218 results match your criteria: "Michael G. DeGroote Institute for Pain Research and Care.[Affiliation]"
Comparative Effectiveness of Phosphate Binders in Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis.
PLoS One
July 2017
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) has been linked to poor health outcomes, including diminished quality and length of life. This condition is characterized by high phosphate levels and requires phosphate-lowering agents-phosphate binders. The objective of this systematic review is to compare the effects of available phosphate binders on patient-important outcomes in patients with CKD-MBD.
View Article and Find Full Text PDFBrazilian oral herbal medication for osteoarthritis: a systematic review protocol.
Syst Rev
May 2016
Department of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, São Paulo, Brazil.
Background: Osteoarthritis affects 1 % of the world's population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to systematically review the efficacy and safety of 13 oral herbal medications used in Brazil for the treatment of osteoarthritis.
View Article and Find Full Text PDFGlucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: systematic review and meta-analysis of randomized and observational studies.
BMC Cardiovasc Disord
May 2016
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 37 GuoXue Xiang, Chengdu, 610041, Sichuan, China.
Background: The effect of glucagon-like peptide-1(GLP-1) receptor agonists on heart failure remains uncertain. We therefore conducted a systematic review to assess the possible impact of GLP-1 agonists on heart failure or hospitalization for heart failure in patients with type 2 diabetes.
Methods: We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.
Tumour-Derived Glutamate: Linking Aberrant Cancer Cell Metabolism to Peripheral Sensory Pain Pathways.
Curr Neuropharmacol
January 2018
Department of Pathology and Molecular Medicine; Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON. Canada.
Background: Chronic pain is a major symptom that develops in cancer patients, most commonly emerging during advanced stages of the disease. The nature of cancer-induced pain is complex, and the efficacy of current therapeutic interventions is restricted by the dose-limiting sideeffects that accompany common centrally targeted analgesics.
Methods: This review focuses on how up-regulated glutamate production and export by the tumour converge at peripheral afferent nerve terminals to transmit nociceptive signals through the transient receptor cation channel, TRPV1, thereby initiating central sensitization in response to peripheral disease-mediated stimuli.
Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and meta-analysis.
Ren Fail
July 2016
a Department of Clinical Epidemiology and Biostatistics , McMaster University, Hamilton , Ontario , Canada ;
Background: Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate restricted diet, vitamin D and phosphate binders. Persistently elevated parathyroid hormone levels may require the addition of cinacalcet hydrochloride (cinacalcet), which sensitizes calcium receptors in the parathyroid gland.
View Article and Find Full Text PDFDifferences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain.
Mol Pain
December 2016
Michael G. DeGroote Institute for Pain Research and Care, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Background: Bone cancer pain is often severe, yet little is known about mechanisms generating this type of chronic pain. While previous studies have identified functional alterations in peripheral sensory neurons that correlate with bone tumours, none has provided direct evidence correlating behavioural nociceptive responses with properties of sensory neurons in an intact bone cancer model.
Results: In a rat model of prostate cancer-induced bone pain, we confirmed tactile hypersensitivity using the von Frey test.
Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studies.
BMJ
February 2016
Chinese Evidence-based Medicine Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
Objectives: To examine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and the risk of heart failure or hospital admission for heart failure in patients with type 2 diabetes.
Design: Systematic review and meta-analysis of randomised and observational studies.
Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.
Long-term Impact of Mode of Delivery on Stress Urinary Incontinence and Urgency Urinary Incontinence: A Systematic Review and Meta-analysis.
Eur Urol
July 2016
Departments of Urology and Public Health, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:
Context: Stress urinary incontinence (SUI) and urgency urinary incontinence (UUI) are associated with physical and psychological morbidity, and large societal costs. The long-term effects of delivery modes on each kind of incontinence remain uncertain.
Objective: To investigate the long-term impact of delivery mode on SUI and UUI.
Does preoperative rehabilitation for patients planning to undergo joint replacement surgery improve outcomes? A systematic review and meta-analysis of randomised controlled trials.
BMJ Open
February 2016
Centre for Medical Evidence, Decision Integrity and Clinical Impact (MEDICI), University of Western Ontario, London, Ontario, Canada Department of Anesthesia & Perioperative Medicine, University of Western Ontario, London, Ontario, Canada Department of Epidemiology & Biostatistics, University of Western Ontario, London, Ontario, Canada.
