25 results match your criteria: "Mianyang People's Hospital[Affiliation]"

Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on both individuals and society. The hallmark of presbycusis is a progressive decrease in auditory sensitivity. Irreversible hearing loss occurs due to the limited regenerative capacity of spiral neurons and peripheral cochlear hair cells (HCs).

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This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described.

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Article Synopsis
  • The study investigates the diagnostic significance of CT scan indicators for patients with stable COPD in a plateau region of China, aiming to link these indicators to lung function and symptoms.
  • A total of 106 participants, including 53 COPD patients and 53 healthy individuals, underwent lung function tests, chest CT scans, and symptom assessments during the research period.
  • Key findings reveal that specific CT indicators (%LAA-950, WA%, TDR) were higher in the COPD group, which correlated negatively with lung function and positively with symptoms and acute exacerbations, indicating their potential role in diagnosing COPD in high-altitude areas.
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Interventional chemotherapy is a common operation in the clinical treatment of liver cancer. The aim of this study was to investigate the expression and molecular mechanism of serum miR-4746-5p in liver cancer patients before and after interventional chemotherapy. The levels of miR-4746-5p and CDKN1C in serum samples from liver cancer patients were detected using real-time fluorescence quantitative polymerase chain reaction.

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Purpose: To innovatively use the FOCUS-PDCA quality improvement strategy to establish an external quality assessment (EQA) working group to continuously improve EQA performance, an important indicator of the national tertiary public hospital performance appraisal.

Methods: The project was carried out at the National Center for Clinical Laboratories. Using FOCUS-PDCA, which combines problem-focused steps (FOCUS) and improvement steps (PDCA), a project team was established to carry out improvement work.

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In addition to hemostasis and coagulation, years of studies have proved that platelets are involved in the whole process of tumor progression, including tumor invasion, intravasation, extravasation, and so on. It means that this property of platelets can be used in anti-tumor therapy. However, traditional platelet-based antitumor drugs often cause autologous platelet damage due to lack of targeting, resulting in serious side effects.

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Retrospective analysis on incidence and risk factors for early acute renal injury after lung transplantation.

Transpl Immunol

October 2023

Department of ICU, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address:

Background: Acute renal injury (AKI) is a common complication of lung transplantation. However, there has been no related research on whether the relationship between fluid balance and input and output influences the occurrence of early AKI. This study aimed to explore the relationship between early fluid balance and input and output on the incidence of early AKI after lung transplantation.

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Introduction: The geriatric nutritional risk index (GNRI), a nutritional screening tool specifically for the aging population, has been proven to be associated with worse outcomes in chronic kidney disease patients, especially in the hemodialysis population. However, the predictive validity of GNRI in critically ill elderly patients with acute kidney injury (AKI) is yet to be determined. This analysis sought to examine the prognostic effects of GNRI on elderly AKI patients in intensive care units (ICUs).

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Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome.

Cell Death Dis

December 2022

SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Despite the high prevalence of Down syndrome (DS) and early identification of the cause (trisomy 21), its molecular pathogenesis has been poorly understood and specific treatments have consequently been practically unavailable. A number of medical conditions throughout the body associated with DS have prompted us to investigate its molecular etiology from the viewpoint of the embryonic organizer, which can steer the development of surrounding cells into specific organs and tissues. We established a DS zebrafish model by overexpressing the human DYRK1A gene, a highly haploinsufficient gene located at the "critical region" within 21q22.

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Background: Recently, a new metabolic health (MH) definition was developed from NHANES-III. In the origin study, the definition may stratify mortality risks in people who are overweight or normal weight. We aimed to investigate the association between the new MH definition and all-cause mortality in a nonobese Chinese population.

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Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress.

Commun Biol

August 2022

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Cancer cells evolve various mechanisms to overcome cellular stresses and maintain progression. Protein kinase R (PKR) and its protein activator (PACT) are the initial responders in monitoring diverse stress signals and lead to inhibition of cell proliferation and cell apoptosis in consequence. However, the regulation of PACT-PKR pathway in cancer cells remains largely unknown.

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To examine the association of fetal fraction with a wide spectrum of pregnancy-related complications among Chinese population, we carried out a single-institution retrospective cohort study of women with negative Noninvasive prenatal testing (NIPT) results and singleton pregnancies between May 2018 and May 2020. Indicators of pregnancy-related complications were examined individually, including preterm birth, low birth weight, hypertensive disorders of pregnancy, gestational diabetes, oligohydramnios and intrahepatic cholestasis. We evaluated disease odds ratios (ORs) and 95% confidence intervals (CIs), after controlling for potential confounders including body mass index (BMI), maternal age and gestational week at NIPT.

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The Efficacy and Safety of Brolucizumab for the Treatment of nAMD: A Systematic Review and Meta-Analysis.

Front Pharmacol

May 2022

Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

As demonstrated in pivotal clinical trials, brolucizumab can be used to treat neovascular age-related macular degeneration (nAMD) because it antagonizes vascular endothelial growth factor (VEGF) in the vitreous. However, brolucizumab may cause retinal vasculitis obliterans in the presence of inflammation in the eyes. In the present study, a meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of brolucizumab.

