the removal of procaine penicillin from aqueous solution.

The present study was designed to synthesize and characterize calcium oxide nanoparticles (using mangrove oyster shell as a precursor) and apply the synthesized nanoparticles as a photocatalyst to degrade procaine penicillin in an aqueous solution. The photocatalyst exhibited an average band gap of 4.42 eV, showed a maximum wavelength of absorbance in the UV region (i.

Mathematical modeling and numerical simulation technique for selected heavy metal transport in MSW dumpsite.

The study focused on development of mathematical modeling and numerical simulation technique for selected heavy metal transport in Uyo municipal solid waste dumpsite in Akwa Ibom State to investigate the level in depth to which leachate from the dumpsite extends and the quantity of leachate at various depth of the dumpsite soil. Uyo waste dumpsite is operating open dumping system where provisions are not made for preservation and conservation of soil and water quality, hence, the need for this study. Three monitoring pits within Uyo waste dumpsite were constructed and infiltration runs were measured, and soil samples were collected beside infiltration points from nine designated depths ranging from 0 to 0.

Detection of Selected Canine Viruses in Nigerian Free-Ranging Dogs Traded for Meat Consumption.

Animal trade favors the spreading of emerging and re-emerging pathogens. Concerns have been previously expressed regarding the risks of dog trade in spreading zoonotic pathogens in Nigeria. However, the role of these dogs in disseminating highly pathogenic canine viruses has not yet been explored.

Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins.

The challenges posed by COVID-19's emergence have led to a search for its therapies. There is no cure for COVID-19 infection yet, but there is significant progress in vaccine formulation for prophylaxis and drug development (such as Paxlovid) for high-risk patients. As a contribution to the ongoing quest for solutions, this study shows potent phytocompounds identification as inhibitors of SARS-CoV-2 targets using in silico methods.

Extensive overview of soil constitutive relations and applications for geotechnical engineering problems.

A state-of-the-art review has been conducted in this work on soil constitutive modeling, which has emphasized on: soil type, ground-water conditions, loading conditions, structural behavior, constitutive relation discipline, and dimensions. By extension also, the soil constitutive applications were reviewed on the bases of: single discipline dealing with soil mechanical properties constitutive modeling which included slope stability problems, bearing capacity, settlement of foundations, earth pressure problems, soil dynamics, soil structure interaction, thermal and hydrological conditions; bi-discipline (coupled problems) which solve problems related to thermomechanical (freeze/thaw conditions), smoothed particle hydrodynamics (SPH) and hydromechanical (consolidation, collapse and liquefaction) conditions in soils and rocks and multi-discipline constitutive models which solve complex problems related to thermo-hydromechanical (THM) conditions in soils and rocks. This work has shown that smoothed particle hydrodynamics (SPH) and hydromechanical (HM) models, which belong to bi-discipline or coupled conditions are better suited for geotechnical applications, generally, while thermo-hydromechanical (THM) models, which belong to multi-discipline are better suited to solving freeze/thaw and thermal piles problems and these are proven with high performance and flexibility.

Community burden of intestinal parasites and its public health concerns in Obizi, Amakama Olokoro, Umuahia South, Abia State, Nigeria.

Intestinal parasitic infections are the leading cause of morbidity and mortality in sub-Saharan Africa. This could be due to the dominance of factors such as poverty, poor hygiene, and the absence of basic infrastructures. The migration of people from parasite endemic regions due to insecurity has caused public health concerns.

Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice.

Metabolic and mood-related disturbances can increase the risks of developing adverse mental health problems. The medicinal mushroom, Ganoderma lucidum, is utilized in indigenous medicine to improve quality of life, promote health, and boost vitality. This study investigated the effects of Ganoderma lucidum ethanol extract (EEGL) on feeding behavioral parameters, depressive-like symptoms, and motor activity in Swiss mice.

Drying kinetics and thermo-economic analysis of drying hot water blanched ginger rhizomes in a hybrid composite solar dryer with heat exchanger.

This research aimed to examine the need of adding hot water blanching pre-treatment on the drying of ginger rhizomes using a hybrid solar-dryer with paraffin liquid as thermal storage infused into a copper tube to form a compact heat exchanger. Blanching duration quickened the drying rate of the ginger rhizomes and the average drying rate for blanching at 90 s, 60 s, 30 s and un-blanched ginger varied between 0.0147 kg/h to 0.

Evaluation of sisal fiber and aluminum waste concrete blend for sustainable construction using adaptive neuro-fuzzy inference system.