Objectives: The clinical impact of preoperative physiotherapy on recovery after joint replacement remains controversial. This systematic review aimed to assess the clinical impact of prehabilitation before joint replacement.
Design: We searched PubMed, Embase and Cochrane CENTRAL up to November 2015 for randomised controlled trials comparing prehabilitation versus no prehabilitation before joint replacement surgery.
Local anesthetic injections with or without steroid for chronic non-cancer pain: a protocol for a systematic review and meta-analysis of randomized controlled trials.
Syst Rev
February 2016
Department of Anesthesia, McMaster University, St. Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6, Canada.
Background: Steroids are often combined with local anesthetic (LA) and injected to reduce pain associated with various chronic non-cancer pain (CNCP) complaints. The biological rationale behind injection of a steroid solution is unclear, and it is uncertain whether the addition of steroids offers any additional benefits over injection of LA alone. We propose to conduct a systematic review and meta-analysis to summarize the evidence for using steroids and LA vs.
View Article and Find Full Text PDFPreoperative celecoxib in noncardiac surgery: A systematic review and meta-analysis of randomised controlled trials.
Eur J Anaesthesiol
March 2016
From the Department of Anaesthesia, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (JSK, CM, SC), Department of Clinical Epidemiology and Biostatistics, McMaster University (JSK, PJD), Population Health Research Institute (JSK, PJD), Michael G. DeGroote Institute for Pain Research and Care (JSK), Department of Medicine, McMaster University, Hamilton (PJD), Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto (HC), and McMaster University, Hamilton, Canada (AM).
Background: Postoperative pain continues to be undertreated after noncardiac surgery. Preoperative analgesic administration may enhance postoperative analgesia.
Objective: To determine the effects of preoperative administration of celecoxib in noncardiac surgery on pain and postoperative outcomes.
Cinacalcet versus standard treatment for chronic kidney disease: a protocol for a systematic review and meta-analysis.
Syst Rev
January 2016
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
Background: Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate-restricted diet, active vitamin D, vitamin D analogs, and phosphate binders. Persistently elevated parathyroid hormone (PTH) levels may require the addition of Cinacalcet hydrochloride (cinacalcet) which sensitizes calcium receptors on the parathyroid glands.
View Article and Find Full Text PDFReporting missing participant data in randomised trials: systematic survey of the methodological literature and a proposed guide.
BMJ Open
December 2015
Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Objectives: We conducted a systematic survey of the methodological literature to identify recommended approaches for how and what randomised clinical trial (RCT) authors should report on missing participant data and, on the basis of these approaches, to propose guidance for RCT authors.
Methods: We defined missing participant data (MPD) as missing outcome data for trial participants. We considered both categorical and continuous outcome data.
Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials.
Can J Anaesth
March 2016
Centre for Medical Evidence, Decision Integrity and Clinical Impact (MEDICI), Western University, London, ON, Canada.
Purpose: To determine whether ketamine added to morphine or hydromorphone patient-controlled analgesia (PCA) provides clinically relevant reductions in postoperative pain, opioid requirements, and adverse events when compared with morphine or hydromorphone PCA in adults undergoing surgery.
Source: We systematically searched six databases up to June 2, 2015 for randomized controlled trials (RCTs) comparing ketamine plus morphine/hydromorphone PCA vs morphine/hydromorphone PCA for postoperative pain in adults.
Principal Findings: Thirty-six RCTs including 2,502 patients proved eligible, and 22 of these were at low risk of bias.
Planning and reporting of quality-of-life outcomes in cancer trials.
Ann Oncol
January 2016
Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital of Basel, Switzerland Department of Oncology, University Hospital of Basel, Switzerland Department of Medical Oncology, Royal Marsden Hospital, London, UK.
Systematic reviews experience major limitations in reporting absolute effects.
J Clin Epidemiol
April 2016
Department of Clinical Epidemiology & Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada; Department of Medicine, McMaster University, 1280 Main St W, Hamilton, Ontario L8S 4L8, Canada.
Objectives: Expressing treatment effects in relative terms yields larger numbers than expressions in absolute terms, affecting the judgment of the clinicians and patients regarding the treatment options. It is uncertain how authors of systematic reviews (SRs) absolute effect estimates are reported in. We therefore undertook a systematic survey to identify and describe the reporting and methods for calculating absolute effect estimates in SRs.