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[PM dust induces autophagy and epithelial-mesenchymal transition in human bronchial epithelial 16HBE cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi

April 2022

Southwest Medical University, Luzhou 646000; Department of Laboratory Medicine, Sichuan Mianyang 404 Hospital, Mianyang 621000, China. *Corresponding author, E-mail:

Objective To investigate the effect of particulate matter 2.5 (PM) dust on autophagy and epithelial-mesenchymal transition (EMT) in human bronchial epithelial 16HBE cells, and to further explore its underlying mechanism. Methods 16HBE cells were stimulated with PM dust, and the cell viability was evaluated by CCK-8 assay.

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New mechanism of partial duplication and deletion of chromosome 8: A case report.

World J Clin Cases

August 2021

Office of Prenatal Diagnosis, West China Second University Hospital, Sichuan University, Chengdu 610000, Sichuan Province, China.

Background: During meiosis, the recombination of homologous chromosomes produces some new heritable mutations, which are the basis of biological evolution and diversity. However, when there is pericentric inversion of chromosomes, unbalanced gametes will be formed in the process of germ cell meiosis.

Case Summary: A 23-year-old pregnant woman at 25 wk of gestation wanted to terminate her pregnancy due to fetal chromosomal abnormalities.

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[Analysis of complications in diabetic foot treated with tibial transverse transport].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi

August 2020

Department of Medicine, Mianyang People's Hospital, Mianyang Sichuan, 621000, P.R.China.

Objective: To explore the causes and management of the complications in diabetic foot treated with tibial transverse transport (TTT).

Methods: Between September 2015 and September 2019, 196 patients with diabetic foot were treated with TTT. There were 109 males and 87 females, with an average age of 67.

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Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and no effective therapies have been found to prevent or cure AD to date. Berberine and curcumin are extracts from traditional Chinese herbs that have a long history of clinical benefits for AD. Here, using a transgenic AD mouse model, we found that the combined berberine and curcumin treatment had a much better effect on improving the cognitive function of mice than the single-drug treatment, suggesting synergic effects of the combined berberine and curcumin treatment.

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Objectives: Antibacterial use in township health centres (THCs) and community health service centres (CHSCs) in a district of Sichuan Province, China, was investigated. By analysis of the common irrational use of antibacterials in such primary medical institutions, the purpose of promoting rational use of antibacterials can be achieved.

Methods: Outpatient prescriptions were randomly selected from 12 THCs and 5 CHSCs in a district of Sichuan Province from July-September 2015 and antibacterial use in these outpatient prescriptions was investigated.

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Diagnosis of hepatocellular carcinoma using a novel anti-glycocholic acid monoclonal antibody-based method.

Oncol Lett

March 2019

Department of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Glycocholic acid (GCA) is a novel identified biomarker for hepatocellular carcinoma (HCC). However, clinical pathological study of GCA has not been extensive due to the limited availability of anti-GCA monoclonal antibodies (mAbs) and restricted detection methods. In the present study, using human GCA conjugated with bovine serum albumin as the immunogen to immunize BALB/c mice, a novel anti-GCA mAb was generated and characterized.

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Background: Primary pleuropulmonary and mediastinal synovial sarcomas (PPMSSs) are extremely rare. The authors present the largest series in an Asian population.

Methods: Between 2000 and 2015, 26 genetically confirmed PPMSSs were included.

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Hyperuricemia and the Prognosis of Hypertensive Patients: A Systematic Review and Meta-Analysis.

J Clin Hypertens (Greenwich)

December 2016

Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China.

The aim of this study was to assess the prognostic value of hyperuricemia in patients with established hypertension by systematic review and meta-analysis of cohort studies. MEDLINE, Embase, and the Chinese Biomedical Literature Database were searched through January 2015. Seventeen cohort studies were included and their methodological quality was moderate to high, with Newcastle-Ottawa Scale scores ranging from 6 to 9.

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Literature analysis of Acanthopanax anaphylactic shock in China.

J Tradit Complement Med

October 2015

Department of Pharmacy, Mianyang People's Hospital, Mianyang City, China.

The aims of this study are to investigate the occurrence characteristics of Acanthopanax ( cì wǔ jiā) anaphylactic shock and to provide objective evidence for the rational use of the medicine. Fifty-seven cases of Acanthopanax anaphylactic shock were collected from several professional databases in China. The statistical data of the patients were analyzed with Visual FoxPro 6.

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The relationship between external and internal validity of randomized controlled trials: A sample of hypertension trials from China.

Contemp Clin Trials Commun

October 2015

Department of Evidence-based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the relationship between the external validity and the internal validity of hypertension RCTs conducted in China.

Methods: Comprehensive literature searches were performed in Medline, Embase, Cochrane Central Register of Controlled Trials (CCTR), CBMdisc (Chinese biomedical literature database), CNKI (China National Knowledge Infrastructure/China Academic Journals Full-text Database) and VIP (Chinese scientific journals database) as well as advanced search strategies were used to locate hypertension RCTs. The risk of bias in RCTs was assessed by a modified scale, Jadad scale respectively, and then studies with 3 or more grading scores were included for the purpose of evaluating of external validity.

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Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies.

PLoS One

December 2015

Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Observational studies of the relationship between hyperuricemia and the incidence of hypertension are controversial. We conducted a systematic review and meta-analysis to assess the association and consistency between uric acid levels and the risk of hypertension development.

Methods: We searched MEDLINE, EMBASE, CBM (Chinese Biomedicine Database) through September 2013 and reference lists of retrieved studies to identify cohort studies and nested case-control studies with uric acid levels as exposure and incident hypertension as outcome variables.

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