This research study presents evaluation of aluminum waste-sisal fiber concrete's mechanical properties using adaptive neuro-fuzzy inference system (ANFIS) to achieve sustainable and eco-efficient engineering works. The deployment of artificial intelligence (AI) tools enables the optimization of building materials combined with admixtures to create durable engineering designs and eliminate the drawbacks encountered in trial-and-error or empirical method. The features of the cement-AW blend's setting time were evaluated in the laboratory and the results revealed that 0-50% of aluminum-waste (AW) inclusion increased both the initial and final setting time from 51-165 min and 585-795 min respectively.

Efficient class of ratio cum median estimators for estimating the population median.

In estimation theory, the use of auxiliary information significantly improves precision while estimating population parameters. In this paper, an efficient class of ratio cum median estimators of the population median is suggested using simple random sampling without replacement. The expressions for bias and mean square error of the proposed class are derived theoretically.

Evaluation and remediation protocol of selected organochlorine pesticides and heavy metals in industrial wastewater using nanoparticles (NPs) in Nigeria.

Limited knowledge of the level of contaminants in industrial wastewater within the Nigerian states together with the global challenge of water supply have compelled our investigation into the analyses and removal of organochlorine pesticides (OCPs) and heavy metal contents in industrial wastewater. Wastewater samples were collected from 13 industries across five states in Nigeria. The OCPs content of the samples was extracted, cleaned up and analysed using gas chromatography-mass spectrometry.

Ecological and health risk assessment of heavy metals: a case study of residential waste sites in Umuahia, South-East Nigeria.

This study assessed the human health hazards and ecological risks of heavy metals from waste sites in residential vicinity. The heavy metals analyzed were Cr, Pb, Cd, Ni, Cu, and Zn. A total of 40 soil samples were collected from waste sites in two residential estates located in the urban and suburb areas of Umuahia, Abia state.

Effect of citrus-coconut electrolyte blend on growth performance, haemato-biochemical status, organs development and intestinal morphology of broiler chickens.

Introduction: In a bid to mitigate growing concerns regarding the use of antibiotics in food animals OBJECTIVES: This study determined the growth performance, haemato-biochemical status, organ development and intestinal morphology of Arbor Acre broiler chicken strain on oral administration of citrus-coconut electrolyte blend (CCEB) for 26 days.

Methods: One-hundred ninety-two chicks were brooded for 2 weeks and thereafter divided on a weight equalization basis into four groups (0, 5, 10 and 15 ml CCEB per litre of water) of six replicates each and eight birds per replicate. Phytochemical screening of CCEB was determined, while data collected for growth performance, organ proportions and intestinal morphology were subjected to a one-way analysis of variance.

Scheffe's Simplex Optimization of Flexural Strength of Quarry Dust and Sawdust Ash Pervious Concrete for Sustainable Pavement Construction.

Pervious concrete provides a tailored surface course with high permeability properties which permit the easy flow of water through a larger interconnected porous structure to prevent flooding hazards. This paper reports the modeling of the flexural properties of quarry dust (QD) and sawdust ash (SDA) blended green pervious concrete for sustainable road pavement construction using Scheffe's (5,2) optimization approach. The simplex mixture design method was adapted to formulate the mixture proportion to eliminate the set-backs encountered in empirical or trials and the error design approach, which consume more time and resources to design with experimental runs required to evaluate the response function.

Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications.

The global prevalence of diabetes continues to increase partly due to rapid urbanization and an increase in the aging population. Consequently, this is associated with a parallel increase in the prevalence of diabetic vascular complications which significantly worsen the burden of diabetes. For these diabetic vascular complications, there is still an unmet need for safe and effective alternative/adjuvant therapeutic interventions.

Soil organic carbon, total nitrogen stocks and CO emissions in top- and subsoils with contrasting management regimes in semi-arid environments.

This study aims to investigate soil organic carbon (SOC) and total nitrogen (TN) contents and stocks, CO emissions and selected soil properties in croplands, grazing lands, exclosures and forest lands of semi-arid Ethiopia. Sampling was done at 0-30, 30-60 and 60-90 cm soil depths and concentration and stocks of SOC, TN and selected soil properties were determined using standard routine laboratory procedures. There were variations in distribution of SOC and TN stock over 90 cm depth across land use types and locations, decreasing from topsoils to subsoil, with average values ranging from 48.

A model for analyzing evolutions of neurons by using EEG waves.

It is known that differences between potentials of soma, dendrites and different parts of neural structures may be the origin of electroencephalogram (EEG) waves. These potentials may be produced by some excitatory synapses and currents of charges between neurons and then thereafter may themselves cause the emergence of new synapses and electrical currents. These currents within and between neurons emit some electromagnetic waves which could be absorbed by electrodes on the scalp, and form topographic images.