View Article and Find Full Text PDFCharacteristics of patients receiving long-term opioid therapy for chronic noncancer pain: a cross-sectional survey of patients attending the Pain Management Centre at Hamilton General Hospital, Hamilton, Ontario.
CMAJ Open
October 2015
Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ont. ; Department of Anesthesia, McMaster University, Hamilton, Ont.
Background: Characteristics of patients receiving long-term opioid therapy (≥ 6 months) for chronic noncancer pain are poorly understood. We conducted a cross-sectional survey of this patient population to explore demographic variables, pain relief, functional improvement, adverse effects and impressions of an educational pamphlet on long-term opioid therapy.
Methods: We invited 260 adult patients presenting to the Pain Management Centre at the Hamilton General Hospital, Hamilton, Ontario, with chronic noncancer pain to complete a 20-item survey.
Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey.
BMJ Open
September 2015
Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau-CIBER of Epidemiology and Public Health (CIBERESP- IIB Sant Pau), Barcelona, Spain.
Objectives: To describe how systematic reviewers are reporting missing data for dichotomous outcomes, handling them in the analysis and assessing the risk of associated bias.
Methods: We searched MEDLINE and the Cochrane Database of Systematic Reviews for systematic reviews of randomised trials published in 2010, and reporting a meta-analysis of a dichotomous outcome. We randomly selected 98 Cochrane and 104 non-Cochrane systematic reviews.
Current State of Reporting Pain Outcomes in Cochrane Reviews of Chronic Musculoskeletal Pain Conditions and Considerations for an OMERACT Research Agenda.
J Rheumatol
October 2015
From the Ottawa Hospital Research Institute, Centre for Practice-Changing Research, Ottawa, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa and Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Canada; SDG LLC Cambridge, MA, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; University of Ottawa; Institute of Population Health, University of Ottawa, Ottawa; Institute for Work & Health, Toronto, Canada; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Anesthesia, Department of Clinical Epidemiology and Biostatistics, and the Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Canada; Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Quintiles, Inc., Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland; University Hospital Carl Gustav Carus, Dresden, Germany; University of Washington, Seattle, WA, USA; Department of Health Sciences (VU University) and Department of Epidemiology and Biostatistics (VU University Medical Centre) of the EMGO Institute for Health and Care Research, Amsterdam, The Netherlands; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Laboratory for Pain Research, University of Split School of Medicine, Split, Croatia; Birmingham Veterans Affairs Medical Center and University of Alabama at Birmingham, Birmingham, AL, USA; Division Immunology/Rheumatology Stanford University School of Medicine, Palo Alto, CA, USA; Institute of Infection and Immunity, Cardiff University, Cardiff, UK; Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands; University of Ottawa, Department of Medicine, Faculty of Medicine, Ottawa Hospital Research Institute; Clinical Epidemiology Program, University of Ottawa and School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa; Faculty of Medicine, Institute of Population Health, Ottawa, Canada.
Objective: To assess the current state of reporting of pain outcomes in Cochrane reviews on chronic musculoskeletal painful conditions and to elicit opinions of patients, healthcare practitioners, and methodologists on presenting pain outcomes to patients, clinicians, and policymakers.
Methods: We identified all reviews in the Cochrane Library of chronic musculoskeletal pain conditions from Cochrane review groups (Back, Musculoskeletal, and Pain, Palliative, and Supportive Care) that contained a summary of findings (SoF) table. We extracted data on reported pain domains and instruments and conducted a survey and interviews on considerations for SoF tables (e.
Management of Central Poststroke Pain: Systematic Review of Randomized Controlled Trials.
Stroke
October 2015
From the Departments of Clinical Epidemiology and Biostatistics (S.M.M., R.K., Z.I., L.T., G.H.G., J.W.B.), Anesthesia (D.N.B., L.T., J.W.B.), Medicine (A.P., G.H.G.), and Pediatrics (L.T.) and Michael G. DeGroote Institute for Pain Research and Care (L.W., R.C., D.N.B., A.P., S.M.K., J.W.B.), McMaster University, Hamilton, Ontario, Canada; Outcomes Research Consortium, Cleveland, OH (S.M.M.); Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (A.A.); Departments of Clinical Neurological Sciences and Oncology, Western University, London, Ontario, Canada (D.E.M.); Department of Outcomes Research, Cleveland Clinic, OH (A.T., D.I.S.); and Knowledge and Evaluation Research Unit, Divisions of Endocrinology and Diabetes, and Health Care and Policy Research, Mayo Clinic, Rochester, MN (V.M.M.).
Background And Purpose: Central poststroke pain is a chronic neuropathic disorder that follows a stroke. Current research on its management is limited, and no review has evaluated all therapies for central poststroke pain.
Methods: We conducted a systematic review of randomized controlled trials to evaluate therapies for central poststroke pain.
Association of worker characteristics and early reimbursement for physical therapy, chiropractic and opioid prescriptions with workers' compensation claim duration, for cases of acute low back pain: an observational cohort study.
BMJ Open
August 2015
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Objective: To assess the association between early reimbursement for physiotherapy, chiropractic and opioid prescriptions for acute low back pain (LBP) with disability claim duration.
Design: Observational cohort study.
Setting And Participants: From a random sample of 6665 claims for acute, uncomplicated LBP approved by the Ontario Workplace Safety and Insurance Board (WSIB) in 2005, we analysed 1442 who remained on full benefits at 4 weeks after claim approval.
Attitudes towards evaluation of psychiatric disability claims: a survey of Swiss stakeholders.
Swiss Med Wkly
March 2016
Swiss Academy of Insurance Medicine, University of Basel Hospital, Basel, Switzerland.
Questions: In Switzerland, evaluation of work capacity in individuals with mental disorders has come under criticism. We surveyed stakeholders about their concerns and expectations of the current claim process.
Methods: We conducted a nationwide online survey among five stakeholder groups.
Depressive-like behaviours and decreased dendritic branching in the medial prefrontal cortex of mice with tumors: A novel validated model of cancer-induced depression.
Behav Brain Res
November 2015
Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address:
Depression is commonly comorbid in cancer patients and has detrimental effects on disease progression. Evidence suggests that biological mechanisms may induce the onset of cancer-induced depression (CID). The present investigation aims to establish a validated preclinical animal model of CID.
View Article and Find Full Text PDFOPTIMa Review Suffered From High Risk of Selection Bias, and Misinterpreted Prior Findings.
Clin J Pain
December 2015
Departments of *Clinical Epidemiology and Biostatistics †Anesthesia ∥The Michael G. DeGroote Institute for Pain Research and Care #Faculty of Medicine, McMaster University, Hamilton §Department of Anaesthesia & Pain Medicine, Hospital for Sick Children ¶Department of Trauma and Orthopaedics University Health Network,Toronto, ON, Canada ‡Meta-Research Innovation Center at Stanford, Stanford University, Stanford, CA.
Reporting of IMMPACT-recommended core outcome domains among trials assessing opioids for chronic non-cancer pain.
Pain
September 2015
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Outcomes Research Consortium, Cleveland, OH, USA Faculty of Science, McMaster University, Hamilton, ON, Canada Pharmaceutical Sciences Postgraduate Course, University of Sorocaba, Sao Paulo, Brazil Swiss Academy of Insurance Medicine, University Hospital Basel, Basel, Switzerland Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland Department of Family Medicine, McMaster University, Hamilton, ON, Canada Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway Accident and Emergency Department, Tseung Kwan O Hospital, Hong Kong, China Accident and Emergency Department, Tuen Mun Hospital, Hong Kong, China Department of Anesthesia, McMaster University, Hamilton, ON, Canada Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, CA, USA Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Department of Anesthesia, University of Calgary, Calgary, AB, Canada Department of Dentistry, Santo Tomas University, Bogota, Colombia Department of Anesthesia, University Hospital Basel, Basel, Switzerland Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON, Canada Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA Department of Medicine, McMaster University, Hamilton, ON, Canada.
The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) has recommended that trialists evaluating treatments for chronic pain should consider reporting 9 patient-important outcome domains. We examined the extent to which clinical trials evaluating the effect of opioids for chronic non-cancer pain (CNCP) report outcome domains recommended by IMMPACT. We systematically searched electronic databases for English-language studies that randomized patients with CNCP to receive an opioid or a non-opioid control.
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